Back to resultsA Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease (Dapa-CKD)
Primary Purpose
Chronic Kidney Disease
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Dapagliflozin
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Chronic Kidney Disease focused on measuring Chronic Kidney Disease (CKD), Cardiovascular Events (CV), Phase III outcome trial
Eligibility Criteria
Inclusion Criteria:
- Provision of signed informed consent prior to any study specific procedures
- Female or male aged ≥18 years at the time of consent
- eGFR ≥25 and ≤75 mL/min/1.73m2 (CKD-EPI Formula) at visit 1
- Evidence of increased albuminuria 3 months or more before visit 1 and UACR ≥200 and ≤5000 mg/g at visit 1
- Stable, and for the patient maximum tolerated labelled daily dose, treatment with ACE-I or ARB for at least 4 weeks before visit 1, if not medically contraindicated,
Exclusion Criteria:
- Autosomal dominant or autosomal recessive polycystic kidney disease, lupus nephritis or ANCA-associated vasculitis
- Receiving cytotoxic therapy, immunosuppressive therapy or other immunotherapy for primary or secondary renal disease within 6 months prior to enrolment
- History of organ transplantation
- Receiving therapy with an SGLT2 inhibitor within 8 weeks prior to enrolment or previous intolerance of an SGLT2 inhibitor
- Type 1 diabetes mellitus
- New York Heart Association (NYHA) class IV Congestive Heart Failure at the time of enrolment
- MI, unstable angina, stroke or transient ischemic attack within 12 weeks prior to enrolment
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Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Dapagliflozin
Placebo
Arm Description
Patients will be randomized 1:1 to either dapagliflozin or placebo.
Placebo matching dapagliflozin.
Outcomes
Primary Outcome Measures
Time to the First Occurrence of Any of the Components of the Composite: ≥50% Sustained Decline in eGFR or Reaching ESRD or CV Death or Renal Death.
End Stage Renal Disease (ESRD) is defined as:
Sustained eGFR <15 mL/min/1.73m2 or,
Chronic dialysis treatment or,
Receiving a renal transplant The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Secondary Outcome Measures
Time to the First Occurrence of Any of the Components of the Composite: ≥50% Sustained Decline in eGFR or Reaching ESRD or Renal Death.
End Stage Renal Disease (ESRD) is defined as:
Sustained eGFR <15 mL/min/1.73m2 or,
Chronic dialysis treatment or,
Receiving a renal transplant The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time to the First Occurrence of Either of the Components of the Composite: CV Death or Hospitalization for Heart Failure.
The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time to Death From Any Cause.
The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03036150
Brief Title
A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease
Acronym
Dapa-CKD
Official Title
A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease
Study Type
Interventional
2. Study Status
Record Verification Date
June 2021
Overall Recruitment Status
Completed
Study Start Date
February 2, 2017 (Actual)
Primary Completion Date
June 12, 2020 (Actual)
Study Completion Date
June 12, 2020 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AstraZeneca
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to evaluate the effect of dapagliflozin on renal outcomes and cardiovascular mortality in patients with chronic kidney disease.
Detailed Description
This is an international, multicentre, event-driven, randomized, double-blind, parallel group, placebo-controlled study, evaluating the effect of dapagliflozin versus placebo, given once daily in addition to standard of care, to prevent the progression of chronic kidney disease (CKD) or cardiovascular (CV)/renal death.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Kidney Disease
Keywords
Chronic Kidney Disease (CKD), Cardiovascular Events (CV), Phase III outcome trial
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
4304 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Dapagliflozin
Arm Type
Experimental
Arm Description
Patients will be randomized 1:1 to either dapagliflozin or placebo.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo matching dapagliflozin.
Intervention Type
Drug
Intervention Name(s)
Dapagliflozin
Other Intervention Name(s)
Forxiga TM, Farxiga TM
Intervention Description
10 mg or 5 mg tablets given once daily, per oral use.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo matching dapagliflozin 10 mg or 5 mg
Primary Outcome Measure Information:
Title
Time to the First Occurrence of Any of the Components of the Composite: ≥50% Sustained Decline in eGFR or Reaching ESRD or CV Death or Renal Death.
Description
End Stage Renal Disease (ESRD) is defined as:
Sustained eGFR <15 mL/min/1.73m2 or,
Chronic dialysis treatment or,
Receiving a renal transplant The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time Frame
Up to 38.2 months
Secondary Outcome Measure Information:
Title
Time to the First Occurrence of Any of the Components of the Composite: ≥50% Sustained Decline in eGFR or Reaching ESRD or Renal Death.
Description
End Stage Renal Disease (ESRD) is defined as:
Sustained eGFR <15 mL/min/1.73m2 or,
Chronic dialysis treatment or,
Receiving a renal transplant The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time Frame
Up to 38.2 months
Title
Time to the First Occurrence of Either of the Components of the Composite: CV Death or Hospitalization for Heart Failure.
Description
The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time Frame
Up to 38.2 months
Title
Time to Death From Any Cause.
Description
The proportional hazards Cox regression model takes into account the time to the event. Data is reported as the numbers of subjects with the event and the Hazard ratio is included in the Statistical Analysis section attached to the Outcome Measure data table.
