Back to resultsStudy to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure (DAPA-HF)
Primary Purpose
Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Dapagliflozin
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) focused on measuring HFrEF, Heart Failure (HF), Cardiovascular Events (CV), Phase III outcome trial
Eligibility Criteria
Inclusion Criteria:
- Provision of signed informed consent prior to any study specific procedures
- Male or female, aged ≥18 years
- Established documented diagnosis of symptomatic HFrEF (NYHA functional class II-IV), which has been present for at least 2 months
- LVEF≤40%
- Elevated NT-proBNP levels
- Patients should receive background standard of care for HFrEF and be treated according to locally recognized guidelines
- eGFR ≥30 mL/min/1.73 m^2 (CKD-EPI formula) at enrolment (visit 1)
Exclusion Criteria:
- Receiving therapy with an SGLT2 inhibitor within 8 weeks prior to enrolment or previous intolerance of an SGLT2 inhibitor
- Type 1 diabetes mellitus
- Symptomatic hypotension or systolic BP <95 mmHg at 2 out of 3 measurements either at visit 1 or visit 2
- Current acute decompensated HF or hospitalization due to decompensated HF <4 weeks prior to enrolment
- MI, unstable angina, stroke or transient ischemic attack within 12 weeks prior to enrolment
- Coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or valvular repair/replacement within 12 weeks prior to enrolment or planned to undergo any of these operations after randomization
- Implantation of a CRT within 12 weeks prior to enrolment or intent to implant a CRT device
- Previous cardiac transplantation or implantation of a ventricular assistance device or similar device, or implantation expected after randomization
- HF due to restrictive cardiomyopathy, active myocarditis, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease
- Symptomatic bradycardia or second or third degree heart block without a pacemaker
- Severe (eGFR <30 mL/min/1.73 m^2 by CKD-EPI), unstable or rapidly progressing renal disease at the time of randomization
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Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Dapagliflozin
Placebo
Arm Description
Patients will be randomized 1:1 to either dapagliflozin or placebo.
Placebo matching dapagliflozin.
Outcomes
Primary Outcome Measures
Subjects Included in the Composite Endpoint of CV Death, Hospitalization Due to Heart Failure or Urgent Visit Due to Heart Failure.
Primary efficacy
Secondary Outcome Measures
Subjects Included in the Composite Endpoint of CV Death or Hospitalization Due to Heart Failure.
Secondary
Events Included in the Composite Endpoint of Recurrent Hospitalizations Due to Heart Failure and CV Death.
Secondary
Change From Baseline in the KCCQ Total Symptom Score
KCCQ is a 23-item, self-administered instrument that quantifies physical function, symptoms (frequency, severity and recent change), social function, self-efficacy and knowledge, and quality of life. The KCCQ total symptom score incorporates the symptom domains into a single score. Scores are transformed to a range of 0-100, in which higher scores reflect better health status.
Subjects Included in the Composite Endpoint of ≥50% Sustained Decline in eGFR, ESRD or Renal Death.
Secondary
Subjects Included in the Endpoint of All-cause Mortality.
Secondary
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03036124
Brief Title
Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure
Acronym
DAPA-HF
Official Title
Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure With Reduced Ejection Fraction
Study Type
Interventional
2. Study Status
Record Verification Date
August 2020
Overall Recruitment Status
Completed
Study Start Date
February 8, 2017 (Actual)
Primary Completion Date
July 17, 2019 (Actual)
Study Completion Date
July 17, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AstraZeneca
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of worsening heart failure or cardiovascular death in patients with chronic heart failure with reduced ejection fraction
Detailed Description
This is an international, multicentre, parallel group, event-driven, randomized, double-blind, placebo-controlled study in patients with chronic heart failure with reduced ejection fraction (HFrEF), evaluating the effect of dapagliflozin versus placebo, given once daily in addition to background regional standard of care therapy, for the prevention of cardiovascular (CV) death or reduction of heart failure (HF) events.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Keywords
HFrEF, Heart Failure (HF), Cardiovascular Events (CV), Phase III outcome trial
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
4744 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Dapagliflozin
Arm Type
Experimental
Arm Description
Patients will be randomized 1:1 to either dapagliflozin or placebo.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo matching dapagliflozin.
Intervention Type
Drug
Intervention Name(s)
Dapagliflozin
Other Intervention Name(s)
Forxiga TM, Farxiga TM
Intervention Description
10 mg or 5 mg tablets given once daily, per oral use.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo matching dapagliflozin 10 mg or 5 mg.
Primary Outcome Measure Information:
Title
Subjects Included in the Composite Endpoint of CV Death, Hospitalization Due to Heart Failure or Urgent Visit Due to Heart Failure.
Description
Primary efficacy
Time Frame
Up to 27.8 months.
Secondary Outcome Measure Information:
Title
Subjects Included in the Composite Endpoint of CV Death or Hospitalization Due to Heart Failure.
Description
Secondary
Time Frame
Up to 27.8 months.
Title
Events Included in the Composite Endpoint of Recurrent Hospitalizations Due to Heart Failure and CV Death.
Description
Secondary
Time Frame
Up to 27.8 months.
Title
Change From Baseline in the KCCQ Total Symptom Score
Description
KCCQ is a 23-item, self-administered instrument that quantifies physical function, symptoms (frequency, severity and recent change), social function, self-efficacy and knowledge, and quality of life. The KCCQ total symptom score incorporates the symptom domains into a single score. Scores are transformed to a range of 0-100, in which higher scores reflect better health status.
Time Frame
Baseline and 8 months or death before 8 months
Title
Subjects Included in the Composite Endpoint of ≥50% Sustained Decline in eGFR, ESRD or Renal Death.
Description
Secondary
Time Frame
Up to 27.8 months.
Title
Subjects Included in the Endpoint of All-cause Mortality.
