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Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

Primary Purpose

Invasive Breast Carcinoma, Stage II Breast Cancer, Stage IIA Breast Cancer

Status

Suspended

Phase

Phase 2

Locations

International

Study Type

Interventional

Intervention

Biopsy of Breast

About this trial

This is an interventional other trial for Invasive Breast Carcinoma

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Patients must have had ER analysis performed on the primary breast tumor collected prior to neoadjuvant therapy according to current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for hormone receptor testing; if negative for ER, assessment of progesterone receptor (PgR) must also be performed according to current ASCO/CAP Guideline Recommendations for hormone receptor testing. Patients who have a primary tumor that is hormone receptor-positive or hormone receptor-negative are eligible.
Patients must have had HER2 testing performed on the primary breast tumor collected prior to neoadjuvant chemotherapy according to the current ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer; patients who have a primary tumor that is HER2-positive, HER2-equivocal, or HER2-negative are eligible
Patients must have had a biopsy marker placed within the tumor bed with imaging confirmation (preferably mammogram but ultrasound or magnetic resonance imaging [MRI] is acceptable) of marker placement prior to neoadjuvant chemotherapy
Patients with operable focal or multifocal (T1-T3, stage II or III invasive ductal carcinoma [all receptor phenotypes]), and who have completed neoadjuvant chemotherapy with a clinical complete response (by clinical examination)
Patients with synchronous bilateral breast cancer are eligible if at least one of the synchronous breast cancers has a cCR, and the side with a cCR meets criteria. (Patients with previous contralateral invasive breast cancer treated with anti-cancer therapy are eligible.)
Patients must have achieved a complete or near complete radiologic tumor response on breast imaging with mammogram, ultrasound, and MRI during or after completion of appropriate neoadjuvant chemotherapy defined as:
- Mammogram with malignant appearing calcification or mass ≤ 1 cm; or
- Ultrasound with a hypoechoic area ≤ 2 cm; or
- Breast MRI not demonstrating a residual mass with rapid rise and washout type III kinetics.
At the time of consent, the patient's intent must be to undergo breast conserving therapy.
Patient must be able to undergo stereotactic-vacuum-assisted breast biopsy with clip placement after completion of neoadjuvant chemotherapy. (The patient must be enrolled on the study before performing the post-neoadjuvant stereotactic-vacuum-assisted breast biopsy.)
Patient must have completed neoadjuvant chemotherapy.
Patients with HER2-positive tumors must have received neoadjuvant anti-HER2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen), unless medically contraindicated.
Patients treated with PD-1 or PD-L1 inhibitors, CDK 4/6 inhibitors, or other immune-based therapy are eligible.

Exclusion Criteria:

T4 tumors including inflammatory breast cancer
Patients with distant metastatic disease
Lumpectomy performed prior to study entry
Patients with any history of prior radiation therapy in the affected breast
Patients with a prior history of ipsilateral invasive breast cancer; (patients with previous ipsilateral/contralateral DCIS or previous contralateral invasive breast cancer treated with anti-cancer therapy are eligible)
Patients with invasive lobular carcinoma
Patients who have multicentric disease
Patients treated with neoadjuvant hormonal therapy only are not eligible
Patients who are medically unfit to undergo surgical resection
Patients without breast biopsy marker documented by imaging at tumor bed site prior to initiation of neoadjuvant therapy
Patients with one or more of the following imaging criteria from any of the 3 imaging modalities after completion of NCT demonstrating incomplete radiologic response are not eligible:
- Mammogram with malignant appearing calcifications or mass > 1 cm; or
- Ultrasound with a hypoechoic area > 2 cm; or
- Breast MRI demonstrating a residual mass with rapid rise and washout type III kinetics.
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements or interfere with interpretation of study results
Pregnancy or lactation at the time of study registration; (Note: Pregnancy testing according to institutional standards for women of childbearing potential must be performed within 2 weeks prior to study registration.)

