Back to resultsEMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
Primary Purpose
Heart Failure
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Empagliflozin
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Heart Failure
Eligibility Criteria
Inclusion criteria:
- Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years at screening
- Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
- Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
- Stable dose of oral diuretics, if prescribed
- Signed and dated written ICF (informed consent form)
- Further inclusion criteria apply
Exclusion criteria:
- Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
- Heart transplant recipient or listed for heart transplant
- Acute decompensated HF (Heart Failure)
- Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
- Symptomatic hypotension and/or a SBP < 100 mmHg
- Indication of liver disease,
- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
- History of ketoacidosis
- Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
- Currently enrolled in another investigational device or drug trial
- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
- Further exclusion criteria may apply
Sites / Locations
- Pinnacle Research Group, LLC
- University of Alabama at Birmingham
- Heart Center Research, LLC
- University of California San Francisco
- La Mesa Cardiac Center
- Purushotham, Akther & Roshan Kotha, MD Inc.
- Long Beach Center for Clinical Research
- VA Greater Los Angeles Healthcare System
- Merced Vein and Vascular Center
- Valley Clinical Trials, Inc.
- University of California Irvine
- Covigilant Research, LLC
- University of California San Francisco
- University of California
- Orange County Research Center
- Blue Coast Cardiology
- South Denver Cardiology Associates, PC
- Integrated Heart Care
- Southeast Clinical Research, LLC
- Morton Plant Mease Health Care
- Accel Research Sites
- Integrative Research Associates
- Nature Coast Clinical Research
- East Coast Institute for Research, LLC
- Jacksonville Center for Clinical Research
- Elite Clinical Research
- Cardiovascular Research Center of South Florida
- Orlando Health Inc.
- Peninsula Research, Inc.
- Clearwater Cardiovascular Consultants
- Sarasota Memorial Hospital
- University of South Florida
- Advent Health Medical Group
- Grady Clinical Research Center
- Columbus Regional Research Institute
- Cardiovascular Group PC
- Meridian Clinical Research, LLC
- Atlanta Heart Specialists, LLC
- Northwest Heart Clinical Research, LLC
- Mount Sinai Hospital
- Advocate Health and Hospitals Corporation
- Captain James A. Lovell Federal Health Care Center
- Rockford Cardiovascular Associates
- Midwest Cardiovascular Research and Education Foundation
- St. Francis Medical Group-Indiana Heart Physicians, Inc
- Reid Hospital
- Beacon Medical Group Clinical Research
- Iowa Heart Center
- Norton Heart Specialists
- Research Integrity, LLC
- Grace Research, LLC
- Clinical Trials of America, LLC
- LSU Health Sciences Center
- Maine Research Associates
- Anne Arundel Medical Center
- Maryland Cardiovascular Specialists
- MedStar Health Research Institute
- Metropolitan Cardiovascular Consultants
- MD Medical Research
- Tufts Medical Center
- Massachusetts General Hospital
- East Mountain Medical Associates, PC
- Alpena General Hospital
- McLaren Northern Michigan Hospital
- Regions Hospital
- Jackson Heart Clinic, P.A.
- Saint Luke's Hospital of Kansas City
- Saint Louis University
- St. Louis Center for Clinical Research
- St. Louis Heart and Vascular, P.C.
- Deaconess Billings Clinic Research Center
- Bozeman Health Clinical Research
- Nebraska Heart Institute
- CHI Health Midlands
- Healthcare Partners LLC
- Palm Research Center
- Advanced Heart Care, LLC
- Garden State Heart Care, PC
- Capital Cardiology Associates, PC
- CHEAR Center LLC
- Cardiac Care and Vascular Medicine, PLLC
- Trinity Medical WNY, PC
- North Shore University Hospital
- Long Island Cardiovascular Consultants
- Mount Sinai - PRIME
- Harlem Cardiology
- Laurelton Heart Specialist, PC
- Saratoga Clinical Research, LLC
- Northwell Health
- Stony Brook University Medical Center
- Asheville Cardiology Associates
- Kernodle Clinic West
- The University of North Carolina at Chapel Hill
- Novant Health Heart and Vascular Institute
- Clinical Research of Gastonia
- Clinical Trials of America, Inc
- VA Northeast Ohio Healthcare System
- Rama Research LLC
- South Oklahoma Heart Research Group
- Doylestown Health Cardiology
- Lycoming Internal Medicine, Inc
- Richard M Kastelic and Associates
- York Hospital, WellSpan Health
- Lowcountry Center for Veterans Research
- Palmetto Health
- Clinical Research of Rock Hill
- Palmetto Research Center, LLC
- Sanford Research
- The Stern Cardiovascular Center
- Apex Cardiology/ Research Associates of Jackson
- Methodist University Hospital
- Seton Heart Institute
- Baylor Heart and Vascular Hospital
- Soltero Cardiovascular Research Center
- University of Texas Southwestern Medical Center
- University of North Texas Health Science Center
- University of Texas Medical Branch at Galveston
- Angiocardiac Care of Texas
- The Methodist Hospital
- Biopharma Informatic, Inc. Research Center
- Private Practice Leadership, LLC
- Baylor Scott and White Health
- Alpine Research Organization
- Cardiac Health Management Network, P.C.
- Cardiology Consultants of Danville, Inc
- Carient Heart and Vascular
- Hunter Holmes McGuire VA Medical Center
- Medical College of Virginia Hospitals
- Roanoke Heart Institute PLC
- Salem VA Medical Center
- Virginia Mason Medical Center
- Cardiology Associates of Bellin Health
- Meriter Wisconsin Heart
- Marshfield Clinic
- Aspirus Research Institute
- Hospital Interzonal General de Agudos Dr Jose Penna
- Hospital Italiano Regional del Sur, Bahia Blanca
- CIPREC
- Hospital Italiano de Buenos Aires
- Instituto Cardiovascular de Buenos Aires
- Glenny Corp. S.A. Bioclinica Argentina
- Centro Médico Viamonte
- Consultorios Asociados de Endocrinología e Invest Clínica
- Sanatorio Güemes
- Instituto Medico Elsa Perez SRL (IMEP)
- Clinica Privada Colombo- Fundacion Clinica Colombo
- Instituto Médico DAMIC S.R.L.
- Clinica Coronel Suarez SA
- Instituto de Cardiología de Corrientes
- Sanatorio Mayo Privado SA
- Centro de Investigaciones Clinicas Instituto del Corazon
- Sanatorio Allende S.A.
- Hospital Privado
- Hospital Italiano de La Plata
- Centro de Investigaciones Médicas
- Hospital Privado de Comunidad
- CER Instituto Médico
- Instituto de Investigaciones Clínicas de Quilmes
- Instituto de Investigaciones Clinicas de Rosario
- Instituto Medico Fundación Grupo Colaborativo Rosario
- Sanatorio Británico
- Sanatorio Plaza
- Instituto CAICI
- CORDIS S.A., Salta
- Centro Cardiovascular Salta
- Corporacion Medica de Gral. San Martin S.A.
- Instituto de Cardiología
- Clinica Mayo
- Investigaciones Clinicas Tucuman
- Centro Medico Luquez
- Centro de Investigaciones Clínicas del Litoral
- Hospital "Dr. José Maria Cullen"
- Clínica Olivos
- CEMEDIC - Centro de Especialidades Medicas
- Pendlebury Research
- John Hunter Hospital
- CORE Research Group
- Gold Coast University Hospital
- Royal Adelaide Hospital
- Adelaide Medical Research
- Flinders Medical Centre
- Heart and Vascular Research
- The Queen Elizabeth Hospital
- The Northern Hospital
- Peninsula Private Hospital
- University Hospital Geelong
- Mount Hospital
- C.H.U. de Charleroi
- AZ Sint-Blasius
- Ziekenhuis Oost-Limburg - Campus Sint-Jan
- AZ Maria Middelares
- Grand Hôpital de Charleroi
- Jessa Ziekenhuis - Campus Virga Jesse
- La Louvière - UNIV CHU Tivoli
- UZ Leuven
- Liège - HOSP CHR de la Citadelle
- FGM - Clínica Paulista de Doenças Cardiovasculares
- Hospital Felicio Rocho
- Hospital Vera Cruz
- L2IP -Instituto de Pesquisas Clínicas Ltda.
- ICDF - Instituto de Cardiologia do Distrito Federal
- CECAP - Centro de Cardiologia Clínica
- Irmandade da Santa Casa de Misericordia de Curitiba
- Centro Especializado em Cardiol Loema Instituto de Pesq Clin
- IPECC - Instituto de Pesquisa Clínica de Campinas
- CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
- Hospital Universitário
- IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
- Irmandade da Santa Casa de Misericórdia de Curitiba
- Via Medica
- HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
- ICM - Instituto do Coracao de Marilia
- Hospital São Vicente de Paulo
- Santa Casa de Misericórdia de Porto Alegre
- Centro de Pesquisas em Diabetes
- Hospital de Clínicas de Porto Alegre
- Instituto de Cardiologia Rio Grande do Sul
- Hospital Agamenon Magalhaes
- H.C.da Fac. de Medicina de Ribeirao Preto
- Hospital Universitário Pedro Ernesto UERJ
- CCBR - Rio de Janeiro - BR
- Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
- Pesquisare
- Praxis Pesquisa Médica
- Hospital de Base - Fac Med de Sao Jose do Rio Preto
- Centro de Pesquisa Clinica - CPCLIN
- CEPIC - Centro Paulista de Investigacao Clinica
- INCOR e Hospital das Clínicas da Universidade de São Paulo
- CEMEC - Centro Multidisciplinar de Estudos Clínicos
- CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
- Dr. Consulta
- CEDOES - Diagnóstico e Pesquisa,Vitória
- Santa Casa de Votuporanga
- Royal Alexandra Hospital
- Medical Arts Health Research Group
- Vancouver General Hospital
- Victoria Heart Institute Foundation
- St. Boniface General Hospital
- G.A. Research Associates Ltd
- QEII Health Sciences Centre
- Brampton Cardio Pulmonary Clinic
- Brampton Research Associates
- JBN Medical Diagnostic Services Inc.
- Cambridge Cardiac Care Inc.
- Dr. Saul Vizel
- Curnew Medicine Professional Corporation
- Hamilton General Hospital
- University Hospital (LHSC)
- PACE (Partners in Advanced Cardiac Evaluation)
- M Heffernan Medicine Professional Corp.
- Kawartha Cardiology Clinical Trials
- Heart Health Institute
- Scarborough Cardiology Research
- Cardiovascular Contract Research Organization LTD
- Canadian Phase Onward Inc.
- North York Diagnostic and Cardiac Centre
- Mohan Babapulle Medicine Professional Medicine
- Dr. Louis C.H. Yao
- ViaCar Recherche Clinique Inc
- ViaCar Recherche Clinique Inc
- Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
- Montreal Heart Institute
- Clinique Santé Cardio MC
- Montreal General Hospital - McGill University Health Centre
- McGill University Health Centre (MUHC)
- Royal University Hospital
- IUCPQ (Laval University)
- Cardiovascular Institute and Fu Wai Hospital
- Beijing Friendship Hospital
- First Hospital of Jilin University
- Hunan Provincial People's Hospital
- 2nd Xiangya Hospital of Central South University
- The Third Hospital of Changsha
- Dongguan People's Hospital
- The First Affiliated Hospital of Fujian Medical University
- The First Afiliated Hospital, Sun Yet-sen University
- Guangzhou First Municipal People's Hospital
- Haikou People's Hospital
- HaiNan Provincial People's Hospital
- The First Affiliated Hospital of Lanzhou University
- The Second Affiliated Hospital of Lanzhou Medical University
- The Affiliated Hospital of Southwest Medical University
- Nanchang University Affiliated 3rd Hospital
- First Hospital Affiliated with Nanjing Medical University
- Huashan Hospital, Fudan University
- General Hospital of Shenyang Military Region
- Shengjing Hospital of China Medical University
- Tianjin Union Medical Center Nankai University Affiliated Hospital
- Tongji Hospital, Tongji University
- Renmin Hospital of Wuhan University
- First Affiliated Hospital of Xi'an JiaoTong University
- Yanbian University Hospital
- the first people hospital of Yue Yang
- Affiliated Hospital of Jiangsu University
- Corazon IPS S.A.S.
- Centro de Reumatologia y Ortopedia SAS, Barranquilla
- IPS Centro Cientifico Asistencia
- CardioColombia S.A.S.
- Endocare Research Institute
- IPS Centro Medico Julián Coronel S.A.