Description
Secondary
Time Frame
Up to 27.8 months.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
130 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Provision of signed informed consent prior to any study specific procedures
Male or female, aged ≥18 years
Established documented diagnosis of symptomatic HFrEF (NYHA functional class II-IV), which has been present for at least 2 months
LVEF≤40%
Elevated NT-proBNP levels
Patients should receive background standard of care for HFrEF and be treated according to locally recognized guidelines
eGFR ≥30 mL/min/1.73 m^2 (CKD-EPI formula) at enrolment (visit 1)
Exclusion Criteria:
Receiving therapy with an SGLT2 inhibitor within 8 weeks prior to enrolment or previous intolerance of an SGLT2 inhibitor
Type 1 diabetes mellitus
Symptomatic hypotension or systolic BP <95 mmHg at 2 out of 3 measurements either at visit 1 or visit 2
Current acute decompensated HF or hospitalization due to decompensated HF <4 weeks prior to enrolment
MI, unstable angina, stroke or transient ischemic attack within 12 weeks prior to enrolment
Coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or valvular repair/replacement within 12 weeks prior to enrolment or planned to undergo any of these operations after randomization
Implantation of a CRT within 12 weeks prior to enrolment or intent to implant a CRT device
Previous cardiac transplantation or implantation of a ventricular assistance device or similar device, or implantation expected after randomization
HF due to restrictive cardiomyopathy, active myocarditis, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease
Symptomatic bradycardia or second or third degree heart block without a pacemaker
Severe (eGFR <30 mL/min/1.73 m^2 by CKD-EPI), unstable or rapidly progressing renal disease at the time of randomization
Facility Information:
Facility Name
Research Site
City
Fairhope
State/Province
Alabama
ZIP/Postal Code
36532
Country
United States
Facility Name
Research Site
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
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Research Site
City
Sheffield
State/Province
Alabama
ZIP/Postal Code
35660
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United States
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Research Site
City
Bakersfield
State/Province
California
ZIP/Postal Code
93309
Country
United States
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Research Site
City
Beverly Hills
State/Province
California
ZIP/Postal Code
90211
Country
United States
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Research Site
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
Facility Name
Research Site
City
Palm Springs
State/Province
California
ZIP/Postal Code
92262
Country
United States
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Research Site
City
Stockton
State/Province
California
ZIP/Postal Code
95204
Country
United States
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Research Site
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
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Research Site
City
Vista
State/Province
California
ZIP/Postal Code
92083
Country
United States
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Research Site
City
Wilmington
State/Province
Delaware
ZIP/Postal Code
19803
Country
United States
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Research Site
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33472
Country
United States
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Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
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Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
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Research Site
City
Lake Worth
State/Province
Florida
ZIP/Postal Code
33461
Country
United States
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Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
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Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
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Research Site
City
Naples
State/Province
Florida
ZIP/Postal Code
34102
Country
United States
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Research Site
City
New Smyrna Beach
State/Province
Florida
ZIP/Postal Code
32169
Country
United States
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Research Site
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33024
Country
United States
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Research Site
City
Port Charlotte
State/Province
Florida
ZIP/Postal Code
33952
Country
United States
Facility Name
Research Site
City
Saint Augustine
State/Province
Florida
ZIP/Postal Code
32086
Country
United States
Facility Name
Research Site
City
Wellington
State/Province
Florida
ZIP/Postal Code
33449
Country
United States
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
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Research Site
City
Cumming
State/Province
Georgia
ZIP/Postal Code
30041
Country
United States
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Research Site
City
Tucker
State/Province
Georgia
ZIP/Postal Code
30084
Country
United States
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Research Site
City
Hazel Crest
State/Province
Illinois
ZIP/Postal Code
60429
Country
United States
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Research Site
City
Jerseyville
State/Province
Illinois
ZIP/Postal Code
62052
Country
United States
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Research Site
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61614
Country
United States
Facility Name
Research Site
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40205
Country
United States
Facility Name
Research Site
City
Alexandria
State/Province
Louisiana
ZIP/Postal Code
71301
Country
United States
Facility Name
Research Site
City
Chalmette
State/Province
Louisiana
ZIP/Postal Code
70043
Country
United States
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Research Site
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
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United States
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Research Site
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21120
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United States
Facility Name
Research Site
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21228
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United States
Facility Name
Research Site
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21044
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United States
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Research Site
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
