The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies
Sterility, Infertility
About this trial
This is an interventional treatment trial for Sterility focused on measuring GnRH agonist, In Vitro fertilization, Assisted Reproductive Technology, Follicule Maturation, Pregnancy
Eligibility Criteria
Inclusion Criteria:
- Normal uterine cavity (as assessed by hysteroscopy or HSG).
- Normal hormonal investigation: TSH, PRL.
- More than 15 follicles (≥12 mm in diameter) on ultrasound, and/or estradiol level of > 3500 pg/ml on the day of trigger.
Exclusion Criteria:
- History of three or more miscarriages.
- History of three or more previous IVF failures.
- Abnormal uterine cavity (Hysteroscopy or HSG).
Sites / Locations
- American University of Beirut Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Repeated 3-dose GnRHa " Triptorelin"
Conventional 1-dose GnRHa " Triptorelin"
Triptorelin pre-filled syringes (Gonapeptyl 0.1mg; Ferring GmbH, Germany) will be administered subcutaneously in three repeated doses 12 hours apart (0.3/0.2/0.2mg) when at least three follicles 18 mm in diameter have been observed by ultrasound examination.
Triptorelin pre-filled syringes will be administered subcutaneously in a single dose (0.3 mg) when at least three follicles 18 mm in diameter have been observed by ultrasound examination.