- Fundación Valle del Lili
- Centro de Investigaciones Clinicas S.A.S
- Centro de Diagnostico Cardilogico
- Centro cardiovascular Aristides
- Fundación Cardiovascular de Colombia
- Asociacion IPS Medicos Internistas de Caldas
- Promotora Medica Las Americas SA
- Poliklinika Humanitas
- Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
- MUDr. Alexandra Ludkova
- University Hospital Brno
- Vojenska nemocnice Brno
- Nemocnice Milosrdnych bratri
- Fakultni nemocnice u sv. Anny v Brne
- Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno
- Edumed s.r.o
- MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
- Hospital Frydek Mistek
- Nemocnice Havlickuv Brod p.o.
- Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove
- KardioLouny s.r.o.
- InterKardioML s.r.o.
- Zdenek Vomacka
- PV-Kardiologie s.r.o.
- Corintez s.r.o.
- Vseobecna fakultni nemocnice V Praze
- University Thomayer's Hospital
- Institute for Clinical and Experimental Medicine
- University Hospital Motol
- Kardio Vaclavik s.r.o.
- Nemocnice Trebic p.o.
- Kardiologicka ambulance
- Kardiologicka ambulance MUDr. Ferkl s.r.o.
- Clinical Trials Services s.r.o
- Cardiology Private Practice
- Angiocor s.r.o
- KIGE s.r.o
- Universitätsklinikum Aachen, AöR
- Praxis Dr. Rieker, Berlin
- Vivantes Netzwerk für Gesundheit GmbH
- Charité - Universitätsmedizin Berlin
- Vivantes Netzwerk für Gesundheit GmbH
- Charité - Universitätsmedizin Berlin
- Klinikum Bielefeld gGmbH
- Augusta-Kranken-Anstalt gGmbH
- Praxis Dr. Menzel
- St. Johannes Hospital Dortmund
- Städtisches Klinikum Dresden
- Universitätsklinikum Carl Gustav Carus Dresden
- Helios Klinikum Erfurt
- Studienzentrum Bocholderstraße
- ClinPhenomics GmbH & Co KG, Frankfurt
- Universitätsmedizin Göttingen, Georg-August-Universität
- Medizinische Hochschule Hannover
- Universitätsklinikum Heidelberg
- Universitätsklinikum des Saarlandes
- Universitätsklinikum Jena
- Universitätsklinikum Schleswig-Holstein, Campus Kiel
- Asklepios Klinik Langen-Seligenstadt GmbH
- Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
- Praxis Dr. Sarnighausen, Lüneburg
- Katholisches Klinikum Mainz
- Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim
- Deutsches Herzzentrum München
- Gemeinschaftspraxis Dres Haggenmiller/Jeserich
- Kardiologische Praxis Papenburg
- Universitätsklinikum Regensburg
- Praxis Dr. Stenzel, Riesa
- Zentrum für Klinische Forschung
- Josephs-Hospital Warendorf
- Kardiologische Praxis, Wermsdorf
- Petrus-Krankenhaus
- Lausmed Kft. Outpatient Unit of Internal Medicine
- Belgyogyaszati es Kardiologiai Maganrendelo
- Budai Irgalmasrendi Korhaz
- Clinexpert Kft.
- Bajcsy-Zsilinszky Hospital and Clinic
- Semmelweis University
- Milit.Hosp.-State Health Cent.
- Uzsoki Street Hospital, Budapest
- Nehezlegzes Ambulancia
- University Debrecen Hospital
- Bugat Pal Hospital, Gyongyos
- Studium Egeszseghaz Kft.
- Selye Janos Hospital Komarom
- Dorottya Kanizsai Hospital
- Medifarma-98 Kft.
- Dr. Nagy Laszlo Kardiologiai Maganrendeles
- University of Pecs
- Da Vinci Private Clinic
- Fejer County Saint George University Teaching Hospital
- Veszpremi Sziv es Egeszseg Centrum
- Doctor Jivraj Mehta Smarak Health Foundation
- Kamalnayan Bajaj Hospital
- Narayana Institute of Cardiac Sciences
- Rajarajeswari Medical College
- Madras Medical Mission,
- Apollo Speciality Hospital
- Medanta-The Medicity
- GNRC Hospital
- B.M. Birla Heart research Centre
- Siddhi Hospital
- Vijan Cardiac and Critical Care Centre
- GB Pant Hospital
- Fortis Escorts Heart Institute
- Sir Gangaram Hospital
- Batra Hospital and Medical Research Centre
- Azienda Ospedaliera G. Rummo
- ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
- Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
- Ospedale della Val di Chiana Santa Margherita
- Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
- Centro Cardiologico Monzino-IRCCS
- Azienda Ospedaliera Universitaria "Federico II"
- Azienda Ospedaliera Universitaria Pisana
- AOU Policlinico Umberto I
- Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
- Istituto Clinico Humanitas
- IRCCS Gruppo Multimedica
- Azienda Servizi Sanitari 1 Triestina
- Kasugai Municipal Hospital
- Japanese Red Cross Nagoya Daini Hospital
- Chiba Heart Clinic
- Kimitsu Chuo Hospital
- Seikeikai New Tokyo Heart Clinic
- Ehime Prefectural Central Hospital
- Matsuyama Shimin Hospital
- Uwajima City Hospital
- Fukuiken Saiseikai Hospital
- Fukuoka University Chikushi Hospital
- Fukuokaken Saiseikai Futsukaichi Hospital
- Saiseikai Fukuoka General Hospital
- National Hospital Organization Kyushu Medical Center
- Kyushu University Hospital
- Steel Memorial Yawata Hospital
- Japan Community Health Care Organization Kyushu Hospital
- Shirakawa Kosei General Hospital
- Ogaki Municipal Hospital
- Chuno Kosei Hospital
- Fukuyama City Hospital
- Shobara Red Cross Hospital
- Matsuda Cardiovascular Clinic
- Teine Keijinkai Clinic
- Tomakomai City Hospital
- Otaru Kyokai Hospital
- Hyogo Prefectural Amagasaki General Medical Center
- Hyogo Brain and Heart Center
- National Hospital Organization Kobe Medical Center
- Mito Medical Center
- Tokushukai Koga General Hospital
- National Hospital Organization Kanazawa Medical Center
- Mitoyo General Hospital
- Kagawa Prefectural Central Hospital
- Sekishinkai Second Kawasaki Saiwai Clinic
- Yamamoto Clinic
- Kanagawa Cardiovascular and Respiratory Center
- Japanese Red Cross Kumamoto Hospital
- Seiwakai Suizenji Touya Hospital
- Kumamoto Rosai Hospital
- Omi Medical Center
- Uji-Tokushukai Medical Center
- Sendai Kousei Hospital
- Sendai Tokushukai Hospital
- National Hospital Organization Sendai Medical Center
- Miyazaki Medical Association Hospital
- Hokushin General Hospital
- Nagasaki Medical Center
- Oita Medical Center
- Okayama City General Medical Center
- Naha City Hospital
- Nanbu Tokushukai Hospital
- Urasoe General Hospital
- Higashiosaka City Medical Center
- Kitano Hospital
- Yodogawa Christian Hospital
- Hokusetsu General Hospital
- San-Ai Hospital
- Kosekai Iwatsuki-minami Hospital
- Tokushima Prefectural Central Hospital
- National Hospital Organization Tokyo Medical Center
- Ome Municipal General Hospital
- Tokyo Rosai Hospital
- Sekino Hospital
- Minami Wakayama Medical Center
- Kanmon Medical Center
- Inje University Busan Paik Hospital
- Dong-A University Hospital
- Chungbuk National University Hospital
- Chungnam National University Hospital
- Chonnam National University Hospital
- Seoul National University Bundang Hospital
- Gachon University Gil Medical Center
- Seoul National University Hospital
- Severance Hospital
- Asan Medical Center
- Samsung Medical Center
- Korea University Guro Hospital
- Wonju Severance Christian Hosp
- Hospital Cardiologica Aguascalientes
- Centro de Investigacion Biomedica y Farmaceutica, S.C.
- Hospital Ramon Garibay
- Diseño y Planeación en Investigación Médica SC
- Unidad de Investigacion Clinica Cardiometabolica de Occident
- Cardiologia Clinica e Intervencionista
- Centro de Investigación Clinica Acelerada, S.C.
- Instituto Cardiovascular de Monclova, S de RL de CV
- CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
- Hospital Universitario Dr Jose Eleuterio Gonzalez
- Centro Integral Medico SJR S.C.
- Cardioarritmias e Investigación S.C
- Centro de Investigacion Cardiovascular y Metabolica
- Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
- Ziekenhuisgroep Twente locatie Almelo
- BovenIJ Ziekenhuis
- Onze Lieve Vrouwe Gasthuis, Locatie West
- Amsterdam UMC Locatie VUMC
- Onze Lieve Vrouwe Gasthuis
- Amsterdam UMC, Locatie AMC
- Rode Kruis Ziekenhuis Beverwijk
- Tergooiziekenhuizen locatie Blaricum
- Amphia Ziekenhuis
- Ziekenhuis Gelderse Vallei
- Catharina Ziekenhuis
- Universitair Medisch Centrum Groningen
- Zuyderland Medisch Centrum
- Maastricht University
- Diaconessenhuis Meppel
- St. Antonius ziekenhuis, locatie Nieuwegein
- Radboud Universitair Medisch Centrum
- Franciscus Gasthuis
- De Heel - Zaans Medisch Centrum
- Gelre Ziekenhuis Zutphen
- Univ. Clinic Hosp, Bialystok
- KLIMED Marek Klimkiewicz
- ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok
- American Heart of Poland Sp. z o.o.
- NZOZ Centrum Medyczne KERmed
- Polsko-Amerykanskie Kliniki Serca
- American Heart of Poland Sp. z o.o.
- Poradnia Kardiologiczna Jaroslaw Jurowiecki
- University Clinical Center, Gdansk
- Indywidualna Specjalistyczna Praktyka Lekarska
- NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
- Szpital Zakonu Bonifratow Sp. z o.o.
- Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
- Leszek Bryniarski Specialized Medical Cabinet
- Krakow Specialistic Hospital of John Paul II
- ETG Lodz
- Nzoz Salus
- Individual Specialized Practice
- Lowickie Cardiology Center
- American Heart of Poland Sp. z o.o.
- Medicome Sp. z o.o.
- NZOZ HEUREKA, Piaseczno
- Specialized Practice Dr. Janusz Spyra
- Centrum Medyczne Medyk
- Lukmed Lukasz Wozniak
- ETG Skierniewice
- KO-MED Centra Kliniczne Staszow
- The Provincial Polyclinical Hospital in Torun
- American Heart of Poland Sp. z o.o.
- American Heart of Poland Sp. z o.o.
- Samodzielny Publiczny Centralny Szpital Kliniczny
- ETG Warszawa
- 4. Military Clinical Hospital with Polyclinic SP ZOZ
- Zgierskie Center of Cardiology MED-PRO
- Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
- Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"
- C.M.D.T.A. NEOMED, Brasov
- CMDTA Washington, Bucharest
- Emergency Clinical Hospital 'Sf. Panteliomon'
- Emergency University Hospital, Bucharest
- Prof.C.C.Iliescu Hospital, National Institute of Cardiology
- Emergency University Hospital, Bucharest
- Spitalul Clinic Colentina
- Spitalul Clinic "Prof. Dr. Theodor Burghele"
- Clinica Medicala Data Plus SRL
- S.C Cardiomed S.R.L
- Spital Judetean Deva
- S.C Medicali's S.R.L
- Spitalul Clinic Judetean de Urgenta, Timisoara
- National University Hospital
- National Heart Center
- Tan Tock Seng Hospital
- Khoo Teck Puat Hospital
- Cardiology Clinical Research
- Iatros International
- Universitas Hospital Cardiology Research
- Corbod Research
- TREAD Research
- Tiervlei Trial Centre
- Excellentis Clinical Trials
- Clinresco
- Chris Hani Baragwanath Hospital: Cardiology Department
- MERC Research
- Into Research
- Dr JM Engelbrecht
- Clinical Projects Research
- Hospital Quiron. I.C.U.
- Hospital Santa Creu i Sant Pau
- Hospital Sanitas CIMA
- Hospital Universitario Virgen de la Arrixaca
- Hospital General Universitario Gregorio Marañón
- Hospital Ramón y Cajal
- Hospital La Paz
- Hospital Puerta de Hierro
- Hospital Virgen de la Victoria
- Hospital Clínico de Santiago
- Hospital Virgen Macarena
- Hospital General Universitario de Valencia
- Hospital Arnau de Vilanova
- Barnet General Hospital
- University Hospital of Wales
- Park & St Francis Surgery
- Wycombe General Hospital
- Glenfield Hospital
- St Bartholomew's Hospital
- St Mary's Hospital
- Morriston Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
10 mg Empagliflozin
Placebo
Arm Description
Outcomes
Primary Outcome Measures
Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Secondary Outcome Measures
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
Reported is the total number of adjudicated HHF events (first and recurrent) which occurred.
eGFR (CKD-EPI) cr Slope of Change From Baseline
Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR(CKD-EPI)cr) slope of change from baseline.