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United States
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Research Site
City
Haverhill
State/Province
Massachusetts
ZIP/Postal Code
01830
Country
United States
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Research Site
City
Flint
State/Province
Michigan
ZIP/Postal Code
48504
Country
United States
Facility Name
Research Site
City
Flint
State/Province
Michigan
ZIP/Postal Code
48532
Country
United States
Facility Name
Research Site
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
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Research Site
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Research Site
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55417
Country
United States
Facility Name
Research Site
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
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Research Site
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
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Research Site
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
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Research Site
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
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Research Site
City
Grand Island
State/Province
Nebraska
ZIP/Postal Code
68803
Country
United States
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Research Site
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68526
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United States
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Research Site
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68105
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United States
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Research Site
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Las Vegas
State/Province
Nevada
ZIP/Postal Code
89128
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United States
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Research Site
City
Bridgewater
State/Province
New Jersey
ZIP/Postal Code
08807
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United States
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Research Site
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
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Research Site
City
Somerset
State/Province
New Jersey
ZIP/Postal Code
08873
Country
United States
Facility Name
Research Site
City
Bronx
State/Province
New York
ZIP/Postal Code
10459
Country
United States
Facility Name
Research Site
City
Buffalo
State/Province
New York
ZIP/Postal Code
14203
Country
United States
Facility Name
Research Site
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215
Country
United States
Facility Name
Research Site
City
Cortlandt Manor
State/Province
New York
ZIP/Postal Code
10567
Country
United States
Facility Name
Research Site
City
New York
State/Province
New York
ZIP/Postal Code
10001
Country
United States
Facility Name
Research Site
City
Orchard Park
State/Province
New York
ZIP/Postal Code
14127
Country
United States
Facility Name
Research Site
City
Poughkeepsie
State/Province
New York
ZIP/Postal Code
12601
Country
United States
Facility Name
Research Site
City
Rosedale
State/Province
New York
ZIP/Postal Code
11422
Country
United States
Facility Name
Research Site
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
Research Site
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106-6010
Country
United States
Facility Name
Research Site
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Research Site
City
Altoona
State/Province
Pennsylvania
ZIP/Postal Code
16602
Country
United States
Facility Name
Research Site
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Research Site
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
Research Site
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15240
Country
United States
Facility Name
Research Site
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701
Country
United States
Facility Name
Research Site
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37912
Country
United States
Facility Name
Research Site
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
Research Site
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37212
Country
United States
Facility Name
Research Site
City
Tullahoma
State/Province
Tennessee
ZIP/Postal Code
37388
Country
United States
Facility Name
Research Site
City
Beaumont
State/Province
Texas
ZIP/Postal Code
77702
Country
United States
Facility Name
Research Site
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Research Site
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77002
Country
United States
Facility Name
Research Site
City
Kingwood
State/Province
Texas
ZIP/Postal Code
77339
Country
United States
Facility Name
Research Site
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78234
Country
United States
Facility Name
Research Site
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Research Site
City
Farmington
State/Province
Utah
ZIP/Postal Code
84025
Country
United States
Facility Name
Research Site
City
Falls Church
State/Province
Virginia
ZIP/Postal Code
22042
Country
United States
Facility Name
Research Site
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Research Site
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
Research Site
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1180AAX
Country
Argentina
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1425AGC
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
1428
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
1437
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1120AAC
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1425DQI
Country
Argentina
Facility Name
Research Site
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1093
Country
Argentina
Facility Name
Research Site
City
Ciudad Autonoma de Buenos Aire
ZIP/Postal Code
C1407GTN
Country
Argentina
Facility Name
Research Site
City
Ciudad de Buenos Aires
ZIP/Postal Code
1221
Country
Argentina
Facility Name
Research Site
City
Cordoba
ZIP/Postal Code
5003
Country
Argentina
Facility Name
Research Site
City
Cordoba
ZIP/Postal Code
X5006CBI
Country
Argentina
Facility Name
Research Site
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
Research Site
City
Córdoba
ZIP/Postal Code
X5004BAL
Country
Argentina
Facility Name
Research Site
City
Esperanza
ZIP/Postal Code
S3080BQU
Country
Argentina
Facility Name
Research Site
City
Mar del Plata
ZIP/Postal Code
7600
Country
Argentina
Facility Name
Research Site
City
Mar del Plata
ZIP/Postal Code
B7600FZN
Country
Argentina
Facility Name
Research Site
City
Quilmes
ZIP/Postal Code
B1878DVB
Country
Argentina
Facility Name
Research Site
