Fish Oil vs. Placebo on Subjective Effects of Alcohol
Alcohol Dependence
About this trial
This is an interventional treatment trial for Alcohol Dependence focused on measuring Alcohol Dependence, Fish Oil
Eligibility Criteria
Inclusion Criteria:
- Male and females, between the ages of 21 and 55;
- No current drug use disorder of any drugs of abuse (except tobacco or marijuana);
- No current medical problems and normal ECG;
- For women, not pregnant as determined by pregnancy screening nor breast feeding, and using acceptable birth control methods.
Exclusion Criteria:
- Current major psychiatric illnesses including mood, psychotic, or anxiety disorders;
- History of major medical illnesses; including liver diseases, heart disease, chronic pain or other medical conditions that the physician investigator deems contraindicated for the subject to be in the study;
- Liver function tests (ALT or AST) greater than 3 times normal;
- Allergy to seafood.
Sites / Locations
- VA Connecticut Healtcare System
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Fish Oil with ethanol and placebo ethanol infusions
Placebo with ethanol and placebo ethanol infusions
Between days 30-40 subjects will participate in 2 test days at least 2 days apart and during the test day will receive an IV infusion of ethanol (placebo vs. targeted Breath Alcohol Concentration ((BrAC) of 100mg%) in a clamped fashion. Test days will be in a randomized order.
Between days 30-40 subjects will participate in 2 test days at least 2 days apart and during the test day will receive an IV infusion of ethanol (placebo vs. targeted Breath Alcohol Concentration ((BrAC) of 100mg%) in a clamped fashion. Test days will be in a randomized order.