Back to resultsEMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
Primary Purpose
Heart Failure
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Empagliflozin
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Heart Failure
Eligibility Criteria
Inclusion criteria:
- Male or female patient age >= 18 years at screening. For Japan only: Age >= 20 years at screening
Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association Classification) class II-IV and reduced EF (Ejection Fraction) (LVEF (Left Ventricular Ejection Fraction) <=40%) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide)
- If EF >= 36% to <= 40%: NT-proBNP >= 2500 pg/ml or patients without AF (atrial fibrillation/atrial flutter) and NT-proBNP >= 5000 pg/ml for patients with AF
- If EF >= 31% to <= 35%: NT-proBNP >= 1000 pg/ml for patients without AF and NT-proBNP >=2000 pg/ml for patients with AF
- If EF<= 30%: NT-proBNP >= 600 pg/ml for patients without AF and NT-proBNP >=1200 pg/ml for patients with AF
- EF ≤ 40% and hospitalization for heart failure in the past 12 months: NTproBNP ≥ 600 pg/ml for patients without AF and NT-proBNP >= 1200 pg/ml for patients with AF
- Appropriate dose of medical therapy for HF consistent with prevailing local and international CV (Cardiovascular) guidelines, stable for at least 1 week prior to Visit 1
- Appropriate use of medical devices such as cardioverter defibrillator (ICD) or a cardiac resynchronization therapy (CRT) consistent with prevailing local or international CV guidelines
- Signed and dated written ICF (Informed Consent Form)
- Further inclusion criteria apply
Exclusion criteria:
- Myocardial infarction, coronary artery bypass graft surgery, or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
- Heart transplant recipient, or listed for heart transplant
- Acute decompensated HF
- Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
- Symptomatic hypotension and/or a SBP < 100 mmHg
- Indication of liver disease
- Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration Equation)) or requiring dialysis
- History of ketoacidosis
- Current use or prior use of a SGLT (Sodium-glucose co-transporter)-2 inhibitor or combined SGLT-1 and 2 inhibitor
- Currently enrolled in another investigational device or drug study
- Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
- Further exclusion criteria apply
Sites / Locations
- La Mesa Cardiac Center
- Long Beach Center for Clinical Research
- VA Greater Los Angeles Healthcare System
- Merced Vein and Vascular Center
- University of California Irvine
- Covigilant Research, LLC
- University of California
- Orange County Research Center
- Blue Coast Cardiology
- South Denver Cardiology Associates, PC
- Integrated Heart Care
- Morton Plant Mease Health Care
- Nature Coast Clinical Research
- Avail Clinical Research, LLC
- Holy Cross Hospital
- Integrative Research Associates
- Nature Coast Clinical Research
- East Coast Institute for Research, LLC
- Jacksonville Center for Clinical Research
- Cardiovascular Research Center of South Florida
- Peninsula Research, Inc.
- Cardiology Consultants, Inc
- Sarasota Memorial Hospital
- Grady Clinical Research Center
- Augusta University
- Columbus Regional Research Institute
- Cardiovascular Group PC
- Meridian Clinical Research, LLC
- Northwest Heart Clinical Research, LLC
- University of Chicago
- Captain James A. Lovell Federal Health Care Center
- Rockford Cardiovascular Associates
- Midwest Cardiovascular Research and Education Foundation
- St. Francis Medical Group-Indiana Heart Physicians, Inc
- Reid Hospital
- Beacon Medical Group Clinical Research
- Research Integrity, LLC
- Cambridge Medical Trials
- Louisiana Heart Center
- Clinical Trials of America, LLC
- Tulane University Hospital and Clinic
- Anne Arundel Medical Center
- Johns Hopkins University Hospital School of Medicine
- MedStar Health Research Institute
- Metropolitan Cardiovascular Consultants
- Spectrum Clinical Research
- Tufts Medical Center
- East Mountain Medical Associates, PC
- Alpena General Hospital
- Regions Hospital
- Saint Louis University
- SLHV
- Palm Research Center
- Advanced Heart Care, LLC
- Cardiac Care and Vascular Medicine, PLLC
- Trinity Medical WNY, PC
- Northwell Health
- Mount Sinai School of Medicine
- St. Luke's Roosevelt Hospital
- Harlem Cardiology
- Stony Brook University Medical Center
- Asheville Cardiology Associates
- Kernodle Clinic West
- The University of North Carolina at Chapel Hill
- Novant Health Heart and Vascular Institute
- Duke University Medical Center
- Clinical Research of Gastonia
- Clinical Trials of America, Inc
- Rama Research LLC
- University of Toledo
- South Oklahoma Heart Research Group
- Doylestown Health Cardiology
- York Hospital, WellSpan Health
- AnMed Health Clinical Research
- Ralph H. Johnson VA Medical Center
- Palmetto Health
- William Jennings Bryan Dorn VA Medical Center
- Clinical Research of Rock Hill
- Palmetto Research Center, LLC
- Methodist University Hospital
- Baylor Heart and Vascular Hospital
- Soltero Cardiovascular Research Center
- University of Texas Southwestern Medical Center
- University of North Texas Health Science Center
- The Methodist Hospital
- The Heart Hospital
- Alpine Research Organization
- Cardiac Health Management Network, P.C.
- Hunter Holmes McGuire VA Medical Center
- Roanoke Heart Institute PLC
- Salem VA Medical Center
- Marshfield Clinic
- Hospital Interzonal General de Agudos Dr Jose Penna
- Hospital Italiano Regional del Sur, Bahia Blanca
- CIPREC
- Hospital Italiano de Buenos Aires
- Consultorios Asociados de Endocrinología e Invest Clínica
- Instituto Cardiovascular de Buenos Aires
- CCBR - Buenos Aires - AR
- Centro Médico Viamonte
- Sanatorio Güemes
- Instituto Medico Elsa Perez SRL (IMEP)
- Clínica Colombo
- Instituto Médico DAMIC S.R.L.
- Clinica Coronel Suarez SA
- Instituto de Cardiología de Corrientes
- Sanatorio Mayo Privado SA
- Centro de Investigaciones Clinicas Instituto del Corazon
- Sanatorio Allende S.A.
- Hospital Privado
- Hospital Italiano de La Plata
- Centro de Investigaciones Médicas
- Hospital Privado de Comunidad
- Clínica Olivos
- CER Instituto Médico
- Instituto de Investigaciones Clínicas de Quilmes
- Instituto de Investigaciones Clinicas de Rosario
- Instituto Medico Fundación Grupo Colaborativo Rosario
- Sanatorio Británico
- Sanatorio Plaza
- Sanatorio Parque
- Instituto CAICI
- CORDIS S.A., Salta
- Centro Cardiovascular Salta
- Corporacion Medica de Gral. San Martin S.A.
- Investigaciones Clinicas Tucuman
- CCBR Tucuman
- Centro Medico Luquez
- Centro de Investigaciones Clínicas del Litoral
- Hospital "Dr. José Maria Cullen "
- Instituto de Cardiología
- CEMEDIC - Centro de Especialidades Medicas
- John Hunter Hospital
- CORE Research Group
- Mater Hospital Brisbane
- SA-Heart Ashford Specialist Centre
- Heart and Vascular Research
- The Northern Hospital
- St Vincent's Hospital Melbourne
- University Hospital Geelong
- Royal Melbourne Hospital
- AZ Sint-Jan Brugge
- C.H.U. de Charleroi
- AZ Sint-Blasius
- Ziekenhuis Oost-Limburg - Campus Sint-Jan
- AZ Sint-Lucas - Campus Sint Lucas
- Grand Hôpital de Charleroi
- Jessa Ziekenhuis - Campus Virga Jesse
- La Louvière - UNIV CHU Tivoli
- UZ Leuven
- AZ Sint-Maarten
- Hospital Felicio Rocho
- Hospital Vera Cruz
- Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
- CCBR - Brasília
- ICDF - Instituto de Cardiologia do Distrito Federal
- CECAP - Centro de Cardiologia Clínica
- Hospital Angelina Caron
- Centro Especializado em Cardiol Loema Instituto de Pesq Clin
- IPECC - Instituto de Pesquisa Clínica de Campinas
- CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
- Hospital Universitário
- IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
- Irmandade da Santa Casa de Misericórdia de Curitiba
- Hospital de Messejana Dr. Carlos Alberto Studart Gomes
- Barroso e Sebba Ltda
- HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
- ICM - Instituto do Coracao de Marilia
- Hospital São Vicente de Paulo
- Santa Casa de Misericórdia de Porto Alegre
- Centro de Pesquisas em Diabetes
- Hospital de Clínicas de Porto Alegre
- Instituto de Cardiologia Rio Grande do Sul
- Hospital Agamenon Magalhaes
- H.C.da Fac. de Medicina de Ribeirao Preto
- Hospital Universitário Pedro Ernesto UERJ
- CCBR - Rio de Janeiro - BR
- Pesquisare
- Praxis Pesquisa Médica
- Fundacao Faculdade Regional de Medicina, Sao Jose
- Centro de Pesquisa Clinica - CPCLIN
- FGM - Clínica Paulista de Doenças Cardiovasculares
- CEPIC - Centro Paulista de Investigacao Clinica
- INCOR e Hospital das Clínicas da Universidade de São Paulo
- CEMEC - Centro Multidisciplinar de Estudos Clínicos
- CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
- Dr. Consulta
- CEDOES - Diagnóstico e Pesquisa,Vitória
- Santa Casa de Votuporanga
- Royal Alexandra Hospital
- Vancouver General Hospital
- St. Paul's Hospital
- Victoria Heart Institute Foundation
- St. Boniface General Hospital
- G.A. Research Associates Ltd
- QEII Health Sciences Centre
- Brampton Cardio Pulmonary Clinic
- JBN Medical Diagnostic Services Inc.
- Cambridge Cardiac Care Inc.
- Curnew Medicine Professional Corporation
- Hamilton General Hospital
- Southlake Regional Health Centre
- M Heffernan Medicine Professional Corp.
- Kawartha Cardiology Clinical Trials
- Heart Health Institute
- Scarborough Cardiology Research
- Health Sciences North
- Canadian Phase Onward Inc.
- North York Diagnostic and Cardiac Centre
- Diabetes Heart Research Centre
- Mohan Babapulle Medicine Professional Medicine
- Dr. Louis C.H. Yao
- ViaCar Recherche Clinique Inc
- Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
- Clinique Santé Cardio MC
- Montreal General Hospital - McGill University Health Centre
- McGill University Health Centre (MUHC)
- Centre de sante et de services sociaux de Beauce
- IUCPQ (Laval University)
- Cardiovascular Institute and Fu Wai Hospital
- Beijing Friendship Hospital
- First Hospital of Jilin University
- Hunan Provincial People's Hospital
- 2nd Xiangya Hospital of Central South University
- The Third Hospital of Changsha
- Dongguan People's Hospital
- The First Affiliated Hospital of Fujian Medical University
- The First Afiliated Hospital, Sun Yet-sen University
- Guangzhou First Municipal People's Hospital
- Haikou People's Hospital
- HaiNan Provincial People's Hospital
- The First Affiliated Hospital of Lanzhou University
- The Second Affiliated Hospital of Lanzhou Medical University
- The Affiliated Hospital of Southwest Medical University
- Nanchang University Affiliated 3rd Hospital
- First Hospital Affiliated with Nanjing Medical University
- Huashan Hospital, Fudan University
- General Hospital of Shenyang Military Region
- Shengjing Hospital of China Medical University
- Tianjin Union Medical Center Nankai University Affiliated Hospital
- Tongji Hospital, Tongji University
- Renmin Hospital of Wuhan University
- First Affiliated Hospital of Xi'an JiaoTong University
- Yanbian University Hospital
- the first people hospital of Yue Yang
- Affiliated Hospital of Jiangsu University
- Poliklinika Humanitas
- Medicus Services Ltd.
- Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
- MUDr. Alexandra Ludkova
- Vojenska nemocnice Brno
- Nemocnice Milosrdnych bratri
- Edumed s.r.o
- MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
- Nemocnice ve Frydku-Mistku, prispevkova organizace
- MUDr. Ladislav Busak
- Zdenek Vomacka
- PV-Kardiologie s.r.o.
- University Hospital Motol
- General Faculty Hospital, Prague
- Thomayer Hospital
- Kardio Vaclavik s.r.o.
- Clinic of Cardiology, Pribram
- Hospital Trebic, p.o.
- Masaryk Hospital, Usti nad Labem
- Angiocor s.r.o
- KIGE s.r.o
- HOP de Bayonne
- HOP Jean Minjoz
- HOP Louis Pradel
- HOP Côte de Nacre
- HOP Arnaud de Villeneuve
- HOP La Pitié Salpêtrière
- Centre Hospitalier de Pau
- HOP Haut-Lévêque
- HOP Rangueil
- INS Louis Mathieu
- Universitätsklinikum Aachen, AöR
- Praxis Dr. Rieker, Berlin
- Charité - Universitätsmedizin Berlin
- Vivantes Netzwerk für Gesundheit GmbH
- Charité - Universitätsmedizin Berlin
- Klinikum Bielefeld gGmbH
- Praxis Dr. Menzel
- St. Johannes Hospital Dortmund
- Städtisches Klinikum Dresden
- GWT-TUD GmbH
- Helios Klinikum Erfurt
- Studienzentrum Bocholderstraße
- ClinPhenomics GmbH & Co KG, Frankfurt
- Universitätsmedizin Göttingen, Georg-August-Universität
- Asklepios Klinik St. Georg
- Medizinische Hochschule Hannover
- Universitätsklinikum Heidelberg
- Universitätsklinikum des Saarlandes
- Universitätsklinikum Jena
- Universitätsklinikum Schleswig-Holstein, Campus Kiel
- Asklepios Klinik Langen-Seligenstadt GmbH
- Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
- Praxis Dr. Sarnighausen, Lüneburg
- Katholisches Klinikum St. Hildegardiskrankenhaus, Mainz
- Deutsches Herzzentrum München
- Kardiologische Gemeinschaftspraxis Nienburg
- Kardiologische Praxis Papenburg
- Universitätsklinikum Regensburg
- Praxis Dr. Stenzel, Riesa
- Zentrum für Klinische Forschung
- Josephs-Hospital Warendorf
- Petrus-Krankenhaus
- Lausmed Kft. Outpatient Unit of Internal Medicine
- Belgyogyaszati es Kardiologiai Maganrendelo
- Clinexpert Kft.
- Gottsegen Gyorgy Hungarian Instit.of Cardiology,Budapest
- Bajcsy-Zsilinszky Hospital and Clinic
- Semmelweis University
- Milit.Hosp.-State Health Cent.
- Uzsoki Street Hospital, Budapest
- Nehezlegzes Ambulancia
- Bugat Pal Hospital, Gyongyos
- Selye Janos Hospital Komarom
- Dorottya Kanizsai Hospital
- Dr. Nagy Laszlo Kardiologiai Maganrendeles
- Da Vinci Maganklinika
- Pecsi Tudomanyegyetem
- Fejer County Saint George University Teaching Hospital
- Veszpremi Sziv es Egeszseg Centrum
- Doctor Jivraj Mehta Smarak Health Foundation
- Kamalnayan Bajaj Hospital
- Narayana Institute of Cardiac Sciences
- Rajarajeswari Medical College
- Madras Medical Mission,
- Apollo Speciality Hospital
- Medanta-The Medicity
- B.M. Birla Heart research Centre
- Siddhi Hospital
- Vijan Cardiac and Critical Care Centre
- Batra Hospital and Medical Research Centre
- GB Pant Hospital
- Fortis Escorts Heart Institute
- Sir Gangaram Hospital
- Azienda Ospedaliera G. Rummo
- ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
- Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
- Ospedale della Val di Chiana Santa Margherita
- Centro Cardiologico Monzino-IRCCS
- Azienda Ospedaliera Universitaria "Federico II"
- Azienda Ospedaliera Universitaria Pisana
- Umberto I Pol. di Roma-Università di Roma La Sapienza
- Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
- Azienda Servizi Sanitari 1 Triestina
- Kasugai Municipal Hospital
- Nagoya Kyoritsu Hospital
- Japanese Red Cross Nagoya Daini Hospital
- Toyota Memorial Hospital
- Chiba Heart Clinic
- Kimitsu Chuo Hospital
- Seikeikai New Tokyo Heart Clinic
- Ehime Prefectural Central Hospital
- Matsuyama Shimin Hospital
- Uwajima City Hospital
- Fukuiken Saiseikai Hospital
- Fukuoka University Chikushi Hospital
- Fukuokaken Saiseikai Futsukaichi Hospital
- Saiseikai Fukuoka General Hospital
- National Hospital Organization Kyushu Medical Center
- Kyushu University Hospital
- Aso Co.,Ltd Iizuka Hospital
- Steel Memorial Yawata Hospital
- Japan Community Health Care Organization Kyushu Hospital
- Ogaki Municipal Hospital
- Chuno Kosei Hospital
- Fukuyama City Hospital
- JA Hiroshima General Hospital
- Shobara Red Cross Hospital
- National Hospital Organization Hakodate Hospital
- Teine Keijinkai Clinic
- Tomakomai City Hospital
- Hyogo Prefectural Amagasaki General Medical Center
- Hyogo Brain and Heart Center
- National Hospital Organization Kobe Medical Center
- Mito Medical Center
- National Hospital Organization Kanazawa Medical Center
- Mitoyo General Hospital
- Kagawa Prefectural Central Hospital
- Yamamoto Clinic
- Kanagawa Cardiovascular and Respiratory Center
- Japanese Red Cross Kumamoto Hospital
- Seiwakai Suizenji Touya Hospital
- Kumamoto Rosai Hospital
- Uji-Tokushukai Medical Center
- Sendai Kousei Hospital
- Sendai Tokushukai Hospital
- The Cardiovascular Center of Sendai
- National Hospital Organization Sendai Medical Center
- Miyazaki Medical Association Hospital
- Hokushin General Hospital
- Nagasaki Medical Center
- Okayama City General Medical Center
- Naha City Hospital
- Nanbu Tokushukai Hospital
- Urasoe General Hospital
- Higashiosaka City Medical Center
- Kitano Hospital
- Yodogawa Christian Hospital
- Seichokai Bell Land General Hospital
- Hokusetsu General Hospital
- San-Ai Hospital
- Kosekai Iwatsuki-minami Hospital
- Kusatsu General Hospital
- Tokushima Prefectural Central Hospital
- National Hospital Organization Tokyo Medical Center
- Ome Municipal General Hospital
- Tokyo Rosai Hospital
- Sekino Hospital
- Minami Wakayama Medical Center
- Kanmon Medical Center
- Dong-A University Hospital
- Inje University Busan Paik Hospital
- Chungbuk National University Hospital
- Chungnam National University Hospital
- Gachon University Gil Medical Center
- Seoul National University Hospital
- Severance Hospital
- Asan Medical Center
- Samsung Medical Center
- Korea University Guro Hospital
- Seoul National University Bundang Hospital
- Wonju Severance Christian Hosp
- Hospital Cardiologica Aguascalientes
- Instituto Nacional de Cardiologia Ignacio Chavez
- Centro de Investigacion Biomedica y Farmaceutica, S.C.
- Unidad de Investigacion Clinica Cardiometabolica de Occident
- Diseño y Planeación en Investigación Médica SC
- Cardiologia Clinica e Intervencionista
- Centro de Investigación Clinica Acelerada, S.C.
- Instituto Cardiovascular de Monclova, S de RL de CV
- CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
- Hospital Universitario Dr Jose Eleuterio Gonzalez
- Centro Integral Medico SJR S.C.
- Cardioarritmias e Investigación S.C
- Centro de Investigacion Cardiovascular y Metabolica
- Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
- Hospital Dr Angel Leano
- Ziekenhuisgroep Twente locatie Almelo
- BovenIJ Ziekenhuis
- Onze Lieve Vrouwe Gasthuis, Locatie West
- Amsterdam UMC Locatie VUMC
- Onze Lieve Vrouwe Gasthuis
- Amsterdam UMC, Locatie AMC
- Rode Kruis Ziekenhuis Beverwijk
- Tergooiziekenhuizen locatie Blaricum
- Amphia Ziekenhuis
- HMC Bronovo
- Ziekenhuis Gelderse Vallei
- Catharina Ziekenhuis
- Universitair Medisch Centrum Groningen
- Zuyderland Medisch Centrum
- Vasculair Onderzoek Centrum
- Maastricht Universitair Medisch Centrum
- Diaconessenhuis Meppel
- St. Antonius ziekenhuis, locatie Nieuwegein
- Radboud Universitair Medisch Centrum
- Ziekenhuis Bernhoven Uden
- Vie Curi Medisch Centrum
- De Heel - Zaans Medisch Centrum
- Gelre Ziekenhuis Zutphen
- KLIMED Marek Klimkiewicz
- Univ. Clinic Hosp, Bialystok
- American Heart of Poland Sp. z o.o.
- NZOZ Centrum Medyczne KERmed
- Polsko-Amerykanskie Kliniki Serca
- American Heart of Poland Sp. z o.o.
- Poradnia Kardiologiczna Jaroslaw Jurowiecki
- University Clinical Center, Gdansk
- Indywidualna Specjalistyczna Praktyka Lekarska
- Saint Wincenty a Paulo Hosp., Cardiology Dept., Gdynia
- Szpital Zakonu Bonifratow Sp. z o.o.
- Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
- Leszek Bryniarski Specialized Medical Cabinet
- Krakow Specialistic Hospital of John Paul II
- SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
- Nzoz Salus
- Individual Specialized Practice
- Lowickie Cardiology Center
- American Heart of Poland Sp. z o.o.
- Medicome Sp. z o.o.
- Specialized Practice Dr. Janusz Spyra
- Centrum Medyczne Medyk
- Lukmed Lukasz Wozniak
- Clinmedica Research Omc sp. z o.o. sp.k., Skierniewice
- KO-MED Centra Kliniczne Staszow
- The Provincial Polyclinical Hospital in Torun
- American Heart of Poland Sp. z o.o.
- American Heart of Poland Sp. z o.o.
- Central Hospital of Medical Academy, Warsaw
- McM Polimedica
- 4. Military Clinical Hospital with Polyclinic SP ZOZ
- Zgierskie Center of Cardiology MED-PRO
- Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
- Hospital Quiron. I.C.U.