Sites / Locations

University of Alabama at Birmingham Cancer Center
University of South Alabama Mitchell Cancer Institute
Cancer Center at Saint Joseph's
Banner University Medical Center - Tucson
University of Arizona Cancer Center-North Campus
Mercy Hospital Fort Smith
Kaiser Permanente-Deer Valley Medical Center
Sutter Auburn Faith Hospital
Sutter Cancer Centers Radiation Oncology Services-Auburn
Alta Bates Summit Medical Center-Herrick Campus
Mills-Peninsula Medical Center
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Eden Hospital Medical Center
Sutter Davis Hospital
Epic Care-Dublin
Bay Area Breast Surgeons Inc
Epic Care Partners in Cancer Care
Kaiser Permanente-Fremont
Palo Alto Medical Foundation-Fremont
Fresno Cancer Center
Kaiser Permanente-Fresno
Los Angeles County-USC Medical Center
USC / Norris Comprehensive Cancer Center
Contra Costa Regional Medical Center
Memorial Medical Center
Kaiser Permanente-Modesto
Palo Alto Medical Foundation-Camino Division
Palo Alto Medical Foundation-Gynecologic Oncology
Sutter Cancer Research Consortium
Alta Bates Summit Medical Center - Summit Campus
Bay Area Tumor Institute
Kaiser Permanente Oakland-Broadway
Kaiser Permanente-Oakland
Palo Alto Medical Foundation Health Care
Stanford Cancer Institute Palo Alto
Keck Medical Center of USC Pasadena
Kaiser Permanente-Rancho Cordova Cancer Center
Kaiser Permanente-Redwood City
Kaiser Permanente-Richmond
Rohnert Park Cancer Center
Kaiser Permanente-Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Sutter Roseville Medical Center
The Permanente Medical Group-Roseville Radiation Oncology
Kaiser Permanente Downtown Commons
Sutter Medical Center Sacramento
Kaiser Permanente-South Sacramento
South Sacramento Cancer Center
Kaiser Permanente - Sacramento
Naval Medical Center -San Diego
California Pacific Medical Center-Pacific Campus
Kaiser Permanente-San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Kaiser Permanente San Leandro
Kaiser Permanente-San Rafael
Kaiser San Rafael-Gallinas
Kaiser Permanente Medical Center - Santa Clara
Palo Alto Medical Foundation-Santa Cruz
Kaiser Permanente-Santa Rosa
Sutter Pacific Medical Foundation
Kaiser Permanente Cancer Treatment Center
Kaiser Permanente-South San Francisco
Kaiser Permanente-Stockton
Palo Alto Medical Foundation-Sunnyvale
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Kaiser Permanente Medical Center-Vacaville
Kaiser Permanente-Vallejo
Sutter Solano Medical Center/Cancer Center
Kaiser Permanente-Walnut Creek
Epic Care Cyberknife Center
Rocky Mountain Cancer Centers-Aurora
University of Colorado Hospital
Boulder Community Hospital
Rocky Mountain Cancer Centers-Boulder
Denver Health Medical Center
National Jewish Health-Main Campus
The Women's Imaging Center
Colorado Blood Cancer Institute
Presbyterian - Saint Lukes Medical Center - Health One
Rocky Mountain Cancer Centers-Midtown
SCL Health Saint Joseph Hospital
Rocky Mountain Cancer Centers-Rose
Rose Medical Center
Western Surgical Care
Mountain Blue Cancer Care Center - Swedish
Swedish Medical Center
Poudre Valley Hospital
National Jewish Health-Western Hematology Oncology
Saint Mary's Hospital and Regional Medical Center
Grand Valley Oncology
North Colorado Medical Center
Good Samaritan Medical Center
Rocky Mountain Cancer Centers-Littleton
Rocky Mountain Cancer Centers-Sky Ridge
McKee Medical Center
National Jewish Health-Northern Hematology Oncology
SCL Health Lutheran Medical Center
Smilow Cancer Center/Yale-New Haven Hospital
Yale University
Beebe Medical Center
Delaware Clinical and Laboratory Physicians PA
Helen F Graham Cancer Center
Medical Oncology Hematology Consultants PA
Christiana Care Health System-Christiana Hospital
Beebe Health Campus
TidalHealth Nanticoke / Allen Cancer Center
Christiana Care Health System-Wilmington Hospital
John Fitzgerald Kennedy Medical Center
University of Florida Health Science Center - Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Orlando Health Cancer Institute
Memorial Hospital West
Emory University Hospital Midtown
Piedmont Hospital
Emory University Hospital/Winship Cancer Institute
Emory Saint Joseph's Hospital
Dekalb Medical Center
Piedmont Fayette Hospital
Medical Center of Central Georgia
Hawaii Cancer Care - Westridge
Pali Momi Medical Center
Queen's Cancer Center - Pearlridge
The Cancer Center of Hawaii-Pali Momi
Hawaii Cancer Care Inc - Waterfront Plaza
Island Urology
Queen's Cancer Cenrer - POB I
Queen's Medical Center
Straub Clinic and Hospital
University of Hawaii Cancer Center
Hawaii Cancer Care Inc-Liliha
Kuakini Medical Center
Queen's Cancer Center - Kuakini
The Cancer Center of Hawaii-Liliha
Kaiser Permanente Moanalua Medical Center
Kapiolani Medical Center for Women and Children
Wilcox Memorial Hospital and Kauai Medical Clinic
Saint Alphonsus Cancer Care Center-Boise
Saint Alphonsus Cancer Care Center-Caldwell
Kootenai Health - Coeur d'Alene
Walter Knox Memorial Hospital
Idaho Urologic Institute-Meridian
Saint Alphonsus Cancer Care Center-Nampa
Kootenai Clinic Cancer Services - Post Falls
Kootenai Cancer Clinic
Rush - Copley Medical Center
Northwestern University
John H Stroger Jr Hospital of Cook County
Rush University Medical Center
University of Chicago Comprehensive Cancer Center
Carle at The Riverfront
Carle Physician Group-Effingham
Northwestern Medicine Lake Forest Hospital
Carle Physician Group-Mattoon/Charleston
Loyola University Medical Center
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Trinity Medical Center
Good Samaritan Regional Health Center
UC Comprehensive Cancer Center at Silver Cross
University of Chicago Medicine-Orland Park
Carle Cancer Center
The Carle Foundation Hospital
Rush-Copley Healthcare Center
Deaconess Clinic Downtown
Parkview Hospital Randallia
Parkview Regional Medical Center
Goshen Center for Cancer Care
Chancellor Center for Oncology
University of Iowa/Holden Comprehensive Cancer Center
Coffeyville Regional Medical Center
Central Care Cancer Center - Garden City
Central Care Cancer Center - Great Bend
HaysMed University of Kansas Health System
University of Kansas Cancer Center
Kansas Institute of Medicine Cancer and Blood Center
Minimally Invasive Surgery Hospital
Olathe Health Cancer Center
Menorah Medical Center
University of Kansas Cancer Center-Overland Park
University of Kansas Hospital-Indian Creek Campus
Ascension Via Christi - Pittsburg
Salina Regional Health Center
University of Kansas Health System Saint Francis Campus
University of Kansas Hospital-Westwood Cancer Center
Louisiana State University Health Science Center
University Medical Center New Orleans
Anne Arundel Medical Center
Greater Baltimore Medical Center
