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Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) (TAHOE)

Primary Purpose

Small Cell Lung Cancer

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Rovalpituzumab tesirine

Topotecan

Dexamethasone

About this trial

This is an interventional treatment trial for Small Cell Lung Cancer focused on measuring Small cell lung cancer (SCLC), Delta-like protein 3 (DLL3), rovalpituzumab tesirine, topotecan, metastatic

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Participant must have histologically or cytologically confirmed advanced or metastatic Small Cell Lung Cancer (SCLC) with documented first disease progression during or following front-line platinum-based systemic regimen
Tumor must have high Delta-like protein 3 (DLL3) expression defined as having ≥ 75% tumor cells staining positive according to the VENTANA DLL3 (SP347) IHC Assay.
Participant must have measurable disease, as defined per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Participant must have recovery to Grade 0 or 1 of any clinically significant toxicity (excluding alopecia) prior to initiation of study drug administration.

Exclusion Criteria:

Participant has a documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms consistent with New York Heart Association Class (NYHA) III - IV within 6 months prior to their first dose of study drug.
Participant has known leptomeningeal metastases.
Participant has received more than one prior systemic therapy regimen for SCLC.
Participant had a serious infection within 2 weeks prior to randomization, including any Grade 3 or higher viral, bacterial, or fungal infection.
Participant has a history of active malignancies other than SCLC within the past 2 years prior to study entry, with the exception of in situ cancer which was curatively treated.
Participant had prior exposure to topotecan, irinotecan or any other topoisomerase I inhibitors.

