Blood Pressure During ESD is Related With the Postoperative Bleeding
Gastrointestinal Disease, Gastrointestinal Bleeding
About this trial
This is an interventional prevention trial for Gastrointestinal Disease focused on measuring endoscopic submucosal dissection, postoperation bleeding
Eligibility Criteria
Inclusion Criteria:
- A. The indications for ESD for gastric neoplasms, such as intramucosal gastric cancer and adenoma, include intramucosal differentiated tubular adenocarcinoma of any size without ulceration or signs of submucosal invasion and intramucosal differentiated-type adenocarcinoma of less than 3 cm with an ulcer scar. The histology, tumor location, and depth of invasion fulfilled the criteria of the Japanese Research Society for Gastric Cancer.
B. The eligible patients' blood coagulation function should be normal without any associated medicine influenced.
Exclusion Criteria:
- A. Previously treated by radical gastrectomy. B. Pregnant or on breast feeding. C. Patients who are unwilling or unable to provide informed consent, such as those with psychiatric problem, drug abuse or alcoholism.
D. Coagulopathy: liver cirrhosis, thrombocytopenia. E. Anti-platelet agents. Allergic to PPI or norepinephrine. F. Patients with sever hypertension(systolic pressure>180mmHg), or the hypotensor cann't control blood pressure suitably.
G. Patients with cardiovascular and cerebrovascular events within 6 months.
Sites / Locations
- Zhongshan HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Increasing blood pressure
Control group
Using norepinephrine pump as the initial dose is 0.05μg/Kg.min to increase the patient's blood pressure up to about 150 mmHg for 5 min during ESD.
Patients received normal ESD manipulation.