Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE). (GABATHOMIE)
Postoperative Pain, Chronic Pain
About this trial
This is an interventional treatment trial for Postoperative Pain focused on measuring gabapentin, thoracotomy, chronic post-thoracotomy pain, acute post-thoracotomy pain, quality of life, neuropathic pain
Eligibility Criteria
Inclusion Criteria:
- age > 18 years
- elective lung resection via thoracotomy
Exclusion Criteria:
- extended pleurectomy and chest wall resection
- previous ipsilateral thoracotomy
- previous ipsilateral radiotherapy
- thoracotomy for pyothorax
- chest injury
- palliative surgery
- contraindicated placement of a thoracic epidural catheter
- allergy to medications on protocol
- pre-existing pain syndrome
- current treatment with morphine, gabapentin, pregabalin, anticonvulsivants or tricyclic antidepressants
- a history of past or current drug addiction
- severe hepatic, renal or cardiovascular disorders
- inability to understand the study protocol or to answer the questionnaires on pain and quality of life
- severe psychiatric disorders
- incompetent adults under some form of guardianship
- refusal of the protocol
- persons without social security coverage
- pregnant or lactating woman
Sites / Locations
- Department of Thoracic Surgery, Lille University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
gabapentin group
placebo group
the day before surgery : gabapentin 400 mg orally preoperatively (2 hours before surgery) : 3 capsules each containing 400 mg gabapentin (total gabapentin dose 1200 mg) and intravenous infusion of 50 ml of normal saline solution postoperative day 1 to 10 : 400 mg x 3 ( gabapentin 1200 mg daily)
The day before surgery: 1 placebo capsule orally preoperatively (2 hours before surgery) : 3 placebo capsules and intravenous infusion of 75 mg hydroxyzine postoperative day 1 to 10: 1 placebo capsule x 3