Available on-treatment change-from-baseline data were used. The slope represents the long term effect of eGFR change from baseline and provides the yearly rate of decline.
Timepoints after baseline were included in calculation of slope of change from baseline.
The slope per patient was calculated using a random coefficient model with terms for treatment, region, baseline status of diabetes, age, sex, left ventricular ejection fraction (LVEF) and glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula (eGFR (CKD-EPI)cr) at baseline and in addition the factors "time", "treatment-by-time interaction", and "baseline eGFR (CKD-EPI)cr-by-time interaction".
Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr
Chronic dialysis was defined as dialysis with a frequency of twice per week or more for at least 90 days.
Sustained was determined by two or more consecutive post-baseline central laboratory measurement separated by at least 30 days.
Reduction in glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) was defined as reduction in eGFR from baseline ≥40%, eGFR <15 mL/min/1.73 m^2 for patients with baseline eGFR ≥30 mL/min/1.73 m^2, or eGFR <10 mL/min/1.73 m^2 for patients with baseline eGFR <30 mL/min/1.73 m^2.
The incidence rate per 100 patient years (100 * number of patients with event / time at risk [years]) is reported. Time at risk [year] is calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Abbreviation:
Patient-years (pt-yrs).
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
Time to first adjudicated HHF. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time to Adjudicated Cardiovascular (CV) Death
Time to adjudicated CV death. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time to All-cause Mortality
Time to all-cause mortality. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time to Onset of Diabetes Mellitus (DM) in Patients With Pre-DM
Time to onset of DM (defined as HbA1c ≥6.5% or as diagnosed by the investigator) in patients with pre-DM.
Pre-DM was defined as no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of ≥5.7% and <6.5%.
The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Change From Baseline in Kansas City Cardiomyopathy Questionaire (KCCQ) Clinical Summary Score at Week 52
The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) was imputed for the score at all subsequent scheduled visits after the date of death where the score would have been assessed.
Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.
Occurrence of All-cause Hospitalisation (First and Recurrent)
Occurrence of all-cause hospitalisation (first and recurrent). Total number of all cause hospitalisations is reported.
Full Information
NCT ID
NCT03057951
First Posted
February 16, 2017
Last Updated
June 3, 2022
Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company
1. Study Identification
Unique Protocol Identification Number
NCT03057951
Brief Title
EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
Official Title
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
Study Type
Interventional
2. Study Status
Record Verification Date
June 2022
Overall Recruitment Status
Completed
Study Start Date
March 2, 2017 (Actual)
Primary Completion Date
April 26, 2021 (Actual)
Study Completion Date
April 26, 2021 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction.
Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine.
Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heart Failure
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
5988 (Actual)
8. Arms, Groups, and Interventions
Arm Title
10 mg Empagliflozin
Arm Type
Experimental
Arm Title
Placebo
Arm Type
Placebo Comparator
Intervention Type
Drug
Intervention Name(s)
Empagliflozin
Other Intervention Name(s)
JARDIANCE, JARDIANZ, GIBTULIO
Intervention Description
once daily
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
once daily
Primary Outcome Measure Information:
Title
Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Description
Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Secondary Outcome Measure Information:
Title
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
Description
Reported is the total number of adjudicated HHF events (first and recurrent) which occurred.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Title
eGFR (CKD-EPI) cr Slope of Change From Baseline
Description
Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR(CKD-EPI)cr) slope of change from baseline.
Available on-treatment change-from-baseline data were used. The slope represents the long term effect of eGFR change from baseline and provides the yearly rate of decline.
Timepoints after baseline were included in calculation of slope of change from baseline.
The slope per patient was calculated using a random coefficient model with terms for treatment, region, baseline status of diabetes, age, sex, left ventricular ejection fraction (LVEF) and glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula (eGFR (CKD-EPI)cr) at baseline and in addition the factors "time", "treatment-by-time interaction", and "baseline eGFR (CKD-EPI)cr-by-time interaction".
Time Frame
At baseline, week 4, 12, 32, 52, 76, 100, 124, 148, 172 and week 196, up to 1043 days.
Title
Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr
Description
Chronic dialysis was defined as dialysis with a frequency of twice per week or more for at least 90 days.
Sustained was determined by two or more consecutive post-baseline central laboratory measurement separated by at least 30 days.
Reduction in glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) was defined as reduction in eGFR from baseline ≥40%, eGFR <15 mL/min/1.73 m^2 for patients with baseline eGFR ≥30 mL/min/1.73 m^2, or eGFR <10 mL/min/1.73 m^2 for patients with baseline eGFR <30 mL/min/1.73 m^2.
The incidence rate per 100 patient years (100 * number of patients with event / time at risk [years]) is reported. Time at risk [year] is calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Abbreviation:
Patient-years (pt-yrs).
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Title
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
Description
Time to first adjudicated HHF. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Title
Time to Adjudicated Cardiovascular (CV) Death
Description
Time to adjudicated CV death. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Title
Time to All-cause Mortality
Description
Time to all-cause mortality. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
Title
Time to Onset of Diabetes Mellitus (DM) in Patients With Pre-DM
Description
Time to onset of DM (defined as HbA1c ≥6.5% or as diagnosed by the investigator) in patients with pre-DM.
Pre-DM was defined as no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of ≥5.7% and <6.5%.
The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 * number of patients with event / time at risk [years].
Time at risk [years] = Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Time Frame
From randomization until completion of the planned treatment phase, to 1403 days.
Title
Change From Baseline in Kansas City Cardiomyopathy Questionaire (KCCQ) Clinical Summary Score at Week 52
Description
The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) was imputed for the score at all subsequent scheduled visits after the date of death where the score would have been assessed.
Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.
Time Frame
At baseline and at week 12, week 32 and week 52.
Title
Occurrence of All-cause Hospitalisation (First and Recurrent)
Description
Occurrence of all-cause hospitalisation (first and recurrent). Total number of all cause hospitalisations is reported.
Time Frame
From randomization until completion of the planned treatment phase, up to 1403 days.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria:
Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years at screening
Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
Stable dose of oral diuretics, if prescribed
Signed and dated written ICF (informed consent form)
Further inclusion criteria apply
Exclusion criteria:
Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
Heart transplant recipient or listed for heart transplant
Acute decompensated HF (Heart Failure)
Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
Symptomatic hypotension and/or a SBP < 100 mmHg
Indication of liver disease,
Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
History of ketoacidosis
Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
Currently enrolled in another investigational device or drug trial
Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
Women who are pregnant, nursing, or who plan to become pregnant while in the trial
Further exclusion criteria may apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Boehringer Ingelheim
Organizational Affiliation
Boehringer Ingelheim
Official's Role
Study Chair
Facility Information:
Facility Name
Pinnacle Research Group, LLC
City
Anniston
State/Province
Alabama
ZIP/Postal Code
36207
Country
United States
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35249
Country
United States
Facility Name
Heart Center Research, LLC
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
University of California San Francisco
City
Fresno
State/Province
California
ZIP/Postal Code
93701
Country
United States
Facility Name
La Mesa Cardiac Center
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Purushotham, Akther & Roshan Kotha, MD Inc.
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Long Beach Center for Clinical Research
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
VA Greater Los Angeles Healthcare System
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
Facility Name
Merced Vein and Vascular Center
City
Merced
State/Province
California
ZIP/Postal Code
95340
Country
United States
Facility Name
Valley Clinical Trials, Inc.
City
Northridge
State/Province
California
ZIP/Postal Code
91325
Country
United States
Facility Name
University of California Irvine
City
Orange
State/Province
California
ZIP/Postal Code
92865
Country
United States
Facility Name
Covigilant Research, LLC
City
Riverside
State/Province
California
ZIP/Postal Code
92506
Country
United States
Facility Name
University of California San Francisco
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
University of California
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Facility Name
Orange County Research Center
City
Tustin
State/Province
California
ZIP/Postal Code
92780
Country
United States
Facility Name
Blue Coast Cardiology
City
Vista
State/Province
California
ZIP/Postal Code
92083
Country
United States
Facility Name
South Denver Cardiology Associates, PC
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120
Country
United States
Facility Name
Integrated Heart Care
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33434
Country
United States
Facility Name
Southeast Clinical Research, LLC
City
Chiefland
State/Province
Florida
ZIP/Postal Code
32626
Country
United States
Facility Name
Morton Plant Mease Health Care
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Accel Research Sites
City
DeLand
State/Province
Florida
ZIP/Postal Code
32720
Country
United States
Facility Name
Integrative Research Associates
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33312
Country
United States
Facility Name
Nature Coast Clinical Research
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452
Country
United States
Facility Name
East Coast Institute for Research, LLC
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Elite Clinical Research
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Facility Name
Cardiovascular Research Center of South Florida
City
Miami
State/Province
Florida
ZIP/Postal Code
33173
Country
United States
Facility Name
Orlando Health Inc.
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Peninsula Research, Inc.
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Clearwater Cardiovascular Consultants
City
Safety Harbor
State/Province
Florida
ZIP/Postal Code
34695
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
University of South Florida
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
Advent Health Medical Group
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Grady Clinical Research Center
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Columbus Regional Research Institute
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31904
Country
United States
Facility Name
Cardiovascular Group PC
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30046
Country
United States
Facility Name
Meridian Clinical Research, LLC
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31406
Country
United States
Facility Name
Atlanta Heart Specialists, LLC
City
Tucker
State/Province
Georgia
ZIP/Postal Code
30084
Country
United States
Facility Name
Northwest Heart Clinical Research, LLC
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
Mount Sinai Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60608
Country
United States
Facility Name
Advocate Health and Hospitals Corporation
City
Naperville
State/Province
Illinois
ZIP/Postal Code
60540
Country
United States
Facility Name
Captain James A. Lovell Federal Health Care Center
City
North Chicago
State/Province
Illinois
ZIP/Postal Code
60064
Country
United States
Facility Name
Rockford Cardiovascular Associates
City
Rockford
State/Province
Illinois
ZIP/Postal Code
61107
Country
United States
Facility Name
Midwest Cardiovascular Research and Education Foundation
City
Elkhart
State/Province
Indiana
ZIP/Postal Code
46514
Country
United States
Facility Name
St. Francis Medical Group-Indiana Heart Physicians, Inc
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46237
Country
United States
Facility Name
Reid Hospital
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47374
Country
United States
Facility Name
Beacon Medical Group Clinical Research
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Iowa Heart Center
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
Facility Name
Norton Heart Specialists
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Research Integrity, LLC
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Grace Research, LLC
City
Bossier City
State/Province
Louisiana
ZIP/Postal Code
71111
Country
United States
Facility Name
Clinical Trials of America, LLC
City
Monroe
State/Province
Louisiana
ZIP/Postal Code
71201
Country
United States
Facility Name
LSU Health Sciences Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Maine Research Associates
City
Lewiston
State/Province
Maine
ZIP/Postal Code
04240
Country
United States
Facility Name
Anne Arundel Medical Center
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Maryland Cardiovascular Specialists
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21229
Country
United States
Facility Name
MedStar Health Research Institute
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Metropolitan Cardiovascular Consultants
City
Beltsville
State/Province
Maryland
ZIP/Postal Code
20705
Country
United States
Facility Name
MD Medical Research
City
Oxon Hill
State/Province
Maryland
ZIP/Postal Code
20745
Country
United States
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
East Mountain Medical Associates, PC
City
Great Barrington
State/Province
Massachusetts
ZIP/Postal Code
01230
Country
United States
Facility Name
Alpena General Hospital
City
Alpena
State/Province
Michigan
ZIP/Postal Code
49707
Country
United States
Facility Name
McLaren Northern Michigan Hospital
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
Regions Hospital
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55101
Country
United States
Facility Name
Jackson Heart Clinic, P.A.
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Saint Luke's Hospital of Kansas City
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
Saint Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
St. Louis Center for Clinical Research
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
Facility Name
St. Louis Heart and Vascular, P.C.