UM Upper Chesapeake Medical Center
Lahey Hospital and Medical Center
Winchester Hospital
Henry Ford Cancer Institute-Downriver
Henry Ford Macomb Hospital-Clinton Township
Henry Ford Medical Center-Fairlane
Henry Ford Hospital
Allegiance Health
Henry Ford Medical Center-Columbus
Henry Ford West Bloomfield Hospital
Sanford Joe Lueken Cancer Center
Fairview Ridges Hospital
Cambridge Medical Center
Mercy Hospital
Fairview Southdale Hospital
Unity Hospital
Fairview Clinics and Surgery Center Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Saint John's Hospital - Healtheast
Abbott-Northwestern Hospital
Hennepin County Medical Center
Health Partners Inc
Monticello Cancer Center
New Ulm Medical Center
North Memorial Medical Health Center
Mayo Clinic in Rochester
Park Nicollet Clinic - Saint Louis Park
Regions Hospital
United Hospital
Saint Francis Regional Medical Center
Lakeview Hospital
Ridgeview Medical Center
Rice Memorial Hospital
Minnesota Oncology Hematology PA-Woodbury
Fairview Lakes Medical Center
Saint Louis Cancer and Breast Institute-Ballwin
Central Care Cancer Center - Bolivar
Cox Cancer Center Branson
Siteman Cancer Center at West County Hospital
Centerpoint Medical Center LLC
Freeman Health System
Mercy Hospital Joplin
Truman Medical Centers
The University of Kansas Cancer Center-South
Research Medical Center
University of Kansas Cancer Center - North
University of Kansas Cancer Center - Lee's Summit
Delbert Day Cancer Institute at PCRMC
Mercy Clinic-Rolla-Cancer and Hematology
Heartland Regional Medical Center
Saint Louis Cancer and Breast Institute-South City
Washington University School of Medicine
Mercy Hospital South
Siteman Cancer Center-South County
Siteman Cancer Center at Christian Hospital
Mercy Hospital Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Mercy Hospital Springfield
CoxHealth South Hospital
Mercy Hospital Washington
Community Hospital of Anaconda
Billings Clinic Cancer Center
Saint Vincent Healthcare
Saint Vincent Frontier Cancer Center
Bozeman Deaconess Hospital
Saint James Community Hospital and Cancer Treatment Center
Benefis Healthcare- Sletten Cancer Institute
Great Falls Clinic
Saint Peter's Community Hospital
Kalispell Regional Medical Center
Community Medical Hospital
The Cancer Institute of New Jersey Hamilton
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
Rutgers Cancer Institute of New Jersey
University of New Mexico Cancer Center
Montefiore Medical Center-Einstein Campus
Montefiore Medical Center-Weiler Hospital
Montefiore Medical Center - Moses Campus
Roswell Park Cancer Institute
Mount Sinai Union Square
Mount Sinai West
Mount Sinai Hospital
State University of New York Upstate Medical University
SUNY Upstate Medical Center-Community Campus
UNC Lineberger Comprehensive Cancer Center
Carolinas Medical Center/Levine Cancer Institute
Atrium Health Pineville/LCI-Pineville
Duke University Medical Center
Wake Forest University at Elkin
Wake Forest University at Lexington
Atrium Health Union/LCI-Union
Wake Forest University at Mount Airy
Wake Forest University Health Sciences
Sanford Bismarck Medical Center
Sanford Broadway Medical Center
Sanford Roger Maris Cancer Center
UHHS-Chagrin Highlands Medical Center
Case Western Reserve University
Ohio State University Comprehensive Cancer Center
UH Seidman Cancer Center at Saint John Medical Center
UHHS-Westlake Medical Center
University of Oklahoma Health Sciences Center
Mercy Hospital Oklahoma City
Saint Alphonsus Medical Center-Baker City
Saint Alphonsus Medical Center-Ontario
Jefferson Abington Hospital
UPMC-Heritage Valley Health System Beaver
Christiana Care Health System-Concord Health Center
Ephrata Cancer Center
Ephrata Community Hospital
Adams Cancer Center
UPMC Cancer Centers - Arnold Palmer Pavilion
Cherry Tree Cancer Center
UPMC Pinnacle Harrisburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Sechler Family Cancer Center
UPMC Cancer Center at UPMC McKeesport
UPMC Hillman Cancer Center in Coraopolis
Allegheny General Hospital
UPMC-Magee Womens Hospital
UPMC-Presbyterian Hospital
UPMC-Saint Margaret
University of Pittsburgh Cancer Institute (UPCI)
UPMC-Shadyside Hospital
UPMC-Passavant Hospital
UPMC-Saint Clair Hospital Cancer Center
UPMC Cancer Center at UPMC Northwest
UPMC Uniontown Hospital Radiation Oncology
UPMC Washington Hospital Radiation Oncology
Reading Hospital
Wexford Health and Wellness Pavilion
WellSpan Health-York Cancer Center
WellSpan Health-York Hospital
Women and Infants Hospital
Prisma Health Cancer Institute - Spartanburg
Prisma Health Cancer Institute - Easley
Prisma Health Cancer Institute - Butternut
Prisma Health Cancer Institute - Faris
Prisma Health Greenville Memorial Hospital
Prisma Health Cancer Institute - Eastside
Prisma Health Cancer Institute - Greer
Prisma Health Cancer Institute - Seneca
Sanford Cancer Center Oncology Clinic
Avera Cancer Institute
Sanford USD Medical Center - Sioux Falls
Vanderbilt-Ingram Cancer Center Cool Springs
Baptist Memorial Hospital and Cancer Center-Memphis
Vanderbilt Breast Center at One Hundred Oaks
Vanderbilt University/Ingram Cancer Center
Houston Methodist Hospital
M D Anderson Cancer Center
Doctor's Hospital of Laredo
Scott and White Healthcare Round Rock
Houston Methodist Sugar Land Hospital
Scott and White Memorial Hospital
Farmington Health Center
Huntsman Cancer Institute/University of Utah
South Jordan Health Center
Sentara Cancer Institute at Sentara CarePlex Hospital
Sentara Leigh Hospital
Sentara Norfolk General Hospital
Virginia Commonwealth University/Massey Cancer Center
Sentara Virginia Beach General Hospital
Sentara Princess Anne Hospital
United Hospital Center
WVUH-Berkely Medical Center
West Virginia University Healthcare
Camden Clark Medical Center
Aurora Cancer Care-Southern Lakes VLCC
Aurora Health Center-Fond du Lac
Aurora Health Care Germantown Health Center
Aurora Cancer Care-Grafton
Aurora BayCare Medical Center
Aurora Cancer Care-Kenosha South
Aurora Bay Area Medical Group-Marinette
Aurora Cancer Care-Milwaukee
Aurora Saint Luke's Medical Center
Aurora Sinai Medical Center
Cancer Center of Western Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh
Aurora Cancer Care-Racine
Vince Lombardi Cancer Clinic-Sheboygan
Aurora Medical Center in Summit
Vince Lombardi Cancer Clinic-Two Rivers
Aurora Cancer Care-Milwaukee West
Aurora West Allis Medical Center
Cheyenne Regional Medical Center-West
Billings Clinic-Cody
Welch Cancer Center
University Health Network-Princess Margaret Hospital
CHUM - Centre Hospitalier de l'Universite de Montreal
The Research Institute of the McGill University Health Centre (MUHC)
Jewish General Hospital

