Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea
Obstructive Sleep Apnoea, Central Sleep Apnoea, Cheyne Stokes Respiration
About this trial
This is an interventional diagnostic trial for Obstructive Sleep Apnoea focused on measuring Sleep-Disordered Breathing, Heart Failure, Leg Fluid Shift
Eligibility Criteria
Inclusion Criteria:
- Chronic Heart Failure
- reduced left ventricular ejection fraction (LVEF) ≤ 45%
- NYHA I - IV
Exclusion Criteria:
- current existing sleep apnoea breathing therapy
- significant chronic obstructive pulmonary disease (COPD) Tiffenau-Index: <70%
- respiratory insufficiency with need for a long time oxygen therapy
- hypercapnic state in rest at day time
- acute myocardial infarction at moment of study
- instable angina pectoris at moment of study
- cardiac surgery in last twelve weeks
- stroke or TIA in last twelve weeks
- implantable cardioverter-defibrillator, if there is no security clearance of the fabricator
- chronic kidney disease > Stage III
Sites / Locations
- Heart - and Diabetes CenteHerz- und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Study Group Basic
Study Group Extended
Patients receive Multi Frequency Bioimpedance Analysis (mfBIA) before and after sleep recording by Polysomnography/Polygraphy (PSG/PG) in hospital. Capillary Blood Gas Analysis (CBGA) is performed before and after sleep according to mfBIA.
Patients receive Multi Frequency Bioimpedance Analysis (mfBIA) before and after sleep recording by Polysomnography/Polygraphy (PSG/PG) in hospital. Capillary Blood Gas Analysis (CBGA) is performed before and after sleep according to mfBIA. Additionally, during daytime a special test with random parts of the study group basic is performed: A tilting table with hemodynamic monitoring is used to induce an artificial LFS by moving patients from vertical into horizontal position. Bodyfluid changes are monitored by mfBIA during this procedure.