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63136
Country
United States
Facility Name
Deaconess Billings Clinic Research Center
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Bozeman Health Clinical Research
City
Bozeman
State/Province
Montana
ZIP/Postal Code
59718
Country
United States
Facility Name
Nebraska Heart Institute
City
Grand Island
State/Province
Nebraska
ZIP/Postal Code
68803
Country
United States
Facility Name
CHI Health Midlands
City
Papillion
State/Province
Nebraska
ZIP/Postal Code
68046
Country
United States
Facility Name
Healthcare Partners LLC
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
Country
United States
Facility Name
Palm Research Center
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89128
Country
United States
Facility Name
Advanced Heart Care, LLC
City
Bridgewater
State/Province
New Jersey
ZIP/Postal Code
08807
Country
United States
Facility Name
Garden State Heart Care, PC
City
Manalapan
State/Province
New Jersey
ZIP/Postal Code
07726
Country
United States
Facility Name
Capital Cardiology Associates, PC
City
Albany
State/Province
New York
ZIP/Postal Code
12211
Country
United States
Facility Name
CHEAR Center LLC
City
Bronx
State/Province
New York
ZIP/Postal Code
10455
Country
United States
Facility Name
Cardiac Care and Vascular Medicine, PLLC
City
Bronx
State/Province
New York
ZIP/Postal Code
10469
Country
United States
Facility Name
Trinity Medical WNY, PC
City
Cheektowaga
State/Province
New York
ZIP/Postal Code
14227
Country
United States
Facility Name
North Shore University Hospital
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030
Country
United States
Facility Name
Long Island Cardiovascular Consultants
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Mount Sinai - PRIME
City
New York
State/Province
New York
ZIP/Postal Code
10025
Country
United States
Facility Name
Harlem Cardiology
City
New York
State/Province
New York
ZIP/Postal Code
10035
Country
United States
Facility Name
Laurelton Heart Specialist, PC
City
Rosedale
State/Province
New York
ZIP/Postal Code
11422
Country
United States
Facility Name
Saratoga Clinical Research, LLC
City
Saratoga Springs
State/Province
New York
ZIP/Postal Code
12866
Country
United States
Facility Name
Northwell Health
City
Southampton
State/Province
New York
ZIP/Postal Code
11968
Country
United States
Facility Name
Stony Brook University Medical Center
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Asheville Cardiology Associates
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28803
Country
United States
Facility Name
Kernodle Clinic West
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
The University of North Carolina at Chapel Hill
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599-5021
Country
United States
Facility Name
Novant Health Heart and Vascular Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Clinical Research of Gastonia
City
Gastonia
State/Province
North Carolina
ZIP/Postal Code
28054
Country
United States
Facility Name
Clinical Trials of America, Inc
City
Lenoir
State/Province
North Carolina
ZIP/Postal Code
28645
Country
United States
Facility Name
VA Northeast Ohio Healthcare System
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44104-1702
Country
United States
Facility Name
Rama Research LLC
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
South Oklahoma Heart Research Group
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73135
Country
United States
Facility Name
Doylestown Health Cardiology
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
Lycoming Internal Medicine, Inc
City
Jersey Shore
State/Province
Pennsylvania
ZIP/Postal Code
17740
Country
United States
Facility Name
Richard M Kastelic and Associates
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
York Hospital, WellSpan Health
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17403
Country
United States
Facility Name
Lowcountry Center for Veterans Research
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29401
Country
United States
Facility Name
Palmetto Health
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29203
Country
United States
Facility Name
Clinical Research of Rock Hill
City
Rock Hill
State/Province
South Carolina
ZIP/Postal Code
29732
Country
United States
Facility Name
Palmetto Research Center, LLC
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29302
Country
United States
Facility Name
Sanford Research
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57104
Country
United States
Facility Name
The Stern Cardiovascular Center
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
Apex Cardiology/ Research Associates of Jackson
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38301
Country
United States
Facility Name
Methodist University Hospital
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
Seton Heart Institute
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Baylor Heart and Vascular Hospital
City
Dallas
State/Province
Texas
ZIP/Postal Code
75226
Country
United States
Facility Name
Soltero Cardiovascular Research Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75226
Country
United States
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-8837
Country
United States
Facility Name
University of North Texas Health Science Center
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76107
Country
United States
Facility Name
University of Texas Medical Branch at Galveston
City
Galveston
State/Province
Texas
ZIP/Postal Code
77555
Country
United States
Facility Name
Angiocardiac Care of Texas
City
Houston
State/Province
Texas
ZIP/Postal Code
77025
Country
United States
Facility Name
The Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Biopharma Informatic, Inc. Research Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77084
Country
United States
Facility Name
Private Practice Leadership, LLC
City
Katy
State/Province
Texas
ZIP/Postal Code
77493
Country
United States
Facility Name
Baylor Scott and White Health
City
Plano
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Alpine Research Organization
City
Farmington
State/Province
Utah
ZIP/Postal Code
84025
Country
United States
Facility Name
Cardiac Health Management Network, P.C.
City
Chester
State/Province
Virginia
ZIP/Postal Code
23836
Country
United States
Facility Name
Cardiology Consultants of Danville, Inc
City
Danville
State/Province
Virginia
ZIP/Postal Code
24541
Country
United States
Facility Name
Carient Heart and Vascular
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20109
Country
United States
Facility Name
Hunter Holmes McGuire VA Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Medical College of Virginia Hospitals
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Roanoke Heart Institute PLC
City
Roanoke
State/Province
Virginia
ZIP/Postal Code
24014
Country
United States
Facility Name
Salem VA Medical Center
City
Salem
State/Province
Virginia
ZIP/Postal Code
24153
Country
United States
Facility Name
Virginia Mason Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
Cardiology Associates of Bellin Health
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54301
Country
United States
Facility Name
Meriter Wisconsin Heart
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53713
Country
United States
Facility Name
Marshfield Clinic
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Aspirus Research Institute
City
Wausau
State/Province
Wisconsin
ZIP/Postal Code
54401
Country
United States
Facility Name
Hospital Interzonal General de Agudos Dr Jose Penna
City
Bahia Blanca
ZIP/Postal Code
B8001DDU
Country
Argentina
Facility Name
Hospital Italiano Regional del Sur, Bahia Blanca
City
Bahia Blanca
ZIP/Postal Code
B8001HXM
Country
Argentina
Facility Name
CIPREC
City
Caba
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
Hospital Italiano de Buenos Aires
City
Caba
ZIP/Postal Code
C1199ABB
Country
Argentina
Facility Name
Instituto Cardiovascular de Buenos Aires
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1428ART
Country
Argentina
Facility Name
Glenny Corp. S.A. Bioclinica Argentina
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1430CKE
Country
Argentina
Facility Name
Centro Médico Viamonte
City
Ciudad Autonoma de Bs As
ZIP/Postal Code
C1120AAC
Country
Argentina
Facility Name
Consultorios Asociados de Endocrinología e Invest Clínica
City
Ciudad Autonoma de BuenosAires
ZIP/Postal Code
C1425AGC
Country
Argentina
Facility Name
Sanatorio Güemes
City
Ciudad Autónoma de Bs As
ZIP/Postal Code
C1180AAX
Country
Argentina
Facility Name
Instituto Medico Elsa Perez SRL (IMEP)
City
Ciudadela
ZIP/Postal Code
1702
Country
Argentina
Facility Name
Clinica Privada Colombo- Fundacion Clinica Colombo
City
Cordoba
ZIP/Postal Code
X5002AOQ
Country
Argentina
Facility Name
Instituto Médico DAMIC S.R.L.
City
Cordoba
ZIP/Postal Code
X5003DCE
Country
Argentina
Facility Name
Clinica Coronel Suarez SA
City
Coronel Suarez
ZIP/Postal Code
B7540GHD
Country
Argentina
Facility Name
Instituto de Cardiología de Corrientes
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
Sanatorio Mayo Privado SA
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Centro de Investigaciones Clinicas Instituto del Corazon
City
Córdoba
ZIP/Postal Code
X5000EVQ
Country
Argentina
Facility Name
Sanatorio Allende S.A.
City
Córdoba
ZIP/Postal Code
X5000JHQ
Country
Argentina
Facility Name
Hospital Privado
City
Córdoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Facility Name
Hospital Italiano de La Plata
City
La Plata
ZIP/Postal Code
B1900AXI
Country
Argentina
Facility Name
Centro de Investigaciones Médicas
City
Mar del Plata
ZIP/Postal Code
B7600FYK
Country
Argentina
Facility Name
Hospital Privado de Comunidad
City
Mar del Plata
ZIP/Postal Code
B7602CBM
Country
Argentina
Facility Name
CER Instituto Médico
City
Quilmes
ZIP/Postal Code
B1878DVB
Country
Argentina
Facility Name
Instituto de Investigaciones Clínicas de Quilmes
City
Quilmes
ZIP/Postal Code
B1878GEG
Country
Argentina
Facility Name
Instituto de Investigaciones Clinicas de Rosario
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Instituto Medico Fundación Grupo Colaborativo Rosario
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Sanatorio Británico
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Sanatorio Plaza
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Instituto CAICI
City
Rosario
ZIP/Postal Code
S2000PBJ
Country
Argentina
Facility Name
CORDIS S.A., Salta
City
Salta
ZIP/Postal Code
A4400ANW
Country
Argentina
Facility Name
Centro Cardiovascular Salta
City
Salta
ZIP/Postal Code
A4406BFP
Country
Argentina
Facility Name
Corporacion Medica de Gral. San Martin S.A.
City
San Martin
ZIP/Postal Code
B1650CSQ
Country
Argentina
Facility Name
Instituto de Cardiología
City
San Miguel de Tucuman
ZIP/Postal Code
T4000JCU
Country
Argentina
Facility Name
Clinica Mayo
City
San Miguel de Tucuman
ZIP/Postal Code
T4000
Country
Argentina
Facility Name
Investigaciones Clinicas Tucuman
City
San Miguel de Tucumán
ZIP/Postal Code
T4000ICL
Country
Argentina
Facility Name
Centro Medico Luquez
City
San Vicente
ZIP/Postal Code
X5006CBI
Country
Argentina
Facility Name
Centro de Investigaciones Clínicas del Litoral
City
Santa Fe
ZIP/Postal Code
S3000FWO
Country
Argentina
Facility Name
Hospital "Dr. José Maria Cullen"
City
Santa Fé
ZIP/Postal Code
S3000EOZ
Country
Argentina
Facility Name
Clínica Olivos
City
Vicente Lopez
ZIP/Postal Code
1602
Country
Argentina
Facility Name
CEMEDIC - Centro de Especialidades Medicas
City
Villa Luro
ZIP/Postal Code
C1440CFD
Country
Argentina
Facility Name
Pendlebury Research
City
Kotara
State/Province
New South Wales
ZIP/Postal Code
2289
Country
Australia
Facility Name
John Hunter Hospital
City
New Lambton Heights
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Facility Name
CORE Research Group
City
Milton
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Gold Coast University Hospital
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Adelaide Medical Research
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
Heart and Vascular Research
City
Fullarton
State/Province
South Australia
ZIP/Postal Code
5063
Country
Australia
Facility Name
The Queen Elizabeth Hospital
City
Woodville South
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
The Northern Hospital
City
Epping
State/Province
Victoria
ZIP/Postal Code
3076
Country
Australia
Facility Name
Peninsula Private Hospital
City
Frankston
State/Province
Victoria
ZIP/Postal Code
3199
Country
Australia
Facility Name
University Hospital Geelong
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Facility Name
Mount Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
C.H.U. de Charleroi
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
Facility Name
AZ Sint-Blasius
City
Dendermonde
ZIP/Postal Code
9200
Country
Belgium
Facility Name
Ziekenhuis Oost-Limburg - Campus Sint-Jan
City
Genk
ZIP/Postal Code
3600
Country
Belgium
Facility Name
AZ Maria Middelares
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Grand Hôpital de Charleroi
City
Gilly
ZIP/Postal Code
6060
Country
Belgium
Facility Name
Jessa Ziekenhuis - Campus Virga Jesse
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
La Louvière - UNIV CHU Tivoli
City
La Louvière
ZIP/Postal Code
7100
Country
Belgium
Facility Name
UZ Leuven
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Liège - HOSP CHR de la Citadelle
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
FGM - Clínica Paulista de Doenças Cardiovasculares
City
Bela Vista
ZIP/Postal Code
01323-000
Country
Brazil
Facility Name
Hospital Felicio Rocho
City
Belo Horizonte
ZIP/Postal Code
30110-060
Country
Brazil
Facility Name
Hospital Vera Cruz
City
Belo Horizonte
ZIP/Postal Code
30140-092
Country
Brazil
Facility Name
L2IP -Instituto de Pesquisas Clínicas Ltda.
