Support for Perinatal Adherence and Depression (INSPireD)
Human Immunodeficiency Virus, Depression
About this trial
This is an interventional treatment trial for Human Immunodeficiency Virus focused on measuring HIV, Medication adherence, PMTCT, Depression
Eligibility Criteria
Inclusion Criteria:
- Currently pregnant
- HIV-infected and diagnosed with HIV during the index pregnancy
- Meet criteria for a major depressive episode
- Currently on antiretroviral therapy
- Receiving antenatal care at PMMH Gateway clinic
- Primary language English or isiZulu
- Access to a phone and willing to give researchers permission to reach them via phone
- Resident of Umlazi
Exclusion Criteria:
- Unable or unwilling to provide informed consent
- Active untreated, major mental illness (untreated psychosis, bipolar disorder, dementia, or active suicidality) that would interfere with study participation
- Less than 18 years of age
Sites / Locations
- Massachusetts General Hospital
- MatCH Research
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Intervention: INSPireD
Treatment-as-usual + abbreviated intervention
This 5-8 session group intervention, "Integrating Nuanced Support for Perinatal adherence and Depression", aimed to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women. Intervention content was based on two established cognitive-behavioral interventions: problem-solving therapy and Cognitive Behavioral Therapy for Adherence and Depression.
This group received treatment-as usual, plus the option of completing an abbreviated version of the intervention (one session of problem-solving related to adherence and mental health) at the conclusion of study.