Visualize Nociceptor Changes in Neuropathic Human
Chemotherapy-induced Peripheral Neuropathy, Peripheral Neuropathy
About this trial
This is an interventional diagnostic trial for Chemotherapy-induced Peripheral Neuropathy
Eligibility Criteria
Inclusion Criteria:
- Healthy subjects of different ages
- abandoned extra digit specimen in polydactyly
- diagnosed with peripheral neuropathy
- diabetic neuropathy patients have been removed after the completion of clinical diagnosis of the specimen, And then the skin slices of the nerve endings of the optical image observation
- because of chemotherapy during chemotherapy, is expected to have peripheral neuropathy: before the occurrence of peripheral neuropathy , after cured peripheral nerve lesions
Exclusion Criteria:
- systemic infection or have been infected with the site by the physician assessment is not suitable for examination.
Sites / Locations
- National Taiwan University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
Healthy subjects
peripheral neuropathy
diabetic neuropathy
chemotherapy induced neuropathy
Polydactyly
Healthy subjects of different ages (20 persons), Interventions: harmonic generation microscopy
the participant have symptoms and diagnosed with peripheral neuropathy (90 persons), Interventions:harmonic generation microscopy
the participant have symptoms and diagnosed with diabetic neuropathy (20 persons), Interventions:harmonic generation microscopy
before chemotherapy, during chemotherapy, after peripheral nerve lesions were cured (30 persons). Interventions:harmonic generation microscopy
Abandoned extra digit specimen of polydactyly(10 persons): the normal skin and nerve endings in extra digit: Interventions: harmonic generation microscopy