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Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure (CONNECT-HF)

Primary Purpose

Heart Failure

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Digital Engagement
Direct Engagement
Sponsored by
Duke University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Heart Failure focused on measuring Heart Failure, Quality Improvement

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Age ≥ 18 years

  • Acute HF as a primary cause of hospitalization

    • Hospitalizations for acute HF will be determined by local clinician-investigators but should include the following:
    • Symptoms (eg, dyspnea, fatigue), signs (eg, elevated jugular venous pressure, peripheral edema), or laboratory/imaging evidence of HF (eg, pulmonary congestion on chest x-ray, elevated natriuretic peptide levels) during the hospitalization and
    • Treatments aimed at acute HF (eg, intravenous diuretics, vasodilators, or inotropes)
  • LVEF ≤ 40% based on last local measurement using echocardiography, multigated acquisition scan, computed tomography (CT) scanning, magnetic resonance imaging, or ventricular angiography
  • Planned discharge to home or other supported care facility where patients are individually responsible for medication management

Exclusion Criteria:

  • Prior heart transplant or current/planned left ventricular assistance device
  • Chronic kidney disease requiring dialysis
  • Terminal illness other than HF, such as malignancy, or with a life expectancy of less than 1 year as determined by the enrolling clinician-investigator
  • Unable to participate in longitudinal follow-up, such as plans to move outside the US in the following year

Sites / Locations

  • University of Alabama Hospital
  • Providence Alaska Medical Center
  • Sparks Regional Medical Center
  • Arkansas Heart Hospital and Clinics
  • San Gorgonio Memorial Hospital
  • Memorial Medical Center
  • Dignity Health Sequoia Hospital
  • Riverside Community Hospital
  • Sutter Medical Center
  • Stanford University
  • Torrance Memorial Medical Center
  • University of Colorado Hospital
  • UC Health Memorial
  • Northern Colorado Medical Center
  • Stamford Hospital
  • JFK Medical Center
  • Manatee Memorial Hospital
  • Blake Medical Center
  • Broward Health Imperial Point
  • Holy Cross Hospital
  • Broward Health Medical Center
  • Mayo Clinic Florida
  • Orlando Health
  • Cardiovascular Institute of Northwest Florida
  • Baptist Hospital
  • Sacred Heart Hospital
  • Bayfront Health - St. Petersburg
  • Northside Hospital
  • Sarasota Memorial Hospital
  • South Miami Hospital
  • Florida Hospital Tampa
  • St. Joseph's Hospital
  • Winter Haven Hospital
  • Piedmont Athens Regional Medical Center
  • Grady Memorial Hospital
  • AU Medical Center
  • Northeast Georgia Medical Center
  • Medical Center, Navicent Health (THE)
  • The Queens Medical Center
  • Copley Memorial Hospital
  • Presence Mercy Medical Center
  • John H. Stroger Jr. Hospital of Cook County
  • University of Illinois Hospital and Health Sciences System
  • Specialty Physicians of Illinois
  • Saint Anthony Medical Center
  • St Johns Hospital
  • The Carle Foundation Hospital
  • Indiana University Health Bloomington
  • Indiana University Health Ball Memorial Hospital
  • Reid Health
  • Genesis Medical Center-Davenport
  • King's Daughters Medical Center
  • KentuckyOne Health - Saint Joseph Hospital
  • Norton Women and Children's Hospital
  • Norton Brownsboro Hospital
  • Baptist Health Madisonville
  • Rapides Regional Medical Center
  • Natchitoches Regional Medical Center
  • Ochsner Medical Center
  • Louisiana State University-Health Science Center- Shreveport
  • Anne Arundel Medical Center
  • Sinai Hospital of Baltimore
  • Suburban Hospital
  • MedStar Southern Maryland Hospital Center
  • Johns Hopkins University
  • Adventist HealthCare Shady Grove
  • Beth Israel Deaconess Medical Center
  • Cape Code Hospital
  • St. Joseph Mercy Hospital
  • Wayne State University
  • Henry Ford Health System
  • St. John Hospital and Medical Center
  • Hurley Medical Center
  • Spectrum Health
  • McLaren Greater Lansing
  • St. John Macomb-Oakland
  • MidMichigan Medical Center Midland
  • McLaren Macomb
  • McLaren - Northern Michigan
  • Lakeland Hospital
  • St. John Macomb Hospital
  • St Lukes Hospital
  • Memorial Hospital at Gulfport
  • St. Mary's Medical Center
  • St. Joseph Medical Center
  • North Kansas City Hospital
  • Cox Medical Centers
  • Billings Clinic Hospital
  • Glacier View Research Institute-Cardiology
  • Bryan Medical Center
  • University Medical Center
  • Southern NH Medical Center
  • Our Lady of Lourdes Medical Center
  • Englewood Hospital and Medical Center
  • Monmouth Medical Center
  • Jersey Shore University Medical Center
  • Saint Michael's Medical Center
  • AtlantiCare Regional Medical Center
  • Valley Hospital
  • Robert Wood Johnson University Hospital Somerset
  • Holy Name Medical Center
  • University of New Mexico Health Sciences Center
  • Albany Medical Center Hospital
  • St. Peter's Hospital
  • Montefiore Medical Center
  • Huntington Hospital
  • United Health Services Hospitals
  • Mount Sinai Beth Israel
  • Ellis Hospital
  • Staten Island University Hospital
  • Richmond University Medical Center
  • University Hospital (Stony Brook)
  • St. Joseph's Hospital
  • Charlotte-Mecklenburg Hospital Authority
  • Duke University Hospital
  • Duke Cardiology of Lumberton
  • Duke Raleigh Hospital
  • WakeMed
  • New Hanover Regional Medical Center
  • Novant Health Forsyth Medical Center
  • Altru Health System
  • Summa Health
  • Miami Valley Hospital
  • University Hospitals - Elyria Medical Center
  • Springfield Regional Medical Center
  • Oklahoma University Health Science Center
  • Integris Baptist Medical Center
  • OHSU Hospital and Clinics
  • Memorial Medical Center
  • WellSpan Good Samaritan Hospital
  • Self Regional Healthcare
  • Jackson-Madison County General Hospital
  • University of Tennessee Medical Center
  • Baptist Memorial Hospital
  • Centennial Medical Center
  • Texas Cardiac Arrhythmia Research Foundation
  • Medical City Dallas Hospital
  • Plaza Medical Center of Fort Worth
  • Ben Taub General Hospital
  • Christus Good Shepherd Medical Center
  • The Heart Hospital Baylor Plano
  • Methodist Hospital
  • Guadalupe Regional Medical Center
  • University of Texas Health Science Center at Tyler
  • Inova Alexandria Hospital
  • Riverside Regional Medical Center
  • Sentara Norfolk General Hospital
  • CJW Medical Center
  • Harborview Medical Center
  • Wheeling Hospital
  • Mayo Clinic Health System Franciscan Medical Center
  • Ascension Columbia St. Mary's Hospital
  • Ascension-All Saints
  • Waukesha Memorial Hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Other

