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A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

Primary Purpose

Crohn's Disease

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
placebo for risankizumab
risankizumab IV
risankizumab SC
Sponsored by
AbbVie
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Crohn's Disease focused on measuring Crohn's Disease (CD), Risankizumab, ABBV-066, BI 655066

Eligibility Criteria

16 Years - 80 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Male or female aged >=18 to <= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to < 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
  • Diagnosis of CD for at least 3 months prior to Baseline.
  • Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD).
  • Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD.
  • If female, participant must meet the contraception recommendations.

Exclusion Criteria:

  • Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
  • Participants with unstable doses of concomitant Crohn's disease therapy.
  • Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within 35 days or 5 half-lives prior to Baseline, whichever is longer.
  • Prior exposure to p19 inhibitors (e.g., risankizumab).
  • Complications of Crohn's disease.
  • Having an ostomy or ileoanal pouch.
  • Known active Coronavirus Disease 2019 (COVID-19) infection.

Sites / Locations

  • Phoenix VA Health Care System /ID# 162267
  • HonorHealth Research Institute - Shea /ID# 161783
  • Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211883
  • University of Arizona /ID# 158469
  • Atria Clinical Research /ID# 164740
  • Newport Huntington Medica /ID# 213033
  • United Medical Doctors /ID# 207040
  • TLC Clinical Research Inc /ID# 212503
  • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162656
  • United Medical Doctors - Murrieta /ID# 158424
  • Southern CA Research Ctr., Inc /ID# 167875
  • University of California, San Francisco /ID# 157143
  • Cedars-Sinai Medical Center-West Hollywood /ID# 163842
  • Peak Gastroenterology Associates, PC /ID# 165834
  • Rocky Mountain Pediatric Gastroenterology /ID# 207169
  • Western Connecticut Medical Group /ID# 165849
  • Seffner Premier Health Care, PA /ID# 162265
  • Clinical Research of West Florida, Inc /ID# 204859
  • Clinical Research of West Florida, Inc /ID# 207450
  • South Lake Pain Institute, Inc /ID# 162825
  • Universal Axon Clinical Research /ID# 165432
  • Nature Coast Clinical Research - Inverness /ID# 159414
  • SIH Research Mumtaz, Inc /ID# 163082
  • Alliance Medical Research /ID# 163840
  • Cfagi Llc /Id# 201571
  • Vista Health Research, LLC /ID# 212664
  • ITB Research /ID# 161334
  • Coral Research Clinic /ID# 158549
  • South Florida Research Ph I-IV, Inc. /ID# 161836
  • Gastroenterology Group Naples /ID# 165206
  • Advanced Research Institute, Inc /ID# 161959
  • Endoscopic Research, Inc. /ID# 205901
  • Omega Research Maitland, LLC /ID# 171081
  • IMIC Inc. Medical Research /ID# 154943
  • Clinical Research Trials of Florida, Inc. /ID# 201014
  • Gastroenterology Associates of Central Georgia, LLC /ID# 154857
  • Northwestern University Division of GI/Hepatology /ID# 158283
  • The University of Chicago Medical Center /ID# 157141
  • NorthShore University HealthSystem /ID# 158287
  • Southwest Gastroenterology /ID# 165002
  • Cotton-O'Neil Clinical Res Ctr /ID# 154738
  • University of Kentucky Chandler Medical Center /ID# 157137
  • University of Louisville /ID# 210521
  • Gastroenterology Associates LLC - Jefferson Hwy /ID# 161956
  • Houma Digestive Health Special /ID# 158286
  • Delricht Research /ID# 206542
  • Nola Research Works, LLC /ID# 161330
  • Louisana Research Center, LLC /ID# 162236
  • MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154839
  • Gastro Center of Maryland /ID# 165004
  • University of Michigan Health Systems /ID# 157144
  • Center for Digestive Health /ID# 154690
  • Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161328
  • Mayo Clinic - Rochester /ID# 163085
  • Southern Therapy and Advanced Research (STAR) LLC /ID# 162388
  • St. Louis University /ID# 161902
  • University of Nebraska Medical Center /ID# 210057
  • Las Vegas Medical Research /ID# 160172
  • Revival Research Institute, Inc /ID# 210984
  • NY Scientific /ID# 158418
  • Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 212036
  • Intercity Advanced Gastroentertology Center /ID# 213399
  • Duplicate_Long Island Clinical Research /ID# 154836
  • Digestive Disease Care /ID# 209619
  • North Shore University Hospital /ID# 168736
  • NYU Langone Medical Center /ID# 160171
  • Columbia Univ Medical Center /ID# 161911
  • Lenox Hill Hospital /ID# 168465
  • DiGiovanna Institute for Medical Education & Research /ID# 171118
  • Univ NC Chapel Hill /ID# 154840
  • Atrium Health Carolinas Medical Center /ID# 158481
  • Clinical Trials America /ID# 158484
  • Vidant Multispecialty Clinic - Kinston /ID# 161111
  • Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154880
  • Plains Clinical Research Center, LLC /ID# 169715
  • Tri-State Endoscopy /ID# 154933
  • Cleveland Clinic Main Campus /ID# 208171
  • The Ohio State University /ID# 164709
  • Optimed Research, Ltd. /ID# 167901
  • Hometown Urgent Care and Resea /ID# 170453
  • Great Lakes Medical Research, LLC /ID# 201732
  • Hightower Clinical /ID# 211938
  • Digestive Disease Specialists /ID# 170774
  • Adult Gastroenterology Associates - Gen 1 Research /ID# 206125
  • Northwest Gastroenterology Clinic /ID# 158288
  • PennState Milton S.Hershey Med /ID# 154883
  • Children's Hospital of Pittsburgh of UPMC /ID# 210920
  • Digestive Disease Associates, LTD /ID# 208847
  • Medical University of South Carolina /ID# 212579
  • Gastroenterology Associates, P.A. of Greenville /ID# 154911
  • Rapid City Medical Center - GI Research /ID# 163841
  • Gastro One /ID# 154742
  • East Tennessee Research Institute /ID# 168737
  • Duplicate_Clinical Neuroscience Solutions /ID# 164181
  • Vanderbilt University Medical Center /ID# 157138
  • TX Clinical Research Institute /ID# 159410
  • Inquest Clinical Research /ID# 165695
  • Texas Digestive Disease Consultants /ID# 209596
  • Texas Digestive Disease Consultants /ID# 209785
  • Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 201848
  • DHAT Research Institute /ID# 158217
  • Vilo Research Group Inc /ID# 206130
  • CliniCore International, LLC /ID# 158209
  • Baylor College of Medicine - Baylor Medical Center /ID# 158212
  • Precision Research Institute, LLC /ID# 200503
  • Centex Studies, Inc. - Houston /ID# 200720
  • Clinical Associates in Research Therapeutics of America, LLC /ID# 161336
  • Southern Star Research Institute, LLC /ID# 168770
  • Tyler Research Institute, LLC /ID# 166796
  • Gastro Health & Nutrition - Victoria /ID# 164296
  • HP Clinical Research /ID# 162998
  • Advanced Research Institute /ID# 154914
  • Velocity Clinical Research - Salt Lake City /ID# 161781
  • McGuire DV AMC /ID# 159990
  • Washington Gastroenterology Associates /ID# 162120
  • Virginia Mason - Seattle Orthapedics /ID# 155545
  • WVU Medicine /ID# 167940
  • Duplicate_HOSPITAL CENTENARIO /ID# 170883
  • Hospital Privado Univesitario /ID# 161988
  • Duplicate_Mater Hospital /ID# 167990
  • Griffith University /ID# 212627
  • Lyell McEwin Hospital /ID# 211363
  • Emeritus Research /ID# 213511
  • Footscray Hospital /ID# 211361
  • Universitaetsklinikum St. Poelten /ID# 166425
  • Medizinische Universitaet Graz /ID# 158137
  • Krankenhaus der Barmherzigen Brueder Wien /ID# 212059
  • Duplicate_Medical University of Vienna /ID# 158138
  • Gomel Regional Clinical Hospital /ID# 159498
  • Grodno city clinical hospital #2 /ID# 159499
  • Vitebsk Regional Advanced Clin /ID# 159497
  • ULB Hospital Erasme /ID# 157397
  • UCL Saint-Luc /ID# 157395
  • CHU UCL Namur - site Godinne /ID# 157401
  • UZ Gent /ID# 157394
  • Universitair Ziekenhuis Leuven /ID# 157396
  • Imelda Ziekenhuis /ID# 157392
  • CHU de Liege /ID# 157398
  • Groupe Sante CHC - Clinique du MontLegia /ID# 157393
  • AZ-Delta /ID# 157391
  • University Clinical Centre of the Republic of Srpska /ID# 157717
  • University Clinical Centre of the Republic of Srpska /ID# 164512
  • Clinical Center University of Sarajevo /ID# 165134
  • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157672
  • Hospital Nossa Senhora das Graças /ID# 157646
  • Hospital de Clinicas de Porto Alegre /ID# 157653
  • Upeclin Fmb - Unesp /Id# 157688
  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157649
  • Faculdade de Medicina do ABC /ID# 159672
  • Kaiser Clinica e Hospital Dia /ID# 157656
  • UMHAT Dr Georgi Stranski EAD /ID# 203977
  • University Multiprofile Hospit /ID# 158644
  • Second Multiprofile Hospital f /ID# 158646
  • Duplicate_Tokuda Hospital Sofia /ID# 158645
  • UMHAT Sveti Ivan Rilski /ID# 204714
  • UMHAT Tsaritsa Joanna - ISUL /ID# 211240
  • MHAT Trakia /ID# 201672
  • University Multiprofile Hospit /ID# 167575
  • University of Calgary - Heritage Medical Research Clinic /ID# 157152
  • Allen Whey Khye Lim Professional Corporation /ID# 169761
  • University of Alberta - Zeidler Ledcor Centre /ID# 157098
  • Covenant Health /ID# 161617
  • Fraser Clinical Trials Inc /ID# 159053
  • GIRI Gastrointestinal Research Institute /ID# 157095
  • Percuro Clinical Research, Ltd /ID# 161616
  • QEII - Health Sciences Centre /ID# 157087
  • IWK Health Center /ID# 165900
  • London Health Sciences Center /ID# 157160
  • Scott Shulman Medicine Professional Corporation /ID# 165903
  • Medicor Research Inc /ID# 157149
  • Mount Sinai Hospital /ID# 169762
  • Toronto Digestive Disease Asso /ID# 157157
  • CISSS de la Monteregie /ID# 161615
  • CHAU- Hotel-Dieu de Levis /ID# 214375
  • CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159054
  • CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167066
  • Montreal General Hospital - McGill University Health Center /ID# 157084
  • Complejo Asistencial Dr. Sotero del Rio /ID# 169382
  • Centro de Investigaciones Clínicas Viña del Mar /ID# 203589
  • Hospital Guillermo Grant Benavente de Concepción /ID# 210759
  • Hospital Las Higueras /ID# 167090
  • Guangdong Provincial People's Hospital /ID# 212948
  • The Sixth Affiliated Hosp Sun /ID# 210785
  • The Second Hospital of Hebei Medical University /ID# 212740
  • Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210856
  • Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211038
  • Renmin Hospital of Wuhan University /ID# 214873
  • The First Affiliated Hospital of Nanchang University /ID# 211034
  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210841
  • Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210707
  • The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210725
  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210624
  • Jinhua Municipal Central Hospital /ID# 215626
  • The Second Hospital Central South University /ID# 211696
  • West China Hospital, Sichuan University /ID# 210889
  • Shanghai East Hospital /ID# 212683
  • Tianjin Medical University General Hospital /ID# 210927
  • Instituto de Coloproctologia /ID# 158741
  • Hospital Pablo Tobon Uribe /ID# 158735
  • Hospital Univ San Ignacio /ID# 158733
  • Hospital Universitario San Vic /ID# 171487
  • Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157565
  • Klinicki bolnicki centar Sestre milosrdnice /ID# 157721
  • Klinicki bolnicki centar Zagreb /ID# 157566
  • UHC Osijek /ID# 157564
  • Klinicki bolnicki centar Split /ID# 157567
  • Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165463
  • Hepato-Gastroenterologie HK, s.r.o. /ID# 163134
  • CTCenter MaVe s.r.o. /ID# 163149
  • Nemocnice Pardubickeho kraje, a.s. /ID# 163182
  • Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211305
  • Axon Clinical, s.r.o. /ID# 163176
  • Thomayerova nemocnice /ID# 162940
  • ResTrial s.r.o. /ID# 211075
  • NH Hospital a.s. /ID# 211076
  • East Tallinn Central Hospital /ID# 157076
  • West Tallinn Central Hospital /ID# 157077
  • North Estonia Medical Centre /ID# 163507
  • Universitaetsklinikum Freiburg /ID# 162019
  • Praxis fuer Gastroenterologie /ID# 166145
  • Universitatsklinikum Mannheim /ID# 162020
  • Universitaetsklinikum Tuebingen /ID# 159324
  • Universitaetsklinikum Ulm /ID# 164986
  • Universitaetsklinikum Erlangen /ID# 159315
  • Universitaetsklinikum Frankfurt /ID# 212978
  • Evangelisches Krankenhaus Kalk /ID# 212725
  • Praxiszentrum fuer Gastroenterologie /ID# 211964
  • Universitaetsklinikum Koeln /ID# 164985
  • Universitaetsklinikum Muenster /ID# 159316
  • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210529
  • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159321
  • Universitaetsklinikum Jena /ID# 159323
  • Krankenhaus Waldfriede /ID# 212728
  • Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212219
  • Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212893
  • Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211972
  • MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159322
  • DRK Kliniken Berlin Westend /ID# 166146
  • Stadtisches Klinikum Braunschweig /ID# 163666
  • Medizinisches Versorgunszentrum Dachau /ID# 211557
  • Agaplesion Markus Krankenhaus /ID# 159317
  • Asklepios Westklinikum Hamburg /ID# 159319
  • Medizinische Hochschule Hannover /ID# 162021
  • EUGASTRO GmbH /ID# 212076
  • Klinikum Lueneburg /ID# 163664
  • Universitaetsklinikum Magdeburg /ID# 211847
  • Gastroenterologische Gemeinschaftspraxis Minden /ID# 162018
  • Universitaetsklinikum Regensburg /ID# 163665
  • Duplicate_Gastro-Praxis Wiesbaden /ID# 159318
  • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 171077
  • Tzaneio general hospital of Piraeus /ID# 206445
  • University General Hospital of Heraklion PA.G.N.I /ID# 157427
  • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157428
  • University General Hospital of Ioannina /ID# 157425
  • General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157429
  • Theageneio Anticancer Hospital /ID# 163921
  • Queen Mary Hospital /ID# 163902
  • Tuen Mun Hospital /ID# 163901
  • Beaumont Hospital /ID# 157515
  • St Vincent's University Hospital /ID# 157512
  • University Hospital Galway /ID# 157513
  • Soroka University Medical Center /ID# 157798
  • Sheba Medical Center /ID# 157797
  • Sheba Medical Center /ID# 171074
  • Tel Aviv Sourasky Medical Center /ID# 157796
  • Duplicate_Rambam Medical Center /ID# 171072
  • The Edith Wolfson Medical Center /ID# 217329
  • Shaare Zedek Medical Center /ID# 163540
  • Shaare Zedek Medical Center /ID# 171073
  • Hadassah Medical Center-Hebrew University /ID# 165913
  • Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162427
  • University of Catanzaro /ID# 212012
  • Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212019
  • Policlinico Universitario Campus Bio-Medico /ID# 162429
  • Azienda Ospedaliera San Camillo Forlanini /ID# 155636
  • Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166911
  • Istituto Clinico Humanitas /ID# 155634
  • Fondazione PTV Policlinico Tor Vergata /ID# 158021
  • Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155632
  • Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168051
  • IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161305
  • A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155635
  • A.O. Per L'Emergenza Cannizzaro /ID# 161306
  • Ospedale Policlinico San Martino /ID# 162430
  • ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155631
  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155633
  • A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155637
  • Duplicate_Fondazione IRCCS Policlinico San Matteo /ID# 212029
  • Aichi Medical University Hospital /ID# 160159
  • Nagoya City University Hospital /ID# 160162
  • Daido Clinic /ID# 211477
  • Nagoya University Hospital /ID# 160150
  • Fujita Health University Hospital /ID# 163214
  • Tokatsu Tsujinaka Hospital /ID# 163362
  • Chiba University Hospital /ID# 217532
  • Tsujinaka Hospital Kashiwanoha /ID# 213847
  • The Jikei University Kashiwa Hospital /ID# 200007
  • Toho University Sakura Medical Center /ID# 160161
  • Fukuoka University Hospital /ID# 217792
  • Kurume University Hospital /ID# 160138
  • NHO Fukuyama Medical Center /ID# 163578
  • Hiroshima University Hospital /ID# 160139
  • Asahikawa Medical University Hospital /ID# 162844
  • Sapporo Tokushukai Hospital /ID# 213493
  • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160158
  • Sapporo Medical University Hospital /ID# 163028
  • Nishinomiya Munic Central Hospital /ID# 210104
  • Hyogo College of Medicine College Hospital /Id# 160164
  • National Hospital Organization Mito Medical Center /ID# 160154
  • Kanazawa University Hospital /ID# 201766
  • Gokeikai Ofuna Chuo Hospital /ID# 171070
  • Kitasato University Hospital /ID# 171071
  • Yokohama City University Medical Center /ID# 163906
  • Yokohama Municipal Citizen's Hospital /ID# 204126
  • Mie University Hospital /ID# 203639
  • Yokkaichi Hazu Medical Center /ID# 163741
  • Tohoku University Hospital /ID# 162843
  • Duplicate_Tohoku Rosai Hospital /ID# 163189
  • Osaka City University Hospital /ID# 160146
  • Saitama Medical Center /ID# 160155
  • Tokitokai Tokito clinic /ID# 160145
  • Shiga University of Medical Science Hospital /ID# 164022
  • Hamamatsu University Hospital /ID# 205689
  • NHO Shizuoka Medical Center /ID# 163029
  • Tokyo Medical And Dental University, Medical Hospital /ID# 160157
  • Duplicate_Tokai University Hachioji Hospital /ID# 160160
  • The Jikei University Hospital /ID# 163190
  • Duplicate_Kitasato University Kitasato Institute Hospital /ID# 160144
  • Kyorin University Hospital /ID# 160149
  • Tokyo Women's Medical University Hospital /ID# 205973
  • Wakayama Medical University Hospital /ID# 200183
  • Yamagata University Hospital /ID# 200154
  • Yamanashi Prefectural Central Hospital /ID# 160156
  • Hanyang University Guri Hospital /ID# 158673
  • Duplicate_CHA bundang medical center CHA University /ID# 158672
  • Duplicate_The Catholic University of Korea, ST. Vincent's Hospital /ID# 158681
  • Kangbuk Samsung Hospital /ID# 158676
  • Severance Hospital /ID# 158671
  • Dong-A University Hospital /ID# 158675
  • Pusan National University Hospital /ID# 158677
  • Yeungnam University Medical Center /ID# 158680
  • The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213552
  • Asan Medical Center /ID# 158678
  • Samsung Medical Center /ID# 158674
  • Pauls Stradins Clinical University Hospital /ID# 159614
  • Digestive Disease Center Gastro /ID# 163105
  • Riga East Clinical University Hospital /ID# 159613
  • Duplicate_Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162582
  • Duplicate_Vilnius University Hospital /ID# 162507
  • Queen Elizabeth Hospital /ID# 160654
  • Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 163654
  • Universiti Sains Malaysia /ID# 160656
  • Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 167648
  • JM Research SC /ID# 161733
  • Unidad de Atencion Medica e Investigacion en Salud /ID# 163624
  • Health Pharma Professional Research S.A de C.V /ID# 161734
  • Academisch Medisch Centrum /ID# 157950
  • Elisabeth Tweesteden Ziekenhuis /ID# 163631
  • Christchurch Hospital /ID# 163074
  • Dunedin Hospital /ID# 167989
  • Wellington Regional Hospital /ID# 167987
  • Akershus universitetssykehus /ID# 169378
  • Vestre viken - Baerum Sykehus /ID# 157886
  • Sykehuset Levanger Helse NT /ID# 157885
  • Helse More og Romsdal HF, Alesund sjukehus /ID# 212811
  • Planetmed Sp. z o.o. /ID# 202798
  • Gastromed /Id# 212099
  • Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212297
  • 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209985
  • Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209981
  • Centrum Zdrowia MDM /ID# 160794
  • Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 160797
  • Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213579
  • Centrum Medyczne Medyk /ID# 212889
  • Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212081
  • H-T. Centrum Medyczne - Endoterapia /ID# 212459
  • Wojewodzki Szpital Specjalistyczny /ID# 212402
  • Duplicate_SOLUMED Sp. z o.o., Sp.k. /ID# 160793
  • Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 205160
  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212602
  • Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160739
  • Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167750
  • Centro Hospitalar de Entre Douro e Vouga /ID# 160674
  • Hospital Garcia de Orta, EPE /ID# 160747
  • Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160715
  • Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160675
  • Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167749
  • Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160694
  • Hospital Beatriz Ângelo /ID# 207757
  • Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160695
  • Centro Hosp de Tondela-Viseu /ID# 160697
  • Institutul Clinic Fundeni /ID# 163046
  • Institutul Clinic Fundeni /ID# 163264
  • Tvm Med Serv Srl /Id# 166294
  • Duplicate_Centrul Medical Tuculanu SRL /ID# 166295
  • Cabinet Particular Policlinic Algomed /ID# 163047
  • Kuzbass Regional Clinical Hospital /ID# 161310
  • Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207440
  • Duplicate_St. Petersburg State Pediatric Medical University /ID# 211977
  • Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 156949
  • Tver Regional Clinical Hospital /ID# 205925
  • Regional Clinical Hospital #1 /ID# 163453
  • Alliance Biomedical Ural Group /ID# 156950
  • State Scientific Ctr Coloproct /ID# 204809
  • Novosibirski Gastrocenter /ID# 217554
  • City Clinical Hospital No. 31 /ID# 208866
  • Duplicate_Ulyanovsk State clinical hospi /ID# 156946
  • Clinical Hosp Center Zvezdara /ID# 156978
  • Military Medical Academy /ID# 156979
  • University Clinical Center Serbia /ID# 156973
  • Clin Hosp Ctr Bezanijska Kosa /ID# 156976
  • University Clinical Center Kragujevac /ID# 156975
  • Clinical Center Vojvodina /ID# 156972
  • University Children's Hospital 'Tirsova' /ID# 211481
  • Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212797
  • General Hospital Leskovac /ID# 209574
  • National University Hospital /ID# 160658
  • Singapore General Hospital /ID# 160657
  • KL Ling Gastroenterology and Liver Clinic /ID# 205737
  • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156465
  • Univerzitna nemocnica Martin /ID# 163200
  • KM Management, spol. s.r.o. /ID# 206763
  • GASTRO I., s.r.o. /ID# 156466
  • Clinresco Centers /ID# 163864
  • Wits Clinical Research Site /ID# 158115
  • Spoke Research Inc /ID# 158117
  • Kingsbury Hospital /ID# 163116
  • Private Practice Dr MN Rajabally /ID# 163115
  • Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157527
  • Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159230
  • Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157575
  • Hospital Universitario Basurto /ID# 205189
  • Hospital Clinic de Barcelona /ID# 157526
  • Hospital General Universitario Gregorio Maranon /ID# 161435
  • Hospital Universitario La Paz /ID# 159228
  • Hospital Clinico Universitario de Salamanca /ID# 157532
  • Hospital Universitario Virgen Macarena /ID# 160819
  • Hospital Universitario y Politecnico La Fe /ID# 157530
  • Hospital Clinico Universitario Lozano Blesa /ID# 212523
  • Hospital Universitario Miguel Servet /ID# 157531
  • Skane University hospital /ID# 211235
  • Duplicate_GHP Stockholm Gastro Center /ID# 210479
  • Ersta diakoni /ID# 157878
  • Danderyd Hospital /ID# 202136
  • Sahlgrenska University Hospital /ID# 157879
  • Duplicate_SU Molndal. /ID# 157880
  • Duplicate_Karolinska Univ Sjukhuset /ID# 209966
  • Universitätsspital Zürich /ID# 163532
  • Duplicate_Universitaetsspital Basel /ID# 164555
  • Inselspital, Universitätsspital Bern /ID# 163531
  • Scientific Research Institute of Invalid Rehabilitation /ID# 211516
  • Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165649
  • Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212050
  • International Institute of Clinical Research LLC /ID# 211997
  • Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165651
  • Medical Center of LLC Medbud-Clinic /ID# 216929
  • Kyiv Railway Clinical Hosp No.2 /ID# 217330
  • Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 206788
  • Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165650
  • Duplicate_Transcarpathian Regional Clin. /ID# 168419
  • MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216265
  • Kyiv Municipal Clinical Hospital #18 /ID# 162521
  • Royal Devon and Exeter NHS Trust Hospital /ID# 157517
  • Barts Health NHS Trust /ID# 163710
  • Guy's and St Thomas' NHS Foundation Trust /ID# 157519
  • Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207937
  • Cambridge University Hospitals NHS Foundation Trust /ID# 158031
  • NHS Lothian /ID# 207447
  • Calderdale and Huddersfield NHS Foundation Trust /ID# 209569
  • Hull University Teaching Hospitals NHS Trust /ID# 158757
  • Leeds Teaching Hospitals NHS Trust /ID# 157523
  • Duplicate_King's College Hospital NHS Foundation Trusts /ID# 158756
  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163709
  • Oxford University Hospitals NHS Foundation Trust /ID# 158033
  • Duplicate_Northern Care Alliance NHS Group /ID# 207764