City
Brasília
ZIP/Postal Code
70200-730
Country
Brazil
Facility Name
ICDF - Instituto de Cardiologia do Distrito Federal
City
Brasília
ZIP/Postal Code
70673-900
Country
Brazil
Facility Name
CECAP - Centro de Cardiologia Clínica
City
Brasília
ZIP/Postal Code
70710-100
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericordia de Curitiba
City
Campina Grande do Sul
ZIP/Postal Code
83430-000
Country
Brazil
Facility Name
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
City
Campinas
ZIP/Postal Code
13010-001
Country
Brazil
Facility Name
IPECC - Instituto de Pesquisa Clínica de Campinas
City
Campinas
ZIP/Postal Code
13060-080
Country
Brazil
Facility Name
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
City
Campinas
ZIP/Postal Code
13087-567
Country
Brazil
Facility Name
Hospital Universitário
City
Canoas
ZIP/Postal Code
92425-900
Country
Brazil
Facility Name
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
City
Caxias do Sul
ZIP/Postal Code
95070-560
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericórdia de Curitiba
City
Curitiba
ZIP/Postal Code
80230-130
Country
Brazil
Facility Name
Via Medica
City
Goiânia
ZIP/Postal Code
74223-130
Country
Brazil
Facility Name
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
City
Goiânia
ZIP/Postal Code
74605-020
Country
Brazil
Facility Name
ICM - Instituto do Coracao de Marilia
City
Marília
ZIP/Postal Code
17515-000
Country
Brazil
Facility Name
Hospital São Vicente de Paulo
City
Passo Fundo
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Santa Casa de Misericórdia de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90035-074
Country
Brazil
Facility Name
Centro de Pesquisas em Diabetes
City
Porto Alegre
ZIP/Postal Code
90035-170
Country
Brazil
Facility Name
Hospital de Clínicas de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Instituto de Cardiologia Rio Grande do Sul
City
Porto Alegre
ZIP/Postal Code
90620-001
Country
Brazil
Facility Name
Hospital Agamenon Magalhaes
City
Recife
ZIP/Postal Code
52051-380
Country
Brazil
Facility Name
H.C.da Fac. de Medicina de Ribeirao Preto
City
Ribeirao Preto
ZIP/Postal Code
14048-900
Country
Brazil
Facility Name
Hospital Universitário Pedro Ernesto UERJ
City
Rio de Janeiro
ZIP/Postal Code
20551-030
Country
Brazil
Facility Name
CCBR - Rio de Janeiro - BR
City
Rio de Janeiro
ZIP/Postal Code
22271-100
Country
Brazil
Facility Name
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
City
Santa Efigenia
ZIP/Postal Code
30150-240
Country
Brazil
Facility Name
Pesquisare
City
Santo André
ZIP/Postal Code
09080-110
Country
Brazil
Facility Name
Praxis Pesquisa Médica
City
Santo André
ZIP/Postal Code
09090-790
Country
Brazil
Facility Name
Hospital de Base - Fac Med de Sao Jose do Rio Preto
City
Sao Jose do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Centro de Pesquisa Clinica - CPCLIN
City
Sao Paulo
ZIP/Postal Code
01228-200
Country
Brazil
Facility Name
CEPIC - Centro Paulista de Investigacao Clinica
City
Sao Paulo
ZIP/Postal Code
04266-010
Country
Brazil
Facility Name
INCOR e Hospital das Clínicas da Universidade de São Paulo
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
CEMEC - Centro Multidisciplinar de Estudos Clínicos
City
São Bernardo do Campo
ZIP/Postal Code
09780-000
Country
Brazil
Facility Name
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
City
São Paulo
ZIP/Postal Code
04020-060
Country
Brazil
Facility Name
Dr. Consulta
City
São Paulo
ZIP/Postal Code
05016-090
Country
Brazil
Facility Name
CEDOES - Diagnóstico e Pesquisa,Vitória
City
Vitória
ZIP/Postal Code
29055-450
Country
Brazil
Facility Name
Santa Casa de Votuporanga
City
Votuporanga
ZIP/Postal Code
15500-003
Country
Brazil
Facility Name
Royal Alexandra Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5H 3V9
Country
Canada
Facility Name
Medical Arts Health Research Group
City
North Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7M 2H4
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
Victoria Heart Institute Foundation
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R 1B2
Country
Canada
Facility Name
St. Boniface General Hospital
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
Facility Name
G.A. Research Associates Ltd
City
Moncton
State/Province
New Brunswick
ZIP/Postal Code
E1G 1A7
Country
Canada
Facility Name
QEII Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
Facility Name
Brampton Cardio Pulmonary Clinic
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6W 2X7
Country
Canada
Facility Name
Brampton Research Associates
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6Z 4N5
Country
Canada
Facility Name
JBN Medical Diagnostic Services Inc.
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7M 4Y1
Country
Canada
Facility Name
Cambridge Cardiac Care Inc.
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
Dr. Saul Vizel
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 7R1
Country
Canada
Facility Name
Curnew Medicine Professional Corporation
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 0A9
Country
Canada
Facility Name
Hamilton General Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
University Hospital (LHSC)
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
PACE (Partners in Advanced Cardiac Evaluation)
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P6
Country
Canada
Facility Name
M Heffernan Medicine Professional Corp.
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3W7
Country
Canada
Facility Name
Kawartha Cardiology Clinical Trials
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Heart Health Institute
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1B 4Z8
Country
Canada
Facility Name
Scarborough Cardiology Research
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1E 5E9
Country
Canada
Facility Name
Cardiovascular Contract Research Organization LTD
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 3Y9
Country
Canada
Facility Name
Canadian Phase Onward Inc.
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3J 0K2
Country
Canada
Facility Name
North York Diagnostic and Cardiac Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6B 1N6
Country
Canada
Facility Name
Mohan Babapulle Medicine Professional Medicine
City
Waterloo
State/Province
Ontario
ZIP/Postal Code
N2T 0C1
Country
Canada
Facility Name
Dr. Louis C.H. Yao
City
York
State/Province
Ontario
ZIP/Postal Code
M9N 1W4
Country
Canada
Facility Name
ViaCar Recherche Clinique Inc
City
Brossard
State/Province
Quebec
ZIP/Postal Code
J4Z 2K9
Country
Canada
Facility Name
ViaCar Recherche Clinique Inc
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
City
Longeuil
State/Province
Quebec
ZIP/Postal Code
J4M 2X1
Country
Canada
Facility Name
Montreal Heart Institute
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 1C8
Country
Canada
Facility Name
Clinique Santé Cardio MC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 3Y7
Country
Canada
Facility Name
Montreal General Hospital - McGill University Health Centre
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
McGill University Health Centre (MUHC)
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Royal University Hospital
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 0W8
Country
Canada
Facility Name
IUCPQ (Laval University)
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Cardiovascular Institute and Fu Wai Hospital
City
Beijing
ZIP/Postal Code
100037
Country
China
Facility Name
Beijing Friendship Hospital
City
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
First Hospital of Jilin University
City
Changchun
ZIP/Postal Code
130021
Country
China
Facility Name
Hunan Provincial People's Hospital
City
Changsha
ZIP/Postal Code
410005
Country
China
Facility Name
2nd Xiangya Hospital of Central South University
City
Changsha
ZIP/Postal Code
410011
Country
China
Facility Name
The Third Hospital of Changsha
City
Changsha
ZIP/Postal Code
410015
Country
China
Facility Name
Dongguan People's Hospital
City
Dongguan
ZIP/Postal Code
523059
Country
China
Facility Name
The First Affiliated Hospital of Fujian Medical University
City
Fuzhou
ZIP/Postal Code
350005
Country
China
Facility Name
The First Afiliated Hospital, Sun Yet-sen University
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Guangzhou First Municipal People's Hospital
City
Guangzhou
ZIP/Postal Code
510180
Country
China
Facility Name
Haikou People's Hospital
City
Haikou
ZIP/Postal Code
570208
Country
China
Facility Name
HaiNan Provincial People's Hospital
City
Haikou
ZIP/Postal Code
570311
Country
China
Facility Name
The First Affiliated Hospital of Lanzhou University
City
Lanzhou
ZIP/Postal Code
730000
Country
China
Facility Name
The Second Affiliated Hospital of Lanzhou Medical University
City
Lanzhou
ZIP/Postal Code
730030
Country
China
Facility Name
The Affiliated Hospital of Southwest Medical University
City
Luzhou
ZIP/Postal Code
646099
Country
China
Facility Name
Nanchang University Affiliated 3rd Hospital
City
Nanchang
ZIP/Postal Code
330008
Country
China
Facility Name
First Hospital Affiliated with Nanjing Medical University
City
Nanjing
ZIP/Postal Code
210029
Country
China
Facility Name
Huashan Hospital, Fudan University
City
Shanghai
ZIP/Postal Code
200040
Country
China
Facility Name
General Hospital of Shenyang Military Region
City
Shenyang
ZIP/Postal Code
110016
Country
China
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
ZIP/Postal Code
110072
Country
China
Facility Name
Tianjin Union Medical Center Nankai University Affiliated Hospital
City
Tianjin
ZIP/Postal Code
300121
Country
China
Facility Name
Tongji Hospital, Tongji University
City
Wuhan
ZIP/Postal Code
430030
Country
China
Facility Name
Renmin Hospital of Wuhan University
City
Wuhan
ZIP/Postal Code
430060
Country
China
Facility Name
First Affiliated Hospital of Xi'an JiaoTong University
City
Xi'an
ZIP/Postal Code
710061
Country
China
Facility Name
Yanbian University Hospital
City
Yanji
ZIP/Postal Code
133000
Country
China
Facility Name
the first people hospital of Yue Yang
City
Yueyang
ZIP/Postal Code
414000
Country
China
Facility Name
Affiliated Hospital of Jiangsu University
City
Zhenjiang
ZIP/Postal Code
212013
Country
China
Facility Name
Corazon IPS S.A.S.
City
Barranquilla
ZIP/Postal Code
080003
Country
Colombia
Facility Name
Centro de Reumatologia y Ortopedia SAS, Barranquilla
City
Barranquilla
ZIP/Postal Code
080020
Country
Colombia
Facility Name
IPS Centro Cientifico Asistencia
City
Barranquilla
ZIP/Postal Code
080020
Country
Colombia
Facility Name
CardioColombia S.A.S.
City
Bogota D.C
ZIP/Postal Code
111611
Country
Colombia
Facility Name
Endocare Research Institute
City
Bogota
ZIP/Postal Code
111611
Country
Colombia
Facility Name
IPS Centro Medico Julián Coronel S.A.
City
Cali
ZIP/Postal Code
760002
Country
Colombia
Facility Name
Fundación Valle del Lili
City
Cali
ZIP/Postal Code
760032
Country
Colombia
Facility Name
Centro de Investigaciones Clinicas S.A.S
City
Cali
ZIP/Postal Code
760036
Country
Colombia
Facility Name
Centro de Diagnostico Cardilogico
City
Cartagena
ZIP/Postal Code
130001
Country
Colombia
Facility Name
Centro cardiovascular Aristides
City
Cartagena
ZIP/Postal Code
130010
Country
Colombia
Facility Name
Fundación Cardiovascular de Colombia
City
Floridablanca
ZIP/Postal Code
681002
Country
Colombia
Facility Name
Asociacion IPS Medicos Internistas de Caldas
City
Manizales
ZIP/Postal Code
170004
Country
Colombia
Facility Name
Promotora Medica Las Americas SA
City
Medellin
ZIP/Postal Code
050025
Country
Colombia
Facility Name
Poliklinika Humanitas
City
Bilovec
ZIP/Postal Code
74301
Country
Czechia
Facility Name
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
City
Brno
ZIP/Postal Code
603 00
Country
Czechia
Facility Name
MUDr. Alexandra Ludkova
City
Brno
ZIP/Postal Code
615 00
Country
Czechia
Facility Name
University Hospital Brno
City
Brno
ZIP/Postal Code
625 00
Country
Czechia
Facility Name
Vojenska nemocnice Brno
City
Brno
ZIP/Postal Code
63600
Country
Czechia
Facility Name
Nemocnice Milosrdnych bratri
City
Brno
ZIP/Postal Code
63900
Country
Czechia
Facility Name
Fakultni nemocnice u sv. Anny v Brne
City
Brno
ZIP/Postal Code
656 91
Country
Czechia
Facility Name
Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno
City
Brno
ZIP/Postal Code
65691
Country
Czechia
Facility Name
Edumed s.r.o
City
Broumov
ZIP/Postal Code
55001
Country
Czechia
Facility Name
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
City
Chrudim
ZIP/Postal Code
53702
Country
Czechia
Facility Name
Hospital Frydek Mistek
City
Frydek-Mistek
ZIP/Postal Code
73818
Country
Czechia
Facility Name
Nemocnice Havlickuv Brod p.o.
City
Havlickuv Brod
ZIP/Postal Code
580 22
Country
Czechia
Facility Name
Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove
City
Hradec Kralove
ZIP/Postal Code
50002
Country
Czechia
Facility Name
KardioLouny s.r.o.
City
Louny
ZIP/Postal Code
440 01
Country
Czechia
Facility Name
InterKardioML s.r.o.
City
Marianske Lazne
ZIP/Postal Code
353 01
Country
Czechia
Facility Name
Zdenek Vomacka
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
PV-Kardiologie s.r.o.
City
Pardubice
ZIP/Postal Code
53002
Country
Czechia
Facility Name
Corintez s.r.o.
