Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
Keratoconus, Corneal Diseases, Eye Diseases
About this trial
This is an interventional treatment trial for Keratoconus focused on measuring Keratoconus, Forme fruste keratoconus, Post-LASIK ectasia, Pellucid marginal degeneration, Forme fruste pellucid marginal degeneration, Diurnal fluctuation post-radial keratotomy, Terrien's marginal degeneration
Eligibility Criteria
Inclusion Criteria:
A diagnosis of at least one of the following conditions:
- Keratoconus
- Forme fruste keratoconus
- Post-LASIK ectasia
- Pellucid marginal degeneration
- Forme fruste pellucid marginal degeneration
- Diurnal fluctuation post-radial keratotomy
- Terrien's marginal degeneration
Exclusion Criteria:
- Corneal thickness < 375 microns measured by ultrasound or Pentacam.
- Contraindications or hypersensitivities to any study medications or their components.
- Pregnancy or breastfeeding.
- Any history of herpes simplex corneal disease in an eye to be treated.
- Nystagmus or any other condition that would, in the judgement of the investigator, prevent a steady gaze during the treatment.
- Inability to cooperate with diagnostic tests.
- Enrollment in another ophthalmic clinical trial.
Sites / Locations
- Schwartz Laser Eye Center
- Goodman Eye Center
- Cornea Consultants of Colorado
- Woolfson Eye Institute
- Chicago Cornea Consultants
- Chicago Cornea Consultants, Ltd.
- Ophthalmology Associates
- Cleveland Eye Clinic
- Cornea Associates of Texas
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
Group 1
Group 2
Group 3
Ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) using CXLO Corneal Strengthening Solution and a UVA irradiance of 4 mW/cm2 cycled On/Off at 15 second intervals for 20 minutes.
Ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) using CXLO Corneal Strengthening Solution and a UVA irradiance of 6 mW/cm2 cycled On/Off at 15 second intervals for 20 minutes.
Ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) using CXLO Corneal Strengthening Solution and a UVA irradiance of 4 mW/cm2 cycled On/Off at 15 second intervals for 30 minutes.