Sites / Locations

Clearview Cancer Institute /ID# 155873
Mitchell Cancer Institute /ID# 158151
Carti /Id# 156982
Highlands Oncology Group /ID# 155902
Cedars-Sinai Medical Center /ID# 157102
Moore UC San Diego Cancer Center /ID# 156965
Los Angeles Hematology Oncolog /ID# 155879
University of California, Davis Comprehensive Cancer Center /ID# 157001
St Jude Hospital dba St Joseph /ID# 155899
Icri /Id# 157090
Christiana Care Health Service /ID# 158171
Cancer Specialists of North Florida - Southpoint /ID# 155828
Georgia Cancer Center /ID# 160206
St. Luke's Mountain States Tumor Institute - Meridian /ID# 164550
NorthShore University HealthSystem - Evanston Hospital /ID# 157054
Ingalls Memorial Hosp /ID# 155871
Goshen Center for Cancer Care /ID# 155946
University of Louisville /ID# 155947
Ochsner Clinic Foundation /ID# 160807
Dana-Farber Cancer Institute /ID# 160210
Sparrow Regional Cancer Center, Sparrow Health System /ID# 157021
Nebraska Hematology Oncology /ID# 155900
Gabrail Cancer Center Research /ID# 155920
Oregon Health and Science University /ID# 157055
UPMC Hillman Cancer Ctr /ID# 164403
Univ Medical Ctr Brackenridge /ID# 156967
UT Southwestern Medical Center /ID# 158150
University of Vermont Medical Center /ID# 162317
University of Washington /ID# 162626
Medical Oncology Associates /ID# 156856
West Virginia Univ School Med /ID# 155872
Blacktown Hospital /ID# 158907
St George Hospital /ID# 158855
Southern Medical Day Care Ctr /ID# 158853
The Prince Charles Hospital /ID# 158897
Ballarat Health Service /ID# 158904
Austin Hospital /ID# 158898
Bobruysk Interdistrict Onco. /ID# 169394
State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159325
Mogilev Reg. Oncologic dispe /ID# 159326
CHU Saint-Pierre /ID# 159521
Grand Hôpital de Charleroi /ID# 158748
Cliniques universitaires Saint /ID# 158751
Hopital de Jolimont /ID# 159755
UZ Leuven /ID# 158752
CHU de Liege Sart Tilman /ID# 158753
CHU Charleroi (Vesale) /ID# 159756
Liga Norte Rio Grandense Cont. /ID# 159015
Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159668
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159017
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159666
Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159665
UMHAT Tsaritsa Joanna - ISUL /ID# 159641
UMHAT Sv. Ivan Rilski /ID# 159642
Cross Cancer Institute /ID# 159519
Juravinski Cancer Clinic /ID# 159514
Hopital du Sacre Coeur Montreal /ID# 159515
CHU de Quebec-Universite Laval /ID# 159093
Cisss Du Bas-Saint-Laurent Hopital Regional de Rimouski /Id# 208931
Jilin Cancer Hosptial /ID# 204059
Klinicki bolnicki centar Sestre milosrdnice /ID# 158811
Klinika za plucne bolesti Jordanovac /ID# 159502
Klinicki bolnicki centar Rijeka /ID# 159501
Thomayerova nemocnice /ID# 159061
Nemocnice Na Plesi s.r.o. /ID# 161190
Nemocnice Rudolfa a Stefanie /ID# 159652
Nemocnice Horovice a.s. /ID# 161191
Krajska nemocnice Liberec a.s. /ID# 159653
Herlev Hospital /ID# 158049
Odense Universitets Hospital /ID# 158050
Rigshospitalet, Finsen Centre /ID# 158051
Hopital Haut-Lévêque /ID# 160558
Assis.Publique-Hopital Nord /ID# 160554
Centre Leon Berard /ID# 160561
Centre Hosp Intercommunal de Creteil /ID# 162684
Assistance Publique- Hopitaux /ID# 160552
Hospital Pontchaillou /ID# 160555
KH Martha-Maria Halle Dolau /ID# 158796
Evangelische Lungenklinik Berl /ID# 159168
Asklepios Fachkliniken M. Gaut /ID# 158791
Lungen Clinic Grosshansdorf /ID# 158770
Thoraxklinik Heidelberg gGmbH /ID# 159169
Klinikum Kassel /ID# 158788
Klinik Loewenstein GmbH /ID# 159167
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159165
Metropolitan Hospital /ID# 159162
University Hospital of Ioannin /ID# 159163
Euromedica General Clinic /ID# 159161
Torokbalinti Tudogyogyintezet /ID# 207053
Semmelweis Egyetem /ID# 161197
Orszagos Koranyi Pulmonologiai Intezet /ID# 158967
Dup_Debreceni Egyetem Klinikai Központ /ID# 161209
Veszprem Megyei Tuedoegyogyint /ID# 162607
Petz Aladar Megyei Oktato Korh /ID# 158978
Matrai Gyogyintezet /ID# 158979
AUSL 8 Arezzo Ospedale San Don /ID# 160967
Istituto Europeo di Oncologia /ID# 158942
A.O.U. San Luigi Gonzaga /ID# 158945
Ospedale Santa Maria delle Cro /ID# 158940
IFO Istituto Nazionale Tumori /ID# 158941
Aichi Cancer Center Hospital /ID# 164975
National Cancer Center Hospital East /ID# 165726
Kyushu University Hospital /ID# 165723
Kurume University Hospital /ID# 164586
Hokkaido Cancer Center /ID# 165237
Hyogo Cancer Center /ID# 165125
Himeji Medical Center /ID# 165893
Duplicate_Kanazawa University Hospital /ID# 165129
Yokohama City University Hospital /ID# 165748
Kanagawa Cardiovascular and Respiratory Center /ID# 164374
Sendai Kousei Hospital /ID# 166061
Japanese Red Cross Okayama Hospital /ID# 165156
Kansai Medical University Hospital /ID# 165055
Kindai University Hospital /ID# 166394
Osaka City General Hospital /ID# 165717
Shizuoka Cancer Center /ID# 166466
Tokushima University Hospital /ID# 165812
National Cancer Center Hospital /ID# 166768
The Cancer Institute Hospital Of JFCR /ID# 166249
Duplicate_Showa University Hospital /ID# 165574
Wakayama Medical University /ID# 166032
Matsusaka City Hospital /ID# 166126
Kanagawa Cancer Center /ID# 165816
Dong-A University Hospital /ID# 159296
CHA Bundang Medical center CHA University /ID# 204416
Chonnam National University Hospital /ID# 159294
Kyungpook National University Chilgok Hospital /ID# 159292
Yonsei University Health System, Severance Hospital /ID# 159288
Korea University Guro Hospital /ID# 159293
Chungbuk National University /ID# 159291
Asan Medical Center /ID# 159290
Pauls Stradins Clinical /ID# 158713
Riga East Clinical University /ID# 158714
Centro de Investigación Clinica Chapultepec /ID# 161000
Health Pharma Professional Research S.A de C.V /ID# 160020
Universitair Medisch Centrum Groningen /ID# 158088
Ziekenhuis St. Jansdal /ID# 158652
Isala /ID# 158653
Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 160537
Copernicus PL Sp. z o. o., WCO /ID# 160538
Szpitale Pomorskie Sp. z o.o /ID# 160536
Centro Hospitalar Lisboa Norte, EPE /ID# 158687
IPO Lisboa FG, EPE /ID# 158995
Hospital da Luz, SA /ID# 158996
Unidade Local Saude Matosinhos /ID# 158682
Hospital CUF Porto /ID# 158685
IPO Porto FG, EPE /ID# 158686
S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 160847
Oncocenter Oncologie Clinica S /ID# 160848
Spitalul Judetean de Urgenta A /ID# 160846
National Medical Research Cntr /ID# 207436
LLC Novaya Klinika /ID# 205539
Arkhangelsk clinical oncology /ID# 159309
Kaluga Regional Clinical Oncol /ID# 160179
Clinical Onco Dispensary /ID# 159307
PMI Euromedservice /ID# 159311
Smolensk Regional Onc Clin Dis /ID# 159314
LLC BioEq Ltd. /ID# 159310
N.N. Petrov Research Inst Onc /ID# 159312
Clinical Center of Nis /ID# 160059
Institut za onkologiju i radio /ID# 160058
Klinicki centar Srbije /ID# 160024
Institute For Pulmonary Diseas /ID# 158813
National University Hospital /ID# 158802
National Cancer Ctr Singapore /ID# 158803
Hospital Clinic /ID# 159031
Hospital Santa Creu i Sant Pau /ID# 159028
Hospital General Universitario Gregorio Maranon /ID# 159025
Hospital Universitario HM Sanchinarro /ID# 159024
Hospital Clinico Universitario de Valencia /ID# 159027
Sahlgrenska US Gbg /ID# 159534
Uppsala University Hospital /ID# 159050
National Cheng Kung University Hospital /ID# 158844
National Taiwan University Hospital /ID# 158865
Tri-Service General Hospital /ID# 158985
Taichung Veterans General Hosp /ID# 158866
Hacettepe University Medical Faculty /ID# 159238
Inonu Universitesi Turgut Ozal /ID# 159241
Ege University Medical Faculty /ID# 159239
Dr. Suat Seren Gogus Has /ID# 159240
Ataturk Gogus Hastaliklari ve /ID# 160056
CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159122
Municipal institution /ID# 159867
Municipal institution Multifie /ID# 159121
Regional Center of Oncology /ID# 159123
PE PMC Acinus, Medical and Diagnostic Center /ID# 159125
ME Kryviy Rih Oncology Dispensary /ID# 159119
Volyn Regional Medical Oncology Centre /ID# 159124
Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159868
Guy's and St Thomas' NHS Found /ID# 159581
United Lincolnshire Hospitals /ID# 159579
Charing Cross Hospital /ID# 159582
Christie NHS Foundation Trust /ID# 159099
James Cook University Hospital /ID# 159583
Royal Preston Hospital /ID# 159578

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Rovalpituzumab tesirine

Topotecan

Arm Description

Rovalpituzumab tesirine IV administration (dosing based on actual body weight) on Day 1 of a 42-day cycle for 2 cycles, with up to 2 additional cycles permitted. Dexamethasone coadministered orally (PO) twice daily at a dose of 8 mg on Day -1, Day 1, and Day 2 of each 42-day cycle in which rovalpituzumab tesirine is administered.

Topotecan given as an intravenous (IV) infusion over 30 minutes at a dose of 1.5 mg/m^2 on Days 1 to 5 of each 21-day cycle.

Outcomes

Primary Outcome Measures

Overall Survival (OS)

OS is defined as the time from the date of randomization to the date of death from any cause. Participants were censored at the last date they were documented alive. After the End of treatment, survival information was collected at approximately 6-week intervals (or as requested by sponsor to support data analysis) continuing until the endpoint of death, the participant became lost to follow-up, AbbVie terminated the study, or until 12 February 2020. Calculated using the Kaplan-Meier product-limit method.