Other

Other

No Intervention

Arm Label

Direct & Digital

Direct & Registry

Digital & Registry

Registry

Arm Description

Health system engagement to improve local QI programs and patient engagement to improve self-management/medication adherence

Health system engagement to improve local QI programs and patient and control

Patient engagement to improve self-management/medication adherence and control

Control

Outcomes

Primary Outcome Measures

Time-to-first HF rehospitalization or death during the 12-months post-discharge
Improvement in an opportunity-based composite score of adherence to quality metrics for HF.
The opportunity-based composite score will be created to grade the quality of care provided. The numerator will be the number of times that good care is provided; the denominator will be the number of opportunities available. The score will consist of the following quality metrics assessed at the time of hospital discharge and during outpatient follow-up: Use of evidence-based specific β-blockers at ≥ 50% target dose ACE-I, ARB, or sacubitril/valsartan use at ≥ 50% target dose Aldosterone antagonist use Anticoagulation use in participants with atrial fibrillation In participants with an LVEF ≤ 35%, implantable cardioverter defibrillator placement including cardiac resynchronization therapy placement for participants with sinus rhythm, LBBB, and a QRS ≥ 150 ms Attendance at 1 or more of the following: a multidisciplinary HF disease management program, a cardiac rehabilitation program, or HF group educational classes

