Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients
Heart Failure, Diastolic
About this trial
This is an interventional basic science trial for Heart Failure, Diastolic focused on measuring muscle sympathetic nerve activity, exercise tolerance, exercise training, peak oxygen uptake
Eligibility Criteria
Inclusion Criteria for Heart Failure Preserved Ejection Fraction Patients:
- ≥60 years of age, male or female.
- Documented heart failure diagnosis.
- Left ventricular ejection fraction ≥50%.
- Clinically stable (no heart failure hospitalization within prior month).
Inclusion Criteria for Healthy Controls:
- ≥60 years of age, male or female (matched to the age and sex of HFpEF patients).
- No cardiac medications except for statins.
- Sedentary (exercise three days per week or less).
Exclusion Criteria for Heart Failure Preserved Ejection Fraction Patients:
- Greater than moderate valvular disease or congenital heart disease.
- New York Heart Association class IV.
- Any orthopedic or medical condition that would limit exercise testing or training.
- Development of signs and symptoms of myocardial ischemia (1 mm ST segment depression on EKG), or unstable hemodynamics/rhythm, or systolic/diastolic blood pressure >240/110 mmHg during baseline cardiopulmonary (peak VO2) testing.
Exclusion Criteria for Healthy Controls:
- Chronic medical condition (e.g. self reported hypertension, or diabetes, or chronic obstructive pulmonary disease or heart disease)
- Abnormal history or cardiovascular physical exam.
- Segmental wall motion abnormalities or structural valvular abnormalities.
- Left ventricular ejection fraction <50%.
- Any orthopedic or medical condition that would limit exercise testing.
- Development of signs and symptoms of myocardial ischemia (1 mm ST segment depression on EKG), or unstable hemodynamics/rhythm, or systolic/diastolic blood pressure >240/110 mmHg during baseline cardiopulmonary (peak VO2) testing.
Sites / Locations
- University of Texas at Arlington
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise Training
Attention Control
Subjects will perform continuous endurance exercise (arm and leg cycle on Schwinn AD6 Airdyne ergometer, treadmill walking) 3 days per week. During the first 4-weeks, the exercise intensity will be set at 60%-70% of heart rate reserve and will increase by 5% per month. The initial exercise duration be 30 minutes and will gradually increase by 10 minutes every month. A 5-minute warm up and cool-down will precede and follow the aerobic conditioning phase. After the aerobic training phase is completed, patients will also perform unilateral handgrip exercise at an initial intensity of 50% maximal voluntary contraction for 1 set of 10 repetitions, and the intensity and sets will increase by 5% and 1 set, respectively each month.
These subjects will be asked to continue with normal activity and will not be given any exercise training. The subjects will be contacted by the study coordinator at pre-arranged times and dates once a month and involve inquiry regarding overall well-being of the subject.