Secondary Outcome Measures

Progression Free Survival (PFS)

PFS is defined as the number of months from the date of randomization until the date of first progression or the date of a participant's death, whichever occurs first. If a participant neither experienced disease progression nor died, then the participant's data were censored at the last date of radiographic assessment that they were documented to be progression free. Calculated using the Kaplan-Meier product-limit method. Radiographic tumor assessments for response were conducted by CT scanning according to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1. Progressive Disease (PD) was defined as at least a 20% increase in the size of target lesions and an absolute increase of at least 5 mm taking as reference the smallest lesion size recorded since the treatment started (baseline or after), or the appearance of one or more new lesions.

Change From Baseline of the Physical Functioning Scale Score in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15-Palliative Care (EORTC QLQ-C15-PAL) at Week 7

The EORTC QLQ-C15-PAL is an abbreviated 15-item version of the EORTC core quality of life questionnaire (EORTC QLQ-C30) developed for use in palliative care. The score of 'physical functioning scale' score ranges from 0 (very poor) to 100 (excellent).

Objective Response Rate (ORR)

ORR is defined as the percentage of participants whose best overall response is either complete response (CR) or partial response (PR) according to RECIST version 1.1. Radiographic tumor assessments for response were conducted by CT scanning, and assessed from the date of randomization until disease progression or death, whichever came first. Any participant who did not meet CR or PR, including those who did not have post-baseline radiological assessments were considered non-responders. CR: Disappearance of all target and non-target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to < 10 mm. PR: At least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum diameters.

Clinical Benefit Rate (CBR)

CBR is defined as percentage of participants whose best overall response is CR, PR, or stable disease (SD) according to RECIST version 1.1. Radiographic tumor assessments for response were conducted by CT scanning, and assessed from the date of randomization until disease progression or death, whichever came first. Any participant who did not meet CR, PR, or SD, including those who did not have post-baseline radiological assessments were considered as experiencing no clinical benefit. CR: disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm. PR: at least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum diameters. SD: neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum diameters while on study.

Duration of Objective Response (DOR)

DOR is defined as the time between the date of first response (CR or PR, whichever is recorded first) to the date of the first documented tumor progression (per RECIST version 1.1) or death due to any cause, whichever comes first. Radiographic tumor assessments for response were conducted by CT scanning, and assessed from the date of randomization until disease progression or death, whichever came first. Any participant who did not meet CR or PR, including those who did not have post-baseline radiological assessments were considered non-responders. CR: Disappearance of all target and non-target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to < 10 mm. PR: At least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum diameters.

Full Information

NCT ID

NCT03061812

First Posted

February 20, 2017

Last Updated

February 19, 2021

Sponsor

AbbVie

1. Study Identification

Unique Protocol Identification Number

NCT03061812

Brief Title

Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)

Acronym

TAHOE

Official Title

A Randomized, Open-Label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared With Topotecan for Subjects With Advanced or Metastatic DLL3high Small Cell Lung Cancer (SCLC) Who Have First Disease Progression During or Following Front-Line Platinum-Based Chemotherapy (TAHOE)

Study Type

Interventional

2. Study Status

Record Verification Date

February 2021

Overall Recruitment Status

Completed

Study Start Date

April 11, 2017 (Actual)

Primary Completion Date

February 12, 2020 (Actual)

Study Completion Date

February 12, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AbbVie

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Product Manufactured in and Exported from the U.S.

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Small Cell Lung Cancer

Keywords

Small cell lung cancer (SCLC), Delta-like protein 3 (DLL3), rovalpituzumab tesirine, topotecan, metastatic

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

444 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Rovalpituzumab tesirine

Arm Type

Experimental

Arm Description

Arm Title

Topotecan

Arm Type

Active Comparator

Arm Description

Topotecan given as an intravenous (IV) infusion over 30 minutes at a dose of 1.5 mg/m^2 on Days 1 to 5 of each 21-day cycle.

Intervention Type

Drug

Intervention Name(s)

Rovalpituzumab tesirine

Other Intervention Name(s)

Rova-T

Intervention Description

Powder for solution for infusion in vials.

Intervention Type

Drug

Intervention Name(s)

Topotecan

Intervention Description

Powder or solution for infusion in vials. Topotecan is commercially available as both a powder and solution for infusion. Availability will vary by region.

Intervention Type

Drug

Intervention Name(s)

Dexamethasone

Intervention Description

Oral tablet.

Primary Outcome Measure Information:

Title

Overall Survival (OS)

Description

Time Frame

From randomization until the end of study; median time on follow-up was 20 and 20.6 months for the topotecan and rovalpituzumab tesirine arms, respectively.

Secondary Outcome Measure Information:

Title

Progression Free Survival (PFS)

Description

Time Frame

From randomization until the end of study; median time on follow-up was 20 and 20.6 months for the topotecan and rovalpituzumab tesirine arms, respectively.

Title

Description

Time Frame

Baseline, Week 7

Title

Objective Response Rate (ORR)

Description

Time Frame

Radiographic tumor assessments were conducted at baseline, every 6 weeks for 30 weeks, then every 9 weeks until progression or death; median time on follow-up was 20 and 20.6 months for the topotecan and rovalpituzumab tesirine arms, respectively.

Title

Clinical Benefit Rate (CBR)

Description

Time Frame

Title

Duration of Objective Response (DOR)

Description

Time Frame

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Participant must have histologically or cytologically confirmed advanced or metastatic Small Cell Lung Cancer (SCLC) with documented first disease progression during or following front-line platinum-based systemic regimen Tumor must have high Delta-like protein 3 (DLL3) expression defined as having ≥ 75% tumor cells staining positive according to the VENTANA DLL3 (SP347) IHC Assay. Participant must have measurable disease, as defined per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Participant must have recovery to Grade 0 or 1 of any clinically significant toxicity (excluding alopecia) prior to initiation of study drug administration. Exclusion Criteria: Participant has a documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms consistent with New York Heart Association Class (NYHA) III - IV within 6 months prior to their first dose of study drug. Participant has known leptomeningeal metastases. Participant has received more than one prior systemic therapy regimen for SCLC. Participant had a serious infection within 2 weeks prior to randomization, including any Grade 3 or higher viral, bacterial, or fungal infection. Participant has a history of active malignancies other than SCLC within the past 2 years prior to study entry, with the exception of in situ cancer which was curatively treated. Participant had prior exposure to topotecan, irinotecan or any other topoisomerase I inhibitors.