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Experimental

Experimental

Placebo Comparator

Experimental

Experimental

Experimental

Arm Label

Risankizumab Dose 1 (Period 1)

Risankizumab Dose 2 (Period 1)

Placebo (Period 1)

Risankizumab Dose 1 (Period 2)

Risankizumab Dose 2 (Period 2)

Risankizumab Dose 3 (Period 2)

Arm Description

Participants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion.

Participants randomized to receive risankizumab dose 2 administered by intravenous (IV) infusion.

Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion.

Participants who received placebo in Period 1 and participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Period 2.

Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Period 2.

Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Period 2.

Outcomes

Primary Outcome Measures

US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
The CDAI consists of 8 components; 7 are based on participant diary entries, participant interviews, physical examinations, measurement of body weight and height and 1 is based on laboratory analysis. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
US Specific: Percentage of Participants With Endoscopic Response
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD > 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Global Outside of US: Percentage of Participants With Clinical Remission
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Global Outside of US: Percentage of Participants With Endoscopic Response
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD > 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).

Secondary Outcome Measures

US Specific: Percentage of Participants With Clinical Remission
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
US Specific: Percentage of Participants With CDAI Clinical Response and Endoscopic Response
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline. Endoscopic response was a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) > 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).
US Specific: Percentage of Participants With Stool Frequency (SF) Remission
Stool Frequency (SF) remission is defined as an average daily SF <= 2.8 and not worse than baseline.
US Specific: Percentage of Participants With Abdominal Pain (AP) Remission
The Abdominal Pain rating is an assessment that is graded from 0 to 3: 0= None, 1= Mild, 2= Moderate and 3= Severe. AP remission is defined as average daily AP score <= 1 and not worse than baseline.
US Specific: Percentage of Participants With Endoscopic Remission
Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
US Specific: Percentage of Participants With Enhanced Clinical Response
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
US Specific: Percentage of Participants With Ulcer-Free Endoscopy
Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
US Specific: Percentage of Participants With Enhanced Clinical Response
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
US Specific: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at
Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
US Specific: Percentage of Participants With CD-Related Hospitalization
Participants with at least one admission to the hospital due to Crohn's Disease.
US Specific: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
The CDAI consists of 8 components; 6 are based on participant diary entries, participant interviews, and physical examinations, and 2 are based on laboratory analysis, and measurement of body weight and height. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Global Outside of US: Percentage of Participants With Clinical Remission
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Global Outside of US: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
Global Outside of US: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
The IBDQ is a 32-item (ranges 1 - 7) self-report questionnaire for patients with IBD to evaluate the patient reported outcomes across 4 dimensions: bowel symptoms (loose stools, abdominal pain), systemic symptoms (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability). The IBDQ total Score ranges from 32 to 224 with a higher score indicating better outcome.
Global Outside of US: Percentage of Participants With Enhanced Clinical Response and Endoscopic Response
Enhanced clinical response was defined as ≥ 60% decrease in average daily Stool Frequency and/or ≥ 35% decrease in average daily Abdominal Pain score and both not worse than baseline, and/or clinical remission. Endoscopic Response was defined as a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) > 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).
Global Outside of US: Percentage of Participants With Endoscopic Remission
Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
Global Outside of US: Percentage of Participants With Enhanced Clinical Response
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Global Outside of US: Percentage of Participants With Ulcer-Free Endoscopy
Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
Global Outside of US: Percentage of Participants With Enhanced Clinical Response
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Global Outside of US: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline
Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
Global Outside of US: Percentage of Participants With CD-Related Hospitalization
Participants with at least one admission to the hospital due to Crohn's Disease.
Global Outside of US: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
Global Outside of US: Change From Baseline in Work Productivity and Impairment Questionnaire - Crohn's Disease (WPAI-CD) Overall Work Impairment
WPAI: CD is a questionnaire used to evaluate lost productivity due to CD ; scores are presented as percentages (multiplying the scores by 100), with 0% representing no impact on productivity and 100% representing complete impact on productivity. Total work productivity impairment takes into account both hours missed due to CD symptoms and the patient's assessment of the degree to which CD affected their productivity while working (overall work impairment [OWI]). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity.
Global Outside of US: Change From Baseline in Short Form-36 (SF-36) Physical Component Summary (PCS) Score
The Short Form-36 Health Survey determined participants' overall quality of life by assessing 1) limitations in physical functioning due to health problems; 2) limitations in usual role because of physical health problems; 3) bodily pain; 4) general health perceptions; 5) vitality; 6) limitations in social functioning because of physical or emotional problems; 7) limitations in usual role due to emotional problems; and 8) general mental health. Items 1-4 comprise the physical component of the SF-36. Scores on each item were summed and averaged (range = 0-100); a positive change from Baseline indicates improvement.

Full Information

First Posted
April 4, 2017
Last Updated
June 9, 2022
Sponsor
AbbVie
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1. Study Identification

Unique Protocol Identification Number
NCT03105128
Brief Title
A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
Official Title
A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study of the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease
Study Type
Interventional

2. Study Status

Record Verification Date
June 2022
Overall Recruitment Status
Completed
Study Start Date
May 10, 2017 (Actual)
Primary Completion Date
November 9, 2020 (Actual)
Study Completion Date
April 14, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AbbVie

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Crohn's Disease
Keywords
Crohn's Disease (CD), Risankizumab, ABBV-066, BI 655066

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
931 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Risankizumab Dose 1 (Period 1)
Arm Type
Experimental
Arm Description
Participants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion.
Arm Title
Risankizumab Dose 2 (Period 1)
Arm Type
Experimental
Arm Description
Participants randomized to receive risankizumab dose 2 administered by intravenous (IV) infusion.
Arm Title
Placebo (Period 1)
Arm Type
Placebo Comparator
Arm Description
Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion.
Arm Title
Risankizumab Dose 1 (Period 2)
Arm Type
Experimental
Arm Description
Participants who received placebo in Period 1 and participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Period 2.
Arm Title
Risankizumab Dose 2 (Period 2)
Arm Type
Experimental
Arm Description
Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Period 2.
Arm Title
Risankizumab Dose 3 (Period 2)
Arm Type
Experimental
Arm Description
Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Period 2.
Intervention Type
Drug
Intervention Name(s)
placebo for risankizumab
Intervention Description
Placebo for risankizumab administered by intravenous infusion
Intervention Type
Drug
Intervention Name(s)
risankizumab IV
Other Intervention Name(s)
ABBV-066 BI 655066, SKYRIZI
Intervention Description
Risankizumab administered by intravenous infusion
Intervention Type
Drug
Intervention Name(s)
risankizumab SC
Other Intervention Name(s)
ABBV-066 BI 655066, SKYRIZI
Intervention Description
Risankizumab administered by subcutaneous (SC) injection
Primary Outcome Measure Information:
Title
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
Description
The CDAI consists of 8 components; 7 are based on participant diary entries, participant interviews, physical examinations, measurement of body weight and height and 1 is based on laboratory analysis. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Endoscopic Response
Description
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD > 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Clinical Remission
Description
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Endoscopic Response
Description
The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD > 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Time Frame
Week 12
Secondary Outcome Measure Information:
Title
US Specific: Percentage of Participants With Clinical Remission
Description
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Time Frame
Week 4
Title
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Time Frame
Week 12
Title
US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
Description
The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
Time Frame
Week 4
Title
US Specific: Percentage of Participants With CDAI Clinical Response and Endoscopic Response
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline. Endoscopic response was a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) > 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Stool Frequency (SF) Remission
Description
Stool Frequency (SF) remission is defined as an average daily SF <= 2.8 and not worse than baseline.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Abdominal Pain (AP) Remission
Description
The Abdominal Pain rating is an assessment that is graded from 0 to 3: 0= None, 1= Mild, 2= Moderate and 3= Severe. AP remission is defined as average daily AP score <= 1 and not worse than baseline.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Endoscopic Remission
Description
Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Enhanced Clinical Response
Description
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Time Frame
Week 4
Title
US Specific: Percentage of Participants With Ulcer-Free Endoscopy
Description
Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Enhanced Clinical Response
Description
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Time Frame
Week 12
Title
US Specific: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at
Description
Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
Time Frame
Week 12
Title
US Specific: Percentage of Participants With CD-Related Hospitalization
Description
Participants with at least one admission to the hospital due to Crohn's Disease.
Time Frame
Week 12
Title
US Specific: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
Description
Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
Description
The CDAI consists of 8 components; 6 are based on participant diary entries, participant interviews, and physical examinations, and 2 are based on laboratory analysis, and measurement of body weight and height. CDAI clinical remission of Crohn's disease is defined as CDAI < 150.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Time Frame
Week 4
Title
Global Outside of US: Percentage of Participants With Clinical Remission
Description
Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Time Frame
Week 4
Title
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
Description
Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Time Frame
Week 12
Title
Global Outside of US: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
Description
The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
Time Frame
Week 12
Title
Global Outside of US: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
Description
The IBDQ is a 32-item (ranges 1 - 7) self-report questionnaire for patients with IBD to evaluate the patient reported outcomes across 4 dimensions: bowel symptoms (loose stools, abdominal pain), systemic symptoms (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability). The IBDQ total Score ranges from 32 to 224 with a higher score indicating better outcome.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Enhanced Clinical Response and Endoscopic Response
Description
Enhanced clinical response was defined as ≥ 60% decrease in average daily Stool Frequency and/or ≥ 35% decrease in average daily Abdominal Pain score and both not worse than baseline, and/or clinical remission. Endoscopic Response was defined as a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) > 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Endoscopic Remission
Description
Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Enhanced Clinical Response
Description
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Time Frame
Week 4
Title
Global Outside of US: Percentage of Participants With Ulcer-Free Endoscopy
Description
Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Enhanced Clinical Response
Description
Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline
Description
Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants With CD-Related Hospitalization
Description
Participants with at least one admission to the hospital due to Crohn's Disease.
Time Frame
Week 12
Title
Global Outside of US: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
Description
Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
Time Frame
Week 12
Title
Global Outside of US: Change From Baseline in Work Productivity and Impairment Questionnaire - Crohn's Disease (WPAI-CD) Overall Work Impairment
Description
WPAI: CD is a questionnaire used to evaluate lost productivity due to CD ; scores are presented as percentages (multiplying the scores by 100), with 0% representing no impact on productivity and 100% representing complete impact on productivity. Total work productivity impairment takes into account both hours missed due to CD symptoms and the patient's assessment of the degree to which CD affected their productivity while working (overall work impairment [OWI]). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity.
Time Frame
Week 12
Title
Global Outside of US: Change From Baseline in Short Form-36 (SF-36) Physical Component Summary (PCS) Score
Description
The Short Form-36 Health Survey determined participants' overall quality of life by assessing 1) limitations in physical functioning due to health problems; 2) limitations in usual role because of physical health problems; 3) bodily pain; 4) general health perceptions; 5) vitality; 6) limitations in social functioning because of physical or emotional problems; 7) limitations in usual role due to emotional problems; and 8) general mental health. Items 1-4 comprise the physical component of the SF-36. Scores on each item were summed and averaged (range = 0-100); a positive change from Baseline indicates improvement.
Time Frame
Week 12