City
Quilmes
ZIP/Postal Code
B1878GEG
Country
Argentina
Facility Name
Research Site
City
Ramos Mejía
ZIP/Postal Code
B1704ETD
Country
Argentina
Facility Name
Research Site
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Research Site
City
Rosario
ZIP/Postal Code
S2000CVD
Country
Argentina
Facility Name
Research Site
City
San Luis
ZIP/Postal Code
5700
Country
Argentina
Facility Name
Research Site
City
San Martin
ZIP/Postal Code
1650
Country
Argentina
Facility Name
Research Site
City
San Miguel de Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Research Site
City
San Nicolás
ZIP/Postal Code
B2900DMH
Country
Argentina
Facility Name
Research Site
City
Santa Fe
ZIP/Postal Code
S3000FWO
Country
Argentina
Facility Name
Research Site
City
Vicente Lopez
ZIP/Postal Code
1638
Country
Argentina
Facility Name
Research Site
City
Belo Horizonte
ZIP/Postal Code
30140 062
Country
Brazil
Facility Name
Research Site
City
Belo Horizonte
ZIP/Postal Code
30150-240
Country
Brazil
Facility Name
Research Site
City
Brasilia
ZIP/Postal Code
71625-175
Country
Brazil
Facility Name
Research Site
City
Brasillia
ZIP/Postal Code
70200-730
Country
Brazil
Facility Name
Research Site
City
Campina Grande do Sul
ZIP/Postal Code
83430000
Country
Brazil
Facility Name
Research Site
City
Campinas
ZIP/Postal Code
13060-080
Country
Brazil
Facility Name
Research Site
City
Curitiba
ZIP/Postal Code
80730-150
Country
Brazil
Facility Name
Research Site
City
Goiânia
ZIP/Postal Code
74605050
Country
Brazil
Facility Name
Research Site
City
Marilia
ZIP/Postal Code
17515-000
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90620-001
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90840-440
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
91350-200
Country
Brazil
Facility Name
Research Site
City
Rio de Janeiro
ZIP/Postal Code
22271-100
Country
Brazil
Facility Name
Research Site
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
Research Site
City
São José do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Research Site
City
Uberlandia
ZIP/Postal Code
38411-186
Country
Brazil
Facility Name
Research Site
City
Votuporanga
ZIP/Postal Code
15500-003
Country
Brazil
Facility Name
Research Site
City
Blagoevgrad
ZIP/Postal Code
2700
Country
Bulgaria
Facility Name
Research Site
City
Dimitrovgrad
ZIP/Postal Code
6400
Country
Bulgaria
Facility Name
Research Site
City
Haskovo
Country
Bulgaria
Facility Name
Research Site
City
Kyustendil
ZIP/Postal Code
2500
Country
Bulgaria
Facility Name
Research Site
City
Lom
ZIP/Postal Code
3600
Country
Bulgaria
Facility Name
Research Site
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4000
Country
Bulgaria
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4001
Country
Bulgaria
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
Research Site
City
Plovdiv
ZIP/Postal Code
4003
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1309
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1408
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1463
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1750
Country
Bulgaria
Facility Name
Research Site
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
Research Site
City
Abbotsford
State/Province
British Columbia
ZIP/Postal Code
V2S 3N2
Country
Canada
Facility Name
Research Site
City
New Westminster
State/Province
British Columbia
ZIP/Postal Code
V3L 3W4
Country
Canada
Facility Name
Research Site
City
North Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7M 2H4
Country
Canada
Facility Name
Research Site
City
Moncton
State/Province
New Brunswick
ZIP/Postal Code
E1C 2Z3
Country
Canada
Facility Name
Research Site
City
Saint John
State/Province
New Brunswick
ZIP/Postal Code
E2L 4L2
Country
Canada
Facility Name
Research Site
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6W 2X7
Country
Canada
Facility Name
Research Site
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
Research Site
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 7R1
Country
Canada
Facility Name
Research Site
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
Research Site
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
Research Site
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P6
Country
Canada
Facility Name
Research Site
City
North York
State/Province
Ontario
ZIP/Postal Code
M6B 3H7
Country
Canada
Facility Name
Research Site
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3W7
Country
Canada
Facility Name
Research Site
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1J 2K1
Country
Canada
Facility Name
Research Site
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Research Site
City
Port Perry
State/Province
Ontario
ZIP/Postal Code
L9L 1L1
Country
Canada
Facility Name
Research Site
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1B 4Z8
Country
Canada
Facility Name
Research Site
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1E 5E9
Country
Canada
Facility Name
Research Site
City
Waterloo
State/Province
Ontario
ZIP/Postal Code
N2T 0C1
Country
Canada
Facility Name
Research Site
City
York
State/Province
Ontario
ZIP/Postal Code
M9N 1W4
Country
Canada
Facility Name
Research Site
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 1C8
Country
Canada
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 3Y7
Country
Canada
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 0A9
Country
Canada
Facility Name
Research Site
City
Rimouski
State/Province
Quebec
ZIP/Postal Code
G5L 5T1
Country
Canada
Facility Name
Research Site
City
Saint-Jerome
State/Province
Quebec
ZIP/Postal Code
J7Z 5T3
Country
Canada
Facility Name
Research Site
City
Terrebonne
State/Province
Quebec
ZIP/Postal Code
J6V 2H2
Country
Canada
Facility Name
Research Site
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Research Site
City
Baotou
ZIP/Postal Code
014010
Country
China
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
100029
Country
China
Facility Name
Research Site
City
Beijing
Country
China
Facility Name
Research Site
City
Bengbu
ZIP/Postal Code
233060
Country
China
Facility Name
Research Site
City
Changchun
ZIP/Postal Code
130021
Country
China
Facility Name
Research Site
City
Changsha
ZIP/Postal Code
410011
Country
China
Facility Name
Research Site
City
Chifeng
ZIP/Postal Code
024000
Country
China
Facility Name
Research Site
City
Dalian
ZIP/Postal Code
116011
Country
China
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Research Site
City
Haerbin
ZIP/Postal Code
150001
Country
China
Facility Name
Research Site
City
Lanzhou
ZIP/Postal Code
730030
Country
China
Facility Name
Research Site
City
Nanchang
ZIP/Postal Code
330006
Country
China
Facility Name
Research Site
City
Nanjing
ZIP/Postal Code
210009
Country
China
Facility Name
Research Site
City
Nanjing
ZIP/Postal Code
210029
Country
China
Facility Name
Research Site
City
Ningbo
ZIP/Postal Code
