Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis
Aggressive Periodontitis, Generalized
About this trial
This is an interventional treatment trial for Aggressive Periodontitis, Generalized focused on measuring Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin, Metronidazole, Antimicrobial therapy, Photodynamic therapy, Low-level laser therapy
Eligibility Criteria
Inclusion Criteria:
- diagnosis of GAgP (Armitage, 1999; American Academy of Periodontology, 2015);
- presence of ≥20 teeth, excluding third molars and teeth indicated for extraction;
- presence of ≥6 sites presenting PD ≥5 mm with bleeding on probing and ≥2 sites with PD ≥7 mm (including incisors and first molars, in addition to two other non-contiguous teeth between them);
- presence of three non-adjacent periodontal pockets with probing depth ≥5 mm and bleeding on probing not located in furcation area;
- good general health (ASA I/II);
- 18-35 years old;
- agree to participate in the study and sign a written consent (Resolution # 196 of October 1996 and the Brazilian Professional Code of Dental Ethics - 179/93).
Exclusion Criteria:
- pregnant or nursing;
- suffer from any systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc - ASA III/IV/V);
- antimicrobials or anti-inflammatory drugs in the previous 6 months;
- periodontal treatment within the last 12 months;
- smoke ≥10 cigarettes/day;
- reported allergy to amoxicillin, metronidazole or clarithromycin;
- required antibiotic prophylaxis;
- current use of any medication that could interfere with periodontal response were excluded from the study.
Sites / Locations
- College of Dentistry - São José dos Campos, São Paulo State University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
PD + (AMX + MET)
PD + CLM
PD + (AMX + MET) + sPDT
PD + CLM + sPDT
PD + (AMX + MET) + rPDT
PD + CLM + rPDT
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic Amoxicillin 500 mg + Metronidazole 400 mg
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic clarithromycin 500 mg
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic Amoxicillin 500 mg + Metronidazole 400 mg and single application of PDT
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic Clarithromycin 500 mg and single application of PDT
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic Amoxicillin 500 mg + Metronidazole 400 mg and repeated application of PDT
periodontal pockets that will receive full-mouth ultrasonic debridement associated with systemic Clarithromycin 500 mg and repeated application of PDT