- Hospital Santa Creu i Sant Pau
- Hospital Universitario Virgen de la Arrixaca
- Hospital de Bellvitge
- Hospital Ramón y Cajal
- Hospital Clínico San Carlos
- Hospital Universitario 12 de Octubre
- Hospital La Paz
- Hospital Virgen de la Victoria
- Complejo Hospitalario Universitario de Orense
- Hospital Clínico de Santiago
- Hospital Clínico Universitario de Valladolid
- Barnet General Hospital
- University Hospital of Wales
- Park & St Francis Surgery
- Wycombe General Hospital
- Glenfield Hospital
- St Bartholomew's Hospital
- Luton and Dunstable University Hospital
- St Mary's Hospital
- Morriston Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Empagliflozin
Placebo
Arm Description
Outcomes
Primary Outcome Measures
Time to the First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Time to the first event of adjudicated cardiovascular (CV) death or adjudicated hospitalisation for heart failure (HHF). The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Secondary Outcome Measures
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
Reported is the total number of HHF events (first and recurrent) which occurred.
All data up to the end of the planned treatment period (including the data after the end of treatment for patients not completing the treatment period as planned) from all randomised patients was used.
eGFR (CKD-EPI) cr Slope of Change From Baseline
Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) [mL/min/1.73m2] slope of change from baseline.
Available on-treatment change-from-baseline data were to be used. Patients without on-treatment data after randomisation were not to be included in this analysis. Slope represents the long term effect on eGFR.
Timepoints after baseline were included in calculation of slope of change from baseline. Descriptive statistic (mean(standard error)) is reported.
Time to First Event in Composite Renal Endpoint: Chronic Dialysis, Renal Transplant or Sustained Reduction of eGFR(CKD-EPI)cr
Time to the first event in the composite renal endpoint: chronic dialysis (with a frequency of twice per week or more for at least 90 days), renal transplant, or sustained reduction in Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr).
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
Time to first adjudicated Hospitalisation for Heart Failure (HHF). The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25. Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time to Adjudicated Cardiovascular (CV) Death
Time to adjudicated CV (Cardiovascular) death. The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time to All-cause Mortality
Time to all-cause mortality. The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time to Onset of Diabetes Mellitus (DM)
Time to onset of DM (Glycated haemoglobin (HbA1c) ≥6.5% or as diagnosed by the investigator) in patients with pre-DM (no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of 5.7 to <6.5%). The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Change From Baseline in KCCQ (Kansas City Cardiomyopathy Questionnaire) Clinical Summary Score at Week 52
Change from baseline in KCCQ (Kansas City cardiomyopathy questionnaire) clinical summary score at Week 52. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, selfefficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) is imputed at all subsequent scheduled visits after the date of death.
Standard error is adjusted standard error. Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.
Number of All-cause Hospitalizations (First and Recurrent)
Number of all-cause hospitalizations (first and recurrent).
Full Information
NCT ID
NCT03057977
First Posted
February 16, 2017
Last Updated
April 26, 2021
Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company
1. Study Identification
Unique Protocol Identification Number
NCT03057977
Brief Title
EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
Official Title
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Study Type
Interventional
2. Study Status
Record Verification Date
April 2021
Overall Recruitment Status
Completed
Study Start Date
March 6, 2017 (Actual)
Primary Completion Date
May 1, 2020 (Actual)
Study Completion Date
May 28, 2020 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heart Failure
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
3730 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Empagliflozin
Arm Type
Experimental
Arm Title
Placebo
Arm Type
Placebo Comparator
Intervention Type
Drug
Intervention Name(s)
Empagliflozin
Other Intervention Name(s)
JARDIANCE, JARDIANZ, GIBTULIO
Intervention Description
once daily
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
once daily
Primary Outcome Measure Information:
Title
Time to the First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
Description
Time to the first event of adjudicated cardiovascular (CV) death or adjudicated hospitalisation for heart failure (HHF). The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Secondary Outcome Measure Information:
Title
Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
Description
Reported is the total number of HHF events (first and recurrent) which occurred.
All data up to the end of the planned treatment period (including the data after the end of treatment for patients not completing the treatment period as planned) from all randomised patients was used.
Time Frame
From randomisation until completion of the planned treatment phase, up to 1040 days.
Title
eGFR (CKD-EPI) cr Slope of Change From Baseline
Description
Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) [mL/min/1.73m2] slope of change from baseline.
Available on-treatment change-from-baseline data were to be used. Patients without on-treatment data after randomisation were not to be included in this analysis. Slope represents the long term effect on eGFR.
Timepoints after baseline were included in calculation of slope of change from baseline. Descriptive statistic (mean(standard error)) is reported.
Time Frame
Assessed at baseline, week 4, 12, 32, 52, 76, 100, 124, 148 and at end of treatment (EOT), up to 1040 days.
Title
Time to First Event in Composite Renal Endpoint: Chronic Dialysis, Renal Transplant or Sustained Reduction of eGFR(CKD-EPI)cr
Description
Time to the first event in the composite renal endpoint: chronic dialysis (with a frequency of twice per week or more for at least 90 days), renal transplant, or sustained reduction in Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr).
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Title
Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
Description
Time to first adjudicated Hospitalisation for Heart Failure (HHF). The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25. Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Title
Time to Adjudicated Cardiovascular (CV) Death
Description
Time to adjudicated CV (Cardiovascular) death. The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Title
Time to All-cause Mortality
Description
Time to all-cause mortality. The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Title
Time to Onset of Diabetes Mellitus (DM)
Description
Time to onset of DM (Glycated haemoglobin (HbA1c) ≥6.5% or as diagnosed by the investigator) in patients with pre-DM (no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of 5.7 to <6.5%). The incidence rate (patients with events per 100 person years at risk) is reported.
The incidence rate per 100 patient years (100 * number of patients with event /time at risk [years]) is presented. With time at risk [year] calculated as: Sum of time at risk [days] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Unit of Measure: Patients with events per 100 patient-years (pt-yrs) at risk.
Time Frame
From randomisation until completion of the planned treatment period, up to 1040 days.
Title
Change From Baseline in KCCQ (Kansas City Cardiomyopathy Questionnaire) Clinical Summary Score at Week 52
Description
Change from baseline in KCCQ (Kansas City cardiomyopathy questionnaire) clinical summary score at Week 52. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, selfefficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) is imputed at all subsequent scheduled visits after the date of death.
Standard error is adjusted standard error. Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.
Time Frame
Assessed at baseline, week 12, week 32 and week 52.
Title
Number of All-cause Hospitalizations (First and Recurrent)
Description
Number of all-cause hospitalizations (first and recurrent).
Time Frame
From randomisation until completion of the planned treatment phase, up to 1040 days.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria:
Male or female patient age >= 18 years at screening. For Japan only: Age >= 20 years at screening
Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association Classification) class II-IV and reduced EF (Ejection Fraction) (LVEF (Left Ventricular Ejection Fraction) <=40%) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide)
If EF >= 36% to <= 40%: NT-proBNP >= 2500 pg/ml or patients without AF (atrial fibrillation/atrial flutter) and NT-proBNP >= 5000 pg/ml for patients with AF
If EF >= 31% to <= 35%: NT-proBNP >= 1000 pg/ml for patients without AF and NT-proBNP >=2000 pg/ml for patients with AF
If EF<= 30%: NT-proBNP >= 600 pg/ml for patients without AF and NT-proBNP >=1200 pg/ml for patients with AF
EF ≤ 40% and hospitalization for heart failure in the past 12 months: NTproBNP ≥ 600 pg/ml for patients without AF and NT-proBNP >= 1200 pg/ml for patients with AF
Appropriate dose of medical therapy for HF consistent with prevailing local and international CV (Cardiovascular) guidelines, stable for at least 1 week prior to Visit 1
Appropriate use of medical devices such as cardioverter defibrillator (ICD) or a cardiac resynchronization therapy (CRT) consistent with prevailing local or international CV guidelines
Signed and dated written ICF (Informed Consent Form)
Further inclusion criteria apply
Exclusion criteria:
Myocardial infarction, coronary artery bypass graft surgery, or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
Heart transplant recipient, or listed for heart transplant
Acute decompensated HF
Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
Symptomatic hypotension and/or a SBP < 100 mmHg
Indication of liver disease
Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration Equation)) or requiring dialysis
History of ketoacidosis
Current use or prior use of a SGLT (Sodium-glucose co-transporter)-2 inhibitor or combined SGLT-1 and 2 inhibitor
Currently enrolled in another investigational device or drug study
Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
Women who are pregnant, nursing, or who plan to become pregnant while in the trial
Further exclusion criteria apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Boehringer Ingelheim
Organizational Affiliation
Boehringer Ingelheim
Official's Role
Study Chair
Facility Information:
Facility Name
La Mesa Cardiac Center
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Long Beach Center for Clinical Research
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
VA Greater Los Angeles Healthcare System
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
Facility Name
Merced Vein and Vascular Center
City
Merced
State/Province
California
ZIP/Postal Code
95340
Country
United States
Facility Name
University of California Irvine
City
Orange
State/Province
California
ZIP/Postal Code
92865
Country
United States
Facility Name
Covigilant Research, LLC
City
Riverside
State/Province
California
ZIP/Postal Code
92506
Country
United States
Facility Name
University of California
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Facility Name
Orange County Research Center
City
Tustin
State/Province
California
ZIP/Postal Code
92780
Country
United States
Facility Name
Blue Coast Cardiology
City
Vista
State/Province
California
ZIP/Postal Code
92083
Country
United States
Facility Name
South Denver Cardiology Associates, PC
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120
Country
United States
Facility Name
Integrated Heart Care
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33434
Country
United States
Facility Name
Morton Plant Mease Health Care
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Nature Coast Clinical Research
City
Crystal River
State/Province
Florida
ZIP/Postal Code
34429
Country
United States
Facility Name
Avail Clinical Research, LLC
City
DeLand
State/Province
Florida
ZIP/Postal Code
32720
Country
United States
Facility Name
Holy Cross Hospital
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
Integrative Research Associates
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33312
Country
United States
Facility Name
Nature Coast Clinical Research
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452
Country
United States
Facility Name
East Coast Institute for Research, LLC
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Cardiovascular Research Center of South Florida
City
Miami
State/Province
Florida
ZIP/Postal Code
33173
Country
United States
Facility Name
Peninsula Research, Inc.