Secondary Outcome Measures

Improvement in an opportunity-based composite score for adherence to HF discharge quality measures
The opportunity-based composite score will be created to grade the quality of care provided. The numerator will be adherence to medications; the denominator will be the number of opportunities available. The per-opportunity adherence rate will consist of the following quality metrics assessed at the time of hospital discharge: ACE-I, ARB, or sacubitril/valsartan prescription at discharge ß-blocker prescription at discharge Discharge instructions addressing activity level, diet, discharge medications, follow-up appointment, weight monitoring, and how to respond to a change in symptoms LVEF assessment Smoking cessation counseling Medication adherence
If there is a significant positive effect on at least one of the primary endpoints, then participant-level healthcare expenditures
Cumulative number of primary composite events of death and total (first and recurrent) HF hospitalizations

Full Information

First Posted
January 5, 2017
Last Updated
January 22, 2021
Sponsor
Duke University
Collaborators
Duke Clinical Research Institute
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1. Study Identification

Unique Protocol Identification Number
NCT03035474
Brief Title
Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure
Acronym
CONNECT-HF
Official Title
Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure (CONNECT-HF)
Study Type
Interventional

2. Study Status

Record Verification Date
December 2020
Overall Recruitment Status
Completed
Study Start Date
April 21, 2017 (Actual)
Primary Completion Date
December 31, 2020 (Actual)
Study Completion Date
December 31, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Duke University
Collaborators
Duke Clinical Research Institute

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
CONNECT-HF is a large-scale, pragmatic, cluster-randomized clinical trial to evaluate the effect of a customized, multifaceted, health system-level quality-improvement (QI) program compared with usual care on heart failure (HF) outcomes and HF quality-of-care metrics.
Detailed Description
This trial will be a large-scale, pragmatic, cluster-randomized clinical trial to evaluate the effect of a customized, multifaceted, health system-level quality-improvement (QI) program compared with usual care on heart failure (HF) outcomes and HF quality-of-care metrics. Outcomes will be assessed following discharge for participants hospitalized with acute HF and reduced left ventricular ejection fraction. All participants in the trial will be consented for follow-up as part of the CONNECT-HF registry on clinical outcomes, medication use, and participant-centered outcomes, including quality-of-life (QOL) assessments will be collected up to 12 months post-discharge at pre-specified intervals (6 weeks and 3, 6, and 12 months). The health-system QI program will involve site visits and ongoing mentoring from teams of healthcare professionals with specialized training and field experience to help health systems and individual hospitals to design local QI plans. A key substudy will assess a participant-engagement strategy (digital) of a mobile application utilizing behavioral tools to reinforce health behaviors, including self-monitoring/self-management and medication adherence. Follow-up will occur via a centralized telephone interview by trained personnel via the DCRI Call Center. At each interview, participants will be asked to report current medications, rehospitalizations, and QOL assessments. Based on participant-reported events, medical billing data for rehospitalizations, emergency department visits, and procedures will be obtained. Quality of life assessments will include the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQOL five dimensions questionnaire (EQ-5D).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heart Failure
Keywords
Heart Failure, Quality Improvement

