Pericardial Resection to Treat Heart Failure
Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure
Eligibility Criteria
Inclusion
- >17 years old
- Subjects having open sternotomy for either aortic valve stenosis or coronary artery bypass grafting (or both)
- Provide informed consent Exclusion
- <18 years old
Sites / Locations
- Mayo Clinic in Rochester
Arms of the Study
Arm 1
Experimental
Heart Failure Patients
After obtaining written informed consent, patients will undergo induction with general anesthesia as per clinical practice. The chest will be open but pericardium left intact. Cardiac hemodynamics will be measured using PA catheter already in place at rest, and then during conditions of increased cardiac preload, induced by passive leg elevation and saline bolus (300 ml administered over 1-2 minutes). The surgical team will perform anterior pericardiotomy. This will not be a complete pericardiectomy but rather a limited anterior incision to gain access to the heart for surgical exposure. The surgical team will then repeat hemodynamic assessments at rest and with acute volume loading (leg raise + saline) in exactly the same manner as with the pericardium intact.