Preemptive Versus Preventive Antiemetic Treatment
Postoperative Nausea and Vomiting
About this trial
This is an interventional prevention trial for Postoperative Nausea and Vomiting
Eligibility Criteria
Inclusion Criteria:
- ASA physical status I-III patients
- Surgical procedure: scheduled for laparoscopic cholecystectomy
- Type of anesthesia: general
Exclusion Criteria:
- Antihistamines the last three days
- Antiemetic drugs the last three days
- Hiatus hernia
- reflux
- Gastrointestinal disease
- Pregnancy
- BMI > 35
- parkinson
- known allergy to the drugs of the protocol
- epilepsy
Sites / Locations
- Aretaieio University Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Other
preemptive group
intraoperative group
The preemptive group will receive the anti-emetic regimen i.v. (4 mg of ondansetron) 1h before the start of surgery. During surgery, 30 min before the end of operation, this group will receive i.v. 0.9% NaCl in equal volumes.The intervention consists of the different time points of antiemetic treatment, thus 1h before surgery vs intraopertively. Intervention: Antiemetic treatment 1h before surgery
The preventive group will receive i.v. 0.9% NaCl 1h before surgery and ondansetron 4 mg 30 min before the end of surgery at equal volumes. Intervention: Antiemetic treatment intraoperatively