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Factorial Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
5749 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Direct & Digital
Arm Type
Other
Arm Description
Health system engagement to improve local QI programs and patient engagement to improve self-management/medication adherence
Arm Title
Direct & Registry
Arm Type
Other
Arm Description
Health system engagement to improve local QI programs and patient and control
Arm Title
Digital & Registry
Arm Type
Other
Arm Description
Patient engagement to improve self-management/medication adherence and control
Arm Title
Registry
Arm Type
No Intervention
Arm Description
Control
Intervention Type
Other
Intervention Name(s)
Digital Engagement
Intervention Description
Patient engagement to improve self-management/medication adherence
Intervention Type
Other
Intervention Name(s)
Direct Engagement
Intervention Description
Health system engagement to improve local QI programs
Primary Outcome Measure Information:
Title
Time-to-first HF rehospitalization or death during the 12-months post-discharge
Time Frame
12-months after discharge
Title
Improvement in an opportunity-based composite score of adherence to quality metrics for HF.
Description
The opportunity-based composite score will be created to grade the quality of care provided. The numerator will be the number of times that good care is provided; the denominator will be the number of opportunities available. The score will consist of the following quality metrics assessed at the time of hospital discharge and during outpatient follow-up: Use of evidence-based specific β-blockers at ≥ 50% target dose ACE-I, ARB, or sacubitril/valsartan use at ≥ 50% target dose Aldosterone antagonist use Anticoagulation use in participants with atrial fibrillation In participants with an LVEF ≤ 35%, implantable cardioverter defibrillator placement including cardiac resynchronization therapy placement for participants with sinus rhythm, LBBB, and a QRS ≥ 150 ms Attendance at 1 or more of the following: a multidisciplinary HF disease management program, a cardiac rehabilitation program, or HF group educational classes
Time Frame
Baseline to 12 months post discharge
Secondary Outcome Measure Information:
Title
Improvement in an opportunity-based composite score for adherence to HF discharge quality measures
Description
The opportunity-based composite score will be created to grade the quality of care provided. The numerator will be adherence to medications; the denominator will be the number of opportunities available. The per-opportunity adherence rate will consist of the following quality metrics assessed at the time of hospital discharge: ACE-I, ARB, or sacubitril/valsartan prescription at discharge ß-blocker prescription at discharge Discharge instructions addressing activity level, diet, discharge medications, follow-up appointment, weight monitoring, and how to respond to a change in symptoms LVEF assessment Smoking cessation counseling Medication adherence
Time Frame
Baseline through study completion, an average of 3 years
Title
If there is a significant positive effect on at least one of the primary endpoints, then participant-level healthcare expenditures
Time Frame
6 months and 1 year postdischarge
Title
Cumulative number of primary composite events of death and total (first and recurrent) HF hospitalizations
Time Frame
Baseline through study completion, an average of 3 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years Acute HF as a primary cause of hospitalization Hospitalizations for acute HF will be determined by local clinician-investigators but should include the following: Symptoms (eg, dyspnea, fatigue), signs (eg, elevated jugular venous pressure, peripheral edema), or laboratory/imaging evidence of HF (eg, pulmonary congestion on chest x-ray, elevated natriuretic peptide levels) during the hospitalization and Treatments aimed at acute HF (eg, intravenous diuretics, vasodilators, or inotropes) LVEF ≤ 40% based on last local measurement using echocardiography, multigated acquisition scan, computed tomography (CT) scanning, magnetic resonance imaging, or ventricular angiography Planned discharge to home or other supported care facility where patients are individually responsible for medication management Exclusion Criteria: Prior heart transplant or current/planned left ventricular assistance device Chronic kidney disease requiring dialysis Terminal illness other than HF, such as malignancy, or with a life expectancy of less than 1 year as determined by the enrolling clinician-investigator Unable to participate in longitudinal follow-up, such as plans to move outside the US in the following year
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Adam DeVore, MD, MHS
Organizational Affiliation
Duke University
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Alabama Hospital
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233
Country
United States
Facility Name
Providence Alaska Medical Center
City
Anchorage
State/Province
Alaska
ZIP/Postal Code
99508
Country
United States
Facility Name
Sparks Regional Medical Center
City
Fort Smith
State/Province
Arkansas
ZIP/Postal Code
72901
Country
United States
Facility Name
Arkansas Heart Hospital and Clinics
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72211
Country
United States
Facility Name
San Gorgonio Memorial Hospital
City
Banning
State/Province
California
ZIP/Postal Code
92220
Country
United States
Facility Name
Memorial Medical Center
City
Modesto
State/Province
California
ZIP/Postal Code
95355
Country
United States
Facility Name
Dignity Health Sequoia Hospital
City
Redwood City
State/Province
California
ZIP/Postal Code
94062
Country
United States
Facility Name
Riverside Community Hospital
City
Riverside