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Diagnostic (biopsy of breast)

Arm Description

After completion of neoadjuvant therapy, patients undergo stereotactic biopsy of breast tumor any time prior to breast conserving surgery. Patients then undergo breast conserving surgery as per standard of care. Patients may also undergo postoperative radiation therapy per standard of care or adjuvant therapy at the investigator's discretion.

Outcomes

Primary Outcome Measures

Proportion of patients with pCR

The proportion of tumor bed biopsies that are negative among those who are shown to have pCR at surgery will be determined. The point estimate and 95% confidence interval will be calculated.

Secondary Outcome Measures

Improvement of negative predictive value

Analysis will be performed to assess the improvement in the negative predictive value of the trimodality imaging algorithm when the results of tumor bed biopsy are added.

Incidence of adverse events associated with tumor bed biopsy

Descriptive analysis will be performed to determine the frequencies of adverse events associated with tumor bed biopsy.

Number of needle cores performed

Descriptive analysis will be performed to determine the distribution of the number of needle cores performed and the proportion of clips retrieved.

Proportion of clips retrieved

Descriptive analysis will be performed.

Residual cancer burden score

Descriptive analysis will be performed to determine the distribution of residual cancer burden score.

Trimodality imaging algorithm +/- biopsy as a predictor of pCR

Analysis will be performed to assess the improvement in the negative predictive value of the trimodality imaging algorithm when the results of tumor bed biopsy are added.

Full Information

NCT ID

NCT03188393

First Posted

June 13, 2017

Last Updated

May 1, 2023

Sponsor

NRG Oncology

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT03188393

Brief Title

Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

Official Title

A Phase II Trial Assessing the Accuracy of Tumor Bed Biopsies in Predicting Pathologic Response in Patients With Clinical/Radiologic Complete Response After Neoadjuvant Chemotherapy in Order to Explore the Feasibility of Breast Conserving Treatment Without Surgery

Study Type

Interventional

2. Study Status

Record Verification Date

May 2023

Overall Recruitment Status

Suspended

Why Stopped

Phase I analysis

Study Start Date

April 13, 2017 (Actual)

Primary Completion Date

November 30, 2023 (Anticipated)

Study Completion Date

November 30, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

NRG Oncology

Collaborators

National Cancer Institute (NCI)

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

This phase II trial studies how well biopsy of breast after chemotherapy works in predicting pathologic response in patients with stage II-IIIA breast cancer undergoing breast conserving surgery. Tumor tissue collected from biopsy before surgery may help to check if chemotherapy destroyed the breast cancer cells and may be compared to the tumor removed during surgery to check if they are the same.

Detailed Description

PRIMARY OBJECTIVES: I. To assess the accuracy of post-neoadjuvant systemic therapy (NST) image-directed tumor bed biopsy for pathologic complete response (pCR), defined as resolution of both invasive disease and ductal carcinoma in situ (DCIS), in cases of clinical and radiologic complete response with trimodality imaging. SECONDARY OBJECTIVES: I. To collect axillary pathology results, surgical staging methods (sentinel lymph node biopsy and/or axillary lymph node dissection), and management (surgery and/or radiation) in order to determine axillary nodal response to neoadjuvant chemotherapy and its relationship to breast pCR. II. To correlate imaging results with pathologic nodal status following neoadjuvant chemotherapy for future planning of axillary management in the next study. III. To retrospectively assess the negative predictive value (NPV) of a trimodality imaging algorithm in combination with the tumor bed biopsy for predicting pCR. IV. To collect all trimodality imaging data to determine which combination of the trimodality imaging best identifies the group achieving pCR. V. To correlate the number of needle cores and tumor bed clip retrieval with the NPV of the tumor site biopsy. VI. To determine the clinical, imaging, pathologic, and molecular tumor factors associated with the highest NPVs of post-NST tumor bed biopsies. VII. To improve identification and selection of patients with breast and possible axillary pCR for future trial planning, routine biomarkers (estrogen receptor [ER], progesterone receptor [PR], HER2 neu, and Ki67) will be collected to allow comparison to image/clinical complete response (CR), and tumor bed biopsies. OUTLINE: After completion of neoadjuvant therapy, patients undergo stereotactic biopsy of breast tumor any time prior to breast conserving surgery. Patients then undergo breast conserving surgery as per standard of care. Patients may also undergo postoperative radiation therapy per standard of care or adjuvant therapy at the investigator's discretion.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Invasive Breast Carcinoma, Stage II Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer

7. Study Design

Primary Purpose

Other

Study Phase

Phase 2

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

175 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Diagnostic (biopsy of breast)

Arm Type

Experimental

Arm Description

Intervention Type

Procedure

Intervention Name(s)

Biopsy of Breast

Other Intervention Name(s)

Breast Biopsy

Intervention Description

Undergo stereotactic biopsy

Primary Outcome Measure Information:

Title

Proportion of patients with pCR

Description

The proportion of tumor bed biopsies that are negative among those who are shown to have pCR at surgery will be determined. The point estimate and 95% confidence interval will be calculated.

