The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures
Hyperalgesia, Pain Insensitivity, Congenital
About this trial
This is an interventional screening trial for Hyperalgesia focused on measuring Pain Sensitivity, Measurement, Cold Pressor, β-endorphins, saliva, oral surgery
Eligibility Criteria
Inclusion Criteria:
- Patients without reported chronical or acute pain in non-acute-pain group
- Patients with acute pain in oral and maxillofacial region with diagnosed cause of pain in acute-pain group
- Patients older than 18 years
Exclusion Criteria:
- Patients undertaking any pain relieving medicine, including non-steroid and opioid medicine
- Patients with diagnosed endocrine system diseases
- Patients with psychogenic diseases
- Patients with pre-injected local anaesthetics
- Patients with oncologic diseases
- Patients with endocrine system diseases
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
No Intervention
Cold Pressor Test Results
β-endorphins level in saliva
β-endorphin level in blood plasma
Pain perception rating
Participants, enrolling the healthy participants high and low pain perception groups, will undergo cold pressor test. According to the results patients will be assigned according to time (min:s) until first pain felt (pain threshold) and time (min:s) until unbearable pain and test withdraw (pain tolerance). Also, pain ratings (1-10) at same points will be used as participants alignment tool.
Participants will be sorted according to β-endorphin levels in saliva., therefore the β-endorphins evaluation in saliva intervention will be performed.
Participants will be sorted according to β-endorphin levels in blood plasma, therefore β-endorphins evaluation in blood plasma will be performed.
Healthy participants will be sorted in to groups: high and low pain perception groups, according to the results of questionnaires, containing various oral surgery procedures pain ranking.