10. Eligibility

Sex
All
Minimum Age & Unit of Time
16 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male or female aged >=18 to <= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to < 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit. Diagnosis of CD for at least 3 months prior to Baseline. Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD). Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD. If female, participant must meet the contraception recommendations. Exclusion Criteria: Participant with a current diagnosis of ulcerative colitis or indeterminate colitis. Participants with unstable doses of concomitant Crohn's disease therapy. Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within 35 days or 5 half-lives prior to Baseline, whichever is longer. Prior exposure to p19 inhibitors (e.g., risankizumab). Complications of Crohn's disease. Having an ostomy or ileoanal pouch. Known active Coronavirus Disease 2019 (COVID-19) infection.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
ABBVIE INC.
Organizational Affiliation
AbbVie
Official's Role
Study Director
Facility Information:
Facility Name
Phoenix VA Health Care System /ID# 162267
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85012
Country
United States
Facility Name
HonorHealth Research Institute - Shea /ID# 161783
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85258
Country
United States
Facility Name
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211883
City
Tempe
State/Province
Arizona
ZIP/Postal Code
85284-2604
Country
United States
Facility Name
University of Arizona /ID# 158469
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Atria Clinical Research /ID# 164740
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72209-7040
Country
United States
Facility Name
Newport Huntington Medica /ID# 213033
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648-5994
Country
United States
Facility Name
United Medical Doctors /ID# 207040
City
Los Alamitos
State/Province
California
ZIP/Postal Code
90720-3309
Country
United States
Facility Name
TLC Clinical Research Inc /ID# 212503
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162656
City
Los Angeles
State/Province
California
ZIP/Postal Code
90067-2001
Country
United States
Facility Name
United Medical Doctors - Murrieta /ID# 158424
City
Murrieta
State/Province
California
ZIP/Postal Code
92563
Country
United States
Facility Name
Southern CA Research Ctr., Inc /ID# 167875
City
Riverside
State/Province
California
ZIP/Postal Code
92501
Country
United States
Facility Name
University of California, San Francisco /ID# 157143
City
San Francisco
State/Province
California
ZIP/Postal Code
94158
Country
United States
Facility Name
Cedars-Sinai Medical Center-West Hollywood /ID# 163842
City
West Hollywood
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Peak Gastroenterology Associates, PC /ID# 165834
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80907
Country
United States
Facility Name
Rocky Mountain Pediatric Gastroenterology /ID# 207169
City
Lone Tree
State/Province
Colorado
ZIP/Postal Code
80124-6798
Country
United States
Facility Name
Western Connecticut Medical Group /ID# 165849
City
Danbury
State/Province
Connecticut
ZIP/Postal Code
06810-6000
Country
United States
Facility Name
Seffner Premier Health Care, PA /ID# 162265
City
Brandon
State/Province
Florida
ZIP/Postal Code
33510
Country
United States
Facility Name
Clinical Research of West Florida, Inc /ID# 204859
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33765
Country
United States
Facility Name
Clinical Research of West Florida, Inc /ID# 207450
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33765
Country
United States
Facility Name
South Lake Pain Institute, Inc /ID# 162825
City
Clermont
State/Province
Florida
ZIP/Postal Code
34711
Country
United States
Facility Name
Universal Axon Clinical Research /ID# 165432
City
Doral
State/Province
Florida
ZIP/Postal Code
33166
Country
United States
Facility Name
Nature Coast Clinical Research - Inverness /ID# 159414
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452-4717
Country
United States
Facility Name
SIH Research Mumtaz, Inc /ID# 163082
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34741-4161
Country
United States
Facility Name
Alliance Medical Research /ID# 163840
City
Lighthouse Point
State/Province
Florida
ZIP/Postal Code
33064
Country
United States
Facility Name
Cfagi Llc /Id# 201571
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751-6108
Country
United States
Facility Name
Vista Health Research, LLC /ID# 212664
City
Miami
State/Province
Florida
ZIP/Postal Code
33176-1032
Country
United States
Facility Name
ITB Research /ID# 161334
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Coral Research Clinic /ID# 158549
City
Miami
State/Province
Florida
ZIP/Postal Code
33186-4643
Country
United States
Facility Name
South Florida Research Ph I-IV, Inc. /ID# 161836
City
Miami
State/Province
Florida
ZIP/Postal Code
33193
Country
United States
Facility Name
Gastroenterology Group Naples /ID# 165206
City
Naples
State/Province
Florida
ZIP/Postal Code
34102
Country
United States
Facility Name
Advanced Research Institute, Inc /ID# 161959
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34653
Country
United States
Facility Name
Endoscopic Research, Inc. /ID# 205901
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Omega Research Maitland, LLC /ID# 171081
City
Orlando
State/Province
Florida
ZIP/Postal Code
32810-2907
Country
United States
Facility Name
IMIC Inc. Medical Research /ID# 154943
City
Palmetto Bay
State/Province
Florida
ZIP/Postal Code
33157
Country
United States
Facility Name
Clinical Research Trials of Florida, Inc. /ID# 201014
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Facility Name
Gastroenterology Associates of Central Georgia, LLC /ID# 154857
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Northwestern University Division of GI/Hepatology /ID# 158283
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611-2927
Country
United States
Facility Name
The University of Chicago Medical Center /ID# 157141
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637-1443
Country
United States
Facility Name
NorthShore University HealthSystem /ID# 158287
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Facility Name
Southwest Gastroenterology /ID# 165002
City
Oak Lawn
State/Province
Illinois
ZIP/Postal Code
60453
Country
United States
Facility Name
Cotton-O'Neil Clinical Res Ctr /ID# 154738
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
University of Kentucky Chandler Medical Center /ID# 157137
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536
Country
United States
Facility Name
University of Louisville /ID# 210521
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Gastroenterology Associates LLC - Jefferson Hwy /ID# 161956
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Facility Name
Houma Digestive Health Special /ID# 158286
City
Houma
State/Province
Louisiana
ZIP/Postal Code
70360
Country
United States
Facility Name
Delricht Research /ID# 206542
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70115
Country
United States
Facility Name
Nola Research Works, LLC /ID# 161330
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70115
Country
United States
Facility Name
Louisana Research Center, LLC /ID# 162236
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71105-6800
Country
United States
Facility Name
MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154839
City
Chevy Chase
State/Province
Maryland
ZIP/Postal Code
20815
Country
United States
Facility Name
Gastro Center of Maryland /ID# 165004
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21045
Country
United States
Facility Name
University of Michigan Health Systems /ID# 157144
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Center for Digestive Health /ID# 154690
City
Troy
State/Province
Michigan
ZIP/Postal Code
48098-6363
Country
United States
Facility Name
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161328
City
Wyoming
State/Province
Michigan
ZIP/Postal Code
49519
Country
United States
Facility Name
Mayo Clinic - Rochester /ID# 163085
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905-0001
Country
United States
Facility Name
Southern Therapy and Advanced Research (STAR) LLC /ID# 162388
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
St. Louis University /ID# 161902
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63104
Country
United States
Facility Name
University of Nebraska Medical Center /ID# 210057
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198-2000
Country
United States
Facility Name
Las Vegas Medical Research /ID# 160172
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89113
Country
United States
Facility Name
Revival Research Institute, Inc /ID# 210984
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89128-3157
Country
United States
Facility Name
NY Scientific /ID# 158418
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11235
Country
United States
Facility Name
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 212036
City
Burnt Hills
State/Province
New York
ZIP/Postal Code
12027
Country
United States
Facility Name
Intercity Advanced Gastroentertology Center /ID# 213399
City
Fresh Meadows
State/Province
New York
ZIP/Postal Code
11366
Country
United States
Facility Name
Duplicate_Long Island Clinical Research /ID# 154836
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021-5343
Country
United States
Facility Name
Digestive Disease Care /ID# 209619
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11040
Country
United States
Facility Name
North Shore University Hospital /ID# 168736
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11040
Country
United States
Facility Name
NYU Langone Medical Center /ID# 160171
City
New York
State/Province
New York
ZIP/Postal Code
10016-6402
Country
United States
Facility Name
Columbia Univ Medical Center /ID# 161911
City
New York
State/Province
New York
ZIP/Postal Code
10032-3725
Country
United States
Facility Name
Lenox Hill Hospital /ID# 168465
City
New York
State/Province
New York
ZIP/Postal Code
10075
Country
United States
Facility Name
DiGiovanna Institute for Medical Education & Research /ID# 171118
City
North Massapequa
State/Province
New York
ZIP/Postal Code
11758
Country
United States
Facility Name
Univ NC Chapel Hill /ID# 154840
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27514-4220
Country
United States
Facility Name
Atrium Health Carolinas Medical Center /ID# 158481
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Facility Name
Clinical Trials America /ID# 158484
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Vidant Multispecialty Clinic - Kinston /ID# 161111
City
Kinston
State/Province
North Carolina
ZIP/Postal Code
28501-1589
Country
United States
Facility Name
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154880
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27612
Country
United States
Facility Name
Plains Clinical Research Center, LLC /ID# 169715
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58104-5925
Country
United States
Facility Name
Tri-State Endoscopy /ID# 154933
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Cleveland Clinic Main Campus /ID# 208171
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
The Ohio State University /ID# 164709
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Optimed Research, Ltd. /ID# 167901
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43235
Country
United States
Facility Name
Hometown Urgent Care and Resea /ID# 170453
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45424
Country
United States
Facility Name
Great Lakes Medical Research, LLC /ID# 201732
City
Mentor
State/Province
Ohio
ZIP/Postal Code
44060-6211
Country
United States
Facility Name
Hightower Clinical /ID# 211938
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73102
Country
United States
Facility Name
Digestive Disease Specialists /ID# 170774
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Adult Gastroenterology Associates - Gen 1 Research /ID# 206125
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136-7823
Country
United States
Facility Name
Northwest Gastroenterology Clinic /ID# 158288
City
Portland
State/Province
Oregon
ZIP/Postal Code
97210
Country
United States
Facility Name
PennState Milton S.Hershey Med /ID# 154883