Time Frame

Up to 18 months

Secondary Outcome Measure Information:

Title

Improvement of negative predictive value

Description

Analysis will be performed to assess the improvement in the negative predictive value of the trimodality imaging algorithm when the results of tumor bed biopsy are added.

Time Frame

Up to 18 months

Title

Incidence of adverse events associated with tumor bed biopsy

Description

Descriptive analysis will be performed to determine the frequencies of adverse events associated with tumor bed biopsy.

Time Frame

Up to 18 months

Title

Number of needle cores performed

Description

Descriptive analysis will be performed to determine the distribution of the number of needle cores performed and the proportion of clips retrieved.

Time Frame

Up to 18 months

Title

Proportion of clips retrieved

Description

Descriptive analysis will be performed.

Time Frame

Up to 18 months

Title

Residual cancer burden score

Description

Descriptive analysis will be performed to determine the distribution of residual cancer burden score.

Time Frame

Up to 18 months

Title

Trimodality imaging algorithm +/- biopsy as a predictor of pCR

Description

Analysis will be performed to assess the improvement in the negative predictive value of the trimodality imaging algorithm when the results of tumor bed biopsy are added.

Time Frame

Up to18 months

Other Pre-specified Outcome Measures:

Title

Molecular makers from tumor and blood samples

Description

Analysis to assess the association of molecular markers with response to neoadjuvant therapy.

Time Frame

Up to 18 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Patients must have had ER analysis performed on the primary breast tumor collected prior to neoadjuvant therapy according to current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for hormone receptor testing; if negative for ER, assessment of progesterone receptor (PgR) must also be performed according to current ASCO/CAP Guideline Recommendations for hormone receptor testing. Patients who have a primary tumor that is hormone receptor-positive or hormone receptor-negative are eligible. Patients must have had HER2 testing performed on the primary breast tumor collected prior to neoadjuvant chemotherapy according to the current ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer; patients who have a primary tumor that is HER2-positive, HER2-equivocal, or HER2-negative are eligible Patients must have had a biopsy marker placed within the tumor bed with imaging confirmation (preferably mammogram but ultrasound or magnetic resonance imaging [MRI] is acceptable) of marker placement prior to neoadjuvant chemotherapy Patients with operable focal or multifocal (T1-T3, stage II or III invasive ductal carcinoma [all receptor phenotypes]), and who have completed neoadjuvant chemotherapy with a clinical complete response (by clinical examination) Patients with synchronous bilateral breast cancer are eligible if at least one of the synchronous breast cancers has a cCR, and the side with a cCR meets criteria. (Patients with previous contralateral invasive breast cancer treated with anti-cancer therapy are eligible.) Patients must have achieved a complete or near complete radiologic tumor response on breast imaging with mammogram, ultrasound, and MRI during or after completion of appropriate neoadjuvant chemotherapy defined as: Mammogram with malignant appearing calcification or mass ≤ 1 cm; or Ultrasound with a hypoechoic area ≤ 2 cm; or Breast MRI not demonstrating a residual mass with rapid rise and washout type III kinetics. At the time of consent, the patient's intent must be to undergo breast conserving therapy. Patient must be able to undergo stereotactic-vacuum-assisted breast biopsy with clip placement after completion of neoadjuvant chemotherapy. (The patient must be enrolled on the study before performing the post-neoadjuvant stereotactic-vacuum-assisted breast biopsy.) Patient must have completed neoadjuvant chemotherapy. Patients with HER2-positive tumors must have received neoadjuvant anti-HER2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen), unless medically contraindicated. Patients treated with PD-1 or PD-L1 inhibitors, CDK 4/6 inhibitors, or other immune-based therapy are eligible. Exclusion Criteria: T4 tumors including inflammatory breast cancer Patients with distant metastatic disease Lumpectomy performed prior to study entry Patients with any history of prior radiation therapy in the affected breast Patients with a prior history of ipsilateral invasive breast cancer; (patients with previous ipsilateral/contralateral DCIS or previous contralateral invasive breast cancer treated with anti-cancer therapy are eligible) Patients with invasive lobular carcinoma Patients who have multicentric disease Patients treated with neoadjuvant hormonal therapy only are not eligible Patients who are medically unfit to undergo surgical resection Patients without breast biopsy marker documented by imaging at tumor bed site prior to initiation of neoadjuvant therapy Patients with one or more of the following imaging criteria from any of the 3 imaging modalities after completion of NCT demonstrating incomplete radiologic response are not eligible: Mammogram with malignant appearing calcifications or mass > 1 cm; or Ultrasound with a hypoechoic area > 2 cm; or Breast MRI demonstrating a residual mass with rapid rise and washout type III kinetics. Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements or interfere with interpretation of study results Pregnancy or lactation at the time of study registration; (Note: Pregnancy testing according to institutional standards for women of childbearing potential must be performed within 2 weeks prior to study registration.)