Time Frame
Up to 38.2 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
130 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Provision of signed informed consent prior to any study specific procedures
Female or male aged ≥18 years at the time of consent
eGFR ≥25 and ≤75 mL/min/1.73m2 (CKD-EPI Formula) at visit 1
Evidence of increased albuminuria 3 months or more before visit 1 and UACR ≥200 and ≤5000 mg/g at visit 1
Stable, and for the patient maximum tolerated labelled daily dose, treatment with ACE-I or ARB for at least 4 weeks before visit 1, if not medically contraindicated,
Exclusion Criteria:
Autosomal dominant or autosomal recessive polycystic kidney disease, lupus nephritis or ANCA-associated vasculitis
Receiving cytotoxic therapy, immunosuppressive therapy or other immunotherapy for primary or secondary renal disease within 6 months prior to enrolment
History of organ transplantation
Receiving therapy with an SGLT2 inhibitor within 8 weeks prior to enrolment or previous intolerance of an SGLT2 inhibitor
Type 1 diabetes mellitus
New York Heart Association (NYHA) class IV Congestive Heart Failure at the time of enrolment
MI, unstable angina, stroke or transient ischemic attack within 12 weeks prior to enrolment
Facility Information:
Facility Name
Research Site
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233
Country
United States
Facility Name
Research Site
City
Hawaiian Gardens
State/Province
California
ZIP/Postal Code
90716
Country
United States
Facility Name
Research Site
City
Lomita
State/Province
California
ZIP/Postal Code
90717
Country
United States
Facility Name
Research Site
City
Los Angeles
State/Province
California
ZIP/Postal Code
90022
Country
United States
Facility Name
Research Site
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
Research Site
City
San Dimas
State/Province
California
ZIP/Postal Code
91773
Country
United States
Facility Name
Research Site
City
San Ramon
State/Province
California
ZIP/Postal Code
94582
Country
United States
Facility Name
Research Site
City
Vista
State/Province
California
ZIP/Postal Code
92083
Country
United States
Facility Name
Research Site
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
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Research Site
City
Denver
State/Province
Colorado
ZIP/Postal Code
80246
Country
United States
Facility Name
Research Site
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33435
Country
United States
Facility Name
Research Site
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33472
Country
United States
Facility Name
Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
Research Site
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33014
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33015
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33165
Country
United States
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Research Site
City
Naples
State/Province
Florida
ZIP/Postal Code
34102
Country
United States
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Research Site
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34652
Country
United States
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Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342-1797
Country
United States
Facility Name
Research Site
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30904
Country
United States
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60643
Country
United States
Facility Name
Research Site
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Research Site
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Research Site
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Facility Name
Research Site
City
Metairie
State/Province
Louisiana
ZIP/Postal Code
70006
Country
United States
Facility Name
Research Site
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
Research Site
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Research Site
City
Flint
State/Province
Michigan
ZIP/Postal Code
48504
Country
United States
Facility Name
Research Site
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Research Site
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68105
Country
United States
Facility Name
Research Site
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Research Site
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
Research Site
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
Facility Name
Research Site
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Research Site
City
New Bern
State/Province
North Carolina
ZIP/Postal Code
28562
Country
United States
Facility Name
Research Site
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Research Site
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Research Site
City
Maumee
State/Province
Ohio
ZIP/Postal Code
43537
Country
United States
Facility Name
Research Site
City
Jersey Shore
State/Province
Pennsylvania
ZIP/Postal Code
17740
Country
United States
Facility Name
Research Site
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Research Site
City
Greer
State/Province
South Carolina
ZIP/Postal Code
29651
Country
United States
Facility Name
Research Site
City
Kingsport
State/Province
Tennessee
ZIP/Postal Code
37660
Country
United States
Facility Name
Research Site
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Research Site
City
El Paso
State/Province
Texas
ZIP/Postal Code
79935
Country
United States
Facility Name
Research Site
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76116
Country
United States
Facility Name
Research Site
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76117
Country
United States
Facility Name
Research Site
