The Modular Protocol for Mental Health (MPMH) (MPMH)
Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder
About this trial
This is an interventional treatment trial for Major Depressive Disorder
Eligibility Criteria
Inclusion Criteria:
- Patients with a primary diagnosis of a unipolar mood, anxiety, stress or obsessive-compulsive disorder with at least one additional comorbid diagnosis according to the DSM-5. The criteria for diagnosis will be based on the Structured Clinical Interview for the DSM (SCID) which assesses disorders according to DSM-5 diagnostic criteria.
- To be eligible participants will also need to score >10 on either the Patient Health Questionnaire (PHQ-9) or Generalised Anxiety Disorder -7 item scale, GAD-7 (see Study Measures above).
Exclusion Criteria:
- Current/past psychosis or bipolar disorder
- Current full diagnosis of substance use disorder
- Organic brain damage
- Complex trauma history or recurrent self-injury requiring specialist services (as deemed by the NHS Clinical Care team)
- Current suicidality that warrants immediate clinical attention and constitutes a current risk of harm to the individual.
Sites / Locations
- MRC Cognition and Brain Sciences Unit
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
The Modular Protocol for Mental Health
Treatment-as-usual
The Modular Protocol for Mental Health (Psychological Therapy) will last up to 18 regular weekly face-to-face sessions. Treatment follows a standard structured treatment session as per Cognitive Behavioural Therapy. The MPMH Treatment Manual was written by clinical psychologists. The selection and ordering of the modules for treatment will be delivered and determined by the Trial Clinical Psychologist in collaboration with the service-user. The treatment modules include: M1. Getting Acquainted M2. Understanding Emotions M3. Managing and Tolerating Emotions M4. Behavioural activation M5. Tackling Avoidance M6. Tackling Unhelpful Thoughts M7. Tackling Unhelpful Habits M8. Overcoming Repetitive Thinking M9. Managing Upsetting Memories and Images M10. Relapse Prevention and Future Orientation
For Treatment-as-usual (Psychological Therapy), clinicians will be asked to provide whatever treatment they deem appropriate, including psychological services, medication and referral to other services. TAU will be delivered by high-intensity therapists or clinical psychologists.