Postoperative Delirium: Brain Vulnerability and Recovery
Delirium, Postoperative Complications
About this trial
This is an interventional diagnostic trial for Delirium
Eligibility Criteria
Common inclusion criteria:
- Age ≥ 60
- Surgery requiring cardiopulmonary bypass (CPB) for coronary artery bypass grafting, septal myectomy and/or heart valve repair/replacement
- English speaking.
Common exclusion criteria:
- Implanted pacemaker
- Automatic internal cardiac defibrillator or other implant for which non-contrast magnetic resonance imaging (MRI) is contraindicated
- Concomitant aortic or cerebrovascular procedure
- Inability to lay flat or still for MRI
- Legal blindness or severe deafness
- Seizure history
- Known focal brain lesion larger than 3 cm.
Delirium Case Arm:
1. Delirious as diagnosed by the Confusion Assessment Method (CAM)/ Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) at some point during postoperative day 1-5.
Postoperative Control Arm:
1. Not delirious as diagnosed by the CAM/CAM-ICU on postoperative day 1-5.
Sites / Locations
- Barnes-Jewish Hospital/Washington University in St. Louis School of Medicine
Arms of the Study
Arm 1
Arm 2
Other
Other
delirium
no delirium
Patients in the cardiothoracic ICU diagnosed with postoperative delirium. Subjects will wear a diffuse optical tomography device in addition to the normal monitors. A non-contrast functional MRI will be performed.
Patients in the cardiothoracic ICU not diagnosed with postoperative delirium. Subjects will be monitored in the same way as the delirium arm