City
Prague
ZIP/Postal Code
158 00
Country
Czechia
Facility Name
Vseobecna fakultni nemocnice V Praze
City
Praha 2
ZIP/Postal Code
128 00
Country
Czechia
Facility Name
University Thomayer's Hospital
City
Praha 4 - Krc
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Institute for Clinical and Experimental Medicine
City
Praha 4
ZIP/Postal Code
140 21
Country
Czechia
Facility Name
University Hospital Motol
City
Praha 5
ZIP/Postal Code
15006
Country
Czechia
Facility Name
Kardio Vaclavik s.r.o.
City
Prerov
ZIP/Postal Code
75000
Country
Czechia
Facility Name
Nemocnice Trebic p.o.
City
Trebic
ZIP/Postal Code
674 01
Country
Czechia
Facility Name
Kardiologicka ambulance
City
Tremosna
ZIP/Postal Code
33011
Country
Czechia
Facility Name
Kardiologicka ambulance MUDr. Ferkl s.r.o.
City
Trutnov
ZIP/Postal Code
541 01
Country
Czechia
Facility Name
Clinical Trials Services s.r.o
City
Uherske Hradiste
ZIP/Postal Code
68601
Country
Czechia
Facility Name
Cardiology Private Practice
City
Unicov
ZIP/Postal Code
783 91
Country
Czechia
Facility Name
Angiocor s.r.o
City
Zlin
ZIP/Postal Code
76001
Country
Czechia
Facility Name
KIGE s.r.o
City
Znojmo
ZIP/Postal Code
66902
Country
Czechia
Facility Name
Universitätsklinikum Aachen, AöR
City
Aachen
ZIP/Postal Code
52074
Country
Germany
Facility Name
Praxis Dr. Rieker, Berlin
City
Berlin
ZIP/Postal Code
10789
Country
Germany
Facility Name
Vivantes Netzwerk für Gesundheit GmbH
City
Berlin
ZIP/Postal Code
10967
Country
Germany
Facility Name
Charité - Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
12203
Country
Germany
Facility Name
Vivantes Netzwerk für Gesundheit GmbH
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Facility Name
Charité - Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
Klinikum Bielefeld gGmbH
City
Bielefeld
ZIP/Postal Code
33604
Country
Germany
Facility Name
Augusta-Kranken-Anstalt gGmbH
City
Bochum
ZIP/Postal Code
44791
Country
Germany
Facility Name
Praxis Dr. Menzel
City
Dessau-Roßlau
ZIP/Postal Code
06846
Country
Germany
Facility Name
St. Johannes Hospital Dortmund
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
Städtisches Klinikum Dresden
City
Dresden
ZIP/Postal Code
01067
Country
Germany
Facility Name
Universitätsklinikum Carl Gustav Carus Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Helios Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Studienzentrum Bocholderstraße
City
Essen
ZIP/Postal Code
45355
Country
Germany
Facility Name
ClinPhenomics GmbH & Co KG, Frankfurt
City
Frankfurt
ZIP/Postal Code
60596
Country
Germany
Facility Name
Universitätsmedizin Göttingen, Georg-August-Universität
City
Göttingen
ZIP/Postal Code
37075
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Universitätsklinikum Heidelberg
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Universitätsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
66421
Country
Germany
Facility Name
Universitätsklinikum Jena
City
Jena
ZIP/Postal Code
07740
Country
Germany
Facility Name
Universitätsklinikum Schleswig-Holstein, Campus Kiel
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Asklepios Klinik Langen-Seligenstadt GmbH
City
Langen
ZIP/Postal Code
63225
Country
Germany
Facility Name
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
City
Lüdenscheid
ZIP/Postal Code
58515
Country
Germany
Facility Name
Praxis Dr. Sarnighausen, Lüneburg
City
Lüneburg
ZIP/Postal Code
21339
Country
Germany
Facility Name
Katholisches Klinikum Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim
City
Mannheim
ZIP/Postal Code
68165
Country
Germany
Facility Name
Deutsches Herzzentrum München
City
München
ZIP/Postal Code
80636
Country
Germany
Facility Name
Gemeinschaftspraxis Dres Haggenmiller/Jeserich
City
Nürnberg
ZIP/Postal Code
90402
Country
Germany
Facility Name
Kardiologische Praxis Papenburg
City
Papenburg
ZIP/Postal Code
26871
Country
Germany
Facility Name
Universitätsklinikum Regensburg
City
Regensburg
ZIP/Postal Code
93053
Country
Germany
Facility Name
Praxis Dr. Stenzel, Riesa
City
Riesa
ZIP/Postal Code
01587
Country
Germany
Facility Name
Zentrum für Klinische Forschung
City
Wangen im Allgäu
ZIP/Postal Code
88239
Country
Germany
Facility Name
Josephs-Hospital Warendorf
City
Warendorf
ZIP/Postal Code
48231
Country
Germany
Facility Name
Kardiologische Praxis, Wermsdorf
City
Wermsdorf
ZIP/Postal Code
04779
Country
Germany
Facility Name
Petrus-Krankenhaus
City
Wuppertal
ZIP/Postal Code
42283
Country
Germany
Facility Name
Lausmed Kft. Outpatient Unit of Internal Medicine
City
Baja
ZIP/Postal Code
6500
Country
Hungary
Facility Name
Belgyogyaszati es Kardiologiai Maganrendelo
City
Bekescsaba
ZIP/Postal Code
5600
Country
Hungary
Facility Name
Budai Irgalmasrendi Korhaz
City
Budapest
ZIP/Postal Code
1023
Country
Hungary
Facility Name
Clinexpert Kft.
City
Budapest
ZIP/Postal Code
1033
Country
Hungary
Facility Name
Bajcsy-Zsilinszky Hospital and Clinic
City
Budapest
ZIP/Postal Code
1106
Country
Hungary
Facility Name
Semmelweis University
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Milit.Hosp.-State Health Cent.
City
Budapest
ZIP/Postal Code
1134
Country
Hungary
Facility Name
Uzsoki Street Hospital, Budapest
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Nehezlegzes Ambulancia
City
Debrecen
ZIP/Postal Code
4027
Country
Hungary
Facility Name
University Debrecen Hospital
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Bugat Pal Hospital, Gyongyos
City
Gyongyos
ZIP/Postal Code
3200
Country
Hungary
Facility Name
Studium Egeszseghaz Kft.
City
Kalocsa
ZIP/Postal Code
6300
Country
Hungary
Facility Name
Selye Janos Hospital Komarom
City
Komarom
ZIP/Postal Code
2921
Country
Hungary
Facility Name
Dorottya Kanizsai Hospital
City
Nagykanizsa
ZIP/Postal Code
8800
Country
Hungary
Facility Name
Medifarma-98 Kft.
City
Nyiregyhaza
ZIP/Postal Code
4400
Country
Hungary
Facility Name
Dr. Nagy Laszlo Kardiologiai Maganrendeles
City
Oroshaza
ZIP/Postal Code
5900
Country
Hungary
Facility Name
University of Pecs
City
Pecs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Da Vinci Private Clinic
City
Pecs
ZIP/Postal Code
7635
Country
Hungary
Facility Name
Fejer County Saint George University Teaching Hospital
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Veszpremi Sziv es Egeszseg Centrum
City
Veszprem
ZIP/Postal Code
8200
Country
Hungary
Facility Name
Doctor Jivraj Mehta Smarak Health Foundation
City
Ahmedabad
ZIP/Postal Code
380007
Country
India
Facility Name
Kamalnayan Bajaj Hospital
City
Aurangabad
ZIP/Postal Code
431 005
Country
India
Facility Name
Narayana Institute of Cardiac Sciences
City
Bangalore
ZIP/Postal Code
560099
Country
India
Facility Name
Rajarajeswari Medical College
City
Bengaluru
ZIP/Postal Code
560074
Country
India
Facility Name
Madras Medical Mission,
City
Chennai
ZIP/Postal Code
600 037
Country
India
Facility Name
Apollo Speciality Hospital
City
Chennai
ZIP/Postal Code
600006
Country
India
Facility Name
Medanta-The Medicity
City
Gurgaon
ZIP/Postal Code
122001
Country
India
Facility Name
GNRC Hospital
City
Guwahati
ZIP/Postal Code
781006
Country
India
Facility Name
B.M. Birla Heart research Centre
City
Kolkatta
ZIP/Postal Code
700027
Country
India
Facility Name
Siddhi Hospital
City
Nashik
ZIP/Postal Code
422007
Country
India
Facility Name
Vijan Cardiac and Critical Care Centre
City
Nasik
ZIP/Postal Code
422005
Country
India
Facility Name
GB Pant Hospital
City
New Delhi
ZIP/Postal Code
110002
Country
India
Facility Name
Fortis Escorts Heart Institute
City
New Delhi
ZIP/Postal Code
110025
Country
India
Facility Name
Sir Gangaram Hospital
City
New Delhi
ZIP/Postal Code
110060
Country
India
Facility Name
Batra Hospital and Medical Research Centre
City
New Delhi
ZIP/Postal Code
110062
Country
India
Facility Name
Azienda Ospedaliera G. Rummo
City
Benevento
ZIP/Postal Code
82100
Country
Italy
Facility Name
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
City
Cona (FE)
ZIP/Postal Code
44124
Country
Italy
Facility Name
Ospedale della Val di Chiana Santa Margherita
City
Cortona
ZIP/Postal Code
52040
Country
Italy
Facility Name
Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
City
Milano
ZIP/Postal Code
20122
Country
Italy
Facility Name
Centro Cardiologico Monzino-IRCCS
City
Milano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria "Federico II"
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Pisana
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
AOU Policlinico Umberto I
City
Roma
ZIP/Postal Code
00161
Country
Italy
Facility Name
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
City
Roma
ZIP/Postal Code
00189
Country
Italy
Facility Name
Istituto Clinico Humanitas
City
Rozzano (MI)
ZIP/Postal Code
20089
Country
Italy
Facility Name
IRCCS Gruppo Multimedica
City
Sesto San Giovanni (MI)
ZIP/Postal Code
20099
Country
Italy
Facility Name
Azienda Servizi Sanitari 1 Triestina
City
Trieste
ZIP/Postal Code
34128
Country
Italy
Facility Name
Kasugai Municipal Hospital
City
Aichi, Kasugai
ZIP/Postal Code
486-8510
Country
Japan
Facility Name
Japanese Red Cross Nagoya Daini Hospital
City
Aichi, Nagoya
ZIP/Postal Code
466-8650
Country
Japan
Facility Name
Chiba Heart Clinic
City
Chiba, Chiba
ZIP/Postal Code
263-0043
Country
Japan
Facility Name
Kimitsu Chuo Hospital
City
Chiba, Kisarazu
ZIP/Postal Code
292-8535
Country
Japan
Facility Name
Seikeikai New Tokyo Heart Clinic
City
Chiba, Matsudo
ZIP/Postal Code
271-0077
Country
Japan
Facility Name
Ehime Prefectural Central Hospital
City
Ehime, Matsuyama
ZIP/Postal Code
790-0024
Country
Japan
Facility Name
Matsuyama Shimin Hospital
City
Ehime, Matsuyama
ZIP/Postal Code
790-0067
Country
Japan
Facility Name
Uwajima City Hospital
City
Ehime, Uwajima
ZIP/Postal Code
798-8510
Country
Japan
Facility Name
Fukuiken Saiseikai Hospital
City
Fukui, Fukui
ZIP/Postal Code
918-8503
Country
Japan
Facility Name
Fukuoka University Chikushi Hospital
City
Fukuoka, Chikushino
ZIP/Postal Code
818-8502
Country
Japan
Facility Name
Fukuokaken Saiseikai Futsukaichi Hospital
City
Fukuoka, Chikushino
ZIP/Postal Code
818-8516
Country
Japan
Facility Name
Saiseikai Fukuoka General Hospital
City
Fukuoka, Fukuoka
ZIP/Postal Code
810-0001
Country
Japan
Facility Name
National Hospital Organization Kyushu Medical Center
City
Fukuoka, Fukuoka
ZIP/Postal Code
810-8563
Country
Japan
Facility Name
Kyushu University Hospital
City
Fukuoka, Fukuoka
ZIP/Postal Code
812-8582
Country
Japan
Facility Name
Steel Memorial Yawata Hospital
City
Fukuoka, Kitakyushu
ZIP/Postal Code
805-8508
Country
Japan
Facility Name
Japan Community Health Care Organization Kyushu Hospital
City
Fukuoka, Kitakyushu
ZIP/Postal Code
806-8501
Country
Japan
Facility Name
Shirakawa Kosei General Hospital
City