315010
Country
China
Facility Name
Research Site
City
Pingxiang
ZIP/Postal Code
337055
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200032
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200062
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200090
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200120
Country
China
Facility Name
Research Site
City
Shenyang
ZIP/Postal Code
110001
Country
China
Facility Name
Research Site
City
Shenzhen
ZIP/Postal Code
518036
Country
China
Facility Name
Research Site
City
Tianjin
ZIP/Postal Code
300211
Country
China
Facility Name
Research Site
City
Wuhan
ZIP/Postal Code
430033
Country
China
Facility Name
Research Site
City
Wuhan
ZIP/Postal Code
430060
Country
China
Facility Name
Research Site
City
Xuzhou
ZIP/Postal Code
221006
Country
China
Facility Name
Research Site
City
Xuzhou
ZIP/Postal Code
221009
Country
China
Facility Name
Research Site
City
Yinchuan
ZIP/Postal Code
750004
Country
China
Facility Name
Research Site
City
Zhuhai
ZIP/Postal Code
519000
Country
China
Facility Name
Research Site
City
Benesov
ZIP/Postal Code
256 01
Country
Czechia
Facility Name
Research Site
City
Brno
ZIP/Postal Code
62500
Country
Czechia
Facility Name
Research Site
City
Brno
ZIP/Postal Code
656 91
Country
Czechia
Facility Name
Research Site
City
Kolin
ZIP/Postal Code
280 00
Country
Czechia
Facility Name
Research Site
City
Louny
ZIP/Postal Code
440 01
Country
Czechia
Facility Name
Research Site
City
Ostrava-Dubina
ZIP/Postal Code
700 30
Country
Czechia
Facility Name
Research Site
City
Plzen
ZIP/Postal Code
320 00
Country
Czechia
Facility Name
Research Site
City
Praha 2
ZIP/Postal Code
12808
Country
Czechia
Facility Name
Research Site
City
Praha 4
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
Research Site
City
Praha 5
ZIP/Postal Code
150 00
Country
Czechia
Facility Name
Research Site
City
Praha
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Research Site
City
Trebic
ZIP/Postal Code
674 01
Country
Czechia
Facility Name
Research Site
City
Hellerup
ZIP/Postal Code
2900
Country
Denmark
Facility Name
Research Site
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Research Site
City
Hvidovre
ZIP/Postal Code
2650
Country
Denmark
Facility Name
Research Site
City
København Ø
ZIP/Postal Code
2100
Country
Denmark
Facility Name
Research Site
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Facility Name
Research Site
City
Svendborg
ZIP/Postal Code
DK-5700
Country
Denmark
Facility Name
Research Site
City
Bad Oeynhausen
ZIP/Postal Code
32545
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
13347
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
13597
Country
Germany
Facility Name
Research Site
City
Dresden
ZIP/Postal Code
01099
Country
Germany
Facility Name
Research Site
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Research Site
City
Hamburg
ZIP/Postal Code
22041
Country
Germany
Facility Name
Research Site
City
Homburg
ZIP/Postal Code
66424
Country
Germany
Facility Name
Research Site
City
Kassel
ZIP/Postal Code
34121
Country
Germany
Facility Name
Research Site
City
Leipzig
ZIP/Postal Code
04107
Country
Germany
Facility Name
Research Site
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Research Site
City
Papenburg
ZIP/Postal Code
26871
Country
Germany
Facility Name
Research Site
City
Stuttgart
ZIP/Postal Code
70199
Country
Germany
Facility Name
Research Site
City
Wermsdorf
ZIP/Postal Code
04779
Country
Germany
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1115
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1135
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1139
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
H-1106
Country
Hungary
Facility Name
Research Site
City
Kecskemét
ZIP/Postal Code
6000
Country
Hungary
Facility Name
Research Site
City
Mosonmagyaróvár
ZIP/Postal Code
9200
Country
Hungary
Facility Name
Research Site
City
Szentes
ZIP/Postal Code
6600
Country
Hungary
Facility Name
Research Site
City
Székesfehérvár
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Research Site
City
Zalaegerszeg
ZIP/Postal Code
8900
Country
Hungary
Facility Name
Research Site
City
Ahmedabad
ZIP/Postal Code
380060
Country
India
Facility Name
Research Site
City
Aurangabad
ZIP/Postal Code
431003
Country
India
Facility Name
Research Site
City
Bangalore
ZIP/Postal Code
560074
Country
India
Facility Name
Research Site
City
Belagavi
ZIP/Postal Code
590010
Country
India
Facility Name
Research Site
City
Ernakulam
ZIP/Postal Code
683594
Country
India
Facility Name
Research Site
City
Gurgaon
ZIP/Postal Code
122001
Country
India
Facility Name
Research Site
City
Kanpur
ZIP/Postal Code
208002
Country
India
Facility Name
Research Site
City
Karamsad
ZIP/Postal Code
388345
Country
India
Facility Name
Research Site
City
Kolkata
ZIP/Postal Code
700020
Country
India
Facility Name
Research Site
City
Maharashtra
ZIP/Postal Code
411013
Country
India
Facility Name
Research Site
City
Nadiad
ZIP/Postal Code
387002
Country
India
Facility Name
Research Site
City
Nagpur
ZIP/Postal Code
420012
Country
India
Facility Name
Research Site
City
Nagpur
ZIP/Postal Code
440003
Country
India
Facility Name
Research Site
City
New Delhi
ZIP/Postal Code
110002
Country
India
Facility Name
Research Site
City
Pune
ZIP/Postal Code
411001
Country
India
Facility Name
Research Site
City
Pune
ZIP/Postal Code
411011
Country
India
Facility Name
Research Site
City
Adachi-ku
ZIP/Postal Code
123-0845
Country
Japan
Facility Name
Research Site
City
Aki-gun,
ZIP/Postal Code
735-8585
Country
Japan
Facility Name
Research Site
City
Azumino-shi
ZIP/Postal Code
399-8292
Country
Japan
Facility Name
Research Site
City
Beppu-shi
ZIP/Postal Code
874-0011
Country
Japan
Facility Name
Research Site
City
Bunkyo-ku
ZIP/Postal Code
113-8431
Country
Japan
Facility Name
Research Site
City
Chikushino-shi
ZIP/Postal Code
818-8516
Country
Japan
Facility Name
Research Site
City
Chuo-ku
ZIP/Postal Code
103-0027
Country
Japan
Facility Name
Research Site
City
Chuo-ku
ZIP/Postal Code
104-8560
Country
Japan
Facility Name
Research Site
City
Fujisawa-shi
ZIP/Postal Code
251-0041
Country
Japan
Facility Name
Research Site
City
Fujisawa-shi
ZIP/Postal Code
251-8550
Country
Japan
Facility Name
Research Site
City
Fukuoka-shi
ZIP/Postal Code
815-8555
Country
Japan
Facility Name
Research Site
City
Hachioji-shi
ZIP/Postal Code
192-0918
Country
Japan
Facility Name
Research Site
City
Hamamatsu-shi
ZIP/Postal Code
430-0929
Country
Japan
Facility Name
Research Site
City
Himeji-shi
ZIP/Postal Code
670-0981
Country
Japan
Facility Name
Research Site
City
Hiratsuka-shi
ZIP/Postal Code
254-8502
Country
Japan
Facility Name
Research Site
City
Hitachinaka-shi
ZIP/Postal Code
312-0057
Country
Japan
Facility Name
Research Site
City
Iizuka-shi
ZIP/Postal Code
820-8505
Country
Japan
Facility Name
Research Site
City
Itabashi-ku