State/Province
California
ZIP/Postal Code
92501
Country
United States
Facility Name
Sutter Medical Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Stanford University
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
Facility Name
Torrance Memorial Medical Center
City
Torrance
State/Province
California
ZIP/Postal Code
90505
Country
United States
Facility Name
University of Colorado Hospital
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
UC Health Memorial
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Northern Colorado Medical Center
City
Greeley
State/Province
Colorado
ZIP/Postal Code
80631
Country
United States
Facility Name
Stamford Hospital
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06904
Country
United States
Facility Name
JFK Medical Center
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
Manatee Memorial Hospital
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34208
Country
United States
Facility Name
Blake Medical Center
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Facility Name
Broward Health Imperial Point
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
Holy Cross Hospital
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
Broward Health Medical Center
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Mayo Clinic Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
Orlando Health
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Cardiovascular Institute of Northwest Florida
City
Panama City
State/Province
Florida
ZIP/Postal Code
32401
Country
United States
Facility Name
Baptist Hospital
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32501
Country
United States
Facility Name
Sacred Heart Hospital
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32504
Country
United States
Facility Name
Bayfront Health - St. Petersburg
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33701
Country
United States
Facility Name
Northside Hospital
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33709
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
South Miami Hospital
City
South Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Florida Hospital Tampa
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
St. Joseph's Hospital
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Winter Haven Hospital
City
Winter Haven
State/Province
Florida
ZIP/Postal Code
33881
Country
United States
Facility Name
Piedmont Athens Regional Medical Center
City
Athens
State/Province
Georgia
ZIP/Postal Code
30606
Country
United States
Facility Name
Grady Memorial Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
AU Medical Center
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Northeast Georgia Medical Center
City
Gainesville
State/Province
Georgia
ZIP/Postal Code
30501
Country
United States
Facility Name
Medical Center, Navicent Health (THE)
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
The Queens Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Copley Memorial Hospital
City
Aurora
State/Province
Illinois
ZIP/Postal Code
60504
Country
United States
Facility Name
Presence Mercy Medical Center
City
Aurora
State/Province
Illinois
ZIP/Postal Code
60506
Country
United States
Facility Name
John H. Stroger Jr. Hospital of Cook County
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
University of Illinois Hospital and Health Sciences System
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Specialty Physicians of Illinois
City
Olympia Fields
State/Province
Illinois
ZIP/Postal Code
60461
Country
United States
Facility Name
Saint Anthony Medical Center
City
Rockford
State/Province
Illinois
ZIP/Postal Code
61108
Country
United States
Facility Name
St Johns Hospital
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62702
Country
United States
Facility Name
The Carle Foundation Hospital
City
Urbana
State/Province
Illinois
ZIP/Postal Code
61801
Country
United States
Facility Name
Indiana University Health Bloomington
City
Bloomington
State/Province
Indiana
ZIP/Postal Code
47403
Country
United States
Facility Name
Indiana University Health Ball Memorial Hospital
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47303
Country
United States
Facility Name
Reid Health
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47374
Country
United States
Facility Name
Genesis Medical Center-Davenport
City
Davenport
State/Province
Iowa
ZIP/Postal Code
52803
Country
United States
Facility Name
King's Daughters Medical Center
City
Ashland
State/Province
Kentucky
ZIP/Postal Code
41101
Country
United States
Facility Name
KentuckyOne Health - Saint Joseph Hospital
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40504
Country
United States
Facility Name
Norton Women and Children's Hospital
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40205
Country
United States
Facility Name
Norton Brownsboro Hospital
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40241
Country
United States
Facility Name
Baptist Health Madisonville
City
Madisonville
State/Province
Kentucky
ZIP/Postal Code
42431
Country
United States
Facility Name
Rapides Regional Medical Center
City
Alexandria
State/Province
Louisiana
ZIP/Postal Code
71301
Country
United States
Facility Name
Natchitoches Regional Medical Center
City
Natchitoches
State/Province
Louisiana
ZIP/Postal Code
71457
Country
United States
Facility Name
Ochsner Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Louisiana State University-Health Science Center- Shreveport
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71103
Country
United States
Facility Name
Anne Arundel Medical Center
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Sinai Hospital of Baltimore
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21215
Country
United States
Facility Name
Suburban Hospital
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20814