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Mark Basik

Organizational Affiliation

NRG Oncology

Official's Role

Principal Investigator

Facility Information:

Facility Name

University of Alabama at Birmingham Cancer Center

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35233

Country

United States

Facility Name

University of South Alabama Mitchell Cancer Institute

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36688

Country

United States

Facility Name

Cancer Center at Saint Joseph's

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85004

Country

United States

Facility Name

Banner University Medical Center - Tucson

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85719

Country

United States

Facility Name

University of Arizona Cancer Center-North Campus

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85719

Country

United States

Facility Name

Mercy Hospital Fort Smith

City

Fort Smith

State/Province

Arkansas

ZIP/Postal Code

72903

Country

United States

Facility Name

Kaiser Permanente-Deer Valley Medical Center

City

Antioch

State/Province

California

ZIP/Postal Code

94531

Country

United States

Facility Name

Sutter Auburn Faith Hospital

City

Auburn

State/Province

California

ZIP/Postal Code

95602

Country

United States

Facility Name

Sutter Cancer Centers Radiation Oncology Services-Auburn

City

Auburn

State/Province

California

ZIP/Postal Code

95603

Country

United States

Facility Name

Alta Bates Summit Medical Center-Herrick Campus

City

Berkeley

State/Province

California

ZIP/Postal Code

94704

Country

United States

Facility Name

Mills-Peninsula Medical Center

City

Burlingame

State/Province

California

ZIP/Postal Code

94010

Country

United States

Facility Name

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

City

Cameron Park

State/Province

California

ZIP/Postal Code

95682

Country

United States

Facility Name

Eden Hospital Medical Center

City

Castro Valley

State/Province

California

ZIP/Postal Code

94546

Country

United States

Facility Name

Sutter Davis Hospital

City

Davis

State/Province

California

ZIP/Postal Code

95616

Country

United States

Facility Name

Epic Care-Dublin

City

Dublin

State/Province

California

ZIP/Postal Code

94568

Country

United States

Facility Name

Bay Area Breast Surgeons Inc

City

Emeryville

State/Province

California

ZIP/Postal Code

94608

Country

United States

Facility Name

Epic Care Partners in Cancer Care

City

Emeryville

State/Province

California

ZIP/Postal Code

94608

Country

United States

Facility Name

Kaiser Permanente-Fremont

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

Palo Alto Medical Foundation-Fremont

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

Fresno Cancer Center

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Kaiser Permanente-Fresno

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Los Angeles County-USC Medical Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Facility Name

USC / Norris Comprehensive Cancer Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Facility Name

Contra Costa Regional Medical Center

City

Martinez

State/Province

California

ZIP/Postal Code

94553-3156

Country

United States

Facility Name

Memorial Medical Center

City

Modesto

State/Province

California

ZIP/Postal Code

95355

Country

United States

Facility Name

Kaiser Permanente-Modesto

City

Modesto

State/Province

California

ZIP/Postal Code

95356

Country

United States

Facility Name

Palo Alto Medical Foundation-Camino Division

City

Mountain View

State/Province

California

ZIP/Postal Code

94040

Country

United States

Facility Name

Palo Alto Medical Foundation-Gynecologic Oncology

City

Mountain View

State/Province

California

ZIP/Postal Code

94040

Country

United States

Facility Name

Sutter Cancer Research Consortium

City

Novato

State/Province

California

ZIP/Postal Code

94945

Country

United States

Facility Name

Alta Bates Summit Medical Center - Summit Campus

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Bay Area Tumor Institute

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Kaiser Permanente Oakland-Broadway

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Kaiser Permanente-Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Palo Alto Medical Foundation Health Care

City

Palo Alto

State/Province

California

ZIP/Postal Code

94301

Country

United States

Facility Name

Stanford Cancer Institute Palo Alto

City

Palo Alto

State/Province

California

ZIP/Postal Code

94304

Country

United States

Facility Name

Keck Medical Center of USC Pasadena

City

Pasadena

State/Province

California

ZIP/Postal Code

91105

Country

United States

Facility Name

Kaiser Permanente-Rancho Cordova Cancer Center

City

Rancho Cordova

State/Province

California

ZIP/Postal Code

95670

Country

United States

Facility Name

Kaiser Permanente-Redwood City

City

Redwood City

State/Province

California

ZIP/Postal Code

94063

Country

United States

Facility Name

Kaiser Permanente-Richmond

City

Richmond

State/Province

California

ZIP/Postal Code

94801

Country

United States

Facility Name

Rohnert Park Cancer Center

City

Rohnert Park

State/Province

California

ZIP/Postal Code

94928

Country

United States

Facility Name

Kaiser Permanente-Roseville

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

Sutter Cancer Centers Radiation Oncology Services-Roseville

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

Sutter Roseville Medical Center

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

The Permanente Medical Group-Roseville Radiation Oncology

City

Roseville

State/Province

California

ZIP/Postal Code

95678

Country

United States

Facility Name

Kaiser Permanente Downtown Commons

City

Sacramento

State/Province

California

ZIP/Postal Code

95814

Country

United States

Facility Name

Sutter Medical Center Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95816

Country

United States

Facility Name

Kaiser Permanente-South Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

South Sacramento Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

Kaiser Permanente - Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Naval Medical Center -San Diego

City

San Diego

State/Province

California

ZIP/Postal Code

92134

Country

United States

Facility Name

California Pacific Medical Center-Pacific Campus

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Kaiser Permanente-San Francisco

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Kaiser Permanente-Santa Teresa-San Jose

City

San Jose

State/Province

California

ZIP/Postal Code

95119

Country

United States

Facility Name

Kaiser Permanente San Leandro

City

San Leandro

State/Province

California

ZIP/Postal Code

94577

Country

United States

Facility Name

Kaiser Permanente-San Rafael

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser San Rafael-Gallinas

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser Permanente Medical Center - Santa Clara