ZIP/Postal Code
173-8610
Country
Japan
Facility Name
Research Site
City
Iwakuni-shi
ZIP/Postal Code
740-8510
Country
Japan
Facility Name
Research Site
City
Kagoshima-shi
ZIP/Postal Code
890-8520
Country
Japan
Facility Name
Research Site
City
Kakamigahara-shi
ZIP/Postal Code
504-8601
Country
Japan
Facility Name
Research Site
City
Kasama-shi
ZIP/Postal Code
309-1793
Country
Japan
Facility Name
Research Site
City
Kishiwada-shi
ZIP/Postal Code
596-8522
Country
Japan
Facility Name
Research Site
City
Kitakyusyu-shi
ZIP/Postal Code
806-8501
Country
Japan
Facility Name
Research Site
City
Kumamoto-shi
ZIP/Postal Code
860-0008
Country
Japan
Facility Name
Research Site
City
Kure-shi
ZIP/Postal Code
737-0023
Country
Japan
Facility Name
Research Site
City
Kusatsu-shi
ZIP/Postal Code
525-8585
Country
Japan
Facility Name
Research Site
City
Kyoto-shi
ZIP/Postal Code
601-1434
Country
Japan
Facility Name
Research Site
City
Matsudo-shi
ZIP/Postal Code
270-2251
Country
Japan
Facility Name
Research Site
City
Matsudo-shi
ZIP/Postal Code
271-0077
Country
Japan
Facility Name
Research Site
City
Matsumoto-shi
ZIP/Postal Code
390-8621
Country
Japan
Facility Name
Research Site
City
Matsuyama-shi
ZIP/Postal Code
790-0067
Country
Japan
Facility Name
Research Site
City
Meguro-ku
ZIP/Postal Code
152-8902
Country
Japan
Facility Name
Research Site
City
Mito-shi
ZIP/Postal Code
311-4198
Country
Japan
Facility Name
Research Site
City
Miura-gun
ZIP/Postal Code
240-0116
Country
Japan
Facility Name
Research Site
City
Nagasaki-shi
ZIP/Postal Code
850-8555
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
453-8511
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
455-8530
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
457-8511
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
460-0001
Country
Japan
Facility Name
Research Site
City
Nishinomiya-shi
ZIP/Postal Code
663-8501
Country
Japan
Facility Name
Research Site
City
Okayama-shi
ZIP/Postal Code
700-0804
Country
Japan
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
530-0001
Country
Japan
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
540-0006
Country
Japan
Facility Name
Research Site
City
Sagamihara-shi
ZIP/Postal Code
252-5188
Country
Japan
Facility Name
Research Site
City
Sakai-shi,Kita-ku
ZIP/Postal Code
591-8025
Country
Japan
Facility Name
Research Site
City
Sakaide-shi
ZIP/Postal Code
762-0007
Country
Japan
Facility Name
Research Site
City
Sanyoonoda-shi
ZIP/Postal Code
756-0095
Country
Japan
Facility Name
Research Site
City
Sayama-shi
ZIP/Postal Code
350-1305
Country
Japan
Facility Name
Research Site
City
Sendai-shi
ZIP/Postal Code
980-0803
Country
Japan
Facility Name
Research Site
City
Sendai-shi
ZIP/Postal Code
983-0045
Country
Japan
Facility Name
Research Site
City
Shimonoseki-shi
ZIP/Postal Code
750-0061
Country
Japan
Facility Name
Research Site
City
Shinjuku-ku
ZIP/Postal Code
169-0073
Country
Japan
Facility Name
Research Site
City
Suita-shi
ZIP/Postal Code
564-8565
Country
Japan
Facility Name
Research Site
City
Suwa-shi
ZIP/Postal Code
392-8510
Country
Japan
Facility Name
Research Site
City
Tachikawa-shi
ZIP/Postal Code
190-8531
Country
Japan
Facility Name
Research Site
City
Takamatsu-shi
ZIP/Postal Code
760-0018
Country
Japan
Facility Name
Research Site
City
Takasaki-shi
ZIP/Postal Code
370-0829
Country
Japan
Facility Name
Research Site
City
Toride-shi
ZIP/Postal Code
302-0022
Country
Japan
Facility Name
Research Site
City
Tsuchiura-shi
ZIP/Postal Code
300-0028
Country
Japan
Facility Name
Research Site
City
Tsukuba-shi
ZIP/Postal Code
305-0005
Country
Japan
Facility Name
Research Site
City
Ueda-shi
ZIP/Postal Code
386-8610
Country
Japan
Facility Name
Research Site
City
Wakayama-shi
ZIP/Postal Code
640-8505
Country
Japan
Facility Name
Research Site
City
Wakayama-shi
ZIP/Postal Code
649-6335
Country
Japan
Facility Name
Research Site
City
Wako-shi
ZIP/Postal Code
351-0102
Country
Japan
Facility Name
Research Site
City
Yokohama-shi
ZIP/Postal Code
236-0051
Country
Japan
Facility Name
Research Site
City
Apeldoorn
ZIP/Postal Code
7334 DZ
Country
Netherlands
Facility Name
Research Site
City
Den Bosch
ZIP/Postal Code
5223 GZ
Country
Netherlands
Facility Name
Research Site
City
Den Haag
ZIP/Postal Code
2545 AA
Country
Netherlands
Facility Name
Research Site
City
Gouda
ZIP/Postal Code
2803 HH
Country
Netherlands
Facility Name
Research Site
City
Groningen
ZIP/Postal Code
9713 GZ
Country
Netherlands
Facility Name
Research Site
City
Nijmegen
ZIP/Postal Code
6525 GA
Country
Netherlands
Facility Name
Research Site
City
Rotterdam
ZIP/Postal Code
3045 PM
Country
Netherlands
Facility Name
Research Site
City
Rotterdam
ZIP/Postal Code
3083 AN
Country
Netherlands
Facility Name
Research Site
City
Sneek
ZIP/Postal Code
8601 ZR
Country
Netherlands
Facility Name
Research Site
City
Veldhoven
ZIP/Postal Code
5504 DB
Country
Netherlands
Facility Name
Research Site
City
Bochnia
ZIP/Postal Code
32-700
Country
Poland
Facility Name
Research Site
City
Gdynia
ZIP/Postal Code
81-423
Country
Poland
Facility Name
Research Site
City
Jasło
ZIP/Postal Code
38-200
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-081
Country
Poland
Facility Name
Research Site
City
Kraków
ZIP/Postal Code
30-082
Country
Poland
Facility Name
Research Site
City
Kędzierzyn Koźle
ZIP/Postal Code
47-200
Country
Poland
Facility Name
Research Site
City
Legnica
ZIP/Postal Code
59-220
Country
Poland
Facility Name
Research Site
City
Lublin
ZIP/Postal Code
20-044
Country
Poland
Facility Name
Research Site
City
Oława
ZIP/Postal Code
55-200
Country
Poland
Facility Name
Research Site
City
Płock
ZIP/Postal Code
09-402
Country
Poland
Facility Name
Research Site
City
Sokółka
ZIP/Postal Code
16-100
Country
Poland
Facility Name
Research Site
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Research Site
City
Wierzchosławice
ZIP/Postal Code
33-122
Country
Poland
Facility Name
Research Site
City
Łódź
ZIP/Postal Code
92-213
Country
Poland
Facility Name
Research Site
City
Ekaterinburg
ZIP/Postal Code
620039
Country
Russian Federation
Facility Name
Research Site
City
Gatchina
ZIP/Postal Code
188300
Country
Russian Federation
Facility Name
Research Site
City
Izhevsk
ZIP/Postal Code
426063
Country
Russian Federation
Facility Name
Research Site
City
Kazan
ZIP/Postal Code
420012
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
109263
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
119435
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
121551
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Research Site
City
Novosibirsk
ZIP/Postal Code
630055
Country
Russian Federation
Facility Name
Research Site
City
Perm
ZIP/Postal Code
6144090
Country
Russian Federation
Facility Name
Research Site
City
Ryazan
ZIP/Postal Code
390039
Country
Russian Federation
Facility Name
Research Site
City
Saint Petersburg
ZIP/Postal Code
196601