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Children's Hospital of Pittsburgh of UPMC /ID# 210920
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15224-1334
Country
United States
Facility Name
Digestive Disease Associates, LTD /ID# 208847
City
Wyomissing
State/Province
Pennsylvania
ZIP/Postal Code
19610-2002
Country
United States
Facility Name
Medical University of South Carolina /ID# 212579
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Gastroenterology Associates, P.A. of Greenville /ID# 154911
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615-3593
Country
United States
Facility Name
Rapid City Medical Center - GI Research /ID# 163841
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701
Country
United States
Facility Name
Gastro One /ID# 154742
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
East Tennessee Research Institute /ID# 168737
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37604
Country
United States
Facility Name
Duplicate_Clinical Neuroscience Solutions /ID# 164181
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38119-4823
Country
United States
Facility Name
Vanderbilt University Medical Center /ID# 157138
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-0011
Country
United States
Facility Name
TX Clinical Research Institute /ID# 159410
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
Inquest Clinical Research /ID# 165695
City
Baytown
State/Province
Texas
ZIP/Postal Code
77521-2415
Country
United States
Facility Name
Texas Digestive Disease Consultants /ID# 209596
City
Cedar Park
State/Province
Texas
ZIP/Postal Code
78613-5028
Country
United States
Facility Name
Texas Digestive Disease Consultants /ID# 209785
City
Cedar Park
State/Province
Texas
ZIP/Postal Code
78613-5028
Country
United States
Facility Name
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 201848
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
DHAT Research Institute /ID# 158217
City
Garland
State/Province
Texas
ZIP/Postal Code
75044-2208
Country
United States
Facility Name
Vilo Research Group Inc /ID# 206130
City
Houston
State/Province
Texas
ZIP/Postal Code
77017-2337
Country
United States
Facility Name
CliniCore International, LLC /ID# 158209
City
Houston
State/Province
Texas
ZIP/Postal Code
77027-6812
Country
United States
Facility Name
Baylor College of Medicine - Baylor Medical Center /ID# 158212
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-3411
Country
United States
Facility Name
Precision Research Institute, LLC /ID# 200503
City
Houston
State/Province
Texas
ZIP/Postal Code
77036
Country
United States
Facility Name
Centex Studies, Inc. - Houston /ID# 200720
City
Houston
State/Province
Texas
ZIP/Postal Code
77058
Country
United States
Facility Name
Clinical Associates in Research Therapeutics of America, LLC /ID# 161336
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78212
Country
United States
Facility Name
Southern Star Research Institute, LLC /ID# 168770
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229-5390
Country
United States
Facility Name
Tyler Research Institute, LLC /ID# 166796
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701-4464
Country
United States
Facility Name
Gastro Health & Nutrition - Victoria /ID# 164296
City
Victoria
State/Province
Texas
ZIP/Postal Code
77904
Country
United States
Facility Name
HP Clinical Research /ID# 162998
City
Bountiful
State/Province
Utah
ZIP/Postal Code
84010
Country
United States
Facility Name
Advanced Research Institute /ID# 154914
City
Ogden
State/Province
Utah
ZIP/Postal Code
84403
Country
United States
Facility Name
Velocity Clinical Research - Salt Lake City /ID# 161781
City
West Jordan
State/Province
Utah
ZIP/Postal Code
84088
Country
United States
Facility Name
McGuire DV AMC /ID# 159990
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Washington Gastroenterology Associates /ID# 162120
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004
Country
United States
Facility Name
Virginia Mason - Seattle Orthapedics /ID# 155545
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
WVU Medicine /ID# 167940
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506-1200
Country
United States
Facility Name
Duplicate_HOSPITAL CENTENARIO /ID# 170883
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Hospital Privado Univesitario /ID# 161988
City
Cordoba
ZIP/Postal Code
5016
Country
Argentina
Facility Name
Duplicate_Mater Hospital /ID# 167990
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Griffith University /ID# 212627
City
Southport
State/Province
Queensland
ZIP/Postal Code
4222
Country
Australia
Facility Name
Lyell McEwin Hospital /ID# 211363
City
Elizabeth Vale
State/Province
South Australia
ZIP/Postal Code
5112
Country
Australia
Facility Name
Emeritus Research /ID# 213511
City
Camberwell
State/Province
Victoria
ZIP/Postal Code
3124
Country
Australia
Facility Name
Footscray Hospital /ID# 211361
City
Footscray
State/Province
Victoria
ZIP/Postal Code
3011
Country
Australia
Facility Name
Universitaetsklinikum St. Poelten /ID# 166425
City
Sankt Poelten
State/Province
Niederoesterreich
ZIP/Postal Code
3100
Country
Austria
Facility Name
Medizinische Universitaet Graz /ID# 158137
City
Graz
State/Province
Steiermark
ZIP/Postal Code
8036
Country
Austria
Facility Name
Krankenhaus der Barmherzigen Brueder Wien /ID# 212059
City
Vienna
State/Province
Wien
ZIP/Postal Code
1020
Country
Austria
Facility Name
Duplicate_Medical University of Vienna /ID# 158138
City
Vienna
State/Province
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Gomel Regional Clinical Hospital /ID# 159498
City
Gomel
ZIP/Postal Code
246029
Country
Belarus
Facility Name
Grodno city clinical hospital #2 /ID# 159499
City
Grodno
ZIP/Postal Code
230011
Country
Belarus
Facility Name
Vitebsk Regional Advanced Clin /ID# 159497
City
Витебск
ZIP/Postal Code
210001
Country
Belarus
Facility Name
ULB Hospital Erasme /ID# 157397
City
Brussels
State/Province
Bruxelles-Capitale
ZIP/Postal Code
1070
Country
Belgium
Facility Name
UCL Saint-Luc /ID# 157395
City
Woluwe-Saint-Lambert
State/Province
Bruxelles-Capitale
ZIP/Postal Code
1200
Country
Belgium
Facility Name
CHU UCL Namur - site Godinne /ID# 157401
City
Godinne
State/Province
Namur
ZIP/Postal Code
5530
Country
Belgium
Facility Name
UZ Gent /ID# 157394
City
Gent
State/Province
Oost-Vlaanderen
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Universitair Ziekenhuis Leuven /ID# 157396
City
Leuven
State/Province
Vlaams-Brabant
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Imelda Ziekenhuis /ID# 157392
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
Facility Name
CHU de Liege /ID# 157398
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Groupe Sante CHC - Clinique du MontLegia /ID# 157393
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
AZ-Delta /ID# 157391
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
Facility Name
University Clinical Centre of the Republic of Srpska /ID# 157717
City
Banja Luka
State/Province
Republika Srpska
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
Facility Name
University Clinical Centre of the Republic of Srpska /ID# 164512
City
Banja Luka
State/Province
Republika Srpska
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
Facility Name
Clinical Center University of Sarajevo /ID# 165134
City
Sarajevo
ZIP/Postal Code
71000
Country
Bosnia and Herzegovina
Facility Name
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157672
City
Goiânia
State/Province
Goias
ZIP/Postal Code
74535-170
Country
Brazil
Facility Name
Hospital Nossa Senhora das Graças /ID# 157646
City
Curitiba
State/Province
Parana
ZIP/Postal Code
80810-040
Country
Brazil
Facility Name
Hospital de Clinicas de Porto Alegre /ID# 157653
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Upeclin Fmb - Unesp /Id# 157688
City
Botucatu
State/Province
Sao Paulo
ZIP/Postal Code
18618-686
Country
Brazil
Facility Name
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157649
City
Ribeirão Preto
State/Province
Sao Paulo
ZIP/Postal Code
14051-140
Country
Brazil
Facility Name
Faculdade de Medicina do ABC /ID# 159672
City
Santo André
State/Province
Sao Paulo
ZIP/Postal Code
09060-870
Country
Brazil
Facility Name
Kaiser Clinica e Hospital Dia /ID# 157656
City
Sao Jose Do Rio Preto
State/Province
Sao Paulo
ZIP/Postal Code
15015-110
Country
Brazil
Facility Name
UMHAT Dr Georgi Stranski EAD /ID# 203977
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
University Multiprofile Hospit /ID# 158644
City
Plovdiv
ZIP/Postal Code
4001
Country
Bulgaria
Facility Name
Second Multiprofile Hospital f /ID# 158646
City
Sofia
ZIP/Postal Code
1202
Country
Bulgaria
Facility Name
Duplicate_Tokuda Hospital Sofia /ID# 158645
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Facility Name
UMHAT Sveti Ivan Rilski /ID# 204714
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
UMHAT Tsaritsa Joanna - ISUL /ID# 211240
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
MHAT Trakia /ID# 201672
City
Stara Zagora
ZIP/Postal Code
6004
Country
Bulgaria
Facility Name
University Multiprofile Hospit /ID# 167575
City
Varna
ZIP/Postal Code
9010
Country
Bulgaria
Facility Name
University of Calgary - Heritage Medical Research Clinic /ID# 157152
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
Allen Whey Khye Lim Professional Corporation /ID# 169761
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5R 1W2
Country
Canada
Facility Name
University of Alberta - Zeidler Ledcor Centre /ID# 157098
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2X8
Country
Canada
Facility Name
Covenant Health /ID# 161617
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6K 4B2
Country
Canada
Facility Name
Fraser Clinical Trials Inc /ID# 159053
City
New Westminster
State/Province
British Columbia
ZIP/Postal Code
V3L 3W4
Country
Canada
Facility Name
GIRI Gastrointestinal Research Institute /ID# 157095
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 2K5
Country
Canada
Facility Name
Percuro Clinical Research, Ltd /ID# 161616
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8V 3M9
Country
Canada
Facility Name
QEII - Health Sciences Centre /ID# 157087
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Facility Name
IWK Health Center /ID# 165900
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3K 6R8
Country
Canada
Facility Name
London Health Sciences Center /ID# 157160
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5W9
Country
Canada
Facility Name
Scott Shulman Medicine Professional Corporation /ID# 165903
City
North Bay
State/Province
Ontario
ZIP/Postal Code
P1B 2H3
Country
Canada
Facility Name
Medicor Research Inc /ID# 157149
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3A 1W8
Country
Canada
Facility Name
Mount Sinai Hospital /ID# 169762
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X5
Country
Canada
Facility Name
Toronto Digestive Disease Asso /ID# 157157
City
Vaughan
State/Province
Ontario
ZIP/Postal Code
L4L 4Y7
Country
Canada
Facility Name
CISSS de la Monteregie /ID# 161615
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
CHAU- Hotel-Dieu de Levis /ID# 214375
City
Levis
State/Province
Quebec
ZIP/Postal Code
G6V 3Z1
Country
Canada
Facility Name
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159054
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167066
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 3E4
Country
Canada
Facility Name
Montreal General Hospital - McGill University Health Center /ID# 157084
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
Complejo Asistencial Dr. Sotero del Rio /ID# 169382
City
Santiago
State/Province
Region Metropolitana De Santiago
ZIP/Postal Code
8207257
Country
Chile
Facility Name
Centro de Investigaciones Clínicas Viña del Mar /ID# 203589
City
Viña del Mar
State/Province
Valparaíso
ZIP/Postal Code
2540488
Country
Chile
Facility Name
Hospital Guillermo Grant Benavente de Concepción /ID# 210759
City
Concepción
ZIP/Postal Code
4070038
Country
Chile
Facility Name
Hospital Las Higueras /ID# 167090
City
Talcahuano
ZIP/Postal Code
1740000
Country
Chile
Facility Name
Guangdong Provincial People's Hospital /ID# 212948
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Facility Name
The Sixth Affiliated Hosp Sun /ID# 210785
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510655
Country
China
Facility Name
The Second Hospital of Hebei Medical University /ID# 212740
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Facility Name
