Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial
Thyroid Associated Ophthalmopathy
About this trial
This is an interventional treatment trial for Thyroid Associated Ophthalmopathy
Eligibility Criteria
Inclusion Criteria:
- The diagnostic standard of TAO is according to Bartley's criteria.
- Patients with active moderate-to-severe TAO based on 2016 EUGOGO guidelines.
- CAS≥3/7.
- None of the patients received any glucocorticoids therapy or orbital radiotherapy in the previous 3 months.
Exclusion Criteria:
- NOSPECS is 0 or 1.Only signs,no symptoms.Signs include:reduced blink(Stellwag symptoms),two reduced cohesion(Mobius levy),moving slowly on the eyelids(Von Graefe sign),to the point of view,the forehead wrinkled skin should not(Joffroyv levy).
- Suffering from other eye diseases or wearing contact lenses.
- Suffering from other autoimmune diseases.
- Acute and chronic infectious diseases.
- Diabetic retinopathy or hypertensive fundus lesions.
- Patients received orbital decompression or other orbital surgery.
- Suffering from eye trauma or ocular surface disease.
- Special occupants, and the working environment has obvious air pollution etc.
Sites / Locations
- the Third Affiliated Hospital of Southern Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Group Ia
Group Ib
Group IIa
Group IIb
I:The increase of fat volume dominates . a:The weekly protocol was as follows: 0.5 g glucocorticoids weekly for 6 weeks, followed by 0.25 g weekly for 6 weeks.
I:The increase of fat volume dominates. b:The "qod" protocol was as follows: 0.5 g glucocorticoids qod. for 3 interval days per month for 3 months.
II:The increase of extraocular muscles volume dominates . a:The weekly protocol was as follows: 0.5 g glucocorticoids weekly for 6 weeks, followed by 0.25 g weekly for 6 weeks.
II:The increase of extraocular muscles volume dominates . b:The "qod" protocol was as follows: 0.5 g glucocorticoids qod. for 3 interval days per month for 3 months.