Effect of UGIR in Adults With Compromised Gut Function and Malabsorption

This study assessed the effect of a nutrition support product on quality of life in adults with compromised gut function and malabsorption.

This prospective, non-randomized, open-label study assessed the effect of a nutrition support product on quality of life in adults with compromised gut function and malabsorption. Adults with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) or celiac disease were enrolled in the study and asked to take the study product for 6 weeks. The primary measure of the study was a validated quality of life questionnaire, the Gastrointestinal Quality of Life Index (GIQLI). Secondary measures included the Inflammatory Bowel Disease Questionnaire (IBDQ), the Celiac Disease Questionnaire (CDQ), and the Digestive Symptom Frequency Questionnaire (DSFQ).

Nutrition support product contains macronutrients, micronutrients, glutamine, and prebiotics. Product is in powder form (41 grams per serving) and is mixed with water or juice before consumption. Taken orally as a nutritional shake twice per day.

Inclusion Criteria: Body mass index 19 - 40 kg/m2 Previous diagnosis of ulcerative colitis (UC), Crohn's disease, irritable bowel syndrome (IBS), or celiac disease Exclusion Criteria: Gastroenterologic surgery within 3 months before the study period Have a colostomy or ileostomy bag Malignancy within the last 5 years Women who are lactating, pregnant or planning pregnancy during the study period Taking antibiotic, antiparasitic, or antifungal medications Initiation of or changes to supplements or medications within 28 days prior to screening

Ryan JJ, Monteagudo-Mera A, Contractor N, Gibson GR. Impact of 2'-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings. Nutrients. 2021 Mar 14;13(3):938. doi: 10.3390/nu13030938.