Health Benefits of HIT for Breast Cancer Patients
Breast Cancer
About this trial
This is an interventional prevention trial for Breast Cancer focused on measuring Exercise, Aerobic capacity, Rehabilitation
Eligibility Criteria
Inclusion Criteria:
- Recent diagnosis of biopsy-proven primary invasive breast cancer
- Pre- or post-menopausal women
- World Health Organisation Performance status 0-2
- No distant metastasis
On a treatment plan of:
- surgery (breast conservation surgery or mastectomy with or without reconstruction, including axillary surgery)
- Adjuvant treatment with hormonal therapy and/or radiotherapy
- Adjuvant chemotherapy with or without anti-Her-2 therapy
- Can start the study within 1 week of diagnosis and prior to surgery
- Have surgery arranged within 1-4 weeks of diagnosis
- All receptor statuses are eligible
Exclusion Criteria:
- BMI > 35 kg·m-2
- Age < 35 y or > 60 y
- Men
- Verbal self-report of undertaking five or more structured exercise sessions per week, perceived as being moderate-to-vigorous intensity, and each session being ≥ 30 minutes in duration
- Contraindications to exercise as determined using the Physical Activity Readiness Questionnaire (PAR-Q)
- Any known significant cardiovascular (except controlled hypertension), pulmonary (except treated/controlled asthma) or metabolic disease (except hypercholesterolemia or type II diabetes)
- Auto-immune disease or exercise-limiting inflammatory arthritis
- Distant metastasis
Secondary breast cancer or previous diagnosis of invasive cancer and treatment within last 5 years except
- Localised basal cell carcinoma or squamous cell carcinoma of skin
- In situ melanoma
- Cervical intraepithelial neoplasia (CIN)
- Neoadjuvant chemotherapy
Sites / Locations
- Manor Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise
Standard care
Patients in the Exercise group will follow a fully-supervised exercise routine (Reduced-exertion, high-intensity interval training (REHIT)) with 3 weekly 10-minute training sessions consisting of easy cycling interspersed with 2 brief 'all-out' cycle sprints. Patients in this group will also be offered up to 6 sessions of cognitive behavioral therapy. The duration of the intervention will be the weeks between enrolling in the study and surgery (~1-4 weeks), as well as an additional period of up to 6 weeks following surgery.
Patients allocated to the Standard Care group will receive the care they would have also received if they would not have participated in the study. They will however undergo the same testing sessions as patients in the Exercise group.