Deep Brain Stimulation for Patients With Chronic, Severe and Resistant Anorexia Nervosa
Anorexia Nervosa
About this trial
This is an interventional treatment trial for Anorexia Nervosa focused on measuring deep brain stimulation
Eligibility Criteria
Inclusion Criteria:
(All criteria for inclusion must be met)
- Age between 18-60 years
- Diagnosis of AN, both restrictive type and compulsion / purge type defined by the DSM-V-TR
- Chronicity: minimum of 10 years of illness.
Resistance to treatment, shown by one or both of the following situations:
A. That of the multiple treatments performed, at least 1 is an intensive treatment (hospitalization or day hospital), with one or more of the following results:
- I have not been able to finish the treatment.
- That it has finished but with little or no answer.
- That in spite of having finished it, and of having answered, Has found a subsequent relapse in the first six months. B. Clinical situation of medical instability, accompanied by refusal to participate in any treatment program and including at least 1 episode of admission for involuntary feeding.
- Extremely serious (BMI less than 15), or severe (BMI between 15-15,99)
- Ability to sign informed consent
- Ability to undergo all tests and follow-ups of the study
Exclusion Criteria:
- BMI less than 13 at the time of recruitment for the study.
- Psychosis in the present moment or in the past.
- Current neurological disease.
- Substance or alcohol abuse and dependence in the last year.
- Contraindications to perform a brain MRI
- Presence of cardiac arrhythmias or other cardiac, respiratory, renal or endocrine affections, as a result of AN or not, that carries risk for the surgical procedure.
- Pregnancy
Sites / Locations
- Gloria Villalba MartinezRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Deep brain stimulation ON
Deep brain stimulation OFF
Surgical procedure is necessary.In surgery, two cerebral electrodes (either in the Subgenual cingulate or in the Accumbens Nucleus) are connected to a subcutaneous generator at abdominal fat level, under general anesthesia. The patient will initiate the stimulation prior to discharge . At 6 months follow up, Deep brain stimulation continue 3 months more activated, patient and psychiatrist don´t know
Surgical procedure is necessary.In surgery, two cerebral electrodes (either in the Subgenual cingulate or in the Accumbens Nucleus) are connected to a subcutaneous generator at abdominal fat level, under general anesthesia. The patient will initiate the stimulation prior to discharge . At 6 months follow up, Deep brain stimulation is stopped during 3 months , patient and psychiatrist don´t know