Vessel Injury in Relation With Strut Thickness Assessed by OCT (VISTA)

Vessel Injury in Relation With Strut Thickness Assessed by OCT (VISTA): A Comparison of Vascular Injury Induced by a Polymer Free Sirolimus and Probucol Eluting Stent and a Biodegradable-polymer Biolimus-eluting Stent

The objective of the present study is to determine the relation between vascular injury induced by the stent and strut thickness.

Thinner struts produce less arterial injury after stent implantation.The objective of the present study is to determine the relation between vascular injury induced by the stent and strut thickness. Vessel injury after stent implantation will be evaluated with optical coherence tomography (OCT). Two stents platforms with different strut thickness (Coroflex ISAR 50 microns and Biomatrix 120 microns) will be compared.

PCI with a polymer-free dual-drug sirolimus- and probucol-eluting stent (Coroflex ISAR stent) with very thin struts (50 µm). During the PCI, an OCT assessment (baseline and post-implantation) will be performed.

PCI with a biodegradable-polymer biolimus-eluting stent (Biomatrix stent) with 120 µm struts. During the PCI, an OCT assessment (baseline and post-implantation) will be performed.

Tissue prolapse area assessed by OCT after implantation of Coroflex-ISAR and Biomatrix will be measured

Inclusion Criteria: Patients older than 18 years Ischemic symptoms or evidence of myocardial ischemia (inducible or spontaneous) in the presence of >50% de novo stenosis located in native coronary vessels Exclusion Criteria: Target lesion located in the left main stem STEMI Restenosis Cardiogenic shock Malignancies or other comorbid conditions with life expectancy less than 12 months or that may result in protocol noncompliance Known allergy to the study medications (probucol, sirolimus, zotarolimus) Pregnancy (present, suspected, or planned)

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