Ischemic Preconditioning, Exercise Tolerance and Multiple Sclerosis
Multiple Sclerosis
About this trial
This is an interventional other trial for Multiple Sclerosis
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of MS as per the McDonald's criteria
- Aged 18 or older
- Sufficient cognitive ability to give informed consent
- Ability to walk for 6 minutes without rest
- Resting Systolic BP of less than 170 mmHg
Exclusion Criteria:
- Cognitive difficulties in giving consent ad understanding the questionnaire
- Inability to walk
- Other systemic illness affecting exercise tolerance
- Resting systolic BP of 170mmHg or more
Sites / Locations
- Royal Hallamshire HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Ischaemic Preconditioning Group
Control group
The participant will rest in a sitting position for 10 minutes before measuring resting blood pressure. Blood pressure will be measured on the arm. IPC will be administered to the upper arm using cuff inflation pressures of 30mm Hg above the systolic BP using a manual BP. The IPC cycles comprised of three cycles of cuff inflation each lasting 5 min in duration followed by 5-min period of cuff deflation
The participant will rest in a sitting position for 10 min before measuring resting blood pressure. Blood pressure will be measured on the upper arm. Sham intervention will be administered to the right upper limb using a manual BP cuff which will be inflated at a pressure 30mmg Hg below the diastolic blood pressure. The sham cycles comprised of three cycles of cuff inflation each lasting 5 minutes in duration followed by 5-min period of cuff deflation