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76164
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77004
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Research Site
City
Odessa
State/Province
Texas
ZIP/Postal Code
79761
Country
United States
Facility Name
Research Site
City
Burke
State/Province
Virginia
ZIP/Postal Code
22015
Country
United States
Facility Name
Research Site
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Research Site
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23606
Country
United States
Facility Name
Research Site
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
ARG 1425
Country
Argentina
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1425BGN
Country
Argentina
Facility Name
Research Site
City
Buenos Aires
ZIP/Postal Code
C1429BWN
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1120AAC
Country
Argentina
Facility Name
Research Site
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1093
Country
Argentina
Facility Name
Research Site
City
Ciudad Autonoma de Buenos Aire
ZIP/Postal Code
C1407GTN
Country
Argentina
Facility Name
Research Site
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Research Site
City
Cordoba
ZIP/Postal Code
X5006CBI
Country
Argentina
Facility Name
Research Site
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
Research Site
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Research Site
City
Córdoba
ZIP/Postal Code
X5016LIG
Country
Argentina
Facility Name
Research Site
City
Mar del Plata
ZIP/Postal Code
7600
Country
Argentina
Facility Name
Research Site
City
Mar del Plata
ZIP/Postal Code
B7600FZN
Country
Argentina
Facility Name
Research Site
City
Nueve de julio
ZIP/Postal Code
B6500EZL
Country
Argentina
Facility Name
Research Site
City
Rosario
ZIP/Postal Code
S2000DEJ
Country
Argentina
Facility Name
Research Site
City
San Luis
ZIP/Postal Code
D5700CTA
Country
Argentina
Facility Name
Research Site
City
San Miguel de Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Research Site
City
San Miguel de Tucuman
ZIP/Postal Code
T4000ICL
Country
Argentina
Facility Name
Research Site
City
San Nicolás
ZIP/Postal Code
B2900DMH
Country
Argentina
Facility Name
Research Site
City
Santa Fe
ZIP/Postal Code
3000
Country
Argentina
Facility Name
Research Site
City
Santa Rosa
ZIP/Postal Code
6300
Country
Argentina
Facility Name
Research Site
City
Botucatu
ZIP/Postal Code
18.618-686
Country
Brazil
Facility Name
Research Site
City
Campinas
ZIP/Postal Code
13010-001
Country
Brazil
Facility Name
Research Site
City
Caxias do Sul
ZIP/Postal Code
95070-560
Country
Brazil
Facility Name
Research Site
City
Curitiba
ZIP/Postal Code
80440-020
Country
Brazil
Facility Name
Research Site
City
Joinville
ZIP/Postal Code
89227-680
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Research Site
City
Porto Alegre
ZIP/Postal Code
90610-000
Country
Brazil
Facility Name
Research Site
City
Salvador
ZIP/Postal Code
40415-065
Country
Brazil
Facility Name
Research Site
City
Santo Andre
ZIP/Postal Code
09090-790
Country
Brazil
Facility Name
Research Site
City
Sao Paulo
ZIP/Postal Code
04039-000
Country
Brazil
Facility Name
Research Site
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
Research Site
City
São José do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Research Site
City
São Paulo
ZIP/Postal Code
01228-000
Country
Brazil
Facility Name
Research Site
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6H 2L4
Country
Canada
Facility Name
Research Site
City
Red Deer
State/Province
Alberta
ZIP/Postal Code
T4N 6V7
Country
Canada
Facility Name
Research Site
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 1Y6
Country
Canada
Facility Name
Research Site
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 1V7
Country
Canada
Facility Name
Research Site
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6S 0C6
Country
Canada
Facility Name
Research Site
City
Concord
State/Province
Ontario
ZIP/Postal Code
L4K 4M2
Country
Canada
Facility Name
Research Site
City
Etobicoke
State/Province
Ontario
ZIP/Postal Code
M9R 4E1
Country
Canada
Facility Name
Research Site
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 2V7
Country
Canada
Facility Name
Research Site
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
Research Site
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3V3
Country
Canada
Facility Name
Research Site
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1G 2B9
Country
Canada
Facility Name
Research Site
City
Smiths Falls
State/Province
Ontario
ZIP/Postal Code
K7A 4W8
Country
Canada
Facility Name
Research Site
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4C 5T2
Country
Canada
Facility Name
Research Site
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2N2
Country
Canada
Facility Name
Research Site
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 7K9
Country
Canada
Facility Name
Research Site
City
Gatineau
State/Province
Quebec
ZIP/Postal Code
J8Y 6S8
Country
Canada
Facility Name
Research Site
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
Research Site
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Facility Name
Research Site
City
Pointe-Claire
State/Province
Quebec
ZIP/Postal Code
H9R 3J1
Country
Canada
Facility Name
Research Site
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
Research Site
City
Baotou
ZIP/Postal Code
14010
Country
China
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
100034
Country
China
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
100044
Country
China
Facility Name
Research Site
City
Beijing
ZIP/Postal Code
102206
Country
China
Facility Name
Research Site
City
Changchun
ZIP/Postal Code
130021
Country
China
Facility Name
Research Site
City
Changchun
ZIP/Postal Code
130041
