Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk
Diabetes Mellitus
About this trial
This is an interventional treatment trial for Diabetes Mellitus focused on measuring Diabetes Mellitus, Cognition
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of T2D
- Diagnosis of MCI
- > the age of 65
- Hebrew fluency
- An informant
Exclusion Criteria:
- Brain disease that affects cognition (e.g. Parkinson's disease, schizophrenia).
- Stroke
- Epilepsy
- Chest pathology incompatible with HBOT
- Inner ear disease
- Claustrophobia
- Cholinesterase inhibitors
- Subjects with an indication for HBOT
- Counter-indication for MRI or PET
- Individuals with severe cataracts must have cataract operations before enrolling in the study
Sites / Locations
- Icahn School of Medicine at Mount SinaiRecruiting
- University of WisconsinRecruiting
- Sheba Medical CenterRecruiting
- Assaf HaRofeh Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
HBOT intervention
Sham intervention
The multiplace HBOT unit at Asaf Harofeh. The inside looks like an airplane, with comfortable chairs for 11 subjects and the nurse who stays throughout the session. The HBOT protocol is 90 minutes, 5 times/week, 60 sessions, 100% oxygen at 2 ATA with 5 minute air breaks every 30 minutes.
Except for pressure, all the conditions of the HBOT intervention are provided in the sham intervention (nurse measures vitals and asks about health before entering the chamber, time in the chamber, number of sessions per week and overall, nurse in the chamber at all times, mask on the face, etc.).