Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome
Moyamoya Disease, Remote Ischemic Preconditioning
About this trial
This is an interventional prevention trial for Moyamoya Disease
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiologists
- Adults 18 to 65 years of age
- In patients with planned MCA-STA anastomosis under general anesthesia
- Patients who pre-agreed to the study
Exclusion Criteria:
- If there is a history of peripheral vascular arterial or venous disease
- If there is a previous history of peripheral nerve disease
- Other brain or cerebrovascular disease
- In case of serious cardiovascular disease, pulmonary disease, kidney disease
- Patients who do not agree with the test
Sites / Locations
- Seoul National Univ. Bundang Hospita
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
The control group
RIPC with RIPostC group
The control group has a sphygmomanometer wound around the upper arm or lower extremity and applies the same pressure, but a 3-way stopcock is installed in the middle so that no pressure is applied.
The sphygmomanometer is closed to the lower limb and the cuff is inflated and the pressure is increased by 30 mmHg higher than the systolic blood pressure of each patient for 5 minutes. The loss of the distal pulse is confirmed by Doppler in the dorsalis pedis pulse. If there is a pulse, increase the pressure until it disappears. After 5 minutes of ischemia time, the cuff is deflated to confirm that the pulse has returned and has a reperfusion time of 5 minutes. A total of 4 cycles of 5 cycles of ischemic time and 5 minutes of reperfusion time are performed. (Estimated total 40 minutes) When the skull is started to close, RIpc with RIPostC group performs RpostC and the method is the same as the above RIPC method. (Estimated total 40 minutes)