Country
China
Facility Name
Research Site
City
Changsha
ZIP/Postal Code
410008
Country
China
Facility Name
Research Site
City
Chengdu
ZIP/Postal Code
610041
Country
China
Facility Name
Research Site
City
Chengdu
ZIP/Postal Code
610072
Country
China
Facility Name
Research Site
City
Foshan
ZIP/Postal Code
528000
Country
China
Facility Name
Research Site
City
Fuzhou
ZIP/Postal Code
350025
Country
China
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510000
Country
China
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Research Site
City
Guangzhou
ZIP/Postal Code
510515
Country
China
Facility Name
Research Site
City
Guiyang
ZIP/Postal Code
550004
Country
China
Facility Name
Research Site
City
Jilin
ZIP/Postal Code
132000
Country
China
Facility Name
Research Site
City
Lanzhou
ZIP/Postal Code
730030
Country
China
Facility Name
Research Site
City
Nan Jin
ZIP/Postal Code
210029
Country
China
Facility Name
Research Site
City
Nanchang
ZIP/Postal Code
330006
Country
China
Facility Name
Research Site
City
Nanjing
ZIP/Postal Code
210009
Country
China
Facility Name
Research Site
City
Nanning
ZIP/Postal Code
530021
Country
China
Facility Name
Research Site
City
Ningbo
ZIP/Postal Code
315010
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200040
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200090
Country
China
Facility Name
Research Site
City
Shanghai
ZIP/Postal Code
200127
Country
China
Facility Name
Research Site
City
Shengyang
ZIP/Postal Code
110004
Country
China
Facility Name
Research Site
City
Shenzhen
ZIP/Postal Code
518053
Country
China
Facility Name
Research Site
City
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Research Site
City
Wuhan
ZIP/Postal Code
430033
Country
China
Facility Name
Research Site
City
Yinchuan
ZIP/Postal Code
750004
Country
China
Facility Name
Research Site
City
Yueyang
ZIP/Postal Code
414000
Country
China
Facility Name
Research Site
City
Aarhus
ZIP/Postal Code
8200
Country
Denmark
Facility Name
Research Site
City
Gentofte
ZIP/Postal Code
2820
Country
Denmark
Facility Name
Research Site
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Research Site
City
Hillerød
ZIP/Postal Code
3400
Country
Denmark
Facility Name
Research Site
City
København Ø
ZIP/Postal Code
2100
Country
Denmark
Facility Name
Research Site
City
Roskilde
ZIP/Postal Code
4000
Country
Denmark
Facility Name
Research Site
City
Aschaffenburg
ZIP/Postal Code
63739
Country
Germany
Facility Name
Research Site
City
Bad Oeynhausen
ZIP/Postal Code
32545
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Research Site
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Research Site
City
Düsseldorf
ZIP/Postal Code
40210
Country
Germany
Facility Name
Research Site
City
Essen
ZIP/Postal Code
45136
Country
Germany
Facility Name
Research Site
City
Frankfurt am Main
ZIP/Postal Code
60590
Country
Germany
Facility Name
Research Site
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Research Site
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
Facility Name
Research Site
City
München
ZIP/Postal Code
81675
Country
Germany
Facility Name
Research Site
City
Münster
ZIP/Postal Code
48145
Country
Germany
Facility Name
Research Site
City
Schweinfurt
ZIP/Postal Code
97421
Country
Germany
Facility Name
Research Site
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
Research Site
City
Ulm
ZIP/Postal Code
89081
Country
Germany
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1083
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1106
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1212
Country
Hungary
Facility Name
Research Site
City
Eger
ZIP/Postal Code
3300
Country
Hungary
Facility Name
Research Site
City
Gyula
ZIP/Postal Code
5700
Country
Hungary
Facility Name
Research Site
City
Kistarcsa
ZIP/Postal Code
2143
Country
Hungary
Facility Name
Research Site
City
Miskolc
ZIP/Postal Code
3526
Country
Hungary
Facility Name
Research Site
City
Nyíregyháza
ZIP/Postal Code
4400
Country
Hungary
Facility Name
Research Site
City
Pécs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Research Site
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Research Site
City
Velence
ZIP/Postal Code
2481
Country
Hungary
Facility Name
Research Site
City
Ahmedabad
ZIP/Postal Code
380016
Country
India
Facility Name
Research Site
City
Bangalore
ZIP/Postal Code
560002
Country
India
Facility Name
Research Site
City
Calicut
ZIP/Postal Code
673008
Country
India
Facility Name
Research Site
City
Chennai
ZIP/Postal Code
600001
Country
India
Facility Name
Research Site
City
Ernakulam
ZIP/Postal Code
683594
Country
India
Facility Name
Research Site
City
Hyderabad
ZIP/Postal Code
500018
Country
India
Facility Name
Research Site
City
Kanpur
ZIP/Postal Code
208002
Country
India
Facility Name
Research Site
City
Kolkata
ZIP/Postal Code
700020
Country
India
Facility Name
Research Site
City
Lucknow
ZIP/Postal Code
226003
Country
India
Facility Name
Research Site
City
Lucknow
ZIP/Postal Code
226005
Country
India
Facility Name
Research Site
City
Madurai
ZIP/Postal Code
625020
Country
India
Facility Name
Research Site
City
Maharashtra
ZIP/Postal Code
411013
Country
India
Facility Name
Research Site
City
Mangalore
ZIP/Postal Code
575003
Country
India
Facility Name
Research Site
City
Nagpur
ZIP/Postal Code
440003
Country
India
Facility Name
Research Site
City
Nagpur
ZIP/Postal Code
440012
Country
India
Facility Name
Research Site
City
New Delhi
ZIP/Postal Code
110017
Country
India
Facility Name
Research Site
City
Pune
ZIP/Postal Code
411001
Country
India
Facility Name
Research Site
City
Pune
ZIP/Postal Code
411040
Country
India
Facility Name
Research Site
City
Vijayawada
ZIP/Postal Code
522002
Country
India
Facility Name
Research Site
City
