Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy
Aggressive Periodontitis, Generalized
About this trial
This is an interventional treatment trial for Aggressive Periodontitis, Generalized focused on measuring clarithromycin, photodynamic therapy, Antimicrobial therapy, Periodontal pocket
Eligibility Criteria
Inclusion Criteria:
- diagnosis of GagP
- presence of ≥20 teeth
- <35 years of age
- periodontal pockets with probing depth (PD) and Clinical Attachment Level (CAL) ≥ 5mm with concomitant bleeding on probing (BOP) in single-rooted teeth from different quadrants - agree to participate in the study and sign a written consent.
Exclusion Criteria:
- pregnant or lactating
- suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease
- received antimicrobials in the previous 6 months
- taking long-term anti-inflammatory drugs
- received a course of periodontal treatment within the last 12 months
- smoked
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Periodontal debridement
Periodontal debridement + CLM
Periodontal debridement + PDT
Periodontal debridement + CLM + PDT
Periodontal pockets that received periodontal debridement associated with placebo (members took with placebo 500 mg b.i.d. for 3 days).
Periodontal pockets that received periodontal debridement associated with systemic clarithromycin (500 mg - 12/12 hours) for 3 days.
Periodontal pockets that received periodontal debridement associated with placebo (members took with placebo 500 mg b.i.d. for 3 days) and a single application of PDT (Photodynamic Therapy).
Periodontal pockets that received periodontal debridement associated with systemic clarithromycin (500 mg - 12/12 hours for 3 days) and single application of PDT.