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Cardiology Consultants, Inc
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32501
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Grady Clinical Research Center
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Augusta University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Columbus Regional Research Institute
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31904
Country
United States
Facility Name
Cardiovascular Group PC
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30046
Country
United States
Facility Name
Meridian Clinical Research, LLC
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31406
Country
United States
Facility Name
Northwest Heart Clinical Research, LLC
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
University of Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Captain James A. Lovell Federal Health Care Center
City
North Chicago
State/Province
Illinois
ZIP/Postal Code
60064
Country
United States
Facility Name
Rockford Cardiovascular Associates
City
Rockford
State/Province
Illinois
ZIP/Postal Code
61107
Country
United States
Facility Name
Midwest Cardiovascular Research and Education Foundation
City
Elkhart
State/Province
Indiana
ZIP/Postal Code
46514
Country
United States
Facility Name
St. Francis Medical Group-Indiana Heart Physicians, Inc
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46237
Country
United States
Facility Name
Reid Hospital
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47374
Country
United States
Facility Name
Beacon Medical Group Clinical Research
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Research Integrity, LLC
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Cambridge Medical Trials
City
Alexandria
State/Province
Louisiana
ZIP/Postal Code
71301
Country
United States
Facility Name
Louisiana Heart Center
City
Covington
State/Province
Louisiana
ZIP/Postal Code
70433
Country
United States
Facility Name
Clinical Trials of America, LLC
City
Monroe
State/Province
Louisiana
ZIP/Postal Code
71201
Country
United States
Facility Name
Tulane University Hospital and Clinic
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Anne Arundel Medical Center
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Johns Hopkins University Hospital School of Medicine
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21205
Country
United States
Facility Name
MedStar Health Research Institute
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Metropolitan Cardiovascular Consultants
City
Beltsville
State/Province
Maryland
ZIP/Postal Code
20705
Country
United States
Facility Name
Spectrum Clinical Research
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
East Mountain Medical Associates, PC
City
Great Barrington
State/Province
Massachusetts
ZIP/Postal Code
01230
Country
United States
Facility Name
Alpena General Hospital
City
Alpena
State/Province
Michigan
ZIP/Postal Code
49707
Country
United States
Facility Name
Regions Hospital
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55101
Country
United States
Facility Name
Saint Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
SLHV
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63136
Country
United States
Facility Name
Palm Research Center
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89148
Country
United States
Facility Name
Advanced Heart Care, LLC
City
Bridgewater
State/Province
New Jersey
ZIP/Postal Code
08807
Country
United States
Facility Name
Cardiac Care and Vascular Medicine, PLLC
City
Bronx
State/Province
New York
ZIP/Postal Code
10469
Country
United States
Facility Name
Trinity Medical WNY, PC
City
Cheektowaga
State/Province
New York
ZIP/Postal Code
14227
Country
United States
Facility Name
Northwell Health
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
Mount Sinai School of Medicine
City
Lake Success
State/Province
New York
ZIP/Postal Code
11041
Country
United States
Facility Name
St. Luke's Roosevelt Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10025
Country
United States
Facility Name
Harlem Cardiology
City
New York
State/Province
New York
ZIP/Postal Code
10035
Country
United States
Facility Name
Stony Brook University Medical Center
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Asheville Cardiology Associates
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28803
Country
United States
Facility Name
Kernodle Clinic West
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
The University of North Carolina at Chapel Hill
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599-5021
Country
United States
Facility Name
Novant Health Heart and Vascular Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
Clinical Research of Gastonia
City
Gastonia
State/Province
North Carolina
ZIP/Postal Code
28054
Country
United States
Facility Name
Clinical Trials of America, Inc
City
Lenoir
State/Province
North Carolina
ZIP/Postal Code
28645
Country
United States
Facility Name
Rama Research LLC
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
University of Toledo
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43614
Country
United States
Facility Name
South Oklahoma Heart Research Group
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73135
Country
United States
Facility Name
Doylestown Health Cardiology
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
York Hospital, WellSpan Health
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17403
Country
United States
Facility Name
AnMed Health Clinical Research
City
Anderson
State/Province
South Carolina
ZIP/Postal Code
29621
Country
United States
Facility Name
Ralph H. Johnson VA Medical Center
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29401
Country
United States
Facility Name
Palmetto Health
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29203
Country
United States
Facility Name
William Jennings Bryan Dorn VA Medical Center
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29209
Country
United States
Facility Name
Clinical Research of Rock Hill
City
Rock Hill
State/Province
South Carolina
ZIP/Postal Code
29732
Country
United States
Facility Name
Palmetto Research Center, LLC
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29302
Country
United States
Facility Name
Methodist University Hospital
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
Baylor Heart and Vascular Hospital
City
Dallas
State/Province
Texas
ZIP/Postal Code
75226
Country
United States
Facility Name
Soltero Cardiovascular Research Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75226
Country
United States
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-8837
Country
United States
Facility Name
University of North Texas Health Science Center
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76107
Country
United States
Facility Name
The Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
The Heart Hospital
City
Plano
State/Province
Texas
ZIP/Postal Code
75093
Country
United States
Facility Name
Alpine Research Organization
City
Farmington
State/Province
Utah
ZIP/Postal Code
84025
Country
United States
Facility Name
Cardiac Health Management Network, P.C.
City
Chester
State/Province
Virginia
ZIP/Postal Code
23836
Country
United States
Facility Name
Hunter Holmes McGuire VA Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Roanoke Heart Institute PLC
City
Roanoke
State/Province
Virginia
ZIP/Postal Code
24014
Country
United States
Facility Name
Salem VA Medical Center
City
Salem
State/Province
Virginia
ZIP/Postal Code
24153
Country
United States
Facility Name
Marshfield Clinic
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Hospital Interzonal General de Agudos Dr Jose Penna
City
Bahia Blanca
ZIP/Postal Code
B8001DDU
Country
Argentina
Facility Name
Hospital Italiano Regional del Sur, Bahia Blanca
City
Bahia Blanca
ZIP/Postal Code
B8001HXM
Country
Argentina
Facility Name
CIPREC
City
Caba
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
Hospital Italiano de Buenos Aires
City
Caba
ZIP/Postal Code
C1199ABB
Country
Argentina
Facility Name
Consultorios Asociados de Endocrinología e Invest Clínica
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1425AGC
Country
Argentina
Facility Name
Instituto Cardiovascular de Buenos Aires
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1428ART
Country
Argentina
Facility Name
CCBR - Buenos Aires - AR
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1430CKE
Country
Argentina
Facility Name
Centro Médico Viamonte
City
Ciudad Autonoma de Bs As
ZIP/Postal Code
C1120AAC
Country
Argentina
Facility Name
Sanatorio Güemes
City
Ciudad Autónoma de Bs As
ZIP/Postal Code
C1180AAX
Country
Argentina
Facility Name
Instituto Medico Elsa Perez SRL (IMEP)
City
Ciudadela
ZIP/Postal Code
1702
Country
Argentina
Facility Name
Clínica Colombo
City
Cordoba
ZIP/Postal Code
X5002AOQ
Country
Argentina
Facility Name
Instituto Médico DAMIC S.R.L.
City
Cordoba
ZIP/Postal Code
X5003DCE
Country
Argentina
Facility Name
Clinica Coronel Suarez SA
City
Coronel Suarez
ZIP/Postal Code
B7540DOL
Country
Argentina
Facility Name
Instituto de Cardiología de Corrientes
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
Sanatorio Mayo Privado SA
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Centro de Investigaciones Clinicas Instituto del Corazon
City
Córdoba
ZIP/Postal Code
X5000EVQ
Country
Argentina
Facility Name
Sanatorio Allende S.A.
City
Córdoba
ZIP/Postal Code
X5000JHQ
Country
Argentina
Facility Name
Hospital Privado
City
Córdoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Facility Name
Hospital Italiano de La Plata
City
La Plata
ZIP/Postal Code
B1900AXI
Country
Argentina
Facility Name
Centro de Investigaciones Médicas
City
Mar del Plata
ZIP/Postal Code
B7600FYK
Country
Argentina
Facility Name
Hospital Privado de Comunidad
City
Mar del Plata
ZIP/Postal Code
B7602CBM
Country
Argentina
Facility Name
Clínica Olivos
City
Olivos
ZIP/Postal Code
1602
Country
Argentina
Facility Name
CER Instituto Médico
City
Quilmes
ZIP/Postal Code
B1878DVB
Country
Argentina
Facility Name
Instituto de Investigaciones Clínicas de Quilmes
City
Quilmes
ZIP/Postal Code
B1878GEG
Country
Argentina
Facility Name
Instituto de Investigaciones Clinicas de Rosario
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Instituto Medico Fundación Grupo Colaborativo Rosario
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Sanatorio Británico
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Sanatorio Plaza
City
Rosario
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Sanatorio Parque
City
Rosario
ZIP/Postal Code
S2000DSV
Country
Argentina
Facility Name
Instituto CAICI
City
Rosario
ZIP/Postal Code
S2000PBJ
Country
Argentina
Facility Name
CORDIS S.A., Salta
City
Salta
ZIP/Postal Code
A4400ANW
Country
Argentina
Facility Name
Centro Cardiovascular Salta
City
Salta
ZIP/Postal Code
A4406BFP
Country
Argentina
Facility Name
Corporacion Medica de Gral. San Martin S.A.
City
San Martin
ZIP/Postal Code
B1650CSQ
Country
Argentina
Facility Name
Investigaciones Clinicas Tucuman
City
San Miguel de Tucumán
ZIP/Postal Code
T4000ICL
Country
Argentina
Facility Name
CCBR Tucuman
City
San Miguel de Tucumán
ZIP/Postal Code
T4000
Country
Argentina
Facility Name
Centro Medico Luquez
City
San Vicente
ZIP/Postal Code
X5006CBI
Country
Argentina
Facility Name
Centro de Investigaciones Clínicas del Litoral
City
Santa Fe
ZIP/Postal Code
S3000FWO
Country
Argentina
Facility Name
Hospital "Dr. José Maria Cullen "
City
Santa Fé
ZIP/Postal Code
S3000EOZ
Country
Argentina
Facility Name
Instituto de Cardiología
City
Tucumán
ZIP/Postal Code
T4000JCU
Country
Argentina
Facility Name
CEMEDIC - Centro de Especialidades Medicas
City
Villa Luro
ZIP/Postal Code
C1440CFD
Country
Argentina
Facility Name
John Hunter Hospital
City
New Lambton Heights
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Facility Name
CORE Research Group
City
Milton
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Mater Hospital Brisbane
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
SA-Heart Ashford Specialist Centre
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Heart and Vascular Research
City
Fullarton
State/Province
South Australia
ZIP/Postal Code
5063
Country
Australia
Facility Name
The Northern Hospital
City
Epping
State/Province
Victoria
ZIP/Postal Code
3076
Country
Australia
Facility Name
St Vincent's Hospital Melbourne
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
University Hospital Geelong
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
AZ Sint-Jan Brugge
City
Brugge