Country
Russian Federation
Facility Name
Research Site
City
Saint Petersburg
ZIP/Postal Code
198260
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
192283
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
194291
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
194354
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
Facility Name
Research Site
City
St. Petersburg
ZIP/Postal Code
196084
Country
Russian Federation
Facility Name
Research Site
City
Tver
ZIP/Postal Code
170036
Country
Russian Federation
Facility Name
Research Site
City
Yekaterinburg
ZIP/Postal Code
620102
Country
Russian Federation
Facility Name
Research Site
City
Brezno
ZIP/Postal Code
97742
Country
Slovakia
Facility Name
Research Site
City
Kosice
ZIP/Postal Code
040 01
Country
Slovakia
Facility Name
Research Site
City
Lucenec
ZIP/Postal Code
984 01
Country
Slovakia
Facility Name
Research Site
City
Martin
ZIP/Postal Code
036 01
Country
Slovakia
Facility Name
Research Site
City
Nove Zamky
ZIP/Postal Code
94001
Country
Slovakia
Facility Name
Research Site
City
Presov
ZIP/Postal Code
080 01
Country
Slovakia
Facility Name
Research Site
City
Svidnik
ZIP/Postal Code
08901
Country
Slovakia
Facility Name
Research Site
City
Trebisov
ZIP/Postal Code
075 01
Country
Slovakia
Facility Name
Research Site
City
Trnava
ZIP/Postal Code
917 01
Country
Slovakia
Facility Name
Research Site
City
Zilina
ZIP/Postal Code
010 01
Country
Slovakia
Facility Name
Research Site
City
Göteborg
ZIP/Postal Code
413 45
Country
Sweden
Facility Name
Research Site
City
Lund
ZIP/Postal Code
222 21
Country
Sweden
Facility Name
Research Site
City
Ostersund
ZIP/Postal Code
831 83
Country
Sweden
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
118 83
Country
Sweden
Facility Name
Research Site
City
Umeå
ZIP/Postal Code
90737
Country
Sweden
Facility Name
Research Site
City
Changhua City
ZIP/Postal Code
50006
Country
Taiwan
Facility Name
Research Site
City
Hsinchu
ZIP/Postal Code
300
Country
Taiwan
Facility Name
Research Site
City
Kaohsiung
ZIP/Postal Code
80756
Country
Taiwan
Facility Name
Research Site
City
Kaohsiung
Country
Taiwan
Facility Name
Research Site
City
Kweishan Shiang
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Research Site
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Research Site
City
Taichung
Country
Taiwan
Facility Name
Research Site
City
Tainan
ZIP/Postal Code
70403
Country
Taiwan
Facility Name
Research Site
City
Tainan
ZIP/Postal Code
710
Country
Taiwan
Facility Name
Research Site
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Research Site
City
Taipei
ZIP/Postal Code
11220
Country
Taiwan
Facility Name
Research Site
City
Taipei
Country
Taiwan
Facility Name
Research Site
City
Airdrie
ZIP/Postal Code
ML6 0JS
Country
United Kingdom
Facility Name
Research Site
City
Clydebank
ZIP/Postal Code
G81 4DY
Country
United Kingdom
Facility Name
Research Site
City
Cottingham
ZIP/Postal Code
HU16 5JQ
Country
United Kingdom
Facility Name
Research Site
City
Dundee
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Facility Name
Research Site
City
Edinburgh
ZIP/Postal Code
EH16 4SA
Country
United Kingdom
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G31 2ER
Country
United Kingdom
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Facility Name
Research Site
City
Inverness
ZIP/Postal Code
IV2 3JH
Country
United Kingdom
Facility Name
Research Site
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Facility Name
Research Site
City
Paisley
ZIP/Postal Code
PA2 9PN
Country
United Kingdom
Facility Name
Research Site
City
Hanoi
ZIP/Postal Code
100000
Country
Vietnam
Facility Name
Research Site
City
Hanoi
Country
Vietnam
Facility Name
Research Site
City
Hcmc
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
7000000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
700000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
70000
Country
Vietnam
12. IPD Sharing Statement
Citations:
PubMed Identifier
36339117
Citation
Docherty KF, Anand IS, Chiang CE, Chopra VK, Desai AS, Kitakaze M, Verma S, Vinh PN, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjostrand M, Solomon SD, Langkilde AM, Jhund PS, McMurray JJV. Effects of Dapagliflozin in Asian Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF. JACC Asia. 2022 Mar 29;2(2):139-153. doi: 10.1016/j.jacasi.2022.02.004. eCollection 2022 Apr.
Results Reference
derived
PubMed Identifier
36189985
Citation
Desai AS, Jhund PS, Claggett BL, Vaduganathan M, Miao ZM, Kondo T, Barkoudah E, Brahimi A, Connolly E, Finn P, Lang NN, Mc Causland FR, McGrath M, Petrie MC, McMurray JJV, Solomon SD. Effect of Dapagliflozin on Cause-Specific Mortality in Patients With Heart Failure Across the Spectrum of Ejection Fraction: A Participant-Level Pooled Analysis of DAPA-HF and DELIVER. JAMA Cardiol. 2022 Dec 1;7(12):1227-1234. doi: 10.1001/jamacardio.2022.3736.
Results Reference
derived
PubMed Identifier
36054568
Citation
Adamson C, Cowan LM, de Boer RA, Diez M, Drozdz J, Dukat A, Inzucchi SE, Kober L, Kosiborod MN, Ljungman CEA, Martinez FA, Ponikowski P, Sabatine MS, Lindholm D, Bengtsson O, Boulton DW, Greasley PJ, Langkilde AM, Sjostrand M, Solomon SD, McMurray JJV, Jhund PS. Liver tests and outcomes in heart failure with reduced ejection fraction: findings from DAPA-HF. Eur J Heart Fail. 2022 Oct;24(10):1856-1868. doi: 10.1002/ejhf.2649. Epub 2022 Aug 22.
Results Reference
derived
PubMed Identifier
35971840
Citation
Docherty KF, Welsh P, Verma S, De Boer RA, O'Meara E, Bengtsson O, Kober L, Kosiborod MN, Hammarstedt A, Langkilde AM, Lindholm D, Little DJ, Sjostrand M, Martinez FA, Ponikowski P, Sabatine MS, Morrow DA, Schou M, Solomon SD, Sattar N, Jhund PS, McMurray JJV; DAPA-HF Investigators and Committees. Iron Deficiency in Heart Failure and Effect of Dapagliflozin: Findings From DAPA-HF. Circulation. 2022 Sep 27;146(13):980-994. doi: 10.1161/CIRCULATIONAHA.122.060511. Epub 2022 Aug 16.
Results Reference
derived
PubMed Identifier
35902157
Citation
Butt JH, Dewan P, DeFilippis EM, Biering-Sorensen T, Docherty KF, Jhund PS, Kosiborod MN, Martinez FA, Bengtsson O, Johansen ND, Langkilde AM, Sjostrand M, Vaduganathan M, Solomon SD, Sabatine MS, Kober L, Fiuzat M, McMurray JJV. Effects of Dapagliflozin According to the Heart Failure Collaboratory Medical Therapy Score: Insights From DAPA-HF. JACC Heart Fail. 2022 Aug;10(8):543-555. doi: 10.1016/j.jchf.2022.03.009. Epub 2022 Jun 8.
Results Reference
derived
PubMed Identifier
35483792
Citation
Yeoh SE, Docherty KF, Jhund PS, Petrie MC, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Bengtsson O, Boulton DW, Greasley PJ, Langkilde AM, Sjostrand M, Solomon SD, McMurray JJV. Relationship of Dapagliflozin With Serum Sodium: Findings From the DAPA-HF Trial. JACC Heart Fail. 2022 May;10(5):306-318. doi: 10.1016/j.jchf.2022.01.019. Epub 2022 Apr 6.
