Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's Phenomenon
Raynaud Phenomenon
About this trial
This is an interventional treatment trial for Raynaud Phenomenon focused on measuring Nitrate, Nitric oxide, Microvascular
Eligibility Criteria
Inclusion Criteria:
- Male or Female, aged 18 years or above.
- Diagnosed with Raynaud's Phenomenon.
- Participant is willing and able to give informed consent for participation in the study.
Exclusion Criteria:
The participant may not enter the study if ANY of the following apply:
- Patients with significant renal impairment (eGFR<30)
- Uncontrolled hypertension,
- Taking regular organic nitrates, nicorandil, or thiazolidinidiones,
- or any medication which may interfere with data interpretation or safety,
- who have had a myocardial infarction or cerebro-vascular event,
- who smoke,
- or any other serious medical condition which would interfere with data interpretation or safety will be excluded from participation.
Sites / Locations
- Department of Sport and Exercise Science
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Beetroot juice then nitrate depleted beetroot juice
Nitrate depleted beetroot juice then beetroot juice
Participants will be asked to consume 140ml of beetroot juice prior to their first experimental visit. Participants will then be asked to consume 70ml a day for 2 weeks and final visit the investigators once more following another 140ml drink.
Participants will be asked to consume 140ml of placebo prior to their first experimental visit. Participants will then be asked to consume 70ml a day for 2 weeks and final visit the investigators once more following another 140ml drink.