City

Santa Clara

State/Province

California

ZIP/Postal Code

95051

Country

United States

Facility Name

Palo Alto Medical Foundation-Santa Cruz

City

Santa Cruz

State/Province

California

ZIP/Postal Code

95065

Country

United States

Facility Name

Kaiser Permanente-Santa Rosa

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Sutter Pacific Medical Foundation

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Kaiser Permanente Cancer Treatment Center

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-South San Francisco

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-Stockton

City

Stockton

State/Province

California

ZIP/Postal Code

95210

Country

United States

Facility Name

Palo Alto Medical Foundation-Sunnyvale

City

Sunnyvale

State/Province

California

ZIP/Postal Code

94086

Country

United States

Facility Name

Sutter Cancer Centers Radiation Oncology Services-Vacaville

City

Vacaville

State/Province

California

ZIP/Postal Code

95687

Country

United States

Facility Name

Kaiser Permanente Medical Center-Vacaville

City

Vacaville

State/Province

California

ZIP/Postal Code

95688

Country

United States

Facility Name

Kaiser Permanente-Vallejo

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Sutter Solano Medical Center/Cancer Center

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Kaiser Permanente-Walnut Creek

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94596

Country

United States

Facility Name

Epic Care Cyberknife Center

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94597

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Aurora

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80012

Country

United States

Facility Name

University of Colorado Hospital

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

Boulder Community Hospital

City

Boulder

State/Province

Colorado

ZIP/Postal Code

80301

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Boulder

City

Boulder

State/Province

Colorado

ZIP/Postal Code

80304

Country

United States

Facility Name

Denver Health Medical Center

City

Denver

State/Province

Colorado

ZIP/Postal Code

80204

Country

United States

Facility Name

National Jewish Health-Main Campus

City

Denver

State/Province

Colorado

ZIP/Postal Code

80206

Country

United States

Facility Name

The Women's Imaging Center

City

Denver

State/Province

Colorado

ZIP/Postal Code

80209

Country

United States

Facility Name

Colorado Blood Cancer Institute

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

Presbyterian - Saint Lukes Medical Center - Health One

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Midtown

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

SCL Health Saint Joseph Hospital

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Rose

City

Denver

State/Province

Colorado

ZIP/Postal Code

80220

Country

United States

Facility Name

Rose Medical Center

City

Denver

State/Province

Colorado

ZIP/Postal Code

80220

Country

United States

Facility Name

Western Surgical Care

City

Denver

State/Province

Colorado

ZIP/Postal Code

80220

Country

United States

Facility Name

Mountain Blue Cancer Care Center - Swedish

City

Englewood

State/Province

Colorado

ZIP/Postal Code

80113

Country

United States

Facility Name

Swedish Medical Center

City

Englewood

State/Province

Colorado

ZIP/Postal Code

80113

Country

United States

Facility Name

Poudre Valley Hospital

City

Fort Collins

State/Province

Colorado

ZIP/Postal Code

80524

Country

United States

Facility Name

National Jewish Health-Western Hematology Oncology

City

Golden

State/Province

Colorado

ZIP/Postal Code

80401

Country

United States

Facility Name

Saint Mary's Hospital and Regional Medical Center

City

Grand Junction

State/Province

Colorado

ZIP/Postal Code

81501

Country

United States

Facility Name

Grand Valley Oncology

City

Grand Junction

State/Province

Colorado

ZIP/Postal Code

81505

Country

United States

Facility Name

North Colorado Medical Center

City

Greeley

State/Province

Colorado

ZIP/Postal Code

80631

Country

United States

Facility Name

Good Samaritan Medical Center

City

Lafayette

State/Province

Colorado

ZIP/Postal Code

80026

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Littleton

City

Littleton

State/Province

Colorado

ZIP/Postal Code

80120

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Sky Ridge

City

Lone Tree

State/Province

Colorado

ZIP/Postal Code

80124

Country

United States

Facility Name

McKee Medical Center

City

Loveland

State/Province

Colorado

ZIP/Postal Code

80539

Country

United States

Facility Name

National Jewish Health-Northern Hematology Oncology

City

Thornton

State/Province

Colorado

ZIP/Postal Code

80260

Country

United States

Facility Name

SCL Health Lutheran Medical Center

City

Wheat Ridge

State/Province

Colorado

ZIP/Postal Code

80033

Country

United States

Facility Name

Smilow Cancer Center/Yale-New Haven Hospital

City

New Haven

State/Province

Connecticut

ZIP/Postal Code

06510

Country

United States

Facility Name

Yale University

City

New Haven

State/Province

Connecticut

ZIP/Postal Code

06520

Country

United States

Facility Name

Beebe Medical Center

City

Lewes

State/Province

Delaware

ZIP/Postal Code

19958

Country

United States

Facility Name

Delaware Clinical and Laboratory Physicians PA

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Helen F Graham Cancer Center

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Medical Oncology Hematology Consultants PA

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Christiana Care Health System-Christiana Hospital