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

AbbVie Inc.

Organizational Affiliation

AbbVie

Official's Role

Study Director

Facility Information:

Facility Name

Clearview Cancer Institute /ID# 155873

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35805

Country

United States

Facility Name

Mitchell Cancer Institute /ID# 158151

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36604

Country

United States

Facility Name

Carti /Id# 156982

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Facility Name

Highlands Oncology Group /ID# 155902

City

Springdale

State/Province

Arkansas

ZIP/Postal Code

72762

Country

United States

Facility Name

Cedars-Sinai Medical Center /ID# 157102

City

Beverly Hills

State/Province

California

ZIP/Postal Code

90211

Country

United States

Facility Name

Moore UC San Diego Cancer Center /ID# 156965

City

La Jolla

State/Province

California

ZIP/Postal Code

92093

Country

United States

Facility Name

Los Angeles Hematology Oncolog /ID# 155879

City

Los Angeles

State/Province

California

ZIP/Postal Code

90017

Country

United States

Facility Name

University of California, Davis Comprehensive Cancer Center /ID# 157001

City

Sacramento

State/Province

California

ZIP/Postal Code

95817

Country

United States

Facility Name

St Jude Hospital dba St Joseph /ID# 155899

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Icri /Id# 157090

City

Whittier

State/Province

California

ZIP/Postal Code

90603

Country

United States

Facility Name

Christiana Care Health Service /ID# 158171

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Cancer Specialists of North Florida - Southpoint /ID# 155828

