Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain
Cardiac Pacing, Artificial, Aneurysm, Brain, Arteriovenous Malformations, Cerebral
About this trial
This is an interventional treatment trial for Cardiac Pacing, Artificial
Eligibility Criteria
Inclusion Criteria:
- elective cerebral aneurysm clipping surgery
- arteriovenous malformation surgery
- craniotomy
- American Society of Anesthesiologists 1,2 and 3
Exclusion Criteria:
- cardiac abnormalities
- coronary heart disease
- valvular heart disease
- pregnancy
Sites / Locations
- University hospital AntwerpRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Active Comparator
Cerebral aneurysm surgery with RVP
Craniotomy without RVP
Subjects receive a Magnetic Resonance Imaging of the brain pre-and postoperatively as standard of care. To screen for rapid ventricular pacing induced micro-infarcts, the contralateral hemisphere (contralateral to the hemisphere operated on) and fossa posterior will be evaluated. Troponin levels will be determinated preoperatively, peroperative and at 6, 12 and 24 hours postoperative by blood sample. Maximum cTnl level and cTnl level 24 hours will be compared. Brain oxygenation (Sct O₂) by near-infrared spectroscopy will be monitored. During surgery subjects allocated in this study arm will undergo RVP.
Subjects receive a Magnetic Resonance Imaging of the brain pre-and postoperatively as standard of care. To screen for rapid ventricular pacing induced micro-infarcts, the contralateral hemisphere (contralateral to the hemisphere operated on) and fossa posterior will be evaluated. Troponin levels will be determinated preoperatively, peroperative and at 6, 12 and 24 hours postoperative by blood sample. Maximum cTnl level and cTnl level 24 hours will be compared. Brain oxygenation (Sct O₂) by near-infrared spectroscopy will be monitored. No rapid ventricular pacing is applied perioperatively.