Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
Knee Osteoarthritis
About this trial
This is an interventional basic science trial for Knee Osteoarthritis focused on measuring Clinical Trial, Phase II
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of knee osteoarthritis
- Urine sample tests negative for common illicit substances of abuse (e.g., cannabis)
- Medically cleared to take study medications
- Are not pregnant or breast feeding
- Willing to comply with the study protocol.
Exclusion Criteria:
- Pain other than Knee Osteoarthritis
- Taking opioids for pain
- Prescribed and taking gabapentinoid, Tricyclic Antidepressants (TCA), venlafaxine, duloxetine, stimulants or benzodiazepines
- Presence of any clinically significant medical/psychiatric illness judged by the investigators to put subject at elevated risk for experiencing an adverse event
- Known allergy to the blinded study medications
Sites / Locations
- Johns HopkinsRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Arm 1
Arm 2
Arm 3
Arm 4
Blinded study medication. This is a within-subject study so all session procedures will be identical. The specific medications administered that study day will be the only change each session. Study days will last approximately 8 hours and will be conducted on an outpatient basis. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.