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32256

Country

United States

Facility Name

Georgia Cancer Center /ID# 160206

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342

Country

United States

Facility Name

St. Luke's Mountain States Tumor Institute - Meridian /ID# 164550

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83712

Country

United States

Facility Name

NorthShore University HealthSystem - Evanston Hospital /ID# 157054

City

Evanston

State/Province

Illinois

ZIP/Postal Code

60201

Country

United States

Facility Name

Ingalls Memorial Hosp /ID# 155871

City

Harvey

State/Province

Illinois

ZIP/Postal Code

60426

Country

United States

Facility Name

Goshen Center for Cancer Care /ID# 155946

City

Goshen

State/Province

Indiana

ZIP/Postal Code

46526

Country

United States

Facility Name

University of Louisville /ID# 155947

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40202

Country

United States

Facility Name

Ochsner Clinic Foundation /ID# 160807

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70836-6455

Country

United States

Facility Name

Dana-Farber Cancer Institute /ID# 160210

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02215

Country

United States

Facility Name

Sparrow Regional Cancer Center, Sparrow Health System /ID# 157021

City

Lansing

State/Province

Michigan

ZIP/Postal Code

48912

Country

United States

Facility Name

Nebraska Hematology Oncology /ID# 155900

City

Lincoln

State/Province

Nebraska

ZIP/Postal Code

68506

Country

United States

Facility Name

Gabrail Cancer Center Research /ID# 155920

City

Canton

State/Province

Ohio

ZIP/Postal Code

44718

Country

United States

Facility Name

Oregon Health and Science University /ID# 157055

City

Portland

State/Province

Oregon

ZIP/Postal Code

97239

Country

United States

Facility Name

UPMC Hillman Cancer Ctr /ID# 164403

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15232

Country

United States

Facility Name

Univ Medical Ctr Brackenridge /ID# 156967

City

Austin

State/Province

Texas

ZIP/Postal Code

78701

Country

United States

Facility Name

UT Southwestern Medical Center /ID# 158150

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390-7208

Country

United States

Facility Name

University of Vermont Medical Center /ID# 162317

City

Burlington

State/Province

Vermont

ZIP/Postal Code

05401-1473

Country

United States

Facility Name

University of Washington /ID# 162626

City

Seattle

State/Province

Washington

ZIP/Postal Code

98109

Country

United States

Facility Name

Medical Oncology Associates /ID# 156856

City

Spokane

State/Province

Washington

ZIP/Postal Code

99208

Country

United States

Facility Name

West Virginia Univ School Med /ID# 155872

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26506

Country

United States

Facility Name

Blacktown Hospital /ID# 158907

City

Blacktown

State/Province

New South Wales

ZIP/Postal Code

2148

Country

Australia

Facility Name

St George Hospital /ID# 158855

City

Kogarah

State/Province

New South Wales

ZIP/Postal Code

2217

Country

Australia

Facility Name

Southern Medical Day Care Ctr /ID# 158853

City

Wollongong

State/Province

New South Wales

ZIP/Postal Code

2500

Country

Australia

Facility Name

The Prince Charles Hospital /ID# 158897

City

Chermside

State/Province

Queensland

ZIP/Postal Code

4032

Country

Australia

Facility Name

Ballarat Health Service /ID# 158904

City

Ballarat

State/Province

Victoria

ZIP/Postal Code

3350

Country

Australia

Facility Name

Austin Hospital /ID# 158898

City

Heidelberg

State/Province

Victoria

ZIP/Postal Code

3084

Country

Australia

Facility Name

Bobruysk Interdistrict Onco. /ID# 169394

City

Bobruisk

ZIP/Postal Code

213825

Country

Belarus

Facility Name

State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159325

City

Lesnoy

ZIP/Postal Code

223040

Country

Belarus

Facility Name

Mogilev Reg. Oncologic dispe /ID# 159326

City

Mogilev

ZIP/Postal Code

212018

Country

Belarus

Facility Name

CHU Saint-Pierre /ID# 159521

City

Bruxelles

State/Province

Bruxelles-Capitale

ZIP/Postal Code

1000

Country

Belgium

Facility Name

Grand Hôpital de Charleroi /ID# 158748

City

Charleroi

State/Province

Hainaut

ZIP/Postal Code

6000

Country

Belgium

Facility Name

Cliniques universitaires Saint /ID# 158751

City

Brussels

ZIP/Postal Code

1200

Country

Belgium

Facility Name

Hopital de Jolimont /ID# 159755

City

Haine Saint Paul

ZIP/Postal Code

7100

Country

Belgium

Facility Name

UZ Leuven /ID# 158752

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

CHU de Liege Sart Tilman /ID# 158753

City

Liege

ZIP/Postal Code

4000

Country

Belgium

Facility Name

CHU Charleroi (Vesale) /ID# 159756

City

Montigny-le-tilleul

ZIP/Postal Code

6110

Country

Belgium

Facility Name

Liga Norte Rio Grandense Cont. /ID# 159015

City

Natal

State/Province

Rio Grande Do Norte

ZIP/Postal Code

59075-740

Country

Brazil

Facility Name

Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159668

City

Passo Fundo

State/Province

Rio Grande Do Sul

ZIP/Postal Code

99010-080

Country

Brazil

Facility Name

Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159017

City

Barretos

State/Province

Sao Paulo

ZIP/Postal Code

14784-400

Country

Brazil

Facility Name

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159666

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15090-000

Country

Brazil

Facility Name

Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159665

City

Rio de Janeiro

ZIP/Postal Code

20231-050

Country

Brazil

Facility Name

UMHAT Tsaritsa Joanna - ISUL /ID# 159641

City

Sofia

ZIP/Postal Code

1527

Country

Bulgaria

Facility Name

UMHAT Sv. Ivan Rilski /ID# 159642

City

Sofia

ZIP/Postal Code

1612

Country

Bulgaria

Facility Name

Cross Cancer Institute /ID# 159519

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 1Z2

Country

Canada

Facility Name

Juravinski Cancer Clinic /ID# 159514

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8V 1C3

Country

Canada

Facility Name

Hopital du Sacre Coeur Montreal /ID# 159515

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4J 1C5

Country

Canada

Facility Name

CHU de Quebec-Universite Laval /ID# 159093

City

Quebec City

State/Province

Quebec

ZIP/Postal Code

G1R 2J6

Country

Canada

Facility Name

Cisss Du Bas-Saint-Laurent Hopital Regional de Rimouski /Id# 208931

City

Rimouski

State/Province

Quebec

ZIP/Postal Code

G5L 5T1

Country

Canada

Facility Name

Jilin Cancer Hosptial /ID# 204059

City

Changchun

State/Province

Jilin

ZIP/Postal Code

130000

Country

China

Facility Name

Klinicki bolnicki centar Sestre milosrdnice /ID# 158811

City

Zagreb

State/Province

Grad Zagreb

ZIP/Postal Code

10000

Country

Croatia

Facility Name

Klinika za plucne bolesti Jordanovac /ID# 159502

City

Zagreb

State/Province

Grad Zagreb

ZIP/Postal Code

10000

Country

Croatia

Facility Name

Klinicki bolnicki centar Rijeka /ID# 159501

City

Rijeka

State/Province

Primorsko-goranska Zupanija

ZIP/Postal Code

51000

Country

Croatia

Facility Name

Thomayerova nemocnice /ID# 159061

City

Prague

State/Province

Praha 4

ZIP/Postal Code

140 59

Country

Czechia

Facility Name

Nemocnice Na Plesi s.r.o. /ID# 161190

City

Nová Ves pod Pleší

State/Province

Pribram

ZIP/Postal Code

262 04

Country

Czechia

Facility Name

Nemocnice Rudolfa a Stefanie /ID# 159652

City

Benesov

ZIP/Postal Code

256 01

Country

Czechia

Facility Name

Nemocnice Horovice a.s. /ID# 161191

City

Horovice

ZIP/Postal Code

268 31

Country

Czechia

Facility Name

Krajska nemocnice Liberec a.s. /ID# 159653

City

Liberec

ZIP/Postal Code

602 00

Country

Czechia

Facility Name

Herlev Hospital /ID# 158049

City

Herlev

State/Province

Hovedstaden

ZIP/Postal Code

2730

Country

Denmark

Facility Name

Odense Universitets Hospital /ID# 158050

City

Odense C

State/Province

Syddanmark

ZIP/Postal Code

5000

Country

Denmark

Facility Name

Rigshospitalet, Finsen Centre /ID# 158051

City

Copenhagen

ZIP/Postal Code

2100

Country

Denmark

Facility Name

Hopital Haut-Lévêque /ID# 160558

City

Pessac CEDEX

State/Province

Gironde

ZIP/Postal Code

33604

Country

France

Facility Name

Assis.Publique-Hopital Nord /ID# 160554

City

Marseille

State/Province

Provence-Alpes-Cote-d Azur

ZIP/Postal Code

13105

Country

France

Facility Name

Centre Leon Berard /ID# 160561

City

Lyon CEDEX 08

State/Province

Rhone

ZIP/Postal Code

69373

Country

France

Facility Name

Centre Hosp Intercommunal de Creteil /ID# 162684

City

Creteil

State/Province

Val-de-Marne

ZIP/Postal Code

94000

Country

France

Facility Name

Assistance Publique- Hopitaux /ID# 160552

City

Paris

ZIP/Postal Code

75020

Country

France

Facility Name

Hospital Pontchaillou /ID# 160555

City

Rennes

ZIP/Postal Code

35033

Country

France

Facility Name

KH Martha-Maria Halle Dolau /ID# 158796

City

Halle (Saale)