Country
United States
Facility Name
MedStar Southern Maryland Hospital Center
City
Clinton
State/Province
Maryland
ZIP/Postal Code
20735
Country
United States
Facility Name
Johns Hopkins University
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21044
Country
United States
Facility Name
Adventist HealthCare Shady Grove
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Cape Code Hospital
City
Hyannis
State/Province
Massachusetts
ZIP/Postal Code
02601
Country
United States
Facility Name
St. Joseph Mercy Hospital
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
Wayne State University
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Henry Ford Health System
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
St. John Hospital and Medical Center
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48236
Country
United States
Facility Name
Hurley Medical Center
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Facility Name
Spectrum Health
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
McLaren Greater Lansing
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
Facility Name
St. John Macomb-Oakland
City
Madison Heights
State/Province
Michigan
ZIP/Postal Code
48071
Country
United States
Facility Name
MidMichigan Medical Center Midland
City
Midland
State/Province
Michigan
ZIP/Postal Code
48670
Country
United States
Facility Name
McLaren Macomb
City
Mount Clemens
State/Province
Michigan
ZIP/Postal Code
48043
Country
United States
Facility Name
McLaren - Northern Michigan
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
Lakeland Hospital
City
Saint Joseph
State/Province
Michigan
ZIP/Postal Code
49085
Country
United States
Facility Name
St. John Macomb Hospital
City
Warren
State/Province
Michigan
ZIP/Postal Code
48093
Country
United States
Facility Name
St Lukes Hospital
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Memorial Hospital at Gulfport
City
Gulfport
State/Province
Mississippi
ZIP/Postal Code
39502
Country
United States
Facility Name
St. Mary's Medical Center
City
Blue Springs
State/Province
Missouri
ZIP/Postal Code
64014
Country
United States
Facility Name
St. Joseph Medical Center
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64114
Country
United States
Facility Name
North Kansas City Hospital
City
North Kansas City
State/Province
Missouri
ZIP/Postal Code
64116
Country
United States
Facility Name
Cox Medical Centers
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65807
Country
United States
Facility Name
Billings Clinic Hospital
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Glacier View Research Institute-Cardiology
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Bryan Medical Center
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68506
Country
United States
Facility Name
University Medical Center
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89102
Country
United States
Facility Name
Southern NH Medical Center
City
Nashua
State/Province
New Hampshire
ZIP/Postal Code
03060
Country
United States
Facility Name
Our Lady of Lourdes Medical Center
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08103
Country
United States
Facility Name
Englewood Hospital and Medical Center
City
Englewood
State/Province
New Jersey
ZIP/Postal Code
07631
Country
United States
Facility Name
Monmouth Medical Center
City
Long Branch
State/Province
New Jersey
ZIP/Postal Code
07740
Country
United States
Facility Name
Jersey Shore University Medical Center
City
Neptune
State/Province
New Jersey
ZIP/Postal Code
07753
Country
United States
Facility Name
Saint Michael's Medical Center
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07102
Country
United States
Facility Name
AtlantiCare Regional Medical Center
City
Pomona
State/Province
New Jersey
ZIP/Postal Code
08240
Country
United States
Facility Name
Valley Hospital
City
Ridgewood
State/Province
New Jersey
ZIP/Postal Code
07450
Country
United States
Facility Name
Robert Wood Johnson University Hospital Somerset
City
Somerville
State/Province
New Jersey
ZIP/Postal Code
08876
Country
United States
Facility Name
Holy Name Medical Center
City
Teaneck
State/Province
New Jersey
ZIP/Postal Code
07666
Country
United States
Facility Name
University of New Mexico Health Sciences Center
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131
Country
United States
Facility Name
Albany Medical Center Hospital
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
St. Peter's Hospital
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Montefiore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10467
Country
United States
Facility Name
Huntington Hospital
City
Huntington
State/Province
New York
ZIP/Postal Code
11743
Country
United States
Facility Name
United Health Services Hospitals
City
Johnson City
State/Province
New York
ZIP/Postal Code
13790
Country
United States
Facility Name
Mount Sinai Beth Israel
City
New York
State/Province
New York
ZIP/Postal Code
10003
Country
United States
Facility Name
Ellis Hospital
City
Schenectady
State/Province
New York
ZIP/Postal Code
12309
Country
United States
Facility Name
Staten Island University Hospital
City
Staten Island
State/Province
New York
ZIP/Postal Code
10305
Country
United States
Facility Name
Richmond University Medical Center
City
Staten Island
State/Province
New York
ZIP/Postal Code
10310
Country
United States
Facility Name
University Hospital (Stony Brook)
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
St. Joseph's Hospital
City
Syracuse
State/Province
New York
ZIP/Postal Code
13203
Country
United States
Facility Name
Charlotte-Mecklenburg Hospital Authority
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Facility Name
Duke University Hospital
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
Duke Cardiology of Lumberton
City
Lumberton
