Enhanced Recovery After Surgery Program for Colorectal Cancer: a Multi-center Study (ERASC1) (ERASC1)
Colorectal Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring enhanced recovery after surgery, colorectal cancer
Eligibility Criteria
Inclusion Criteria:
- Requirements of informed consent and assent of participant, parent or legal guardian as applicable
- Patients with colorectal cancer scheduled for radical coloproctectomy and between the age of 18 and 75 years old without considering sex
- ASA physical status I-III
- Participants can follow the drug doses and visit plan
Exclusion Criteria:
- Patients certified by a doctor that doesn't fit to participate in this study.
- Patients with ischemic heart disease, cerebrovascular disease and peripheral vascular disease, or their cardiac function > II (NYHA) patients, patients received CABG recently, and patients with severe hypertension (systolic pressure≥180mmHg or diastolic pressure≥110mmHg).
- Patients with colorectal cancer with distant metastasis.
- Patients with severe infection, respiratory dysfunction, coagulation disorders, severe liver and renal dysfunction (Child - Pugh≥ 10; creatinine clearance < 25 ml/min).
- Patients allergic to common drugs, such as opioids, non-steroidal drugs, cephalosporins, etc.
- Patients with operations of gastrointestinal cancer and complicated abdominal operations.
- Patients complicated by colorectal cancer with complications such as hemorrhage, perforation, obstruction.
- Patients with dyscrasia and severe malnutrition (albumin≤30g/L, weight loss in half a year>10%, SGA classification C, BMI<18, Hb<70g/L).
- Patients with metabolic complications caused by diabetes.
- Patients can't finish enhanced recovery after surgery programs and have contraindications of enhanced recovery after surgery.
- Pregnancy and lactation women, or have a pregnancy plan within a month after the test of the subjects (also including male participants).
- Patients participated other subjects 3 months before this subject.
- Sponsors or researchers directly involved in the testing or their family members.
Sites / Locations
- The First People's Hospital of ChangzhouRecruiting
- Changzhou Second People's Hospital Affiliated to Nanjing Medical UniversityRecruiting
- The First People's Hospital of Lianyungang CityRecruiting
- The Second People's Hospital of Lianyungang CityRecruiting
- Nanjing First HospitalRecruiting
- Jinling Hospital, Medical School of Nanjing UniversityRecruiting
- Zhongda Hospital, Southeast UniversityRecruiting
- The Second Affiliated Hospital of Nanjing Medical UniversityRecruiting
- The First Affiliated Hospital of Nanjing Medical UniversityRecruiting
- Suqian People's Hospital, Nanjing Drum Tower HospitalRecruiting
- Suzhou Municipal HospitalRecruiting
- The Second Affiliated Hospital of Soochow UniversityRecruiting
- The First Affiliated Hospital of Soochow UniversityRecruiting
- The First People's Hospital of TaicangRecruiting
- The Second People's Hospital of Changshu CityRecruiting
- Zhangjiagang First People's HospitalRecruiting
- The Taizhou People's HospitalRecruiting
- The 101 Hospital of the Chinese People's Liberation ArmyRecruiting
- Affiliated Hospital of Jiangnan University, The Forth People's Hospital of WuxiRecruiting
- Xuzhou Central HospitalRecruiting
- Northern Jiangsu People's HospitalRecruiting
- Affiliated Hospital of Jiangsu UniversityRecruiting
- Affiliated People's Hospital of Jiangsu UniversityRecruiting
Arms of the Study
Arm 1
Experimental
enhanced recovery after surgery
enhanced recovery after surgery includes: Multimodal analgesia Early oral intake A: Drink water after anesthetic awareness. B: Recover semi-liquid diet Management of nasogastric tube and catheter A: Not indwell nasogastric tube conventionally. B: Remove catheter early. Early activity Perioperative controlled infusion A: Load carbohydrate preoperatively B: No preoperative bowel preparation for right hemicolectomy, Miles rectectomy and Hartman rectectomy, simple cleansing enema for left hemicolectomy,sigmoidectomy and Dixon rectectomy; C: Fast six hours before surgery, no drink two hours before surgery D: Intraoperative liquid management: 3-6ml/kg/h, determined by anesthetists E: Stop intravenous infusion upon 2000-2500ml water and semiliquid diet being taken