State/Province

Sachsen-Anhalt

ZIP/Postal Code

06120

Country

Germany

Facility Name

Evangelische Lungenklinik Berl /ID# 159168

City

Berlin

ZIP/Postal Code

13125

Country

Germany

Facility Name

Asklepios Fachkliniken M. Gaut /ID# 158791

City

Gauting

ZIP/Postal Code

82131

Country

Germany

Facility Name

Lungen Clinic Grosshansdorf /ID# 158770

City

Grosshansdorf

ZIP/Postal Code

22927

Country

Germany

Facility Name

Thoraxklinik Heidelberg gGmbH /ID# 159169

City

Heidelberg

ZIP/Postal Code

69126

Country

Germany

Facility Name

Klinikum Kassel /ID# 158788

City

Kassel

ZIP/Postal Code

34125

Country

Germany

Facility Name

Klinik Loewenstein GmbH /ID# 159167

City

Löwenstein

ZIP/Postal Code

74245

Country

Germany

Facility Name

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159165

City

Athens

ZIP/Postal Code

11527

Country

Greece

Facility Name

Metropolitan Hospital /ID# 159162

City

Athens

ZIP/Postal Code

18547

Country

Greece

Facility Name

University Hospital of Ioannin /ID# 159163

City

Ioannina

ZIP/Postal Code

45500

Country

Greece

Facility Name

Euromedica General Clinic /ID# 159161

City

Thessaloniki

ZIP/Postal Code

54645

Country

Greece

Facility Name

Torokbalinti Tudogyogyintezet /ID# 207053

City

Budapest

State/Province

Pest

ZIP/Postal Code

2045

Country

Hungary

Facility Name

Semmelweis Egyetem /ID# 161197

City

Budapest

ZIP/Postal Code

1085

Country

Hungary

Facility Name

Orszagos Koranyi Pulmonologiai Intezet /ID# 158967

City

Budapest

ZIP/Postal Code

1122

Country

Hungary

Facility Name

Dup_Debreceni Egyetem Klinikai Központ /ID# 161209

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Facility Name

Veszprem Megyei Tuedoegyogyint /ID# 162607

City

Farkasgyepu

ZIP/Postal Code

8582

Country

Hungary

Facility Name

Petz Aladar Megyei Oktato Korh /ID# 158978

City

Gyor

ZIP/Postal Code

9023

Country

Hungary

Facility Name

Matrai Gyogyintezet /ID# 158979

City

Matrahaza

ZIP/Postal Code

3233

Country

Hungary

Facility Name

AUSL 8 Arezzo Ospedale San Don /ID# 160967

City

Arezzo

ZIP/Postal Code

52100

Country

Italy

Facility Name

Istituto Europeo di Oncologia /ID# 158942

City

Milan

ZIP/Postal Code

20141

Country

Italy

Facility Name

A.O.U. San Luigi Gonzaga /ID# 158945

City

Orbassano

ZIP/Postal Code

10043

Country

Italy

Facility Name

Ospedale Santa Maria delle Cro /ID# 158940

City

Ravenna

ZIP/Postal Code

48121

Country

Italy

Facility Name

IFO Istituto Nazionale Tumori /ID# 158941

City

Rome

ZIP/Postal Code

00144

Country

Italy

Facility Name

Aichi Cancer Center Hospital /ID# 164975

City

Nagoya-shi

State/Province

Aichi

ZIP/Postal Code

464-8681

Country

Japan

Facility Name

National Cancer Center Hospital East /ID# 165726

City

Kashiwa-shi

State/Province

Chiba

ZIP/Postal Code

277-8577

Country

Japan

Facility Name

Kyushu University Hospital /ID# 165723

City

Fukuoka-shi

State/Province

Fukuoka

ZIP/Postal Code

812-8582

Country

Japan

Facility Name

Kurume University Hospital /ID# 164586

City

Kurume-shi

State/Province

Fukuoka

ZIP/Postal Code

830-0011

Country

Japan

Facility Name

Hokkaido Cancer Center /ID# 165237

City

Sapporo-shi

State/Province

Hokkaido

ZIP/Postal Code

003-0804

Country

Japan

Facility Name

Hyogo Cancer Center /ID# 165125

City

Akashi-shi

State/Province

Hyogo

ZIP/Postal Code

673-8558

Country

Japan

Facility Name

Himeji Medical Center /ID# 165893

City

Himeji-shi

State/Province

Hyogo

ZIP/Postal Code

670-0012

Country

Japan

Facility Name

Duplicate_Kanazawa University Hospital /ID# 165129

City

Kanazawa-shi

State/Province

Ishikawa

ZIP/Postal Code

920-8641

Country

Japan

Facility Name

Yokohama City University Hospital /ID# 165748

City

Yokohama-shi

State/Province

Kanagawa

ZIP/Postal Code

236-0004

Country

Japan

Facility Name

Kanagawa Cardiovascular and Respiratory Center /ID# 164374

City

Yokohama-shi

State/Province

Kanagawa

ZIP/Postal Code

236-0051

Country

Japan

Facility Name

Sendai Kousei Hospital /ID# 166061

City

Sendai-shi

State/Province

Miyagi

ZIP/Postal Code

980-0873

Country

Japan

Facility Name

Japanese Red Cross Okayama Hospital /ID# 165156

City

Okayama-shi

State/Province

Okayama

ZIP/Postal Code

700-8607

Country

Japan

Facility Name

Kansai Medical University Hospital /ID# 165055

City

Hirakata-shi

State/Province

Osaka

ZIP/Postal Code

573-1191

Country

Japan

Facility Name

Kindai University Hospital /ID# 166394

City

Osaka-sayama-shi

State/Province

Osaka

ZIP/Postal Code

589-8511

Country

Japan

Facility Name

Osaka City General Hospital /ID# 165717

City

Osaka-shi

State/Province

Osaka

ZIP/Postal Code

534-0021

Country

Japan

Facility Name

Shizuoka Cancer Center /ID# 166466

City

Sunto-gun

State/Province

Shizuoka

ZIP/Postal Code

411-8777

Country

Japan

Facility Name

Tokushima University Hospital /ID# 165812

City

Tokushima-shi

State/Province

Tokushima

ZIP/Postal Code

770-8503

Country

Japan

Facility Name

National Cancer Center Hospital /ID# 166768

City

Chuo-ku

State/Province

Tokyo

ZIP/Postal Code

104-0045

Country

Japan

Facility Name

The Cancer Institute Hospital Of JFCR /ID# 166249

City

Koto-ku

State/Province

Tokyo

ZIP/Postal Code

135-8550

Country

Japan

Facility Name

Duplicate_Showa University Hospital /ID# 165574

City

Shinagawa-ku

State/Province

Tokyo

ZIP/Postal Code

142-0054

Country

Japan

Facility Name