ZIP/Postal Code
3000
Country
Belgium
Facility Name
C.H.U. de Charleroi
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
Facility Name
AZ Sint-Blasius
City
Dendermonde
ZIP/Postal Code
9200
Country
Belgium
Facility Name
Ziekenhuis Oost-Limburg - Campus Sint-Jan
City
Genk
ZIP/Postal Code
3600
Country
Belgium
Facility Name
AZ Sint-Lucas - Campus Sint Lucas
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Grand Hôpital de Charleroi
City
Gilly
ZIP/Postal Code
6060
Country
Belgium
Facility Name
Jessa Ziekenhuis - Campus Virga Jesse
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
La Louvière - UNIV CHU Tivoli
City
La Louvière
ZIP/Postal Code
7100
Country
Belgium
Facility Name
UZ Leuven
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
AZ Sint-Maarten
City
Mechelen
ZIP/Postal Code
2800
Country
Belgium
Facility Name
Hospital Felicio Rocho
City
Belo Horizonte
ZIP/Postal Code
30110-060
Country
Brazil
Facility Name
Hospital Vera Cruz
City
Belo Horizonte
ZIP/Postal Code
30140-062
Country
Brazil
Facility Name
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
City
Belo Horizonte
ZIP/Postal Code
30150-240
Country
Brazil
Facility Name
CCBR - Brasília
City
Brasília
ZIP/Postal Code
70200-730
Country
Brazil
Facility Name
ICDF - Instituto de Cardiologia do Distrito Federal
City
Brasília
ZIP/Postal Code
70673-900
Country
Brazil
Facility Name
CECAP - Centro de Cardiologia Clínica
City
Brasília
ZIP/Postal Code
70710-100
Country
Brazil
Facility Name
Hospital Angelina Caron
City
Campina Grande do Sul
ZIP/Postal Code
83430-000
Country
Brazil
Facility Name
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
City
Campinas
ZIP/Postal Code
13010-001
Country
Brazil
Facility Name
IPECC - Instituto de Pesquisa Clínica de Campinas
City
Campinas
ZIP/Postal Code
13060-080
Country
Brazil
Facility Name
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
City
Campinas
ZIP/Postal Code
13087-567
Country
Brazil
Facility Name
Hospital Universitário
City
Canoas
ZIP/Postal Code
92425-900
Country
Brazil
Facility Name
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
City
Caxias do Sul
ZIP/Postal Code
95070-560
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericórdia de Curitiba
City
Curitiba
ZIP/Postal Code
80230-130
Country
Brazil
Facility Name
Hospital de Messejana Dr. Carlos Alberto Studart Gomes
City
Fortaleza
ZIP/Postal Code
60846-190
Country
Brazil
Facility Name
Barroso e Sebba Ltda
City
Goiania
ZIP/Postal Code
74223-130
Country
Brazil
Facility Name
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
City
Goiânia
ZIP/Postal Code
74605-020
Country
Brazil
Facility Name
ICM - Instituto do Coracao de Marilia
City
Marília
ZIP/Postal Code
17515-000
Country
Brazil
Facility Name
Hospital São Vicente de Paulo
City
Passo Fundo
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Santa Casa de Misericórdia de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90035-074
Country
Brazil
Facility Name
Centro de Pesquisas em Diabetes
City
Porto Alegre
ZIP/Postal Code
90035-170
Country
Brazil
Facility Name
Hospital de Clínicas de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Instituto de Cardiologia Rio Grande do Sul
City
Porto Alegre
ZIP/Postal Code
90620-001
Country
Brazil
Facility Name
Hospital Agamenon Magalhaes
City
Recife
ZIP/Postal Code
52051-380
Country
Brazil
Facility Name
H.C.da Fac. de Medicina de Ribeirao Preto
City
Ribeirão Preto
ZIP/Postal Code
14048-900
Country
Brazil
Facility Name
Hospital Universitário Pedro Ernesto UERJ
City
Rio De Janeiro - RJ
ZIP/Postal Code
CEP 20551
Country
Brazil
Facility Name
CCBR - Rio de Janeiro - BR
City
Rio de Janeiro
ZIP/Postal Code
22271-100
Country
Brazil
Facility Name
Pesquisare
City
Santo André
ZIP/Postal Code
09080-110
Country
Brazil
Facility Name
Praxis Pesquisa Médica
City
Santo André
ZIP/Postal Code
09090-790
Country
Brazil
Facility Name
Fundacao Faculdade Regional de Medicina, Sao Jose
City
Sao Jose do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Centro de Pesquisa Clinica - CPCLIN
City
Sao Paulo
ZIP/Postal Code
01244-030
Country
Brazil
Facility Name
FGM - Clínica Paulista de Doenças Cardiovasculares
City
Sao Paulo
ZIP/Postal Code
01323-000
Country
Brazil
Facility Name
CEPIC - Centro Paulista de Investigacao Clinica
City
Sao Paulo
ZIP/Postal Code
04266-010
Country
Brazil
Facility Name
INCOR e Hospital das Clínicas da Universidade de São Paulo
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
CEMEC - Centro Multidisciplinar de Estudos Clínicos
City
São Bernardo do Campo
ZIP/Postal Code
09780-000
Country
Brazil
Facility Name
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
City
São Paulo
ZIP/Postal Code
04020-060
Country
Brazil
Facility Name
Dr. Consulta
City
São Paulo
ZIP/Postal Code
04208-002
Country
Brazil
Facility Name
CEDOES - Diagnóstico e Pesquisa,Vitória
City
Vitória
ZIP/Postal Code
29055-450
Country
Brazil
Facility Name
Santa Casa de Votuporanga
City
Votuporanga
ZIP/Postal Code
15500-003
Country
Brazil
Facility Name
Royal Alexandra Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5H 3V9
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
St. Paul's Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 1Y6
Country
Canada
Facility Name
Victoria Heart Institute Foundation
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R 4R2
Country
Canada
Facility Name
St. Boniface General Hospital
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
Facility Name
G.A. Research Associates Ltd
City
Moncton
State/Province
New Brunswick
ZIP/Postal Code
E1G 1A7
Country
Canada
Facility Name
QEII Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Facility Name
Brampton Cardio Pulmonary Clinic
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6W 2X7
Country
Canada
Facility Name
JBN Medical Diagnostic Services Inc.
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7M 4Y1
Country
Canada
Facility Name
Cambridge Cardiac Care Inc.
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
Curnew Medicine Professional Corporation
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 0A9
Country
Canada
Facility Name
Hamilton General Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
Southlake Regional Health Centre
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P6
Country
Canada
Facility Name
M Heffernan Medicine Professional Corp.
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3W7
Country
Canada
Facility Name
Kawartha Cardiology Clinical Trials
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Heart Health Institute
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1B 4Z8
Country
Canada
Facility Name
Scarborough Cardiology Research
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1E 5E9
Country
Canada
Facility Name
Health Sciences North
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 5J1
Country
Canada
Facility Name
Canadian Phase Onward Inc.
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3J 2C5
Country
Canada
Facility Name
North York Diagnostic and Cardiac Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6B 1N6
Country
Canada
Facility Name
Diabetes Heart Research Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6G 1M2
Country
Canada
Facility Name
Mohan Babapulle Medicine Professional Medicine
City
Waterloo
State/Province
Ontario
ZIP/Postal Code
N2T 0C1
Country
Canada
Facility Name
Dr. Louis C.H. Yao
City
York
State/Province
Ontario
ZIP/Postal Code
M9N 1W4
Country
Canada
Facility Name
ViaCar Recherche Clinique Inc
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
City
Longeuil
State/Province
Quebec
ZIP/Postal Code
J4M 2X1
Country
Canada
Facility Name
Clinique Santé Cardio MC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 3Y7
Country
Canada
Facility Name
Montreal General Hospital - McGill University Health Centre
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
McGill University Health Centre (MUHC)
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Centre de sante et de services sociaux de Beauce
City
Saint George-de-Beauce
State/Province
Quebec
ZIP/Postal Code
G5Y 4T8
Country
Canada
Facility Name
IUCPQ (Laval University)
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Cardiovascular Institute and Fu Wai Hospital
City
Beijing
ZIP/Postal Code
100037
Country
China
Facility Name
Beijing Friendship Hospital
City
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
First Hospital of Jilin University
City
Changchun
ZIP/Postal Code
130021
Country
China
Facility Name
Hunan Provincial People's Hospital
City
Changsha
ZIP/Postal Code
410005
Country
China
Facility Name
2nd Xiangya Hospital of Central South University
City
Changsha
ZIP/Postal Code
410011
Country
China
Facility Name
The Third Hospital of Changsha
City
Changsha
ZIP/Postal Code
410015
Country
China
Facility Name
Dongguan People's Hospital
City
Dongguan
ZIP/Postal Code
523059
Country
China
Facility Name
The First Affiliated Hospital of Fujian Medical University
City
Fuzhou
ZIP/Postal Code
350005
Country
China
Facility Name
The First Afiliated Hospital, Sun Yet-sen University
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Guangzhou First Municipal People's Hospital
City
Guangzhou
ZIP/Postal Code
510180
Country
China
Facility Name
Haikou People's Hospital
City
Haikou
ZIP/Postal Code
570208
Country
China
Facility Name
HaiNan Provincial People's Hospital
City
Haikou
ZIP/Postal Code
570311
Country
China
Facility Name
The First Affiliated Hospital of Lanzhou University
City
Lanzhou
ZIP/Postal Code
730000
Country
China
Facility Name
The Second Affiliated Hospital of Lanzhou Medical University
City
Lanzhou
ZIP/Postal Code
730030
Country
China
Facility Name
The Affiliated Hospital of Southwest Medical University
City
Luzhou
ZIP/Postal Code
646099
Country
China
Facility Name
Nanchang University Affiliated 3rd Hospital
City
Nanchang
ZIP/Postal Code
330008
Country
China
Facility Name
First Hospital Affiliated with Nanjing Medical University
City
Nanjing
ZIP/Postal Code
210029
Country
China
Facility Name
Huashan Hospital, Fudan University
City
Shanghai
ZIP/Postal Code
200040
Country
China
Facility Name
General Hospital of Shenyang Military Region
City
Shenyang
ZIP/Postal Code
110015
Country
China
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
ZIP/Postal Code
110072
Country
China
Facility Name
Tianjin Union Medical Center Nankai University Affiliated Hospital
City
Tianjin
ZIP/Postal Code
300121
Country
China
Facility Name
Tongji Hospital, Tongji University
City
Wuhan
ZIP/Postal Code
430030
Country
China
Facility Name
Renmin Hospital of Wuhan University
City
Wuhan
ZIP/Postal Code
430060
Country
China
Facility Name
First Affiliated Hospital of Xi'an JiaoTong University
City
Xi'an
ZIP/Postal Code
710061
Country
China
Facility Name
Yanbian University Hospital
City
Yanji
ZIP/Postal Code
133000
Country
China
Facility Name
the first people hospital of Yue Yang
City
Yueyang
ZIP/Postal Code
414000
Country
China
Facility Name
Affiliated Hospital of Jiangsu University
City
Zhenjiang
ZIP/Postal Code
212013
Country
China
Facility Name
Poliklinika Humanitas
City
Bilovec
ZIP/Postal Code
74301
Country
Czechia
Facility Name
Medicus Services Ltd.
City
Brandys Nad
ZIP/Postal Code
250 01
Country
Czechia
Facility Name
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
City
Brno
ZIP/Postal Code
603 00
Country
Czechia
Facility Name
MUDr. Alexandra Ludkova
City
Brno
ZIP/Postal Code
615 00
Country
Czechia
Facility Name
Vojenska nemocnice Brno
City
Brno
ZIP/Postal Code
63600
Country
Czechia
Facility Name
Nemocnice Milosrdnych bratri
City
Brno
ZIP/Postal Code
63900
Country
Czechia
Facility Name
Edumed s.r.o
City
Broumov
ZIP/Postal Code
55001
Country
Czechia
Facility Name
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
City
Chrudim
ZIP/Postal Code
53702
Country
Czechia
Facility Name
Nemocnice ve Frydku-Mistku, prispevkova organizace
City
Frydek-Mistek
ZIP/Postal Code
73818
Country
Czechia
Facility Name
MUDr. Ladislav Busak
City
Louny
ZIP/Postal Code
440 01
Country
Czechia
Facility Name
Zdenek Vomacka
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
PV-Kardiologie s.r.o.
City
Pardubice
ZIP/Postal Code
53002
Country
Czechia
Facility Name
University Hospital Motol
City
Prag 5
ZIP/Postal Code
15006
Country
Czechia
Facility Name
General Faculty Hospital, Prague
City
Prague 2
ZIP/Postal Code
128 08
Country
Czechia
Facility Name
Thomayer Hospital
City
Praha 4 - Krc
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Kardio Vaclavik s.r.o.
City
Prerov
ZIP/Postal Code
75000
Country
Czechia
Facility Name
Clinic of Cardiology, Pribram
City
Pribram
ZIP/Postal Code
261 01
Country
Czechia
Facility Name
Hospital Trebic, p.o.