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210856
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Facility Name
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211038
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Facility Name
Renmin Hospital of Wuhan University /ID# 214873
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430060
Country
China
Facility Name
The First Affiliated Hospital of Nanchang University /ID# 211034
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210841
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200065
Country
China
Facility Name
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210707
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200127
Country
China
Facility Name
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210725
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310009
Country
China
Facility Name
Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210624
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310020
Country
China
Facility Name
Jinhua Municipal Central Hospital /ID# 215626
City
Jinhua
State/Province
Zhejiang
ZIP/Postal Code
321000
Country
China
Facility Name
The Second Hospital Central South University /ID# 211696
City
Changsha
ZIP/Postal Code
410011
Country
China
Facility Name
West China Hospital, Sichuan University /ID# 210889
City
Chengdu
ZIP/Postal Code
610041
Country
China
Facility Name
Shanghai East Hospital /ID# 212683
City
Pudong New District
ZIP/Postal Code
200136
Country
China
Facility Name
Tianjin Medical University General Hospital /ID# 210927
City
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Instituto de Coloproctologia /ID# 158741
City
Medellin
State/Province
Antioquia
ZIP/Postal Code
050024
Country
Colombia
Facility Name
Hospital Pablo Tobon Uribe /ID# 158735
City
Medellín
State/Province
Antioquia
ZIP/Postal Code
50034
Country
Colombia
Facility Name
Hospital Univ San Ignacio /ID# 158733
City
Bogota
State/Province
Cundinamarca
ZIP/Postal Code
110231
Country
Colombia
Facility Name
Hospital Universitario San Vic /ID# 171487
City
Medellin
ZIP/Postal Code
50010
Country
Colombia
Facility Name
Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157565
City
Zagreb
State/Province
Grad Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Klinicki bolnicki centar Sestre milosrdnice /ID# 157721
City
Zagreb
State/Province
Grad Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Klinicki bolnicki centar Zagreb /ID# 157566
City
Zagreb
State/Province
Grad Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
UHC Osijek /ID# 157564
City
Osijek
State/Province
Osjecko-baranjska Zupanija
ZIP/Postal Code
31000
Country
Croatia
Facility Name
Klinicki bolnicki centar Split /ID# 157567
City
Split
State/Province
Splitsko-dalmatinska Zupanija
ZIP/Postal Code
21000
Country
Croatia
Facility Name
Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165463
City
Prague 4
State/Province
Praha 4
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
Hepato-Gastroenterologie HK, s.r.o. /ID# 163134
City
Hradec Kralove
ZIP/Postal Code
500 12
Country
Czechia
Facility Name
CTCenter MaVe s.r.o. /ID# 163149
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Nemocnice Pardubickeho kraje, a.s. /ID# 163182
City
Pardubice
ZIP/Postal Code
530 03
Country
Czechia
Facility Name
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211305
City
Praha
ZIP/Postal Code
118 33
Country
Czechia
Facility Name
Axon Clinical, s.r.o. /ID# 163176
City
Praha
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
Thomayerova nemocnice /ID# 162940
City
Praha
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
ResTrial s.r.o. /ID# 211075
City
Praha
ZIP/Postal Code
143 00
Country
Czechia
Facility Name
NH Hospital a.s. /ID# 211076
City
Praha
ZIP/Postal Code
155 00
Country
Czechia
Facility Name
East Tallinn Central Hospital /ID# 157076
City
Tallinn
State/Province
Harjumaa
ZIP/Postal Code
10138
Country
Estonia
Facility Name
West Tallinn Central Hospital /ID# 157077
City
Tallinn
ZIP/Postal Code
10617
Country
Estonia
Facility Name
North Estonia Medical Centre /ID# 163507
City
Tallinn
ZIP/Postal Code
13419
Country
Estonia
Facility Name
Universitaetsklinikum Freiburg /ID# 162019
City
Freiburg
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
79106
Country
Germany
Facility Name
Praxis fuer Gastroenterologie /ID# 166145
City
Heidelberg
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
69121
Country
Germany
Facility Name
Universitatsklinikum Mannheim /ID# 162020
City
Mannheim
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
68167
Country
Germany
Facility Name
Universitaetsklinikum Tuebingen /ID# 159324
City
Tübingen
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
72076
Country
Germany
Facility Name
Universitaetsklinikum Ulm /ID# 164986
City
Ulm
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
89081
Country
Germany
Facility Name
Universitaetsklinikum Erlangen /ID# 159315
City
Erlangen
State/Province
Bayern
ZIP/Postal Code
91054
Country
Germany
Facility Name
Universitaetsklinikum Frankfurt /ID# 212978
City
Frankfurt am Main
State/Province
Hessen
ZIP/Postal Code
60590
Country
Germany
Facility Name
Evangelisches Krankenhaus Kalk /ID# 212725
City
Cologne
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
51103
Country
Germany
Facility Name
Praxiszentrum fuer Gastroenterologie /ID# 211964
City
Grevenbroich
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
41515
Country
Germany
Facility Name
Universitaetsklinikum Koeln /ID# 164985
City
Köln
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
50937
Country
Germany
Facility Name
Universitaetsklinikum Muenster /ID# 159316
City
Muenster
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
48149
Country
Germany
Facility Name
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210529
City
Saarbrücken
State/Province
Saarland
ZIP/Postal Code
66111
Country
Germany
Facility Name
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159321
City
Kiel
State/Province
Schleswig-Holstein
ZIP/Postal Code
24105
Country
Germany
Facility Name
Universitaetsklinikum Jena /ID# 159323
City
Jena
State/Province
Thueringen
ZIP/Postal Code
07747
Country
Germany
Facility Name
Krankenhaus Waldfriede /ID# 212728
City
Berlin-Zehlendorf
ZIP/Postal Code
14163
Country
Germany
Facility Name
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212219
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212893
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211972
City
Berlin
ZIP/Postal Code
10787
Country
Germany
Facility Name
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159322
City
Berlin
ZIP/Postal Code
10825
Country
Germany
Facility Name
DRK Kliniken Berlin Westend /ID# 166146
City
Berlin
ZIP/Postal Code
14050
Country
Germany
Facility Name
Stadtisches Klinikum Braunschweig /ID# 163666
City
Braunschweig
ZIP/Postal Code
38126
Country
Germany
Facility Name
Medizinisches Versorgunszentrum Dachau /ID# 211557
City
Dachau
ZIP/Postal Code
85221
Country
Germany
Facility Name
Agaplesion Markus Krankenhaus /ID# 159317
City
Frankfurt am Main
ZIP/Postal Code
60431
Country
Germany
Facility Name
Asklepios Westklinikum Hamburg /ID# 159319
City
Hamburg
ZIP/Postal Code
22559
Country
Germany
Facility Name
Medizinische Hochschule Hannover /ID# 162021
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
EUGASTRO GmbH /ID# 212076
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Klinikum Lueneburg /ID# 163664
City
Lueneburg
ZIP/Postal Code
21339
Country
Germany
Facility Name
Universitaetsklinikum Magdeburg /ID# 211847
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
Facility Name
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162018
City
Minden
ZIP/Postal Code
32423
Country
Germany
Facility Name
Universitaetsklinikum Regensburg /ID# 163665
City
Regensburg
ZIP/Postal Code
93042
Country
Germany
Facility Name
Duplicate_Gastro-Praxis Wiesbaden /ID# 159318
City
Wiesbaden
ZIP/Postal Code
65189
Country
Germany
Facility Name
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 171077
City
Athens
State/Province
Attiki
ZIP/Postal Code
11527
Country
Greece
Facility Name
Tzaneio general hospital of Piraeus /ID# 206445
City
Piraeus
State/Province
Attiki
ZIP/Postal Code
18536
Country
Greece
Facility Name
University General Hospital of Heraklion PA.G.N.I /ID# 157427
City
Heraklion
State/Province
Kriti
ZIP/Postal Code
71307
Country
Greece
Facility Name
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157428
City
Athens
ZIP/Postal Code
10676
Country
Greece
Facility Name
University General Hospital of Ioannina /ID# 157425
City
Ioannina
ZIP/Postal Code
45500
Country
Greece
Facility Name
General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157429
City
Pireaus
ZIP/Postal Code
18454
Country
Greece
Facility Name
Theageneio Anticancer Hospital /ID# 163921
City
Thessaloniki
ZIP/Postal Code
54639
Country
Greece
Facility Name
Queen Mary Hospital /ID# 163902
City
Hong Kong
ZIP/Postal Code
999077
Country
Hong Kong
Facility Name
Tuen Mun Hospital /ID# 163901
City
Tuen Mun
Country
Hong Kong
Facility Name
Beaumont Hospital /ID# 157515
City
Beaumont
State/Province
Dublin
ZIP/Postal Code
D09 XR63
Country
Ireland
Facility Name
St Vincent's University Hospital /ID# 157512
City
Elm Park
State/Province
Dublin
ZIP/Postal Code
D04 T6F4
Country
Ireland
Facility Name
University Hospital Galway /ID# 157513
City
Galway
ZIP/Postal Code
H91 YR71
Country
Ireland
Facility Name
Soroka University Medical Center /ID# 157798
City
Be'er Sheva
State/Province
HaDarom
ZIP/Postal Code
8443901
Country
Israel
Facility Name
Sheba Medical Center /ID# 157797
City
Ramat Gan
State/Province
Tel-Aviv
ZIP/Postal Code
5239424
Country
Israel
Facility Name
Sheba Medical Center /ID# 171074
City
Ramat Gan
State/Province
Tel-Aviv
ZIP/Postal Code
5239424
Country
Israel
Facility Name
Tel Aviv Sourasky Medical Center /ID# 157796
City
Tel Aviv-Yafo
State/Province
Tel-Aviv
ZIP/Postal Code
6423906
Country
Israel
Facility Name
Duplicate_Rambam Medical Center /ID# 171072
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
The Edith Wolfson Medical Center /ID# 217329
City
Holon
ZIP/Postal Code
5822000
Country
Israel
Facility Name
Shaare Zedek Medical Center /ID# 163540
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
Shaare Zedek Medical Center /ID# 171073
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
Hadassah Medical Center-Hebrew University /ID# 165913
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162427
City
Torrette
State/Province
Ancona
ZIP/Postal Code
60123
Country
Italy
Facility Name
University of Catanzaro /ID# 212012
City
Catanzaro
State/Province
Calabria
ZIP/Postal Code
88100
Country
Italy
Facility Name
Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212019
City
Modena
State/Province
Emilia-Romagna
ZIP/Postal Code
41124
Country
Italy
Facility Name
Policlinico Universitario Campus Bio-Medico /ID# 162429
City
Rome
State/Province
Lazio
ZIP/Postal Code
00128
Country
Italy
Facility Name
Azienda Ospedaliera San Camillo Forlanini /ID# 155636
City
Rome
State/Province
Lazio
ZIP/Postal Code
00152
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166911
City
Rome
State/Province
Lazio
ZIP/Postal Code
00161
Country
Italy
Facility Name
Istituto Clinico Humanitas /ID# 155634
City
Rozzano
State/Province
Milano
ZIP/Postal Code
20089
Country
Italy
Facility Name
Fondazione PTV Policlinico Tor Vergata /ID# 158021
City
Rome
State/Province
Roma
ZIP/Postal Code
00133
Country
Italy
Facility Name
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155632
City
Rome
State/Province
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168051
City
Florence
State/Province
Toscana
ZIP/Postal Code
50139
Country
Italy
Facility Name
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161305
City
Negrar
State/Province
Verona
ZIP/Postal Code
37024
Country
Italy
Facility Name
A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155635
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
A.O. Per L'Emergenza Cannizzaro /ID# 161306
City
Catania
ZIP/Postal Code
95126
Country
Italy
Facility Name
Ospedale Policlinico San Martino /ID# 162430
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155631
City
Milano
ZIP/Postal Code
20157
Country
Italy
Facility Name
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155633
City
Milan
ZIP/Postal Code
20122
Country
Italy
Facility Name
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155637
City
Palermo
ZIP/Postal Code
90146
Country
Italy
