Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome
Premature Infants, Intracranial Hemorrhages, Periventricular Leukomalacia
About this trial
This is an interventional treatment trial for Premature Infants
Eligibility Criteria
Inclusion Criteria:
- premature infants who admitted to the neonatal intensive care unit(NICU) Within 72 hours after birth, gestational ages younger than 32 weeks, birth weight less than 1500 gram, informed consent was obtained from the infants' parents or guardians
Exclusion Criteria:
- born with anemia, polycythemia, hemolysis and other hematological diseases
- hypertension,
- convulsions,
- a genetically defined syndrome
- a severe congenital malformation adversely affecting life expectancy or neurodevelopment
- severe intraventricular hemorrhage
- thrombosis disease
- other fatal diseases or which can seriously affect the prognosis
Sites / Locations
- First Affiliated Hospital of Xian JiaotongUniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Erythropoietin
Normal saline
Erythropoietin is administered 750U/kg intravenously every other day for 2 weeks (a cumulative dose of 5,250U/kg over the course of 7 separate intravenous injections regardless of gestational age), starting with the first dose within 72 hours after birth. A single dose consisted of 750U EPO per kg of birth weight dissolved in 3mL/kg normal saline was administered intravenously during a period of 5 minutes.
Normal saline is administered 3ml/kg intravenously every other day for 2 weeks, starting with the first dose within 72 hours after birth. Similarly, the placebo dose consisted of 3mL of normal saline per kilogram birth weight was administered intravenously during a period of 5 minutes.