City
Trebic
ZIP/Postal Code
67401
Country
Czechia
Facility Name
Masaryk Hospital, Usti nad Labem
City
Usti nad Labem
ZIP/Postal Code
40113
Country
Czechia
Facility Name
Angiocor s.r.o
City
Zlin
ZIP/Postal Code
76001
Country
Czechia
Facility Name
KIGE s.r.o
City
Znojmo
ZIP/Postal Code
66902
Country
Czechia
Facility Name
HOP de Bayonne
City
Bayonne
ZIP/Postal Code
64100
Country
France
Facility Name
HOP Jean Minjoz
City
Besançon
ZIP/Postal Code
25030
Country
France
Facility Name
HOP Louis Pradel
City
Bron
ZIP/Postal Code
69500
Country
France
Facility Name
HOP Côte de Nacre
City
Caen
ZIP/Postal Code
14033
Country
France
Facility Name
HOP Arnaud de Villeneuve
City
Montpellier
ZIP/Postal Code
34295
Country
France
Facility Name
HOP La Pitié Salpêtrière
City
Paris
ZIP/Postal Code
75651
Country
France
Facility Name
Centre Hospitalier de Pau
City
Pau
ZIP/Postal Code
64046
Country
France
Facility Name
HOP Haut-Lévêque
City
Pessac
ZIP/Postal Code
33600
Country
France
Facility Name
HOP Rangueil
City
Toulouse
ZIP/Postal Code
31059
Country
France
Facility Name
INS Louis Mathieu
City
Vandoeuvre-lès-Nancy
ZIP/Postal Code
54511
Country
France
Facility Name
Universitätsklinikum Aachen, AöR
City
Aachen
ZIP/Postal Code
52074
Country
Germany
Facility Name
Praxis Dr. Rieker, Berlin
City
Berlin
ZIP/Postal Code
10789
Country
Germany
Facility Name
Charité - Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
12200
Country
Germany
Facility Name
Vivantes Netzwerk für Gesundheit GmbH
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Facility Name
Charité - Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
Klinikum Bielefeld gGmbH
City
Bielefeld
ZIP/Postal Code
33604
Country
Germany
Facility Name
Praxis Dr. Menzel
City
Dessau-Roßlau
ZIP/Postal Code
06846
Country
Germany
Facility Name
St. Johannes Hospital Dortmund
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
Städtisches Klinikum Dresden
City
Dresden
ZIP/Postal Code
01067
Country
Germany
Facility Name
GWT-TUD GmbH
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Helios Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Studienzentrum Bocholderstraße
City
Essen
ZIP/Postal Code
45355
Country
Germany
Facility Name
ClinPhenomics GmbH & Co KG, Frankfurt
City
Frankfurt
ZIP/Postal Code
60594
Country
Germany
Facility Name
Universitätsmedizin Göttingen, Georg-August-Universität
City
Göttingen
ZIP/Postal Code
37075
Country
Germany
Facility Name
Asklepios Klinik St. Georg
City
Hamburg
ZIP/Postal Code
20099
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Universitätsklinikum Heidelberg
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Universitätsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
66421
Country
Germany
Facility Name
Universitätsklinikum Jena
City
Jena
ZIP/Postal Code
07740
Country
Germany
Facility Name
Universitätsklinikum Schleswig-Holstein, Campus Kiel
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Asklepios Klinik Langen-Seligenstadt GmbH
City
Langen
ZIP/Postal Code
63225
Country
Germany
Facility Name
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
City
Lüdenscheid
ZIP/Postal Code
58515
Country
Germany
Facility Name
Praxis Dr. Sarnighausen, Lüneburg
City
Lüneburg
ZIP/Postal Code
21339
Country
Germany
Facility Name
Katholisches Klinikum St. Hildegardiskrankenhaus, Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Deutsches Herzzentrum München
City
München
ZIP/Postal Code
80636
Country
Germany
Facility Name
Kardiologische Gemeinschaftspraxis Nienburg
City
Nienburg
ZIP/Postal Code
31582
Country
Germany
Facility Name
Kardiologische Praxis Papenburg
City
Papenburg
ZIP/Postal Code
26871
Country
Germany
Facility Name
Universitätsklinikum Regensburg
City
Regensburg
ZIP/Postal Code
93053
Country
Germany
Facility Name
Praxis Dr. Stenzel, Riesa
City
Riesa
ZIP/Postal Code
01587
Country
Germany
Facility Name
Zentrum für Klinische Forschung
City
Wangen
ZIP/Postal Code
88239
Country
Germany
Facility Name
Josephs-Hospital Warendorf
City
Warendorf
ZIP/Postal Code
48231
Country
Germany
Facility Name
Petrus-Krankenhaus
City
Wuppertal
ZIP/Postal Code
42283
Country
Germany
Facility Name
Lausmed Kft. Outpatient Unit of Internal Medicine
City
Baja
ZIP/Postal Code
6500
Country
Hungary
Facility Name
Belgyogyaszati es Kardiologiai Maganrendelo
City
Bekescsaba
ZIP/Postal Code
5600
Country
Hungary
Facility Name
Clinexpert Kft.
City
Budapest
ZIP/Postal Code
1033
Country
Hungary
Facility Name
Gottsegen Gyorgy Hungarian Instit.of Cardiology,Budapest
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
Bajcsy-Zsilinszky Hospital and Clinic
City
Budapest
ZIP/Postal Code
1106
Country
Hungary
Facility Name
Semmelweis University
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Milit.Hosp.-State Health Cent.
City
Budapest
ZIP/Postal Code
1134
Country
Hungary
Facility Name
Uzsoki Street Hospital, Budapest
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Nehezlegzes Ambulancia
City
Debrecen
ZIP/Postal Code
4027
Country
Hungary
Facility Name
Bugat Pal Hospital, Gyongyos
City
Gyongyos
ZIP/Postal Code
3200
Country
Hungary
Facility Name
Selye Janos Hospital Komarom
City
Komarom
ZIP/Postal Code
2900
Country
Hungary
Facility Name
Dorottya Kanizsai Hospital
City
Nagykanizsa
ZIP/Postal Code
8800
Country
Hungary
Facility Name
Dr. Nagy Laszlo Kardiologiai Maganrendeles
City
Oroshaza
ZIP/Postal Code
5900
Country
Hungary
Facility Name
Da Vinci Maganklinika
City
Pecs
ZIP/Postal Code
7635
Country
Hungary
Facility Name
Pecsi Tudomanyegyetem
City
Pécs
ZIP/Postal Code
7623
Country
Hungary
Facility Name
Fejer County Saint George University Teaching Hospital
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Veszpremi Sziv es Egeszseg Centrum
City
Veszprem
ZIP/Postal Code
8200
Country
Hungary
Facility Name
Doctor Jivraj Mehta Smarak Health Foundation
City
Ahmedabad
ZIP/Postal Code
380007
Country
India
Facility Name
Kamalnayan Bajaj Hospital
City
Aurangabad
ZIP/Postal Code
431 005
Country
India
Facility Name
Narayana Institute of Cardiac Sciences
City
Bangalore
ZIP/Postal Code
560099
Country
India
Facility Name
Rajarajeswari Medical College
City
Bengaluru
ZIP/Postal Code
560074
Country
India
Facility Name
Madras Medical Mission,
City
Chennai
ZIP/Postal Code
600 037
Country
India
Facility Name
Apollo Speciality Hospital
City
Chennai
ZIP/Postal Code
600035
Country
India
Facility Name
Medanta-The Medicity
City
Gurgaon
ZIP/Postal Code
122001
Country
India
Facility Name
B.M. Birla Heart research Centre
City
Kolkatta
ZIP/Postal Code
700027
Country
India
Facility Name
Siddhi Hospital
City
Nashik
ZIP/Postal Code
422007
Country
India
Facility Name
Vijan Cardiac and Critical Care Centre
City
Nasik
ZIP/Postal Code
422005
Country
India
Facility Name
Batra Hospital and Medical Research Centre
City
New Delhi
ZIP/Postal Code
110 062
Country
India
Facility Name
GB Pant Hospital
City
New Delhi
ZIP/Postal Code
110002
Country
India
Facility Name
Fortis Escorts Heart Institute
City
New Delhi
ZIP/Postal Code
110025
Country
India
Facility Name
Sir Gangaram Hospital
City
New Delhi
ZIP/Postal Code
110060
Country
India
Facility Name
Azienda Ospedaliera G. Rummo
City
Benevento
ZIP/Postal Code
82100
Country
Italy
Facility Name
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
City
Cona (FE)
ZIP/Postal Code
44124
Country
Italy
Facility Name
Ospedale della Val di Chiana Santa Margherita
City
Cortona (AR)
ZIP/Postal Code
52040
Country
Italy
Facility Name
Centro Cardiologico Monzino-IRCCS
City
Milano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria "Federico II"
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Pisana
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Umberto I Pol. di Roma-Università di Roma La Sapienza
City
Roma
ZIP/Postal Code
00161
Country
Italy
Facility Name
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
City
Roma
ZIP/Postal Code
00189
Country
Italy
Facility Name
Azienda Servizi Sanitari 1 Triestina
City
Trieste
ZIP/Postal Code
34128
Country
Italy
Facility Name
Kasugai Municipal Hospital
City
Aichi, Kasugai
ZIP/Postal Code
486-8510
Country
Japan
Facility Name
Nagoya Kyoritsu Hospital
City
Aichi, Nagoya
ZIP/Postal Code
454-0933
Country
Japan
Facility Name
Japanese Red Cross Nagoya Daini Hospital
City
Aichi, Nagoya
ZIP/Postal Code
466-8650
Country
Japan
Facility Name
Toyota Memorial Hospital
City
Aichi, Toyota
ZIP/Postal Code
471-8513
Country
Japan
Facility Name
Chiba Heart Clinic
City
Chiba, Chiba
ZIP/Postal Code
263-0043
Country
Japan
Facility Name
Kimitsu Chuo Hospital
City
Chiba, Kisarazu
ZIP/Postal Code
292-8535
Country
Japan
Facility Name
Seikeikai New Tokyo Heart Clinic
City
Chiba, Matsudo
ZIP/Postal Code
271-0077
Country
Japan
Facility Name
Ehime Prefectural Central Hospital
City
Ehime, Matsuyama
ZIP/Postal Code
790-0024
Country
Japan
Facility Name
Matsuyama Shimin Hospital
City
Ehime, Matsuyama
ZIP/Postal Code
790-0067
Country
Japan
Facility Name
Uwajima City Hospital
City
Ehime, Uwajima
ZIP/Postal Code
798-8510
Country
Japan
Facility Name
Fukuiken Saiseikai Hospital
City
Fukui, Fukui
ZIP/Postal Code
918-8503
Country
Japan
Facility Name
Fukuoka University Chikushi Hospital
City
Fukuoka, Chikushino
ZIP/Postal Code
818-8502
Country
Japan
Facility Name
Fukuokaken Saiseikai Futsukaichi Hospital
City
Fukuoka, Chikushino
ZIP/Postal Code
818-8516
Country
Japan
Facility Name
Saiseikai Fukuoka General Hospital
City
Fukuoka, Fukuoka
ZIP/Postal Code
810-0001
Country
Japan
Facility Name
National Hospital Organization Kyushu Medical Center
City
Fukuoka, Fukuoka
ZIP/Postal Code
810-8563
Country
Japan
Facility Name
Kyushu University Hospital
City
Fukuoka, Fukuoka
ZIP/Postal Code
812-8582
Country
Japan
Facility Name
Aso Co.,Ltd Iizuka Hospital
City
Fukuoka, Iizuka
ZIP/Postal Code
820-8505
Country
Japan
Facility Name
Steel Memorial Yawata Hospital
City
Fukuoka, Kitakyushu
ZIP/Postal Code
805-8508
Country
Japan
Facility Name
Japan Community Health Care Organization Kyushu Hospital
City
Fukuoka, Kitakyushu
ZIP/Postal Code
806-8501
Country
Japan
Facility Name
Ogaki Municipal Hospital
City
Gifu, Ogaki
ZIP/Postal Code
503-8502
Country
Japan
Facility Name
Chuno Kosei Hospital
City
Gifu, Seki
ZIP/Postal Code
501-3802
Country
Japan
Facility Name
Fukuyama City Hospital
City
Hiroshima, Fukuyama
ZIP/Postal Code
721-8511
Country
Japan
Facility Name
JA Hiroshima General Hospital
City
Hiroshima, Hatsukaichi
ZIP/Postal Code
738-8503
Country
Japan
Facility Name