Fukushima, Shirakawa
ZIP/Postal Code
961-0005
Country
Japan
Facility Name
Ogaki Municipal Hospital
City
Gifu, Ogaki
ZIP/Postal Code
503-8502
Country
Japan
Facility Name
Chuno Kosei Hospital
City
Gifu, Seki
ZIP/Postal Code
501-3802
Country
Japan
Facility Name
Fukuyama City Hospital
City
Hiroshima, Fukuyama
ZIP/Postal Code
721-8511
Country
Japan
Facility Name
Shobara Red Cross Hospital
City
Hiroshima, Shobara
ZIP/Postal Code
727-0013
Country
Japan
Facility Name
Matsuda Cardiovascular Clinic
City
Hokkaido, Sapporo
ZIP/Postal Code
003-0026
Country
Japan
Facility Name
Teine Keijinkai Clinic
City
Hokkaido, Sapporo
ZIP/Postal Code
006-0811
Country
Japan
Facility Name
Tomakomai City Hospital
City
Hokkaido, Tomakomai
ZIP/Postal Code
053-8567
Country
Japan
Facility Name
Otaru Kyokai Hospital
City
Hokkaido,Otaru
ZIP/Postal Code
047-8510
Country
Japan
Facility Name
Hyogo Prefectural Amagasaki General Medical Center
City
Hyogo, Amagasaki
ZIP/Postal Code
660-8550
Country
Japan
Facility Name
Hyogo Brain and Heart Center
City
Hyogo, Himeji
ZIP/Postal Code
670-0981
Country
Japan
Facility Name
National Hospital Organization Kobe Medical Center
City
Hyogo, Kobe
ZIP/Postal Code
654-0155
Country
Japan
Facility Name
Mito Medical Center
City
Ibaraki, Higashiibaraki-gun
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
Tokushukai Koga General Hospital
City
Ibaraki, Koga
ZIP/Postal Code
306-0041
Country
Japan
Facility Name
National Hospital Organization Kanazawa Medical Center
City
Ishikawa, Kanazawa
ZIP/Postal Code
920-8650
Country
Japan
Facility Name
Mitoyo General Hospital
City
Kagawa, Kanonji
ZIP/Postal Code
769-1695
Country
Japan
Facility Name
Kagawa Prefectural Central Hospital
City
Kagawa, Takamatsu
ZIP/Postal Code
760-8557
Country
Japan
Facility Name
Sekishinkai Second Kawasaki Saiwai Clinic
City
Kanagawa, Kawasaki
ZIP/Postal Code
212-0021
Country
Japan
Facility Name
Yamamoto Clinic
City
Kanagawa, Sagamihara
ZIP/Postal Code
252-0311
Country
Japan
Facility Name
Kanagawa Cardiovascular and Respiratory Center
City
Kanagawa, Yokohama
ZIP/Postal Code
236-0051
Country
Japan
Facility Name
Japanese Red Cross Kumamoto Hospital
City
Kumamoto, Kumamoto
ZIP/Postal Code
861-8520
Country
Japan
Facility Name
Seiwakai Suizenji Touya Hospital
City
Kumamoto, Kumamoto
ZIP/Postal Code
862-0950
Country
Japan
Facility Name
Kumamoto Rosai Hospital
City
Kumamoto, Yatsushiro
ZIP/Postal Code
866-8533
Country
Japan
Facility Name
Omi Medical Center
City
Kusatsu
ZIP/Postal Code
525-8585
Country
Japan
Facility Name
Uji-Tokushukai Medical Center
City
Kyoto, Uji
ZIP/Postal Code
611-0041
Country
Japan
Facility Name
Sendai Kousei Hospital
City
Miyagi, Sendai
ZIP/Postal Code
980-0873
Country
Japan
Facility Name
Sendai Tokushukai Hospital
City
Miyagi, Sendai
ZIP/Postal Code
981-3131
Country
Japan
Facility Name
National Hospital Organization Sendai Medical Center
City
Miyagi, Sendai
ZIP/Postal Code
983-8520
Country
Japan
Facility Name
Miyazaki Medical Association Hospital
City
Miyazaki, Miyazaki
ZIP/Postal Code
880-2102
Country
Japan
Facility Name
Hokushin General Hospital
City
Nagano, Nakano
ZIP/Postal Code
383-8505
Country
Japan
Facility Name
Nagasaki Medical Center
City
Nagasaki, Omura
ZIP/Postal Code
856-8562
Country
Japan
Facility Name
Oita Medical Center
City
Oita, Oita
ZIP/Postal Code
870-0263
Country
Japan
Facility Name
Okayama City General Medical Center
City
Okayama, Okayama
ZIP/Postal Code
700-8557
Country
Japan
Facility Name
Naha City Hospital
City
Okinawa, Naha
ZIP/Postal Code
902-8511
Country
Japan
Facility Name
Nanbu Tokushukai Hospital
City
Okinawa, Shimajiri-gun
ZIP/Postal Code
901-0493
Country
Japan
Facility Name
Urasoe General Hospital
City
Okinawa, Urasoe
ZIP/Postal Code
901-2132
Country
Japan
Facility Name
Higashiosaka City Medical Center
City
Osaka, Higashiosaka
ZIP/Postal Code
578-8588
Country
Japan
Facility Name
Kitano Hospital
City
Osaka, Osaka
ZIP/Postal Code
530-8480
Country
Japan
Facility Name
Yodogawa Christian Hospital
City
Osaka, Osaka
ZIP/Postal Code
533-0024
Country
Japan
Facility Name
Hokusetsu General Hospital
City
Osaka, Takatsuki
ZIP/Postal Code
569-8585
Country
Japan
Facility Name
San-Ai Hospital
City
Saitama, Saitama
ZIP/Postal Code
338-0837
Country
Japan
Facility Name
Kosekai Iwatsuki-minami Hospital
City
Saitama, Saitama
ZIP/Postal Code
339-0033
Country
Japan
Facility Name
Tokushima Prefectural Central Hospital
City
Tokushima, Tokushima
ZIP/Postal Code
770-8539
Country
Japan
Facility Name
National Hospital Organization Tokyo Medical Center
City
Tokyo, Meguro-ku
ZIP/Postal Code
152-8902
Country
Japan
Facility Name
Ome Municipal General Hospital
City
Tokyo, Ome
ZIP/Postal Code
198-0042
Country
Japan
Facility Name
Tokyo Rosai Hospital
City
Tokyo, Ota-ku
ZIP/Postal Code
143-0013
Country
Japan
Facility Name
Sekino Hospital
City
Tokyo, Toshima-ku
ZIP/Postal Code
171-0014
Country
Japan
Facility Name
Minami Wakayama Medical Center
City
Wakayama, Tanabe
ZIP/Postal Code
646-8558
Country
Japan
Facility Name
Kanmon Medical Center
City
Yamaguchi, Shimonoseki
ZIP/Postal Code
752-8510
Country
Japan
Facility Name
Inje University Busan Paik Hospital
City
Busan
ZIP/Postal Code
47392
Country
Korea, Republic of
Facility Name
Dong-A University Hospital
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Chungbuk National University Hospital
City
Cheongju-si
ZIP/Postal Code
28644
Country
Korea, Republic of
Facility Name
Chungnam National University Hospital
City
Daejeon
ZIP/Postal Code
35015
Country
Korea, Republic of
Facility Name
Chonnam National University Hospital
City
Gwangju
ZIP/Postal Code
61469
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Gyeonggi-Do
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Severance Hospital
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Korea University Guro Hospital
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
Wonju Severance Christian Hosp
City
Wonju-si
ZIP/Postal Code
26426
Country
Korea, Republic of
Facility Name
Hospital Cardiologica Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Centro de Investigacion Biomedica y Farmaceutica, S.C.
City
Distrito Federal
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Hospital Ramon Garibay
City
Guadalajara
ZIP/Postal Code
44100
Country
Mexico
Facility Name
Diseño y Planeación en Investigación Médica SC
City
Guadalajara
ZIP/Postal Code
44130
Country
Mexico
Facility Name
Unidad de Investigacion Clinica Cardiometabolica de Occident
City
Guadalajara
ZIP/Postal Code
44150
Country
Mexico
Facility Name
Cardiologia Clinica e Intervencionista
City
Guadalajara
ZIP/Postal Code
44670
Country
Mexico
Facility Name
Centro de Investigación Clinica Acelerada, S.C.
City
Mexico
ZIP/Postal Code
07020
Country
Mexico
Facility Name
Instituto Cardiovascular de Monclova, S de RL de CV
City
Monclova
ZIP/Postal Code
25750
Country
Mexico
Facility Name
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
City
México
ZIP/Postal Code
C.P. 11650
Country
Mexico
Facility Name
Hospital Universitario Dr Jose Eleuterio Gonzalez
City
Nuevo Leon
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Centro Integral Medico SJR S.C.
City
San Juan del Rio
ZIP/Postal Code
76800
Country
Mexico
Facility Name
Cardioarritmias e Investigación S.C
City
San Luis Potosi
ZIP/Postal Code
78213
Country
Mexico
Facility Name
Centro de Investigacion Cardiovascular y Metabolica
City
Tijuana
ZIP/Postal Code
22500
Country
Mexico
Facility Name
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
City
Torreon
ZIP/Postal Code
27000
Country
Mexico
Facility Name
Ziekenhuisgroep Twente locatie Almelo
City
Almelo
ZIP/Postal Code
7609 PP
Country
Netherlands
Facility Name
BovenIJ Ziekenhuis
City
Amsterdam
ZIP/Postal Code
1034 CS
Country
Netherlands
Facility Name
Onze Lieve Vrouwe Gasthuis, Locatie West
City
Amsterdam
ZIP/Postal Code
1061 AE
Country
Netherlands
Facility Name
Amsterdam UMC Locatie VUMC
City
Amsterdam
ZIP/Postal Code
1081HV
Country
Netherlands
Facility Name
Onze Lieve Vrouwe Gasthuis
City
Amsterdam
ZIP/Postal Code
1091AC
Country
Netherlands
Facility Name
Amsterdam UMC, Locatie AMC
City
Amsterdam
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Rode Kruis Ziekenhuis Beverwijk
City
Beverwijk
ZIP/Postal Code
1942 LE
Country
Netherlands
Facility Name
Tergooiziekenhuizen locatie Blaricum
City
Blaricum
ZIP/Postal Code
1261 AN
Country
Netherlands
Facility Name
Amphia Ziekenhuis
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
Facility Name
Ziekenhuis Gelderse Vallei
City
EDE
ZIP/Postal Code
6716 RP
Country
Netherlands
Facility Name
Catharina Ziekenhuis
City
Eindhoven
ZIP/Postal Code
5623 EJ
Country
Netherlands
Facility Name
Universitair Medisch Centrum Groningen
City
Groningen
ZIP/Postal Code
9713 GZ
Country
Netherlands
Facility Name
Zuyderland Medisch Centrum
City
Heerlen
ZIP/Postal Code
6419 PC
Country
Netherlands
Facility Name
Maastricht University
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Diaconessenhuis Meppel
City
Meppel
ZIP/Postal Code
7943 KA
Country
Netherlands
Facility Name
St. Antonius ziekenhuis, locatie Nieuwegein
City
Nieuwegein
ZIP/Postal Code
3435 CM
Country
Netherlands
Facility Name
Radboud Universitair Medisch Centrum
City
Nijmegen
ZIP/Postal Code
6525 GL
Country
Netherlands
Facility Name
Franciscus Gasthuis
City
Rotterdam
ZIP/Postal Code
3045 PM
Country
Netherlands
Facility Name
De Heel - Zaans Medisch Centrum
City
Zaandam
ZIP/Postal Code
1502 DV
Country
Netherlands
Facility Name
Gelre Ziekenhuis Zutphen
City
Zutphen
ZIP/Postal Code
7207 AE
Country
Netherlands
Facility Name
Univ. Clinic Hosp, Bialystok
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
KLIMED Marek Klimkiewicz
City
Bialystok
ZIP/Postal Code
15-765
Country
Poland
Facility Name
ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok
City
Bialystok
ZIP/Postal Code
15-879
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Bielsko-Biala
ZIP/Postal Code
43-316
Country
Poland
Facility Name
NZOZ Centrum Medyczne KERmed
City
Bydgoszcz
ZIP/Postal Code
85231
Country
Poland
Facility Name
Polsko-Amerykanskie Kliniki Serca
City
Chorzow
ZIP/Postal Code
32-500
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Dabrowa Gornicza
ZIP/Postal Code
41-300
Country
Poland
Facility Name
Poradnia Kardiologiczna Jaroslaw Jurowiecki
City
Gdansk
ZIP/Postal Code
80-286
Country
Poland
Facility Name
University Clinical Center, Gdansk
City
Gdansk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Indywidualna Specjalistyczna Praktyka Lekarska
City
Gdynia
ZIP/Postal Code
81-157
Country
Poland
Facility Name
NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
City
Gdynia
ZIP/Postal Code
81-423
Country
Poland
Facility Name
Szpital Zakonu Bonifratow Sp. z o.o.