Facility Name
Duplicate_Fondazione IRCCS Policlinico San Matteo /ID# 212029
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Aichi Medical University Hospital /ID# 160159
City
Nagakute-shi
State/Province
Aichi
ZIP/Postal Code
480-1195
Country
Japan
Facility Name
Nagoya City University Hospital /ID# 160162
City
Nagoya shi
State/Province
Aichi
ZIP/Postal Code
467-8602
Country
Japan
Facility Name
Daido Clinic /ID# 211477
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
457-0818
Country
Japan
Facility Name
Nagoya University Hospital /ID# 160150
City
Nagoyashi
State/Province
Aichi
ZIP/Postal Code
4668560
Country
Japan
Facility Name
Fujita Health University Hospital /ID# 163214
City
Toyoake-shi
State/Province
Aichi
ZIP/Postal Code
470-1192
Country
Japan
Facility Name
Tokatsu Tsujinaka Hospital /ID# 163362
City
Abiko-shi
State/Province
Chiba
ZIP/Postal Code
270-1168
Country
Japan
Facility Name
Chiba University Hospital /ID# 217532
City
Chiba-shi
State/Province
Chiba
ZIP/Postal Code
260-8677
Country
Japan
Facility Name
Tsujinaka Hospital Kashiwanoha /ID# 213847
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
277-0871
Country
Japan
Facility Name
The Jikei University Kashiwa Hospital /ID# 200007
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
277-8567
Country
Japan
Facility Name
Toho University Sakura Medical Center /ID# 160161
City
Sakura-shi
State/Province
Chiba
ZIP/Postal Code
285-8741
Country
Japan
Facility Name
Fukuoka University Hospital /ID# 217792
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
814-0180
Country
Japan
Facility Name
Kurume University Hospital /ID# 160138
City
Kurume-shi
State/Province
Fukuoka
ZIP/Postal Code
830-0011
Country
Japan
Facility Name
NHO Fukuyama Medical Center /ID# 163578
City
Fukuyama-shi
State/Province
Hiroshima
ZIP/Postal Code
720-8520
Country
Japan
Facility Name
Hiroshima University Hospital /ID# 160139
City
Hiroshima-shi
State/Province
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
Asahikawa Medical University Hospital /ID# 162844
City
Midorigaokahiga-shi
State/Province
Hokkaido
ZIP/Postal Code
078-8510
Country
Japan
Facility Name
Sapporo Tokushukai Hospital /ID# 213493
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
004-0041
Country
Japan
Facility Name
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160158
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-0033
Country
Japan
Facility Name
Sapporo Medical University Hospital /ID# 163028
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-8543
Country
Japan
Facility Name
Nishinomiya Munic Central Hospital /ID# 210104
City
Nishinomiya-shi
State/Province
Hyogo
ZIP/Postal Code
663-8014
Country
Japan
Facility Name
Hyogo College of Medicine College Hospital /Id# 160164
City
Nishinomiya-shi
State/Province
Hyogo
ZIP/Postal Code
663-8501
Country
Japan
Facility Name
National Hospital Organization Mito Medical Center /ID# 160154
City
Higashi Ibaraki-gun
State/Province
Ibaraki
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
Kanazawa University Hospital /ID# 201766
City
Kanazawa-shi
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Facility Name
Gokeikai Ofuna Chuo Hospital /ID# 171070
City
Kamakura-shi
State/Province
Kanagawa
ZIP/Postal Code
247-0056
Country
Japan
Facility Name
Kitasato University Hospital /ID# 171071
City
Sagamihara-shi
State/Province
Kanagawa
ZIP/Postal Code
252-0375
Country
Japan
Facility Name
Yokohama City University Medical Center /ID# 163906
City
Yokohama shi
State/Province
Kanagawa
ZIP/Postal Code
232-0024
Country
Japan
Facility Name
Yokohama Municipal Citizen's Hospital /ID# 204126
City
Yokohama-shi
State/Province
Kanagawa
ZIP/Postal Code
240-8555
Country
Japan
Facility Name
Mie University Hospital /ID# 203639
City
Tsu-shi
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Yokkaichi Hazu Medical Center /ID# 163741
City
Yokkaichi-shi
State/Province
Mie
ZIP/Postal Code
510-0016
Country
Japan
Facility Name
Tohoku University Hospital /ID# 162843
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
9808574
Country
Japan
Facility Name
Duplicate_Tohoku Rosai Hospital /ID# 163189
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
981-8563
Country
Japan
Facility Name
Osaka City University Hospital /ID# 160146
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
545-8586
Country
Japan
Facility Name
Saitama Medical Center /ID# 160155
City
Kawagoe-shi
State/Province
Saitama
ZIP/Postal Code
350-8550
Country
Japan
Facility Name
Tokitokai Tokito clinic /ID# 160145
City
Saitama-shi
State/Province
Saitama
ZIP/Postal Code
336-0963
Country
Japan
Facility Name
Shiga University of Medical Science Hospital /ID# 164022
City
Otsu-shi
State/Province
Shiga
ZIP/Postal Code
520-2192
Country
Japan
Facility Name
Hamamatsu University Hospital /ID# 205689
City
Hamamatsu-shi
State/Province
Shizuoka
ZIP/Postal Code
431-3192
Country
Japan
Facility Name
NHO Shizuoka Medical Center /ID# 163029
City
Sunto-gun
State/Province
Shizuoka
ZIP/Postal Code
411-8611
Country
Japan
Facility Name
Tokyo Medical And Dental University, Medical Hospital /ID# 160157
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-8519
Country
Japan
Facility Name
Duplicate_Tokai University Hachioji Hospital /ID# 160160
City
Hachioji-shi
State/Province
Tokyo
ZIP/Postal Code
192-0032
Country
Japan
Facility Name
The Jikei University Hospital /ID# 163190
City
Minato-ku
State/Province
Tokyo
ZIP/Postal Code
105-8471
Country
Japan
Facility Name
Duplicate_Kitasato University Kitasato Institute Hospital /ID# 160144
City
Minato-ku
State/Province
Tokyo
ZIP/Postal Code
108-8642
Country
Japan
Facility Name
Kyorin University Hospital /ID# 160149
City
Mitaka-shi
State/Province
Tokyo
ZIP/Postal Code
181-8611
Country
Japan
Facility Name
Tokyo Women's Medical University Hospital /ID# 205973
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8666
Country
Japan
Facility Name
Wakayama Medical University Hospital /ID# 200183
City
Wakayama-shi
State/Province
Wakayama
ZIP/Postal Code
641-8510
Country
Japan
Facility Name
Yamagata University Hospital /ID# 200154
City
Yamagata-shi
State/Province
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Facility Name
Yamanashi Prefectural Central Hospital /ID# 160156
City
Kofu-shi
State/Province
Yamanashi
ZIP/Postal Code
400-8506
Country
Japan
Facility Name
Hanyang University Guri Hospital /ID# 158673
City
Guri
State/Province
Gyeonggido
ZIP/Postal Code
11923
Country
Korea, Republic of
Facility Name
Duplicate_CHA bundang medical center CHA University /ID# 158672
City
Seongnam-si
State/Province
Gyeonggido
ZIP/Postal Code
13496
Country
Korea, Republic of
Facility Name
Duplicate_The Catholic University of Korea, ST. Vincent's Hospital /ID# 158681
City
Suwon
State/Province
Gyeonggido
ZIP/Postal Code
16247
Country
Korea, Republic of
Facility Name
Kangbuk Samsung Hospital /ID# 158676
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
03181
Country
Korea, Republic of
Facility Name
Severance Hospital /ID# 158671
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Dong-A University Hospital /ID# 158675
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Pusan National University Hospital /ID# 158677
City
Busan
ZIP/Postal Code
49241
Country
Korea, Republic of
Facility Name
Yeungnam University Medical Center /ID# 158680
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Facility Name
The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213552
City
Daejeon
ZIP/Postal Code
34943
Country
Korea, Republic of
Facility Name
Asan Medical Center /ID# 158678
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center /ID# 158674
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Pauls Stradins Clinical University Hospital /ID# 159614
City
Riga
ZIP/Postal Code
1002
Country
Latvia
Facility Name
Digestive Disease Center Gastro /ID# 163105
City
Riga
ZIP/Postal Code
LV-1079
Country
Latvia
Facility Name
Riga East Clinical University Hospital /ID# 159613
City
Riga
ZIP/Postal Code
LV-1079
Country
Latvia
Facility Name
Duplicate_Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162582
City
Kaunas
ZIP/Postal Code
50161
Country
Lithuania
Facility Name
Duplicate_Vilnius University Hospital /ID# 162507
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Facility Name
Queen Elizabeth Hospital /ID# 160654
City
Division Pantai Barat Utara
State/Province
Sabah
ZIP/Postal Code
88200
Country
Malaysia
Facility Name
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 163654
City
Kuala Lumpur
State/Province
Selangor
ZIP/Postal Code
56000
Country
Malaysia
Facility Name
Universiti Sains Malaysia /ID# 160656
City
Kelantan
ZIP/Postal Code
16150
Country
Malaysia
Facility Name
Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 167648
City
Zapopan
State/Province
Jalisco
ZIP/Postal Code
45070
Country
Mexico
Facility Name
JM Research SC /ID# 161733
City
Cuernavaca
State/Province
Morelos
ZIP/Postal Code
62290
Country
Mexico
Facility Name
Unidad de Atencion Medica e Investigacion en Salud /ID# 163624
City
Merida
State/Province
Yucatan
ZIP/Postal Code
97000
Country
Mexico
Facility Name
Health Pharma Professional Research S.A de C.V /ID# 161734
City
Del. Benito Juárez
ZIP/Postal Code
03810
Country
Mexico
Facility Name
Academisch Medisch Centrum /ID# 157950
City
Amsterdam
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Elisabeth Tweesteden Ziekenhuis /ID# 163631
City
Tilburg
ZIP/Postal Code
5022 GC
Country
Netherlands
Facility Name
Christchurch Hospital /ID# 163074
City
Christchurch
State/Province
Canterbury
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
Dunedin Hospital /ID# 167989
City
Dunedin
State/Province
Otago
ZIP/Postal Code
9016
Country
New Zealand
Facility Name
Wellington Regional Hospital /ID# 167987
City
Newtown Wellington
State/Province
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Facility Name
Akershus universitetssykehus /ID# 169378
City
Nordbyhagen
State/Province
Akershus
ZIP/Postal Code
1474
Country
Norway
Facility Name
Vestre viken - Baerum Sykehus /ID# 157886
City
Gjettum
ZIP/Postal Code
1346
Country
Norway
Facility Name
Sykehuset Levanger Helse NT /ID# 157885
City
Levanger
ZIP/Postal Code
7601
Country
Norway
Facility Name
Helse More og Romsdal HF, Alesund sjukehus /ID# 212811
City
Ålesund
ZIP/Postal Code
6017
Country
Norway
Facility Name
Planetmed Sp. z o.o. /ID# 202798
City
Wroclaw
State/Province
Dolnoslaskie
ZIP/Postal Code
52-210
Country
Poland
Facility Name
Gastromed /Id# 212099
City
Torun
State/Province
Kujawsko-pomorskie
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212297
City
Lodz
State/Province
Lodzkie
ZIP/Postal Code
90-153
Country
Poland
Facility Name
1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209985
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-049
Country
Poland
Facility Name
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209981
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-954
Country
Poland
Facility Name
Centrum Zdrowia MDM /ID# 160794
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
00-635
Country
Poland
Facility Name
Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 160797
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
02-507
Country
Poland
Facility Name
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213579
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
04-730
Country
Poland
Facility Name
Centrum Medyczne Medyk /ID# 212889
City
Rzeszów
State/Province
Podkarpackie
ZIP/Postal Code
35-326
Country
Poland
Facility Name
Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212081
City
Chojnice
State/Province
Pomorskie
ZIP/Postal Code
89-600
Country
Poland
Facility Name
H-T. Centrum Medyczne - Endoterapia /ID# 212459
City
Tychy
State/Province
Slaskie
ZIP/Postal Code
43-100
Country
Poland
Facility Name
Wojewodzki Szpital Specjalistyczny /ID# 212402
City
Olsztyn
State/Province
Warminsko-mazurskie
ZIP/Postal Code
10-561
Country
Poland
Facility Name
Duplicate_SOLUMED Sp. z o.o., Sp.k. /ID# 160793
City
Poznan
ZIP/Postal Code
60-529
Country
Poland
Facility Name
Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 205160
City
Warsaw
ZIP/Postal Code
03-580
Country
Poland
Facility Name
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212602
City
Wroclaw
ZIP/Postal Code
50-556
Country
Poland
Facility Name
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160739
City
Guimaraes
State/Province
Braga
ZIP/Postal Code
4835-044
Country
Portugal
Facility Name
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167750
City
Portimão
State/Province