Results Reference
derived
PubMed Identifier
35467935
Citation
Butt JH, Dewan P, Merkely B, Belohlavek J, Drozdz J, Kitakaze M, Inzucchi SE, Kosiborod MN, Martinez FA, Tereshchenko S, Ponikowski P, Bengtsson O, Lindholm D, Langkilde AM, Schou M, Sjostrand M, Solomon SD, Sabatine MS, Chiang CE, Docherty KF, Jhund PS, Kober L, McMurray JJV. Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction : A Post Hoc Analysis of the DAPA-HF Trial. Ann Intern Med. 2022 Jun;175(6):820-830. doi: 10.7326/M21-4776. Epub 2022 Apr 26.
Results Reference
derived
PubMed Identifier
35442064
Citation
Adamson C, Docherty KF, Heerspink HJL, de Boer RA, Damman K, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Petrie MC, Ponikowski P, Sabatine MS, Schou M, Solomon SD, Verma S, Bengtsson O, Langkilde AM, Sjostrand M, Vaduganathan M, Jhund PS, McMurray JJV. Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF. Circulation. 2022 Aug 9;146(6):438-449. doi: 10.1161/CIRCULATIONAHA.121.058910. Epub 2022 Apr 20.
Results Reference
derived
PubMed Identifier
35115084
Citation
Docherty KF, Simpson J, Jhund PS, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Bengtsson O, Sjostrand M, Lindholm D, Langkilde AM, Solomon SD, McMurray JJV; DAPA-HF Investigators and Committees. Effect of Dapagliflozin, Compared With Placebo, According to Baseline Risk in DAPA-HF. JACC Heart Fail. 2022 Feb;10(2):104-118. doi: 10.1016/j.jchf.2021.09.002. Epub 2022 Jan 12.
Results Reference
derived
PubMed Identifier
34969498
Citation
Docherty KF, Ogunniyi MO, Anand IS, Desai AS, Diez M, Howlett JG, Nicolau JC, O'Meara E, Verma S, Inzucchi SE, Kober L, Kosiborod MN, Lindholm D, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjostrand M, Solomon SD, Langkilde AM, Jhund PS, McMurray JJV. Efficacy of Dapagliflozin in Black Versus White Patients With Heart Failure and Reduced Ejection Fraction. JACC Heart Fail. 2022 Jan;10(1):52-64. doi: 10.1016/j.jchf.2021.08.006. Epub 2021 Nov 10.
Results Reference
derived
PubMed Identifier
34861151
Citation
Ryden L, Ferrannini G. Is the impact of add on heart failure therapy influenced by background therapy? Lancet Diabetes Endocrinol. 2022 Jan;10(1):3-5. doi: 10.1016/S2213-8587(21)00311-9. Epub 2021 Nov 30. No abstract available.
Results Reference
derived
PubMed Identifier
34802253
Citation
Butt JH, Adamson C, Docherty KF, de Boer RA, Petrie MC, Inzucchi SE, Kosiborod MN, Maria Langkilde A, Lindholm D, Martinez FA, Bengtsson O, Schou M, O'Meara E, Ponikowski P, Sabatine MS, Sjostrand M, Solomon SD, Jhund PS, McMurray JJV, Kober L. Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to N-Terminal Pro-B-Type Natriuretic Peptide: Insights From the DAPA-HF Trial. Circ Heart Fail. 2021 Dec;14(12):e008837. doi: 10.1161/CIRCHEARTFAILURE.121.008837. Epub 2021 Nov 22.
Results Reference
derived
PubMed Identifier
34743554
Citation
Berg DD, Docherty KF, Sattar N, Jarolim P, Welsh P, Jhund PS, Anand IS, Chopra V, de Boer RA, Kosiborod MN, Nicolau JC, O'Meara E, Schou M, Hammarstedt A, Langkilde AM, Lindholm D, Sjostrand M, McMurray JJV, Sabatine MS, Morrow DA. Serial Assessment of High-Sensitivity Cardiac Troponin and the Effect of Dapagliflozin in Patients With Heart Failure With Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial. Circulation. 2022 Jan 18;145(3):158-169. doi: 10.1161/CIRCULATIONAHA.121.057852. Epub 2021 Nov 8.
Results Reference
derived
PubMed Identifier
34448003
Citation
Curtain JP, Docherty KF, Jhund PS, Petrie MC, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Bengtsson O, Langkilde AM, Sjostrand M, Solomon SD, McMurray JJV. Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF. Eur Heart J. 2021 Sep 21;42(36):3727-3738. doi: 10.1093/eurheartj/ehab560.
Results Reference
derived
PubMed Identifier
34319398
Citation
Docherty KF, Jhund PS, Claggett B, Ferreira JP, Bengtsson O, Inzucchi SE, Kober L, Kosiborod MN, Langkilde AM, Martinez FA, Ponikowski P, Sabatine MS, Sjostrand M, Solomon SD, McMurray JJV; DAPA-HF Investigators and Committees. Extrapolating Long-term Event-Free and Overall Survival With Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis of a Phase 3 Randomized Clinical Trial. JAMA Cardiol. 2021 Nov 1;6(11):1298-1305. doi: 10.1001/jamacardio.2021.2632.
Results Reference
derived
PubMed Identifier
34272791
Citation
Adamson C, Jhund PS, Docherty KF, Belohlavek J, Chiang CE, Diez M, Drozdz J, Dukat A, Howlett J, Ljungman CEA, Petrie MC, Schou M, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Bengtsson O, Langkilde AM, Lindholm D, Sjostrand M, McMurray JJV. Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index. Eur J Heart Fail. 2021 Oct;23(10):1662-1672. doi: 10.1002/ejhf.2308. Epub 2021 Jul 29.
Results Reference
derived
PubMed Identifier
33832352
Citation
Jhund PS, Ponikowski P, Docherty KF, Gasparyan SB, Bohm M, Chiang CE, Desai AS, Howlett J, Kitakaze M, Petrie MC, Verma S, Bengtsson O, Langkilde AM, Sjostrand M, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Sabatine MS, Solomon SD, McMurray JJV. Dapagliflozin and Recurrent Heart Failure Hospitalizations in Heart Failure With Reduced Ejection Fraction: An Analysis of DAPA-HF. Circulation. 2021 May 18;143(20):1962-1972. doi: 10.1161/CIRCULATIONAHA.121.053659. Epub 2021 Apr 9.
Results Reference
derived
PubMed Identifier
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Learn more about this trial
Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure
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