The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation (HYPAT)
Muscle Atrophy, Disuse Atrophy (Muscle) of Lower Leg
About this trial
This is an interventional basic science trial for Muscle Atrophy focused on measuring Muscle Hypertrophy, Muscle Atrophy, Resistance Training, Immobilization
Eligibility Criteria
Inclusion Criteria:
- Healthy
- Non-Smoker
- Do not heavily consume alcohol
Exclusion Criteria:
- Female
- Younger than 18, or older than 30 years
- use of anti-inflammatory or analgesic medication
- history of neuromuscular disorders
- family history of deep vein thrombosis
- regularly take part in structured physical exercise (greater than 2 days per week)
- take any medications known to influence protein metabolism
Sites / Locations
- Exercise Metabolism Research Laboratory, McMaster Univeristy
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Unilateral Resistance Exercise
Immobilization
One of the participant's legs will be randomized to a unilateral resistance training arm for 10 weeks in duration. The leg chosen to be trained will undergo resistance exercise three days per week (Monday, Wednesday, and Friday) for the entirety of the study.
One of the participant's legs will be chosen to be immobilized during the last two weeks of the study. Therefore, one leg will be resistance exercising from week 0-10 whereas the other leg will be immobilized during weeks 8-10.