Effect of Acute Fructose Load in Human
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
About this trial
This is an interventional basic science trial for Chronic Kidney Diseases focused on measuring Fructose, Uric acid, Oxidised LDL, Interleukin 6
Eligibility Criteria
Inclusion Criteria:
- GFR <30 ml/min or >3 months of dialysis for patients with CKD
- Patients with type 2 diabetes with and without CKD
- Controls without diabetes type 2 or CKD
Exclusion Criteria:
- HbA1c > 100 mmol/mol.
- Signs of fluid overload
- Inability to understand the information provided for the study.
- Ongoing inflammatory disease or infection,
- Treatment with allopurinol or other uric acid lowering agents a
Sites / Locations
- Karolinska University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Blueberry drink
Blueberry and pizza
Soft beverage
Soft beverage and pizza
Fructose
Fructose and pizza
Participant will receive a blueberry drink containing 18 g of fructose and 14 g of glucose.
Participant will receive a blueberry drink and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)
Participant will receive a Soft beverage (Coca-cola containing 17,5 g fructose and 17,5 g glucose)
Participant will receive a Soft beverage and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)
Participant will receive a drink containing 35 g of fructose
Participant will receive a drink containing 35 g of fructose and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)