Shobara Red Cross Hospital
City
Hiroshima, Shobara
ZIP/Postal Code
727-0013
Country
Japan
Facility Name
National Hospital Organization Hakodate Hospital
City
Hokkaido, Hakodate
ZIP/Postal Code
041-8512
Country
Japan
Facility Name
Teine Keijinkai Clinic
City
Hokkaido, Sapporo
ZIP/Postal Code
006-0811
Country
Japan
Facility Name
Tomakomai City Hospital
City
Hokkaido, Tomakomai
ZIP/Postal Code
053-8567
Country
Japan
Facility Name
Hyogo Prefectural Amagasaki General Medical Center
City
Hyogo, Amagasaki
ZIP/Postal Code
660-8550
Country
Japan
Facility Name
Hyogo Brain and Heart Center
City
Hyogo, Himeji
ZIP/Postal Code
670-0981
Country
Japan
Facility Name
National Hospital Organization Kobe Medical Center
City
Hyogo, Kobe
ZIP/Postal Code
654-0155
Country
Japan
Facility Name
Mito Medical Center
City
Ibaraki, Higashiibaraki-gun
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
National Hospital Organization Kanazawa Medical Center
City
Ishikawa, Kanazawa
ZIP/Postal Code
920-8650
Country
Japan
Facility Name
Mitoyo General Hospital
City
Kagawa, Kanonji
ZIP/Postal Code
769-1695
Country
Japan
Facility Name
Kagawa Prefectural Central Hospital
City
Kagawa, Takamatsu
ZIP/Postal Code
760-8557
Country
Japan
Facility Name
Yamamoto Clinic
City
Kanagawa, Sagamihara
ZIP/Postal Code
252-0311
Country
Japan
Facility Name
Kanagawa Cardiovascular and Respiratory Center
City
Kanagawa, Yokohama
ZIP/Postal Code
236-0051
Country
Japan
Facility Name
Japanese Red Cross Kumamoto Hospital
City
Kumamoto, Kumamoto
ZIP/Postal Code
861-8520
Country
Japan
Facility Name
Seiwakai Suizenji Touya Hospital
City
Kumamoto, Kumamoto
ZIP/Postal Code
862-0950
Country
Japan
Facility Name
Kumamoto Rosai Hospital
City
Kumamoto, Yatsushiro
ZIP/Postal Code
866-8533
Country
Japan
Facility Name
Uji-Tokushukai Medical Center
City
Kyoto, Uji
ZIP/Postal Code
611-0041
Country
Japan
Facility Name
Sendai Kousei Hospital
City
Miyagi, Sendai
ZIP/Postal Code
980-0873
Country
Japan
Facility Name
Sendai Tokushukai Hospital
City
Miyagi, Sendai
ZIP/Postal Code
981-3131
Country
Japan
Facility Name
The Cardiovascular Center of Sendai
City
Miyagi, Sendai
ZIP/Postal Code
981-3133
Country
Japan
Facility Name
National Hospital Organization Sendai Medical Center
City
Miyagi, Sendai
ZIP/Postal Code
983-8520
Country
Japan
Facility Name
Miyazaki Medical Association Hospital
City
Miyazaki, Miyazaki
ZIP/Postal Code
880-0834
Country
Japan
Facility Name
Hokushin General Hospital
City
Nagano, Nakano
ZIP/Postal Code
383-8505
Country
Japan
Facility Name
Nagasaki Medical Center
City
Nagasaki, Omura
ZIP/Postal Code
856-8562
Country
Japan
Facility Name
Okayama City General Medical Center
City
Okayama, Okayama
ZIP/Postal Code
700-8557
Country
Japan
Facility Name
Naha City Hospital
City
Okinawa, Naha
ZIP/Postal Code
902-8511
Country
Japan
Facility Name
Nanbu Tokushukai Hospital
City
Okinawa, Shimajiri-gun
ZIP/Postal Code
901-0493
Country
Japan
Facility Name
Urasoe General Hospital
City
Okinawa, Urasoe
ZIP/Postal Code
901-2132
Country
Japan
Facility Name
Higashiosaka City Medical Center
City
Osaka, Higashiosaka
ZIP/Postal Code
578-8588
Country
Japan
Facility Name
Kitano Hospital
City
Osaka, Osaka
ZIP/Postal Code
530-8480
Country
Japan
Facility Name
Yodogawa Christian Hospital
City
Osaka, Osaka
ZIP/Postal Code
533-0024
Country
Japan
Facility Name
Seichokai Bell Land General Hospital
City
Osaka, Sakai
ZIP/Postal Code
599-8247
Country
Japan
Facility Name
Hokusetsu General Hospital
City
Osaka, Takatsuki
ZIP/Postal Code
569-8585
Country
Japan
Facility Name
San-Ai Hospital
City
Saitama, Saitama
ZIP/Postal Code
338-0837
Country
Japan
Facility Name
Kosekai Iwatsuki-minami Hospital
City
Saitama, Saitama
ZIP/Postal Code
339-0033
Country
Japan
Facility Name
Kusatsu General Hospital
City
Shiga, Kusatsu
ZIP/Postal Code
525-8585
Country
Japan
Facility Name
Tokushima Prefectural Central Hospital
City
Tokushima, Tokushima
ZIP/Postal Code
770-8539
Country
Japan
Facility Name
National Hospital Organization Tokyo Medical Center
City
Tokyo, Meguro-ku
ZIP/Postal Code
152-8902
Country
Japan
Facility Name
Ome Municipal General Hospital
City
Tokyo, Ome
ZIP/Postal Code
198-0042
Country
Japan
Facility Name
Tokyo Rosai Hospital
City
Tokyo, Ota-ku
ZIP/Postal Code
143-0013
Country
Japan
Facility Name
Sekino Hospital
City
Tokyo, Toshima-ku
ZIP/Postal Code
171-0014
Country
Japan
Facility Name
Minami Wakayama Medical Center
City
Wakayama, Tanabe
ZIP/Postal Code
646-8558
Country
Japan
Facility Name
Kanmon Medical Center
City
Yamaguchi, Shimonoseki
ZIP/Postal Code
752-8510
Country
Japan
Facility Name
Dong-A University Hospital
City
Busan
ZIP/Postal Code
602-715
Country
Korea, Republic of
Facility Name
Inje University Busan Paik Hospital
City
Busan
ZIP/Postal Code
614-735
Country
Korea, Republic of
Facility Name
Chungbuk National University Hospital
City
Cheongju
ZIP/Postal Code
361-771
Country
Korea, Republic of
Facility Name
Chungnam National University Hospital
City
Daejeon
ZIP/Postal Code
35015
Country
Korea, Republic of
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Severance Hospital
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Korea University Guro Hospital
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Sungnam
ZIP/Postal Code
463-707
Country
Korea, Republic of
Facility Name
Wonju Severance Christian Hosp
City
Wonju
ZIP/Postal Code
26426
Country
Korea, Republic of
Facility Name
Hospital Cardiologica Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Instituto Nacional de Cardiologia Ignacio Chavez
City
Ciudad de Mexico
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Centro de Investigacion Biomedica y Farmaceutica, S.C.
City
Distrito Federal
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Unidad de Investigacion Clinica Cardiometabolica de Occident
City
Guadalajara
ZIP/Postal Code
44150
Country
Mexico
Facility Name
Diseño y Planeación en Investigación Médica SC
City
Guadalajara
ZIP/Postal Code
44656
Country
Mexico
Facility Name
Cardiologia Clinica e Intervencionista
City
Guadalajara
ZIP/Postal Code
44670
Country
Mexico
Facility Name
Centro de Investigación Clinica Acelerada, S.C.
City
Mexico
ZIP/Postal Code
07020
Country
Mexico
Facility Name
Instituto Cardiovascular de Monclova, S de RL de CV
City
Monclova
ZIP/Postal Code
25750
Country
Mexico
Facility Name
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
City
México
ZIP/Postal Code
11650
Country
Mexico
Facility Name
Hospital Universitario Dr Jose Eleuterio Gonzalez
City
Nuevo Leon
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Centro Integral Medico SJR S.C.
City
San Juan del Rio
ZIP/Postal Code
76800
Country
Mexico
Facility Name
Cardioarritmias e Investigación S.C
City
San Luis Potosi
ZIP/Postal Code
78213
Country
Mexico
Facility Name
Centro de Investigacion Cardiovascular y Metabolica
City
Tijuana
ZIP/Postal Code
22500
Country
Mexico
Facility Name
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
City
Torreon
ZIP/Postal Code
27000
Country
Mexico
Facility Name
Hospital Dr Angel Leano
City
Zapopan
ZIP/Postal Code
45200
Country
Mexico
Facility Name
Ziekenhuisgroep Twente locatie Almelo
City
Almelo
ZIP/Postal Code
7609 PP
Country
Netherlands
Facility Name
BovenIJ Ziekenhuis
City
Amsterdam
ZIP/Postal Code
1034 CS
Country
Netherlands
Facility Name
Onze Lieve Vrouwe Gasthuis, Locatie West
City
Amsterdam
ZIP/Postal Code
1061 AE
Country
Netherlands
Facility Name
Amsterdam UMC Locatie VUMC
City
Amsterdam
ZIP/Postal Code
1081HV
Country
Netherlands
Facility Name
Onze Lieve Vrouwe Gasthuis
City
Amsterdam
ZIP/Postal Code
1091AC
Country
Netherlands
Facility Name
Amsterdam UMC, Locatie AMC
City
Amsterdam
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Rode Kruis Ziekenhuis Beverwijk
City
Beverwijk
ZIP/Postal Code
1942 LE
Country
Netherlands
Facility Name
Tergooiziekenhuizen locatie Blaricum
City
Blaricum
ZIP/Postal Code
1261 AN
Country
Netherlands
Facility Name
Amphia Ziekenhuis
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
Facility Name
HMC Bronovo
City
Den Haag
ZIP/Postal Code
2597 AX
Country
Netherlands
Facility Name
Ziekenhuis Gelderse Vallei
City
EDE
ZIP/Postal Code
6716 RP
Country
Netherlands
Facility Name
Catharina Ziekenhuis
City
Eindhoven
ZIP/Postal Code
5623 EJ
Country
Netherlands
Facility Name
Universitair Medisch Centrum Groningen
City
Groningen
ZIP/Postal Code
9713 GZ
Country
Netherlands
Facility Name
Zuyderland Medisch Centrum
City
Heerlen
ZIP/Postal Code
6419 PC
Country
Netherlands
Facility Name
Vasculair Onderzoek Centrum
City
Hoorn
ZIP/Postal Code
1624 NP
Country
Netherlands
Facility Name
Maastricht Universitair Medisch Centrum
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Diaconessenhuis Meppel
City
Meppel
ZIP/Postal Code
7943 KA
Country
Netherlands
Facility Name
St. Antonius ziekenhuis, locatie Nieuwegein
City
Nieuwegein
ZIP/Postal Code
3435 CM
Country
Netherlands
Facility Name
Radboud Universitair Medisch Centrum
City
Nijmegen
ZIP/Postal Code
6525 GL
Country
Netherlands
Facility Name
Ziekenhuis Bernhoven Uden
City
Uden
ZIP/Postal Code
5406 PT
Country
Netherlands
Facility Name
Vie Curi Medisch Centrum
City
Venlo
ZIP/Postal Code
5912 BL
Country
Netherlands
Facility Name
De Heel - Zaans Medisch Centrum
City
Zaandam
ZIP/Postal Code
1502 DV
Country
Netherlands
Facility Name
Gelre Ziekenhuis Zutphen
City
Zutphen
ZIP/Postal Code
7207 AE
Country
Netherlands
Facility Name
KLIMED Marek Klimkiewicz
City
Bialystok
ZIP/Postal Code
15-765
Country
Poland
Facility Name
Univ. Clinic Hosp, Bialystok
City
Bialystok
ZIP/Postal Code
15276
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Bielsko-Biala
ZIP/Postal Code
43-316
Country
Poland
Facility Name
NZOZ Centrum Medyczne KERmed
City
Bydgoszcz
ZIP/Postal Code
85231
Country
Poland
Facility Name
Polsko-Amerykanskie Kliniki Serca
City
Chorzow
ZIP/Postal Code
32-500
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Dabrowa Gornicza
ZIP/Postal Code
41-300
Country
Poland
Facility Name
Poradnia Kardiologiczna Jaroslaw Jurowiecki
City
Gdansk
ZIP/Postal Code
80-286
Country
Poland
Facility Name
University Clinical Center, Gdansk
City
Gdansk
ZIP/Postal Code
80952
Country
Poland
Facility Name
Indywidualna Specjalistyczna Praktyka Lekarska
City
Gdynia
ZIP/Postal Code
81-157
Country
Poland
Facility Name
Saint Wincenty a Paulo Hosp., Cardiology Dept., Gdynia
City
Gdynia
ZIP/Postal Code
81348
Country
Poland
Facility Name
Szpital Zakonu Bonifratow Sp. z o.o.