Faro
ZIP/Postal Code
8500-338
Country
Portugal
Facility Name
Centro Hospitalar de Entre Douro e Vouga /ID# 160674
City
Santa Maria Da Feira
State/Province
Porto
ZIP/Postal Code
4520-211
Country
Portugal
Facility Name
Hospital Garcia de Orta, EPE /ID# 160747
City
Almada
ZIP/Postal Code
2805-267
Country
Portugal
Facility Name
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160715
City
Faro
ZIP/Postal Code
8000-386
Country
Portugal
Facility Name
Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160675
City
Lisboa
ZIP/Postal Code
1169-050
Country
Portugal
Facility Name
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167749
City
Lisboa
ZIP/Postal Code
1349-019
Country
Portugal
Facility Name
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160694
City
Lisboa
ZIP/Postal Code
1649-035
Country
Portugal
Facility Name
Hospital Beatriz Ângelo /ID# 207757
City
Loures
ZIP/Postal Code
2674-514
Country
Portugal
Facility Name
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160695
City
Porto
ZIP/Postal Code
4200-319
Country
Portugal
Facility Name
Centro Hosp de Tondela-Viseu /ID# 160697
City
Viseu
ZIP/Postal Code
3504-509
Country
Portugal
Facility Name
Institutul Clinic Fundeni /ID# 163046
City
Sector 2
State/Province
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Institutul Clinic Fundeni /ID# 163264
City
Sector 2
State/Province
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Tvm Med Serv Srl /Id# 166294
City
Cluj
ZIP/Postal Code
400132
Country
Romania
Facility Name
Duplicate_Centrul Medical Tuculanu SRL /ID# 166295
City
Timisoara
ZIP/Postal Code
300168
Country
Romania
Facility Name
Cabinet Particular Policlinic Algomed /ID# 163047
City
Timișoara
ZIP/Postal Code
300002
Country
Romania
Facility Name
Kuzbass Regional Clinical Hospital /ID# 161310
City
Kemerovo
State/Province
Kemerovskaya Oblast
ZIP/Postal Code
650099
Country
Russian Federation
Facility Name
Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207440
City
Perm
State/Province
Permskiy Kray
ZIP/Postal Code
614990
Country
Russian Federation
Facility Name
Duplicate_St. Petersburg State Pediatric Medical University /ID# 211977
City
Saint Petersburg
State/Province
Sankt-Peterburg
ZIP/Postal Code
194100
Country
Russian Federation
Facility Name
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 156949
City
Stavropol
State/Province
Stavropol Skiy Kray
ZIP/Postal Code
355012
Country
Russian Federation
Facility Name
Tver Regional Clinical Hospital /ID# 205925
City
Tver
State/Province
Tverskaya Oblast
ZIP/Postal Code
170036
Country
Russian Federation
Facility Name
Regional Clinical Hospital #1 /ID# 163453
City
Tyumen
State/Province
Tyumenskaya Oblast
ZIP/Postal Code
625023
Country
Russian Federation
Facility Name
Alliance Biomedical Ural Group /ID# 156950
City
Izhevsk
State/Province
Udmurtskaya Respublika
ZIP/Postal Code
426061
Country
Russian Federation
Facility Name
State Scientific Ctr Coloproct /ID# 204809
City
Moscow
ZIP/Postal Code
123423
Country
Russian Federation
Facility Name
Novosibirski Gastrocenter /ID# 217554
City
Novosibirsk
ZIP/Postal Code
630007
Country
Russian Federation
Facility Name
City Clinical Hospital No. 31 /ID# 208866
City
St. Petersburg
ZIP/Postal Code
197110
Country
Russian Federation
Facility Name
Duplicate_Ulyanovsk State clinical hospi /ID# 156946
City
Ulyanovsk
ZIP/Postal Code
432063
Country
Russian Federation
Facility Name
Clinical Hosp Center Zvezdara /ID# 156978
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Military Medical Academy /ID# 156979
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
University Clinical Center Serbia /ID# 156973
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clin Hosp Ctr Bezanijska Kosa /ID# 156976
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11080
Country
Serbia
Facility Name
University Clinical Center Kragujevac /ID# 156975
City
Kragujevac
State/Province
Sumadijski Okrug
ZIP/Postal Code
34000
Country
Serbia
Facility Name
Clinical Center Vojvodina /ID# 156972
City
Novi Sad
State/Province
Vojvodina
ZIP/Postal Code
21000
Country
Serbia
Facility Name
University Children's Hospital 'Tirsova' /ID# 211481
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212797
City
Belgrade
ZIP/Postal Code
11040
Country
Serbia
Facility Name
General Hospital Leskovac /ID# 209574
City
Leskovac
ZIP/Postal Code
16000
Country
Serbia
Facility Name
National University Hospital /ID# 160658
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
Singapore General Hospital /ID# 160657
City
Singapore
ZIP/Postal Code
169608
Country
Singapore
Facility Name
KL Ling Gastroenterology and Liver Clinic /ID# 205737
City
Singapore
ZIP/Postal Code
228510
Country
Singapore
Facility Name
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156465
City
Banska Bystrica
ZIP/Postal Code
975 17
Country
Slovakia
Facility Name
Univerzitna nemocnica Martin /ID# 163200
City
Martin
ZIP/Postal Code
036 01
Country
Slovakia
Facility Name
KM Management, spol. s.r.o. /ID# 206763
City
Nitra
ZIP/Postal Code
949 01
Country
Slovakia
Facility Name
GASTRO I., s.r.o. /ID# 156466
City
Presov
ZIP/Postal Code
080 01
Country
Slovakia
Facility Name
Clinresco Centers /ID# 163864
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
1619
Country
South Africa
Facility Name
Wits Clinical Research Site /ID# 158115
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Spoke Research Inc /ID# 158117
City
CAPE TOWN Milnerton
State/Province
Western Cape
ZIP/Postal Code
7441
Country
South Africa
Facility Name
Kingsbury Hospital /ID# 163116
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7708
Country
South Africa
Facility Name
Private Practice Dr MN Rajabally /ID# 163115
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7800
Country
South Africa
Facility Name
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157527
City
Ferrol
State/Province
A Coruna
ZIP/Postal Code
15405
Country
Spain
Facility Name
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159230
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
08208
Country
Spain
Facility Name
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157575
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Hospital Universitario Basurto /ID# 205189
City
Bilbao
State/Province
Vizcaya
ZIP/Postal Code
48013
Country
Spain
Facility Name
Hospital Clinic de Barcelona /ID# 157526
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Hospital General Universitario Gregorio Maranon /ID# 161435
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Universitario La Paz /ID# 159228
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Clinico Universitario de Salamanca /ID# 157532
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Facility Name
Hospital Universitario Virgen Macarena /ID# 160819
City
Sevilla
ZIP/Postal Code
41009
Country
Spain
Facility Name
Hospital Universitario y Politecnico La Fe /ID# 157530
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Facility Name
Hospital Clinico Universitario Lozano Blesa /ID# 212523
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Hospital Universitario Miguel Servet /ID# 157531
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Skane University hospital /ID# 211235
City
Malmo
State/Province
Skane Lan
ZIP/Postal Code
214 28
Country
Sweden
Facility Name
Duplicate_GHP Stockholm Gastro Center /ID# 210479
City
Stockholm
State/Province
Stockholms Lan
ZIP/Postal Code
114 28
Country
Sweden
Facility Name
Ersta diakoni /ID# 157878
City
Stockholm
State/Province
Stockholms Lan
ZIP/Postal Code
116 91
Country
Sweden
Facility Name
Danderyd Hospital /ID# 202136
City
Stockholm
State/Province
Stockholms Lan
ZIP/Postal Code
182 88
Country
Sweden
Facility Name
Sahlgrenska University Hospital /ID# 157879
City
Gothenburg
State/Province
Vastra Gotalands Lan
ZIP/Postal Code
413 45
Country
Sweden
Facility Name
Duplicate_SU Molndal. /ID# 157880
City
Molndal
ZIP/Postal Code
431 80
Country
Sweden
Facility Name
Duplicate_Karolinska Univ Sjukhuset /ID# 209966
City
Solna
ZIP/Postal Code
171 64
Country
Sweden
Facility Name
Universitätsspital Zürich /ID# 163532
City
Zürich
State/Province
Zuerich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
Duplicate_Universitaetsspital Basel /ID# 164555
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Inselspital, Universitätsspital Bern /ID# 163531
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Scientific Research Institute of Invalid Rehabilitation /ID# 211516
City
Vinnytsia
State/Province
Vinnytska Oblast
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165649
City
Kharkiv
ZIP/Postal Code
61037
Country
Ukraine
Facility Name
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212050
City
Kherson
ZIP/Postal Code
73000
Country
Ukraine
Facility Name
International Institute of Clinical Research LLC /ID# 211997
City
Kyiv
ZIP/Postal Code
02091
Country
Ukraine
Facility Name
Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165651
City
Kyiv
ZIP/Postal Code
02232
Country
Ukraine
Facility Name
Medical Center of LLC Medbud-Clinic /ID# 216929
City
Kyiv
ZIP/Postal Code
03037
Country
Ukraine
Facility Name
Kyiv Railway Clinical Hosp No.2 /ID# 217330
City
Kyiv
ZIP/Postal Code
03049
Country
Ukraine
Facility Name
Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 206788
City
Lutsk
ZIP/Postal Code
43005
Country
Ukraine
Facility Name
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165650
City
Lviv
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Duplicate_Transcarpathian Regional Clin. /ID# 168419
City
Uzhhorod
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216265
City
Vinnytsia
ZIP/Postal Code
21018
Country
Ukraine
Facility Name
Kyiv Municipal Clinical Hospital #18 /ID# 162521
City
Київ
ZIP/Postal Code
01030
Country
Ukraine
Facility Name
Royal Devon and Exeter NHS Trust Hospital /ID# 157517
City
Exeter
State/Province
Devon
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
Barts Health NHS Trust /ID# 163710
City
London
State/Province
London, City Of
ZIP/Postal Code
E1 2ES
Country
United Kingdom
Facility Name
Guy's and St Thomas' NHS Foundation Trust /ID# 157519
City
London
State/Province
London, City Of
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207937
City
Chertsey
State/Province
Surrey
ZIP/Postal Code
KT16 0PZ
Country
United Kingdom
Facility Name
Cambridge University Hospitals NHS Foundation Trust /ID# 158031
City
Cambridge
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Facility Name
NHS Lothian /ID# 207447
City
Edinburgh
ZIP/Postal Code
EH3 9HE
Country
United Kingdom
Facility Name
Calderdale and Huddersfield NHS Foundation Trust /ID# 209569
City
Huddersfield
ZIP/Postal Code
HX3 0PW
Country
United Kingdom
Facility Name
Hull University Teaching Hospitals NHS Trust /ID# 158757
City
Hull
ZIP/Postal Code
HU3 2JZ
Country
United Kingdom
Facility Name
Leeds Teaching Hospitals NHS Trust /ID# 157523
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Duplicate_King's College Hospital NHS Foundation Trusts /ID# 158756
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163709
City
Newcastle Upon Tyne
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Facility Name
Oxford University Hospitals NHS Foundation Trust /ID# 158033
City
Oxford
ZIP/Postal Code
OX3 9DU
Country
United Kingdom
Facility Name
Duplicate_Northern Care Alliance NHS Group /ID# 207764
City
Salford
ZIP/Postal Code
M6 8HD
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.
IPD Sharing Time Frame
For details on when studies are available for sharing, please refer to the link below.
IPD Sharing Access Criteria
Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Use Agreement (DUA). For more information on the process, or to submit a request, visit the following link.
IPD Sharing URL
https://vivli.org/ourmember/abbvie/
Citations:
PubMed Identifier
35644154
Citation
D'Haens G, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, Dubinsky M, Feagan BG, Hisamatsu T, Lim A, Lindsay JO, Loftus EV Jr, Panes J, Peyrin-Biroulet L, Ran Z, Rubin DT, Sandborn WJ, Schreiber S, Neimark E, Song A, Kligys K, Pang Y, Pivorunas V, Berg S, Duan WR, Huang B, Kalabic J, Liao X, Robinson A, Wallace K, Ferrante M. Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet. 2022 May 28;399(10340):2015-2030. doi: 10.1016/S0140-6736(22)00467-6.
Results Reference
derived
Links:
URL
https://www.rxabbvie.com
Description
Related info

Learn more about this trial

A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

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