Amagasaki-shi
ZIP/Postal Code
660-8550
Country
Japan
Facility Name
Research Site
City
Asahikawa-shi
ZIP/Postal Code
070-8644
Country
Japan
Facility Name
Research Site
City
Beppu-shi
ZIP/Postal Code
874-0011
Country
Japan
Facility Name
Research Site
City
Bunkyo-ku
ZIP/Postal Code
113-8431
Country
Japan
Facility Name
Research Site
City
Chiba-shi
ZIP/Postal Code
260-8712
Country
Japan
Facility Name
Research Site
City
Chuo-ku
ZIP/Postal Code
103-0002
Country
Japan
Facility Name
Research Site
City
Chuo-ku
ZIP/Postal Code
103-0027
Country
Japan
Facility Name
Research Site
City
Chuo-ku
ZIP/Postal Code
104-0031
Country
Japan
Facility Name
Research Site
City
Daito-shi
ZIP/Postal Code
574-0074
Country
Japan
Facility Name
Research Site
City
Fujisawa-shi
ZIP/Postal Code
251-8550
Country
Japan
Facility Name
Research Site
City
Fukuoka-shi
ZIP/Postal Code
810-0065
Country
Japan
Facility Name
Research Site
City
Higashiibaraki-gun
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
Research Site
City
Iizuka-shi
ZIP/Postal Code
820-8505
Country
Japan
Facility Name
Research Site
City
Itabashi-ku
ZIP/Postal Code
173-8610
Country
Japan
Facility Name
Research Site
City
Kamakura-shi
ZIP/Postal Code
247-8533
Country
Japan
Facility Name
Research Site
City
Kanazawa-shi
ZIP/Postal Code
920-8650
Country
Japan
Facility Name
Research Site
City
Kawachinagano-shi
ZIP/Postal Code
586-8521
Country
Japan
Facility Name
Research Site
City
Kawasaki-shi
ZIP/Postal Code
211-8510
Country
Japan
Facility Name
Research Site
City
Kobe-shi
ZIP/Postal Code
654-0155
Country
Japan
Facility Name
Research Site
City
Koga-shi
ZIP/Postal Code
811-3195
Country
Japan
Facility Name
Research Site
City
Koshigaya-shi
ZIP/Postal Code
343-8577
Country
Japan
Facility Name
Research Site
City
Kumamoto-shi
ZIP/Postal Code
860-0008
Country
Japan
Facility Name
Research Site
City
Kurashiki
ZIP/Postal Code
701 0192
Country
Japan
Facility Name
Research Site
City
Matsumoto-shi
ZIP/Postal Code
390-8621
Country
Japan
Facility Name
Research Site
City
Nagano-shi
ZIP/Postal Code
388-8004
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
455-8530
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
456-0058
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
ZIP/Postal Code
457-8511
Country
Japan
Facility Name
Research Site
City
Naha-shi
ZIP/Postal Code
902-0061
Country
Japan
Facility Name
Research Site
City
Neyagawa-shi
ZIP/Postal Code
572-0015
Country
Japan
Facility Name
Research Site
City
Niigata-shi
ZIP/Postal Code
951-8520
Country
Japan
Facility Name
Research Site
City
Oita-shi
ZIP/Postal Code
870-0039
Country
Japan
Facility Name
Research Site
City
Okayama-shi
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Research Site
City
Okayama-shi
ZIP/Postal Code
701-1192
Country
Japan
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
530-8480
Country
Japan
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
540-0006
Country
Japan
Facility Name
Research Site
City
Osaka-shi
ZIP/Postal Code
558-8558
Country
Japan
Facility Name
Research Site
City
Saga-shi
ZIP/Postal Code
840-8571
Country
Japan
Facility Name
Research Site
City
Sapporo-shi
ZIP/Postal Code
063-0005
Country
Japan
Facility Name
Research Site
City
Shizuoka-shi
ZIP/Postal Code
420-8630
Country
Japan
Facility Name
Research Site
City
Takarazuka-shi
ZIP/Postal Code
665-0861
Country
Japan
Facility Name
Research Site
City
Toride-shi
ZIP/Postal Code
302-0022
Country
Japan
Facility Name
Research Site
City
Tsu-shi
ZIP/Postal Code
514-1101
Country
Japan
Facility Name
Research Site
City
Tsu-shi
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Research Site
City
Tsuchiura-shi
ZIP/Postal Code
300-0028
Country
Japan
Facility Name
Research Site
City
Ueda-shi
ZIP/Postal Code
386-8610
Country
Japan
Facility Name
Research Site
City
Uji-shi
ZIP/Postal Code
611-0041
Country
Japan
Facility Name
Research Site
City
Yaizu-shi
ZIP/Postal Code
425-8505
Country
Japan
Facility Name
Research Site
City
Yokohama-shi
ZIP/Postal Code
232-0024
Country
Japan
Facility Name
Research Site
City
Ansan-si
ZIP/Postal Code
15355
Country
Korea, Republic of
Facility Name
Research Site
City
Deagu
ZIP/Postal Code
41944
Country
Korea, Republic of
Facility Name
Research Site
City
Goyang-si
ZIP/Postal Code
10380
Country
Korea, Republic of
Facility Name
Research Site
City
Goyang-si
ZIP/Postal Code
10444
Country
Korea, Republic of
Facility Name
Research Site
City
Gwangju
ZIP/Postal Code
61469
Country
Korea, Republic of
Facility Name
Research Site
City
Jeonju-si
ZIP/Postal Code
54907
Country
Korea, Republic of
Facility Name
Research Site
City
Seongnam-si
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
07061
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
07804
Country
Korea, Republic of
Facility Name
Research Site
City
Seoul
ZIP/Postal Code
07985
Country
Korea, Republic of
Facility Name
Research Site
City
Uijeongbu-si
ZIP/Postal Code
11765
Country
Korea, Republic of
Facility Name
Research Site
City
Wonju-si
ZIP/Postal Code
26426
Country
Korea, Republic of
Facility Name
Research Site
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Research Site
City
Cuernavaca
ZIP/Postal Code
62448
Country
Mexico
Facility Name
Research Site
City
Culiacán
ZIP/Postal Code
80230
Country
Mexico
Facility Name
Research Site
City
D.F
ZIP/Postal Code
14000
Country
Mexico
Facility Name
Research Site
City
Durango
ZIP/Postal Code
34000
Country
Mexico
Facility Name
Research Site
City
Guadalajara
ZIP/Postal Code
44600
Country
Mexico
Facility Name
Research Site
City
Mazatlán
ZIP/Postal Code
82000
Country
Mexico
Facility Name
Research Site
City
Mazatlán
ZIP/Postal Code
82110
Country
Mexico
Facility Name
Research Site
City
Mexico
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Research Site