Wakayama Medical University /ID# 166032

City

Wakayama-shi

State/Province

Wakayama

ZIP/Postal Code

641-8510

Country

Japan

Facility Name

Matsusaka City Hospital /ID# 166126

City

Matsusaka-shi MIE

ZIP/Postal Code

515-8544

Country

Japan

Facility Name

Kanagawa Cancer Center /ID# 165816

City

Yokohama

ZIP/Postal Code

241-0815

Country

Japan

Facility Name

Dong-A University Hospital /ID# 159296

City

Busan

State/Province

Busan Gwang Yeogsi

ZIP/Postal Code

49201

Country

Korea, Republic of

Facility Name

CHA Bundang Medical center CHA University /ID# 204416

City

Seongnam si

State/Province

Gyeonggido

ZIP/Postal Code

13496

Country

Korea, Republic of

Facility Name

Chonnam National University Hospital /ID# 159294

City

Gwangju

State/Province

Jeonranamdo

ZIP/Postal Code

61469

Country

Korea, Republic of

Facility Name

Kyungpook National University Chilgok Hospital /ID# 159292

City

Daegu

State/Province

Seoul Teugbyeolsi

ZIP/Postal Code

41404

Country

Korea, Republic of

Facility Name

Yonsei University Health System, Severance Hospital /ID# 159288

City

Seodaemun-gu

State/Province

Seoul Teugbyeolsi

ZIP/Postal Code

03722

Country

Korea, Republic of

Facility Name

Korea University Guro Hospital /ID# 159293

City

Seoul

State/Province

Seoul Teugbyeolsi

ZIP/Postal Code

08308

Country

Korea, Republic of

Facility Name

Chungbuk National University /ID# 159291

City

Cheongju-si

ZIP/Postal Code

28644

Country

Korea, Republic of

Facility Name

Asan Medical Center /ID# 159290

City

Seoul

ZIP/Postal Code

05505

Country

Korea, Republic of

Facility Name

Pauls Stradins Clinical /ID# 158713

City

Riga

ZIP/Postal Code

LV-1002

Country

Latvia

Facility Name

Riga East Clinical University /ID# 158714

City

Riga

ZIP/Postal Code

LV-1079

Country

Latvia

Facility Name

Centro de Investigación Clinica Chapultepec /ID# 161000

City

Morelia

State/Province

Michoacan

ZIP/Postal Code

58260

Country

Mexico

Facility Name

Health Pharma Professional Research S.A de C.V /ID# 160020

City

Del. Benito Juárez

ZIP/Postal Code

03810

Country

Mexico

Facility Name

Universitair Medisch Centrum Groningen /ID# 158088

City

Groningen

ZIP/Postal Code

9713 GZ

Country

Netherlands

Facility Name

Ziekenhuis St. Jansdal /ID# 158652

City

Harderwijk

ZIP/Postal Code

3844 DG

Country

Netherlands

Facility Name

Isala /ID# 158653

City

Zwolle

ZIP/Postal Code

8025 AB

Country

Netherlands

Facility Name

Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 160537

City

Rzeszów

State/Province

Podkarpackie

ZIP/Postal Code

35-021

Country

Poland

Facility Name

Copernicus PL Sp. z o. o., WCO /ID# 160538

City

Gdansk

ZIP/Postal Code

80-219

Country

Poland

Facility Name

Szpitale Pomorskie Sp. z o.o /ID# 160536

City

Gdynia

ZIP/Postal Code

81-519

Country

Poland

Facility Name

Centro Hospitalar Lisboa Norte, EPE /ID# 158687

City

Lisbon

State/Province

Lisboa

ZIP/Postal Code

1769-001

Country

Portugal

Facility Name

IPO Lisboa FG, EPE /ID# 158995

City

Lisboa

ZIP/Postal Code

1099-023

Country

Portugal

Facility Name

Hospital da Luz, SA /ID# 158996

City

Lisbon

ZIP/Postal Code

1500-650

Country

Portugal

Facility Name

Unidade Local Saude Matosinhos /ID# 158682

City

Matosinhos

ZIP/Postal Code

4464-513

Country

Portugal

Facility Name

Hospital CUF Porto /ID# 158685

City

Porto

ZIP/Postal Code

4100-180

Country

Portugal

Facility Name

IPO Porto FG, EPE /ID# 158686

City

Porto

ZIP/Postal Code

4200-072

Country

Portugal

Facility Name

S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 160847

City

Craiova

State/Province

Dolj

ZIP/Postal Code

200347

Country

Romania

Facility Name

Oncocenter Oncologie Clinica S /ID# 160848

City

Timisoara

State/Province

Timis

ZIP/Postal Code

300166

Country

Romania

Facility Name

Spitalul Judetean de Urgenta A /ID# 160846

City

Alba

ZIP/Postal Code

510077

Country

Romania

Facility Name

National Medical Research Cntr /ID# 207436

City

Moscow

State/Province

Moskovskaya Oblast

ZIP/Postal Code

115478

Country

Russian Federation

Facility Name

LLC Novaya Klinika /ID# 205539

City

Pyatigorsk

State/Province

Stavropol Skiy Kray

ZIP/Postal Code

357500

Country

Russian Federation

Facility Name

Arkhangelsk clinical oncology /ID# 159309

City

Arkhangelsk

ZIP/Postal Code

163045

Country

Russian Federation

Facility Name

Kaluga Regional Clinical Oncol /ID# 160179

City

Kaluga

ZIP/Postal Code

284007

Country

Russian Federation

Facility Name

Clinical Onco Dispensary /ID# 159307

City

Omsk

ZIP/Postal Code

644013

Country

Russian Federation

Facility Name

PMI Euromedservice /ID# 159311

City

Pushkin

ZIP/Postal Code

196603

Country

Russian Federation

Facility Name

Smolensk Regional Onc Clin Dis /ID# 159314

City

Smolensk

ZIP/Postal Code

214009

Country

Russian Federation

Facility Name

LLC BioEq Ltd. /ID# 159310

City

St. Petersburg

ZIP/Postal Code

197342

Country

Russian Federation

Facility Name

N.N. Petrov Research Inst Onc /ID# 159312

City

St. Petersburg

ZIP/Postal Code

197758

Country

Russian Federation

Facility Name

Clinical Center of Nis /ID# 160059

City

NIS

State/Province

Nisavski Okrug

ZIP/Postal Code

18000

Country

Serbia

Facility Name

Institut za onkologiju i radio /ID# 160058

City

Belgrade

ZIP/Postal Code

11000

Country

Serbia

Facility Name

Klinicki centar Srbije /ID# 160024

City

Belgrade

ZIP/Postal Code

11000

Country

Serbia