City
Katowice
ZIP/Postal Code
40-211
Country
Poland
Facility Name
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
City
Kielce
ZIP/Postal Code
25525
Country
Poland
Facility Name
Leszek Bryniarski Specialized Medical Cabinet
City
Krakow
ZIP/Postal Code
30-082
Country
Poland
Facility Name
Krakow Specialistic Hospital of John Paul II
City
Krakow
ZIP/Postal Code
31-202
Country
Poland
Facility Name
ETG Lodz
City
Lodz
ZIP/Postal Code
90-302
Country
Poland
Facility Name
Nzoz Salus
City
Lodz
ZIP/Postal Code
91-002
Country
Poland
Facility Name
Individual Specialized Practice
City
Lodz
ZIP/Postal Code
94-255
Country
Poland
Facility Name
Lowickie Cardiology Center
City
Lowicz
ZIP/Postal Code
99-400
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Nysa
ZIP/Postal Code
48-300
Country
Poland
Facility Name
Medicome Sp. z o.o.
City
Oswiecim
ZIP/Postal Code
32-600
Country
Poland
Facility Name
NZOZ HEUREKA, Piaseczno
City
Piaseczno
ZIP/Postal Code
05-500
Country
Poland
Facility Name
Specialized Practice Dr. Janusz Spyra
City
Ruda Slaska
ZIP/Postal Code
41-709
Country
Poland
Facility Name
Centrum Medyczne Medyk
City
Rzeszow
ZIP/Postal Code
35-055
Country
Poland
Facility Name
Lukmed Lukasz Wozniak
City
Siedlce
ZIP/Postal Code
08-110
Country
Poland
Facility Name
ETG Skierniewice
City
Skierniewice
ZIP/Postal Code
96-100
Country
Poland
Facility Name
KO-MED Centra Kliniczne Staszow
City
Staszow
ZIP/Postal Code
28-200
Country
Poland
Facility Name
The Provincial Polyclinical Hospital in Torun
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Tychy
ZIP/Postal Code
43-100
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Ustron
ZIP/Postal Code
43-450
Country
Poland
Facility Name
Samodzielny Publiczny Centralny Szpital Kliniczny
City
Warszawa
ZIP/Postal Code
02-097
Country
Poland
Facility Name
ETG Warszawa
City
Warszawa
ZIP/Postal Code
02-793
Country
Poland
Facility Name
4. Military Clinical Hospital with Polyclinic SP ZOZ
City
Wroclaw
ZIP/Postal Code
50-981
Country
Poland
Facility Name
Zgierskie Center of Cardiology MED-PRO
City
Zgierz
ZIP/Postal Code
95-100
Country
Poland
Facility Name
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
City
Zychlin
ZIP/Postal Code
62-571
Country
Poland
Facility Name
Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"
City
Balotesti
ZIP/Postal Code
077015
Country
Romania
Facility Name
C.M.D.T.A. NEOMED, Brasov
City
Brasov
ZIP/Postal Code
500283
Country
Romania
Facility Name
CMDTA Washington, Bucharest
City
Bucharest
ZIP/Postal Code
011794
Country
Romania
Facility Name
Emergency Clinical Hospital 'Sf. Panteliomon'
City
Bucharest
ZIP/Postal Code
021659
Country
Romania
Facility Name
Emergency University Hospital, Bucharest
City
Bucharest
ZIP/Postal Code
022328
Country
Romania
Facility Name
Prof.C.C.Iliescu Hospital, National Institute of Cardiology
City
Bucharest
ZIP/Postal Code
022328
Country
Romania
Facility Name
Emergency University Hospital, Bucharest
City
Bucharest
ZIP/Postal Code
050098
Country
Romania
Facility Name
Spitalul Clinic Colentina
City
Bucuresti
ZIP/Postal Code
020125
Country
Romania
Facility Name
Spitalul Clinic "Prof. Dr. Theodor Burghele"
City
Bucuresti
ZIP/Postal Code
050659
Country
Romania
Facility Name
Clinica Medicala Data Plus SRL
City
Bucuresti
ZIP/Postal Code
10192
Country
Romania
Facility Name
S.C Cardiomed S.R.L
City
Craiova
ZIP/Postal Code
200505
Country
Romania
Facility Name
Spital Judetean Deva
City
Deva
ZIP/Postal Code
330084
Country
Romania
Facility Name
S.C Medicali's S.R.L
City
Timisoara
ZIP/Postal Code
300043
Country
Romania
Facility Name
Spitalul Clinic Judetean de Urgenta, Timisoara
City
Timisoara
ZIP/Postal Code
300723
Country
Romania
Facility Name
National University Hospital
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
National Heart Center
City
Singapore
ZIP/Postal Code
169609
Country
Singapore
Facility Name
Tan Tock Seng Hospital
City
Singapore
ZIP/Postal Code
308433
Country
Singapore
Facility Name
Khoo Teck Puat Hospital
City
Singapore
ZIP/Postal Code
768828
Country
Singapore
Facility Name
Cardiology Clinical Research
City
Alberton
ZIP/Postal Code
1449
Country
South Africa
Facility Name
Iatros International
City
Bloemfontein
ZIP/Postal Code
9301
Country
South Africa
Facility Name
Universitas Hospital Cardiology Research
City
Bloemfontein
ZIP/Postal Code
9301
Country
South Africa
Facility Name
Corbod Research
City
Cape Town
ZIP/Postal Code
7500
Country
South Africa
Facility Name
TREAD Research
City
Cape Town
ZIP/Postal Code
7500
Country
South Africa
Facility Name
Tiervlei Trial Centre
City
Cape Town
ZIP/Postal Code
7530
Country
South Africa
Facility Name
Excellentis Clinical Trials
City
George
ZIP/Postal Code
6529
Country
South Africa
Facility Name
Clinresco
City
Johannesburg
ZIP/Postal Code
1619
Country
South Africa
Facility Name
Chris Hani Baragwanath Hospital: Cardiology Department
City
Johannesburg
ZIP/Postal Code
1862
Country
South Africa
Facility Name
MERC Research
City
Kempton Park
ZIP/Postal Code
1619
Country
South Africa
Facility Name
Into Research
City
Pretoria
ZIP/Postal Code
181
Country
South Africa
Facility Name
Dr JM Engelbrecht
City
Somerset West
ZIP/Postal Code
7130
Country
South Africa
Facility Name
Clinical Projects Research
City
Worcester
ZIP/Postal Code
6850
Country
South Africa
Facility Name
Hospital Quiron. I.C.U.
City
Barcelona
ZIP/Postal Code
08023
Country
Spain
Facility Name
Hospital Santa Creu i Sant Pau
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Hospital Sanitas CIMA
City
Barcelona
ZIP/Postal Code
08034
Country
Spain
Facility Name
Hospital Universitario Virgen de la Arrixaca
City
El Palmar
ZIP/Postal Code
30120
Country
Spain
Facility Name
Hospital General Universitario Gregorio Marañón
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Ramón y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital La Paz
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Puerta de Hierro
City
Majadahonda
ZIP/Postal Code
28222
Country
Spain
Facility Name
Hospital Virgen de la Victoria
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hospital Clínico de Santiago
City
Santiago de Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Virgen Macarena
City
Sevilla
ZIP/Postal Code
41009
Country
Spain
Facility Name
Hospital General Universitario de Valencia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Hospital Arnau de Vilanova
City
Valencia
ZIP/Postal Code
46015
Country
Spain
Facility Name
Barnet General Hospital
City
Barnet
ZIP/Postal Code
EN5 3DJ
Country
United Kingdom
Facility Name
University Hospital of Wales
City
Cardiff
ZIP/Postal Code
CF14 4XU
Country
United Kingdom
Facility Name
Park & St Francis Surgery
City
Eastleigh
ZIP/Postal Code
SO53 4ST
Country
United Kingdom
Facility Name
Wycombe General Hospital
City
High Wycombe
ZIP/Postal Code
HP11 2TT
Country
United Kingdom
Facility Name
Glenfield Hospital
City
Leicester
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Facility Name
St Bartholomew's Hospital
City
London
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Facility Name
St Mary's Hospital
City
Newport
ZIP/Postal Code
PO30 5TG
Country
United Kingdom
Facility Name
Morriston Hospital
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
36129693
Citation
Ferreira JP, Zannad F, Butler J, Filippatos G, Pocock SJ, Brueckmann M, Steubl D, Schueler E, Anker SD, Packer M. Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled. JAMA Cardiol. 2022 Nov 1;7(11):1148-1159. doi: 10.1001/jamacardio.2022.2924. Erratum In: JAMA Cardiol. 2022 Nov 1;7(11):1177.
Results Reference
derived
PubMed Identifier
36098051
Citation
Butler J, Filippatos G, Siddiqi TJ, Ferreira JP, Brueckmann M, Bocchi E, Bohm M, Chopra VK, Giannetti N, Iwata T, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Rauch-Krohnert U, Shah SJ, Senni M, Sumin M, Verma S, Zhang J, Pocock SJ, Zannad F, Packer M, Anker SD. Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction. Circulation. 2022 Oct 4;146(14):1046-1055. doi: 10.1161/CIRCULATIONAHA.122.059755. Epub 2022 Sep 13.
Results Reference
derived
PubMed Identifier
35762322
Citation
Filippatos G, Butler J, Farmakis D, Zannad F, Ofstad AP, Ferreira JP, Green JB, Rosenstock J, Schnaidt S, Brueckmann M, Pocock SJ, Packer M, Anker SD; EMPEROR-Preserved Trial Committees and Investigators. Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes. Circulation. 2022 Aug 30;146(9):676-686. doi: 10.1161/CIRCULATIONAHA.122.059785. Epub 2022 Jun 28.
Results Reference
derived
PubMed Identifier
35687107
Citation
Ferreira JP, Zannad F, Butler J, Filipattos G, Ritter I, Schuler E, Kraus BJ, Pocock SJ, Anker SD, Packer M. Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Eur Heart J. 2022 Aug 14;43(31):2984-2993. doi: 10.1093/eurheartj/ehac306. Erratum In: Eur Heart J. 2022 Jul 22;:
Results Reference
derived
PubMed Identifier
35670067
Citation
Januzzi JL Jr, Butler J, Zannad F, Filippatos G, Ferreira JP, Pocock SJ, Sattar N, Verma S, Vedin O, Iwata T, Brueckmann M, Packer M, Anker SD; EMPEROR-Preserved Trial Study Group. Prognostic Implications of N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T in EMPEROR-Preserved. JACC Heart Fail. 2022 Jul;10(7):512-524. doi: 10.1016/j.jchf.2022.05.004. Epub 2022 Jun 1.
Results Reference
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PubMed Identifier
35603667
Citation
Vaduganathan M, Claggett BL, Inciardi RM, Fonarow GC, McMurray JJV, Solomon SD. Estimating the Benefits of Combination Medical Therapy in Heart Failure With Mildly Reduced and Preserved Ejection Fraction. Circulation. 2022 Jun 7;145(23):1741-1743. doi: 10.1161/CIRCULATIONAHA.121.058929. Epub 2022 May 23. No abstract available.
Results Reference
derived
PubMed Identifier
35331406
Citation
Ferreira JP, Butler J, Zannad F, Filippatos G, Schueler E, Steubl D, Zeller C, Januzzi JL, Pocock S, Packer M, Anker SD. Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. doi: 10.1016/j.jacc.2022.01.029.
Results Reference
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PubMed Identifier
34779658
Citation
Butler J, Filippatos G, Jamal Siddiqi T, Brueckmann M, Bohm M, Chopra VK, Pedro Ferreira J, Januzzi JL, Kaul S, Pina IL, Ponikowski P, Shah SJ, Senni M, Vedin O, Verma S, Peil B, Pocock SJ, Zannad F, Packer M, Anker SD. Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial. Circulation. 2022 Jan 18;145(3):184-193. doi: 10.1161/CIRCULATIONAHA.121.057812. Epub 2021 Nov 15.
Results Reference
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PubMed Identifier
34693515
Citation
Kanie T, Mizuno A, Takaoka Y, Suzuki T, Yoneoka D, Nishikawa Y, Tam WWS, Morze J, Rynkiewicz A, Xin Y, Wu O, Providencia R, Kwong JS. Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: a network meta-analysis. Cochrane Database Syst Rev. 2021 Oct 25;10(10):CD013650. doi: 10.1002/14651858.CD013650.pub2.
Results Reference
derived
PubMed Identifier
34449189
Citation
Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bohm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Pina IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
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PubMed Identifier
31081589
Citation
Nassif ME, Kosiborod M. Effects of sodium glucose cotransporter type 2 inhibitors on heart failure. Diabetes Obes Metab. 2019 Apr;21 Suppl 2:19-23. doi: 10.1111/dom.13678.
Results Reference
derived
Links:
URL
https://www.mystudywindow.com
Description
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Learn more about this trial
EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
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