Comparison of Clinical Outcomes Between IVM and Minimal Stimulation IVF in Patients With PCOS
No Condition
About this trial
This is an interventional treatment trial for No Condition focused on measuring in vitro maturation (IVM), polycystic ovarian syndrome (PCOS), ovarian hyperstimulation syndrome (OHSS), assisted reproductive technology (ART)
Eligibility Criteria
Inclusion Criteria:
- Women diagnosed with PCOS under age of 40 years (PCOS diagnosis is based on Revised 2003 Rotterdam criteria of PCOS)
Exclusion Criteria:
- severe male factor subfertility requiring testicular sperm extraction (TESE) or oligoasthenoteratozoospermia
- couples requiring preimplantation genetic screening or diagnosis
- women had undergone ovarian stimulation 30 days before assisted reproductive technology (ART)
- women with severe endometriosis or dysfunctional uterine bleeding
- women with severe uterine factor subfertility (ex. submucosal myoma, intramural myoma protruding endometrium, severe intrauterine adhesion, etc)
- women with ovarian malignancy
- women with severe tubal factor subfertility (ex. persistent hydrosalpinx even after surgery)
- women had undergone treatment of malignancy 5 years before screening of this trial
- women with history of thromboembolism
- women with age of 40 years or more
- women with stimulation dose over 150 IU of exogenous FSH
Sites / Locations
- CHA Fertility Center, Seoul stationRecruiting
- CHA Gangnam medical centerRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
In vitro maturation (IVM)
Minimal stimulation IVF
hCG primed in vitro maturation (IVM) procedure Gonadotropin is not used in this patient group If the endometrial thickness in 6mm or more and the mean diameter of largest follicle is 11 mm or less on menstrual cycle day 9 to 12 on ultrasonography, oocyte retrieval is planned two days later. Recombinant hCG injection (priming) is given 36 hour before oocyte retrieval, followed by intracytoplasmic sperm injection (ICSI) for oocyte fertilization. The biochemical pregnancy is confirmed by serum beta hCG 15 days later oocyte retrieval. The clinical pregnancy is confirmed when gestational sac is detected by transvaginal ultrasonography 3 weeks later oocyte retrieval.
minimal stimulation IVF procedure These patients are stimulated with 150 or less IU of recombinant Follicle-stimulating hormone (FSH) from menstrual cycle day 3 in GnRH antagonist protocol. If the mean diameters of two or more follicles are 17mm or more, oocyte retrieval is planned two days later. Recombinant hCG is triggered 36 hour before oocyte retrieval, followed by intracytoplasmic sperm injection (ICSI) for oocyte fertilization if needed. The biochemical pregnancy is confirmed by serum beta hCG 14 days later oocyte retrieval. The clinical pregnancy is confirmed when gestational sac is detected by transvaginal ultrasonography 3 weeks later oocyte retrieval.