Facility Name

Institute For Pulmonary Diseas /ID# 158813

City

Sremska Kamenica

ZIP/Postal Code

21204

Country

Serbia

Facility Name

National University Hospital /ID# 158802

City

Singapore

ZIP/Postal Code

119074

Country

Singapore

Facility Name

National Cancer Ctr Singapore /ID# 158803

City

Singapore

ZIP/Postal Code

169610

Country

Singapore

Facility Name

Hospital Clinic /ID# 159031

City

Barcelona

ZIP/Postal Code

08036

Country

Spain

Facility Name

Hospital Santa Creu i Sant Pau /ID# 159028

City

Barcelona

ZIP/Postal Code

08041

Country

Spain

Facility Name

Hospital General Universitario Gregorio Maranon /ID# 159025

City

Madrid

ZIP/Postal Code

28007

Country

Spain

Facility Name

Hospital Universitario HM Sanchinarro /ID# 159024

City

Madrid

ZIP/Postal Code

28050

Country

Spain

Facility Name

Hospital Clinico Universitario de Valencia /ID# 159027

City

Valencia

ZIP/Postal Code

46010

Country

Spain

Facility Name

Sahlgrenska US Gbg /ID# 159534

City

Göteborg

State/Province

Vastra Gotalands Lan

ZIP/Postal Code

413 46

Country

Sweden

Facility Name

Uppsala University Hospital /ID# 159050

City

Uppsala

ZIP/Postal Code

75185

Country

Sweden

Facility Name

National Cheng Kung University Hospital /ID# 158844

City

Tainan City

State/Province

Tainan

ZIP/Postal Code

70403

Country

Taiwan

Facility Name

National Taiwan University Hospital /ID# 158865

City

Taipei City

State/Province

Taipei

ZIP/Postal Code

100

Country

Taiwan

Facility Name

Tri-Service General Hospital /ID# 158985

City

Taipei City

State/Province

Taipei

ZIP/Postal Code

11490

Country

Taiwan

Facility Name

Taichung Veterans General Hosp /ID# 158866

City

Taichung City

ZIP/Postal Code

40705

Country

Taiwan

Facility Name

Hacettepe University Medical Faculty /ID# 159238

City

Altindağ

State/Province

Ankara

ZIP/Postal Code

06250

Country

Turkey

Facility Name

Inonu Universitesi Turgut Ozal /ID# 159241

City

Battalgazi/malatya

ZIP/Postal Code

44280

Country

Turkey

Facility Name

Ege University Medical Faculty /ID# 159239

City

Izmir

ZIP/Postal Code

35040

Country

Turkey

Facility Name

Dr. Suat Seren Gogus Has /ID# 159240

City

Izmir

ZIP/Postal Code

35110

Country

Turkey

Facility Name

Ataturk Gogus Hastaliklari ve /ID# 160056

City

Kecioren/ankara

ZIP/Postal Code

06280

Country

Turkey

Facility Name

CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159122

City

Zaporizhzhia

State/Province

Zaporizka Oblast

ZIP/Postal Code

69040

Country

Ukraine

Facility Name

Municipal institution /ID# 159867

City

Chernivtsi

ZIP/Postal Code

58013

Country

Ukraine

Facility Name

Municipal institution Multifie /ID# 159121

City

Dnipro

ZIP/Postal Code

49102

Country

Ukraine

Facility Name

Regional Center of Oncology /ID# 159123

City

Kharkiv

ZIP/Postal Code

61070

Country

Ukraine

Facility Name

PE PMC Acinus, Medical and Diagnostic Center /ID# 159125

City

Kropyvnytskyi

ZIP/Postal Code

25006

Country

Ukraine

Facility Name

ME Kryviy Rih Oncology Dispensary /ID# 159119

City

Kryviy RIH

ZIP/Postal Code

50048

Country

Ukraine

Facility Name

Volyn Regional Medical Oncology Centre /ID# 159124

City

Lutsk

ZIP/Postal Code

43018

Country

Ukraine

Facility Name

Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159868

City

Uzhhorod

ZIP/Postal Code

88000

Country

Ukraine

Facility Name

Guy's and St Thomas' NHS Found /ID# 159581

City

London

State/Province

London, City Of

ZIP/Postal Code

SE1 9RT

Country

United Kingdom

Facility Name

United Lincolnshire Hospitals /ID# 159579

City

Boston

ZIP/Postal Code

PE21 9QS

Country

United Kingdom

Facility Name

Charing Cross Hospital /ID# 159582

City

London

ZIP/Postal Code

W6 8RF

Country

United Kingdom

Facility Name

Christie NHS Foundation Trust /ID# 159099

City

Manchester

ZIP/Postal Code

M20 4BX

Country

United Kingdom

Facility Name

James Cook University Hospital /ID# 159583

City

Middlesborough

ZIP/Postal Code

TS4 3BW

Country

United Kingdom

Facility Name

Royal Preston Hospital /ID# 159578

City

Preston

ZIP/Postal Code

PR2 9HT

Country

United Kingdom

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

IPD Sharing Time Frame

Data requests can be submitted at any time and the data will be accessible for 12 months, with possible extensions considered.

IPD Sharing Access Criteria

Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Sharing Agreement (DSA). For more information on the process, or to submit a request, visit the following link.

IPD Sharing URL

https://www.abbvie.com/our-science/clinical-trials/clinical-trials-data-and-information-sharing/data-and-information-sharing-with-qualified-researchers.html

Citations:

PubMed Identifier

31506387

Citation

Morgensztern D, Besse B, Greillier L, Santana-Davila R, Ready N, Hann CL, Glisson BS, Farago AF, Dowlati A, Rudin CM, Le Moulec S, Lally S, Yalamanchili S, Wolf J, Govindan R, Carbone DP. Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study. Clin Cancer Res. 2019 Dec 1;25(23):6958-6966. doi: 10.1158/1078-0432.CCR-19-1133. Epub 2019 Sep 10.

Results Reference

background

PubMed Identifier

29290251

Citation

Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, Nakanishi Y, Okamoto I. Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. Lung Cancer. 2018 Jan;115:116-120. doi: 10.1016/j.lungcan.2017.11.018. Epub 2017 Nov 22.

Results Reference

derived

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