City
Mexico
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Research Site
City
Minatitlán
ZIP/Postal Code
96730
Country
Mexico
Facility Name
Research Site
City
Monterey
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Research Site
City
Monterrey
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Research Site
City
México
ZIP/Postal Code
06726
Country
Mexico
Facility Name
Research Site
City
Saltillo
ZIP/Postal Code
25230
Country
Mexico
Facility Name
Research Site
City
Arequipa
ZIP/Postal Code
AREQUIPA01
Country
Peru
Facility Name
Research Site
City
Callao
ZIP/Postal Code
CALLAO 2
Country
Peru
Facility Name
Research Site
City
Chorrillos
ZIP/Postal Code
Lima 9
Country
Peru
Facility Name
Research Site
City
Cusco
ZIP/Postal Code
CUSCO 01
Country
Peru
Facility Name
Research Site
City
Ica
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
14
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
36
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
L27
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 01
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 1
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 27
Country
Peru
Facility Name
Research Site
City
Lima
ZIP/Postal Code
LIMA 31
Country
Peru
Facility Name
Research Site
City
Piura
Country
Peru
Facility Name
Research Site
City
San Isidro
ZIP/Postal Code
Lima 27
Country
Peru
Facility Name
Research Site
City
San Miguel
ZIP/Postal Code
Lima 32
Country
Peru
Facility Name
Research Site
City
Bacolod
ZIP/Postal Code
6100
Country
Philippines
Facility Name
Research Site
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
Research Site
City
Cebu
ZIP/Postal Code
6000
Country
Philippines
Facility Name
Research Site
City
Dasmarinas City
ZIP/Postal Code
4114
Country
Philippines
Facility Name
Research Site
City
Davao City
ZIP/Postal Code
PH-8000
Country
Philippines
Facility Name
Research Site
City
Iloilo City
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Research Site
City
Iloilo
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Research Site
City
Makati City
ZIP/Postal Code
1218
Country
Philippines
Facility Name
Research Site
City
Marikina
ZIP/Postal Code
1800
Country
Philippines
Facility Name
Research Site
City
Quezon City
ZIP/Postal Code
1101
Country
Philippines
Facility Name
Research Site
City
Bielsko-Biała
ZIP/Postal Code
43-300
Country
Poland
Facility Name
Research Site
City
Bochnia
ZIP/Postal Code
32-700
Country
Poland
Facility Name
Research Site
City
Chorzów
ZIP/Postal Code
41-500
Country
Poland
Facility Name
Research Site
City
Ciechanów
ZIP/Postal Code
06-400
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-081
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-648
Country
Poland
Facility Name
Research Site
City
Kraków
ZIP/Postal Code
31-156
Country
Poland
Facility Name
Research Site
City
Kraków
ZIP/Postal Code
31-530
Country
Poland
Facility Name
Research Site
City
Legnica
ZIP/Postal Code
59-220
Country
Poland
Facility Name
Research Site
City
Olsztyn
ZIP/Postal Code
10-561
Country
Poland
Facility Name
Research Site
City
Ostrowiec Świętokrzyski
ZIP/Postal Code
27-400
Country
Poland
Facility Name
Research Site
City
Oława
ZIP/Postal Code
55-200
Country
Poland
Facility Name
Research Site
City
Poznań
ZIP/Postal Code
60-821
Country
Poland
Facility Name
Research Site
City
Ruda Śląska
ZIP/Postal Code
41-709
Country
Poland
Facility Name
Research Site
City
Rzeszów
ZIP/Postal Code
35-055
Country
Poland
Facility Name
Research Site
City
Szczecin
ZIP/Postal Code
70-111
Country
Poland
Facility Name
Research Site
City
Tczew
ZIP/Postal Code
83-110
Country
Poland
Facility Name
Research Site
City
Łódź
ZIP/Postal Code
92-213
Country
Poland
Facility Name
Research Site
City
Chelyabinsk
ZIP/Postal Code
454091
Country
Russian Federation
Facility Name
Research Site
City
Ekaterinburg
ZIP/Postal Code
620039
Country
Russian Federation
Facility Name
Research Site
City
Kazan
ZIP/Postal Code
420012
Country
Russian Federation
Facility Name
Research Site
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Research Site
City
Kemerovo
ZIP/Postal Code
650066
Country
Russian Federation
Facility Name
Research Site
City
Krasnoyarsk
ZIP/Postal Code
660062
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
123995
Country
Russian Federation
Facility Name
Research Site
City
Omsk
ZIP/Postal Code
644112
Country
Russian Federation
Facility Name
Research Site
City
Perm
ZIP/Postal Code
614000
Country
Russian Federation
Facility Name
Research Site
City
Perm
ZIP/Postal Code
614068
Country
Russian Federation
Facility Name
Research Site
City
Rostov-on-Don
ZIP/Postal Code
344022
Country
Russian Federation
Facility Name
Research Site
City
Saint Petersburg
ZIP/Postal Code
196601
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
199106
Country
Russian Federation
Facility Name
Research Site
City
Saratov
ZIP/Postal Code
410053
Country
Russian Federation
Facility Name
Research Site
City
St.Petersburg
ZIP/Postal Code
194354
Country
Russian Federation
Facility Name
Research Site
City
Tver
ZIP/Postal Code
170036
Country
Russian Federation
Facility Name
Research Site
City
Ufa
ZIP/Postal Code
450071
Country
Russian Federation
Facility Name
Research Site
City
Vladikavkaz
ZIP/Postal Code
362007
Country
Russian Federation
Facility Name
Research Site
City
Volgograd
ZIP/Postal Code
400131
Country
Russian Federation
Facility Name
Research Site
City
Yaroslavl
ZIP/Postal Code
150062
Country
Russian Federation
Facility Name
Research Site
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Research Site
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Research Site
City
Burela (Lugo)
ZIP/Postal Code
27880
Country
Spain
Facility Name
Research Site
City