City
Katowice
ZIP/Postal Code
40-211
Country
Poland
Facility Name
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
City
Kielce
ZIP/Postal Code
25525
Country
Poland
Facility Name
Leszek Bryniarski Specialized Medical Cabinet
City
Krakow
ZIP/Postal Code
30-082
Country
Poland
Facility Name
Krakow Specialistic Hospital of John Paul II
City
Krakow
ZIP/Postal Code
31-202
Country
Poland
Facility Name
SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
City
Lodz
ZIP/Postal Code
90-302
Country
Poland
Facility Name
Nzoz Salus
City
Lodz
ZIP/Postal Code
91-302
Country
Poland
Facility Name
Individual Specialized Practice
City
Lodz
ZIP/Postal Code
94-255
Country
Poland
Facility Name
Lowickie Cardiology Center
City
Lowicz
ZIP/Postal Code
99-400
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Nysa
ZIP/Postal Code
48-300
Country
Poland
Facility Name
Medicome Sp. z o.o.
City
Oswiecim
ZIP/Postal Code
32-600
Country
Poland
Facility Name
Specialized Practice Dr. Janusz Spyra
City
Ruda Slaska
ZIP/Postal Code
41-709
Country
Poland
Facility Name
Centrum Medyczne Medyk
City
Rzeszow
ZIP/Postal Code
35-055
Country
Poland
Facility Name
Lukmed Lukasz Wozniak
City
Siedlce
ZIP/Postal Code
08-110
Country
Poland
Facility Name
Clinmedica Research Omc sp. z o.o. sp.k., Skierniewice
City
Skierniewice
ZIP/Postal Code
96-100
Country
Poland
Facility Name
KO-MED Centra Kliniczne Staszow
City
Staszow
ZIP/Postal Code
28-200
Country
Poland
Facility Name
The Provincial Polyclinical Hospital in Torun
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Tychy
ZIP/Postal Code
43-100
Country
Poland
Facility Name
American Heart of Poland Sp. z o.o.
City
Ustron
ZIP/Postal Code
43-450
Country
Poland
Facility Name
Central Hospital of Medical Academy, Warsaw
City
Warsaw
ZIP/Postal Code
02-097
Country
Poland
Facility Name
McM Polimedica
City
Warszawa
ZIP/Postal Code
02-777
Country
Poland
Facility Name
4. Military Clinical Hospital with Polyclinic SP ZOZ
City
Wroclaw
ZIP/Postal Code
50-981
Country
Poland
Facility Name
Zgierskie Center of Cardiology MED-PRO
City
Zgierz
ZIP/Postal Code
95-100
Country
Poland
Facility Name
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
City
Zychlin
ZIP/Postal Code
62-571
Country
Poland
Facility Name
Hospital Quiron. I.C.U.
City
Barcelona
ZIP/Postal Code
08023
Country
Spain
Facility Name
Hospital Santa Creu i Sant Pau
City
Barcelona
ZIP/Postal Code
08026
Country
Spain
Facility Name
Hospital Universitario Virgen de la Arrixaca
City
El Palmar
ZIP/Postal Code
30120
Country
Spain
Facility Name
Hospital de Bellvitge
City
L'Hospitalet de Llobregat
ZIP/Postal Code
08907
Country
Spain
Facility Name
Hospital Ramón y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Clínico San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Universitario 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Hospital La Paz
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Virgen de la Victoria
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Complejo Hospitalario Universitario de Orense
City
Orense
ZIP/Postal Code
32005
Country
Spain
Facility Name
Hospital Clínico de Santiago
City
Santiago de Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Clínico Universitario de Valladolid
City
Valladolid
ZIP/Postal Code
47003
Country
Spain
Facility Name
Barnet General Hospital
City
Barnet
ZIP/Postal Code
EN5 3DJ
Country
United Kingdom
Facility Name
University Hospital of Wales
City
Cardiff
ZIP/Postal Code
CF14 4XW
Country
United Kingdom
Facility Name
Park & St Francis Surgery
City
Eastleigh
ZIP/Postal Code
SO53 4ST
Country
United Kingdom
Facility Name
Wycombe General Hospital
City
High Wycombe
ZIP/Postal Code
HP11 2TT
Country
United Kingdom
Facility Name
Glenfield Hospital
City
Leicester
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Facility Name
St Bartholomew's Hospital
City
London
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Facility Name
Luton and Dunstable University Hospital
City
Luton
ZIP/Postal Code
LU4 0DZ
Country
United Kingdom
Facility Name
St Mary's Hospital
City
Newport
ZIP/Postal Code
PO30 5TG
Country
United Kingdom
Facility Name
Morriston Hospital
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
12. IPD Sharing Statement
Citations:
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36129693
Citation
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PubMed Identifier
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Ferreira JP, Zannad F, Butler J, Filipattos G, Ritter I, Schuler E, Kraus BJ, Pocock SJ, Anker SD, Packer M. Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Eur Heart J. 2022 Aug 14;43(31):2984-2993. doi: 10.1093/eurheartj/ehac306. Erratum In: Eur Heart J. 2022 Jul 22;:
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PubMed Identifier
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PubMed Identifier
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Ferreira JP, Anker SD, Butler J, Filippatos G, Iwata T, Salsali A, Zeller C, Pocock SJ, Zannad F, Packer M. Impact of anaemia and the effect of empagliflozin in heart failure with reduced ejection fraction: findings from EMPEROR-Reduced. Eur J Heart Fail. 2022 Apr;24(4):708-715. doi: 10.1002/ejhf.2409. Epub 2022 Jan 9.
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Ryden L, Ferrannini G. Is the impact of add on heart failure therapy influenced by background therapy? Lancet Diabetes Endocrinol. 2022 Jan;10(1):3-5. doi: 10.1016/S2213-8587(21)00311-9. Epub 2021 Nov 30. No abstract available.
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PubMed Identifier
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Bohm M, Anker SD, Butler J, Filippatos G, Ferreira JP, Pocock SJ, Mahfoud F, Brueckmann M, Jamal W, Ofstad AP, Schuler E, Ponikowski P, Wanner C, Zannad F, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin Improves Cardiovascular and Renal Outcomes in Heart Failure Irrespective of Systolic Blood Pressure. J Am Coll Cardiol. 2021 Sep 28;78(13):1337-1348. doi: 10.1016/j.jacc.2021.07.049.
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PubMed Identifier
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Januzzi JL Jr, Zannad F, Anker SD, Butler J, Filippatos G, Pocock SJ, Ferreira JP, Sattar N, Verma S, Vedin O, Schnee J, Iwata T, Cotton D, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Prognostic Importance of NT-proBNP and Effect of Empagliflozin in the EMPEROR-Reduced Trial. J Am Coll Cardiol. 2021 Sep 28;78(13):1321-1332. doi: 10.1016/j.jacc.2021.07.046.
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PubMed Identifier
34459213
Citation
Packer M, Butler J, Zannad F, Filippatos G, Ferreira JP, Pocock SJ, Carson P, Anand I, Doehner W, Haass M, Komajda M, Miller A, Pehrson S, Teerlink JR, Schnaidt S, Zeller C, Schnee JM, Anker SD. Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial. Circulation. 2021 Oct 19;144(16):1284-1294. doi: 10.1161/CIRCULATIONAHA.121.056824. Epub 2021 Aug 29.
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PubMed Identifier
34423361
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Pocock SJ, Ferreira JP, Gregson J, Anker SD, Butler J, Filippatos G, Gollop ND, Iwata T, Brueckmann M, Januzzi JL, Voors AA, Zannad F, Packer M. Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial. Eur Heart J. 2021 Nov 14;42(43):4455-4464. doi: 10.1093/eurheartj/ehab579.
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PubMed Identifier
34184057
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Lam CSP, Ferreira JP, Pfarr E, Sim D, Tsutsui H, Anker SD, Butler J, Filippatos G, Pocock SJ, Sattar N, Verma S, Brueckmann M, Schnee J, Cotton D, Zannad F, Packer M. Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021 Nov 14;42(43):4442-4451. doi: 10.1093/eurheartj/ehab360.
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PubMed Identifier
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PubMed Identifier
33736819
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PubMed Identifier
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Butler J, Anker SD, Filippatos G, Khan MS, Ferreira JP, Pocock SJ, Giannetti N, Januzzi JL, Pina IL, Lam CSP, Ponikowski P, Sattar N, Verma S, Brueckmann M, Jamal W, Vedin O, Peil B, Zeller C, Zannad F, Packer M; EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021 Mar 31;42(13):1203-1212. doi: 10.1093/eurheartj/ehaa1007.
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PubMed Identifier
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Anker SD, Butler J, Filippatos G, Khan MS, Marx N, Lam CSP, Schnaidt S, Ofstad AP, Brueckmann M, Jamal W, Bocchi EA, Ponikowski P, Perrone SV, Januzzi JL, Verma S, Bohm M, Ferreira JP, Pocock SJ, Zannad F, Packer M. Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status: Results From the EMPEROR-Reduced Trial. Circulation. 2021 Jan 26;143(4):337-349. doi: 10.1161/CIRCULATIONAHA.120.051824. Epub 2020 Nov 11.
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PubMed Identifier
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Results Reference
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Links:
URL
http://mystudywindow.com
Description
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EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
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