State/Province
North Carolina
ZIP/Postal Code
28358
Country
United States
Facility Name
Duke Raleigh Hospital
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
WakeMed
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27610
Country
United States
Facility Name
New Hanover Regional Medical Center
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28402
Country
United States
Facility Name
Novant Health Forsyth Medical Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Altru Health System
City
Grand Forks
State/Province
North Dakota
ZIP/Postal Code
58201
Country
United States
Facility Name
Summa Health
City
Akron
State/Province
Ohio
ZIP/Postal Code
44304
Country
United States
Facility Name
Miami Valley Hospital
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45409
Country
United States
Facility Name
University Hospitals - Elyria Medical Center
City
Elyria
State/Province
Ohio
ZIP/Postal Code
44035
Country
United States
Facility Name
Springfield Regional Medical Center
City
Springfield
State/Province
Ohio
ZIP/Postal Code
45504
Country
United States
Facility Name
Oklahoma University Health Science Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Integris Baptist Medical Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
OHSU Hospital and Clinics
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Memorial Medical Center
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
WellSpan Good Samaritan Hospital
City
Lebanon
State/Province
Pennsylvania
ZIP/Postal Code
17042
Country
United States
Facility Name
Self Regional Healthcare
City
Greenwood
State/Province
South Carolina
ZIP/Postal Code
29646
Country
United States
Facility Name
Jackson-Madison County General Hospital
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38301
Country
United States
Facility Name
University of Tennessee Medical Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Facility Name
Baptist Memorial Hospital
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38120
Country
United States
Facility Name
Centennial Medical Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Texas Cardiac Arrhythmia Research Foundation
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Medical City Dallas Hospital
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Plaza Medical Center of Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Ben Taub General Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Christus Good Shepherd Medical Center
City
Longview
State/Province
Texas
ZIP/Postal Code
75601
Country
United States
Facility Name
The Heart Hospital Baylor Plano
City
Plano
State/Province
Texas
ZIP/Postal Code
75093
Country
United States
Facility Name
Methodist Hospital
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Guadalupe Regional Medical Center
City
Seguin
State/Province
Texas
ZIP/Postal Code
78155
Country
United States
Facility Name
University of Texas Health Science Center at Tyler
City
Tyler
State/Province
Texas
ZIP/Postal Code
75708
Country
United States
Facility Name
Inova Alexandria Hospital
City
Alexandria
State/Province
Virginia
ZIP/Postal Code
22304
Country
United States
Facility Name
Riverside Regional Medical Center
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23601
Country
United States
Facility Name
Sentara Norfolk General Hospital
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
CJW Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23235
Country
United States
Facility Name
Harborview Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Wheeling Hospital
City
Wheeling
State/Province
West Virginia
ZIP/Postal Code
26003
Country
United States
Facility Name
Mayo Clinic Health System Franciscan Medical Center
City
La Crosse
State/Province
Wisconsin
ZIP/Postal Code
54601
Country
United States
Facility Name
Ascension Columbia St. Mary's Hospital
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53211
Country
United States
Facility Name
Ascension-All Saints
City
Racine
State/Province
Wisconsin
ZIP/Postal Code
53405
Country
United States
Facility Name
Waukesha Memorial Hospital
City
Waukesha
State/Province
Wisconsin
ZIP/Postal Code
53188
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
35905867
Citation
Rao VN, Kaltenbach LA, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Butler J, Allen LA, Lanfear DE, Ariely D, Miller JM, Brodsky MA, Lalonde TA, Lafferty JC, Granger CB, Hernandez AF, Devore AD; Durham, North Carolina; Los Angeles, California; Cleveland, Ohio; Jackson, Misssissippi, Aurora, Colorado; Detroit, Michigan; Ewa Beach, Hawaii; Staten Island, New York. The Association of Digital Health Application Use With Heart Failure Care and Outcomes: Insights From CONNECT-HF. J Card Fail. 2022 Oct;28(10):1487-1496. doi: 10.1016/j.cardfail.2022.07.050. Epub 2022 Jul 26.
Results Reference
derived
PubMed Identifier
34313687
Citation
DeVore AD, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Lewis EF, Butler J, Pina IL, Allen LA, Yancy CW, Cooper LB, Felker GM, Kaltenbach LA, McRae AT, Lanfear DE, Harrison RW, Disch M, Ariely D, Miller JM, Granger CB, Hernandez AF. Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial. JAMA. 2021 Jul 27;326(4):314-323. doi: 10.1001/jama.2021.8844.
Results Reference
derived
PubMed Identifier
31770656
Citation
DeVore AD, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Lewis EF, Butler J, Pina IL, Heidenreich PA, Allen LA, Yancy CW, Cooper LB, Felker GM, Kaltenbach LA, McRae AT, Lanfear DE, Harrison RW, Kociol RD, Disch M, Ariely D, Miller JM, Granger CB, Hernandez AF. Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF. Am Heart J. 2020 Feb;220:41-50. doi: 10.1016/j.ahj.2019.09.012. Epub 2019 Oct 23.
Results Reference
derived

Learn more about this trial

Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure

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