L'Hospitalet de Llobregat
ZIP/Postal Code
08907
Country
Spain
Facility Name
Research Site
City
La Coruña
ZIP/Postal Code
15006
Country
Spain
Facility Name
Research Site
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Research Site
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Research Site
City
Santiago de Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Research Site
City
Sevilla
ZIP/Postal Code
41071
Country
Spain
Facility Name
Research Site
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Research Site
City
Valencia
ZIP/Postal Code
46017
Country
Spain
Facility Name
Research Site
City
Göteborg
ZIP/Postal Code
413 45
Country
Sweden
Facility Name
Research Site
City
Malmö
ZIP/Postal Code
205 02
Country
Sweden
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
141 86
Country
Sweden
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
182 88
Country
Sweden
Facility Name
Research Site
City
Uppsala
ZIP/Postal Code
751 85
Country
Sweden
Facility Name
Research Site
City
Cherkasy
ZIP/Postal Code
18009
Country
Ukraine
Facility Name
Research Site
City
Chernivtsі
ZIP/Postal Code
58018
Country
Ukraine
Facility Name
Research Site
City
Dnipro
ZIP/Postal Code
49005
Country
Ukraine
Facility Name
Research Site
City
Dnipro
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Research Site
City
Ivano-Frankivsk
ZIP/Postal Code
76008
Country
Ukraine
Facility Name
Research Site
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
Research Site
City
Kharkiv Region
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Research Site
City
Kharkiv Region
ZIP/Postal Code
61103
Country
Ukraine
Facility Name
Research Site
City
Kharkiv Region
ZIP/Postal Code
61166
Country
Ukraine
Facility Name
Research Site
City
Kyiv
ZIP/Postal Code
02091
Country
Ukraine
Facility Name
Research Site
City
Kyiv
ZIP/Postal Code
02125
Country
Ukraine
Facility Name
Research Site
City
Kyiv
ZIP/Postal Code
04053
Country
Ukraine
Facility Name
Research Site
City
Kyiv
ZIP/Postal Code
4050
Country
Ukraine
Facility Name
Research Site
City
Lutsk
ZIP/Postal Code
43005
Country
Ukraine
Facility Name
Research Site
City
Odesa
ZIP/Postal Code
65025
Country
Ukraine
Facility Name
Research Site
City
Poltava
ZIP/Postal Code
36011
Country
Ukraine
Facility Name
Research Site
City
Rivne
ZIP/Postal Code
33027
Country
Ukraine
Facility Name
Research Site
City
Ternopil
ZIP/Postal Code
46000
Country
Ukraine
Facility Name
Research Site
City
Vinnytsia
ZIP/Postal Code
21001
Country
Ukraine
Facility Name
Research Site
City
Vinnytsia
ZIP/Postal Code
21018
Country
Ukraine
Facility Name
Research Site
City
Zaporizhzhia
ZIP/Postal Code
69600
Country
Ukraine
Facility Name
Research Site
City
Cardiff
ZIP/Postal Code
CF14 4XW
Country
United Kingdom
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Facility Name
Research Site
City
Hull
ZIP/Postal Code
HU3 2JZ
Country
United Kingdom
Facility Name
Research Site
City
Kent
ZIP/Postal Code
BR6 8ND
Country
United Kingdom
Facility Name
Research Site
City
Leicester
ZIP/Postal Code
LE5 4PW
Country
United Kingdom
Facility Name
Research Site
City
London
ZIP/Postal Code
E1 1BB
Country
United Kingdom
Facility Name
Research Site
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Research Site
City
Salford
ZIP/Postal Code
M6 8HD
Country
United Kingdom
Facility Name
Research Site
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
Facility Name
Research Site
City
Bien Hoa
ZIP/Postal Code
810000
Country
Vietnam
Facility Name
Research Site
City
Hanoi
ZIP/Postal Code
10000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh city
ZIP/Postal Code
700000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh City
ZIP/Postal Code
70000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh City
ZIP/Postal Code
9000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
10000
Country
Vietnam
Facility Name
Research Site
City
Ho Chi Minh
ZIP/Postal Code
7000000
Country
Vietnam
Facility Name
Research Site
City
Hochiminh
ZIP/Postal Code
700000
Country
Vietnam
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
36323444
Citation
McEwan P, Darlington O, Miller R, McMurray JJV, Wheeler DC, Heerspink HJL, Briggs A, Bergenheim K, Garcia Sanchez JJ. Cost-Effectiveness of Dapagliflozin as a Treatment for Chronic Kidney Disease: A Health-Economic Analysis of DAPA-CKD. Clin J Am Soc Nephrol. 2022 Dec;17(12):1730-1741. doi: 10.2215/CJN.03790322. Epub 2022 Nov 2.
Results Reference
derived
PubMed Identifier
35977807
Citation
Jongs N, Chertow GM, Greene T, McMurray JJV, Langkilde AM, Correa-Rotter R, Kashihara N, Rossing P, Sjostrom CD, Stefansson BV, Toto RD, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators; Members of the DAPA-CKD Trial Committees and Investigators. Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with CKD. J Am Soc Nephrol. 2022 Nov;33(11):2094-2107. doi: 10.1681/ASN.2022030306. Epub 2022 Aug 17.
Results Reference
derived
PubMed Identifier
35497805
Citation
Vart P, Correa-Rotter R, Hou FF, Jongs N, Chertow GM, Langkilde AM, McMurray JJV, Rossing P, Sjostrom CD, Stefansson BV, Toto RD, Douthat W, Escudero E, Isidto R, Khullar D, Bajaj HS, Wheeler DC, Heerspink HJL. Efficacy and Safety of Dapagliflozin in Patients With CKD Across Major Geographic Regions. Kidney Int Rep. 2022 Feb 2;7(4):699-707. doi: 10.1016/j.ekir.2022.01.1060. eCollection 2022 Apr.
Results Reference
derived
PubMed Identifier
35445820
Citation
Waijer SW, Vart P, Cherney DZI, Chertow GM, Jongs N, Langkilde AM, Mann JFE, Mosenzon O, McMurray JJV, Rossing P, Correa-Rotter R, Stefansson BV, Toto RD, Wheeler DC, Heerspink HJL. Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial. Diabetologia. 2022 Jul;65(7):1085-1097. doi: 10.1007/s00125-022-05694-6. Epub 2022 Apr 21.
Results Reference
derived
PubMed Identifier
34619108
Citation
Heerspink HJL, Jongs N, Chertow GM, Langkilde AM, McMurray JJV, Correa-Rotter R, Rossing P, Sjostrom CD, Stefansson BV, Toto RD, Wheeler DC, Greene T; DAPA-CKD Trial Committees and Investigators. Effect of dapagliflozin on the rate of decline in kidney function in patients with chronic kidney disease with and without type 2 diabetes: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021 Nov;9(11):743-754. doi: 10.1016/S2213-8587(21)00242-4. Epub 2021 Oct 4. Erratum In: Lancet Diabetes Endocrinol. 2022 Oct;10(10):e10.
Results Reference
derived
PubMed Identifier
34619106
Citation
Jongs N, Greene T, Chertow GM, McMurray JJV, Langkilde AM, Correa-Rotter R, Rossing P, Sjostrom CD, Stefansson BV, Toto RD, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Effect of dapagliflozin on urinary albumin excretion in patients with chronic kidney disease with and without type 2 diabetes: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021 Nov;9(11):755-766. doi: 10.1016/S2213-8587(21)00243-6. Epub 2021 Oct 4.
Results Reference
derived
PubMed Identifier
34446370
Citation
McMurray JJV, Wheeler DC, Stefansson BV, Jongs N, Postmus D, Correa-Rotter R, Chertow GM, Hou FF, Rossing P, Sjostrom CD, Solomon SD, Toto RD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Effects of Dapagliflozin in Patients With Kidney Disease, With and Without Heart Failure. JACC Heart Fail. 2021 Nov;9(11):807-820. doi: 10.1016/j.jchf.2021.06.017. Epub 2021 Aug 23. Erratum In: JACC Heart Fail. 2022 Jun;10(6):446-447.
Results Reference
derived
PubMed Identifier
34183431
Citation
Persson F, Rossing P, Vart P, Chertow GM, Hou FF, Jongs N, McMurray JJV, Correa-Rotter R, Bajaj HS, Stefansson BV, Toto RD, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial. Diabetes Care. 2021 Aug;44(8):1894-1897. doi: 10.2337/dc21-0300. Epub 2021 Jun 28.
Results Reference
derived
PubMed Identifier
33338413
Citation
Wheeler DC, Stefansson BV, Jongs N, Chertow GM, Greene T, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Toto RD, Sjostrom CD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021 Jan;9(1):22-31. doi: 10.1016/S2213-8587(20)30369-7.
Results Reference
derived
PubMed Identifier
33186054
Citation
McMurray JJV, Wheeler DC, Stefansson BV, Jongs N, Postmus D, Correa-Rotter R, Chertow GM, Greene T, Held C, Hou FF, Mann JFE, Rossing P, Sjostrom CD, Toto RD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease. Circulation. 2021 Feb 2;143(5):438-448. doi: 10.1161/CIRCULATIONAHA.120.051675. Epub 2020 Nov 13.
Results Reference
derived
PubMed Identifier
32970396
Citation
Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjostrom CD, Toto RD, Langkilde AM, Wheeler DC; DAPA-CKD Trial Committees and Investigators. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020 Oct 8;383(15):1436-1446. doi: 10.1056/NEJMoa2024816. Epub 2020 Sep 24.
Results Reference
derived
PubMed Identifier
32862232
Citation
Wheeler DC, Stefansson BV, Batiushin M, Bilchenko O, Cherney DZI, Chertow GM, Douthat W, Dwyer JP, Escudero E, Pecoits-Filho R, Furuland H, Gorriz JL, Greene T, Haller H, Hou FF, Kang SW, Isidto R, Khullar D, Mark PB, McMurray JJV, Kashihara N, Nowicki M, Persson F, Correa-Rotter R, Rossing P, Toto RD, Umanath K, Van Bui P, Wittmann I, Lindberg M, Sjostrom CD, Langkilde AM, Heerspink HJL. The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics. Nephrol Dial Transplant. 2020 Oct 1;35(10):1700-1711. doi: 10.1093/ndt/gfaa234.
Results Reference
derived
PubMed Identifier
32778748
Citation
Piperidou A, Loutradis C, Sarafidis P. SGLT-2 inhibitors and nephroprotection: current evidence and future perspectives. J Hum Hypertens. 2021 Jan;35(1):12-25. doi: 10.1038/s41371-020-00393-4. Epub 2020 Aug 10.
Results Reference
derived
PubMed Identifier
32559465
Citation
Sternlicht HK, Bakris GL. Reductions in albuminuria with SGLT2 inhibitors: a marker for improved renal outcomes in patients without diabetes? Lancet Diabetes Endocrinol. 2020 Jul;8(7):553-555. doi: 10.1016/S2213-8587(20)30185-6. No abstract available.
Results Reference
derived
PubMed Identifier
31939531
Citation
Gonzalez DE, Foresto RD, Ribeiro AB. SGLT-2 inhibitors in diabetes: a focus on renoprotection. Rev Assoc Med Bras (1992). 2020 Jan 13;66Suppl 1(Suppl 1):s17-s24. doi: 10.1590/1806-9282.66.S1.17.
Results Reference
derived
Links:
URL
https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D169AC00001&attachmentIdentifier=c59c2c03-ebfa-46f4-beac-d0b14b62db99&fileName=d169ac00001_csp_Redacted.pdf&versionIdentifier=
Description
redacted protocol
URL
https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D169AC00001&attachmentIdentifier=987ded9e-acd7-4718-a380-431a2b2d1377&fileName=d169ac00001_sap_Redacted.pdf&versionIdentifier=
Description
redacted Statistical Analysis Plan
Learn more about this trial
A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease
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