City

Newark

State/Province

Delaware

ZIP/Postal Code

19718

Country

United States

Facility Name

Beebe Health Campus

City

Rehoboth Beach

State/Province

Delaware

ZIP/Postal Code

19971

Country

United States

Facility Name

TidalHealth Nanticoke / Allen Cancer Center

City

Seaford

State/Province

Delaware

ZIP/Postal Code

19973

Country

United States

Facility Name

Christiana Care Health System-Wilmington Hospital

City

Wilmington

State/Province

Delaware

ZIP/Postal Code

19801

Country

United States

Facility Name

John Fitzgerald Kennedy Medical Center

City

Atlantis

State/Province

Florida

ZIP/Postal Code

33462

Country

United States

Facility Name

University of Florida Health Science Center - Gainesville

City

Gainesville

State/Province

Florida

ZIP/Postal Code

32610

Country

United States

Facility Name

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33021

Country

United States

Facility Name

Orlando Health Cancer Institute

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

Memorial Hospital West

City

Pembroke Pines

State/Province

Florida

ZIP/Postal Code

33028

Country

United States

Facility Name

Emory University Hospital Midtown

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30308

Country

United States

Facility Name

Piedmont Hospital

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30309

Country

United States

Facility Name

Emory University Hospital/Winship Cancer Institute

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30322

Country

United States

Facility Name

Emory Saint Joseph's Hospital

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342

Country

United States

Facility Name

Dekalb Medical Center

City

Decatur

State/Province

Georgia

ZIP/Postal Code

30033

Country

United States

Facility Name

Piedmont Fayette Hospital

City

Fayetteville

State/Province

Georgia

ZIP/Postal Code

30214

Country

United States

Facility Name

Medical Center of Central Georgia

City

Macon

State/Province

Georgia

ZIP/Postal Code

31201

Country

United States

Facility Name

Hawaii Cancer Care - Westridge

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Pali Momi Medical Center

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Queen's Cancer Center - Pearlridge

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

The Cancer Center of Hawaii-Pali Momi

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Hawaii Cancer Care Inc - Waterfront Plaza

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Island Urology

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Cancer Cenrer - POB I

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Straub Clinic and Hospital

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

University of Hawaii Cancer Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Hawaii Cancer Care Inc-Liliha

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Kuakini Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Queen's Cancer Center - Kuakini

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

The Cancer Center of Hawaii-Liliha

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Kaiser Permanente Moanalua Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96819

Country

United States

Facility Name

Kapiolani Medical Center for Women and Children

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96826

Country

United States

Facility Name

Wilcox Memorial Hospital and Kauai Medical Clinic

City

Lihue

State/Province

Hawaii

ZIP/Postal Code

96766

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center-Boise

City

Boise

State/Province

Idaho

ZIP/Postal Code

83706

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center-Caldwell

City

Caldwell

State/Province

Idaho

ZIP/Postal Code

83605

Country

United States

Facility Name

Kootenai Health - Coeur d'Alene

City

Coeur d'Alene

State/Province

Idaho

ZIP/Postal Code

83814

Country

United States

Facility Name

Walter Knox Memorial Hospital

City

Emmett

State/Province

Idaho

ZIP/Postal Code

83617

Country

United States

Facility Name

Idaho Urologic Institute-Meridian

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83642

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center-Nampa

City

Nampa

State/Province

Idaho

ZIP/Postal Code

83687

Country

United States

Facility Name

Kootenai Clinic Cancer Services - Post Falls

City

Post Falls

State/Province

Idaho

ZIP/Postal Code

83854

Country

United States

Facility Name

Kootenai Cancer Clinic

City

Sandpoint

State/Province

Idaho

ZIP/Postal Code

83864

Country

United States

Facility Name

Rush - Copley Medical Center

City

Aurora

State/Province

Illinois

ZIP/Postal Code

60504

Country

United States

Facility Name

Northwestern University

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Facility Name

John H Stroger Jr Hospital of Cook County

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

Rush University Medical Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

University of Chicago Comprehensive Cancer Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637

Country

United States

Facility Name

Carle at The Riverfront

City

Danville

State/Province

Illinois

ZIP/Postal Code

61832

Country

United States

Facility Name

Carle Physician Group-Effingham

City

Effingham

State/Province

Illinois

ZIP/Postal Code

62401

Country

United States

Facility Name

Northwestern Medicine Lake Forest Hospital

City

Lake Forest

State/Province

Illinois

ZIP/Postal Code

60045

Country

United States

Facility Name

Carle Physician Group-Mattoon/Charleston

City

Mattoon

State/Province

Illinois

ZIP/Postal Code

61938

Country

United States

Facility Name

Loyola University Medical Center

City

Maywood

State/Province

Illinois

ZIP/Postal Code

60153

Country

United States

Facility Name

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

City

Melrose Park

State/Province

Illinois

ZIP/Postal Code

60160

Country

United States

Facility Name

Trinity Medical Center

City

Moline

State/Province

Illinois

ZIP/Postal Code

61265

Country

United States

Facility Name

Good Samaritan Regional Health Center

City

Mount Vernon

State/Province

Illinois

ZIP/Postal Code

62864

Country

United States

Facility Name

UC Comprehensive Cancer Center at Silver Cross

City

New Lenox

State/Province

Illinois

ZIP/Postal Code

60451

Country

United States

Facility Name

University of Chicago Medicine-Orland Park

City

Orland Park

State/Province

Illinois

ZIP/Postal Code

60462

Country

United States

Facility Name

Carle Cancer Center

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

The Carle Foundation Hospital

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

Rush-Copley Healthcare Center

City

Yorkville

State/Province

Illinois

ZIP/Postal Code

60560

Country

United States

Facility Name

Deaconess Clinic Downtown

City

Evansville

State/Province

Indiana

ZIP/Postal Code

47713

Country

United States

Facility Name

Parkview Hospital Randallia

City

Fort Wayne

State/Province

Indiana

ZIP/Postal Code

46805

Country

United States

Facility Name

Parkview Regional Medical Center

City

Fort Wayne

State/Province

Indiana

ZIP/Postal Code

46845

Country

United States

Facility Name

Goshen Center for Cancer Care

City

Goshen

State/Province

Indiana

ZIP/Postal Code

46526

Country

United States

Facility Name

Chancellor Center for Oncology

City

Newburgh

State/Province

Indiana

ZIP/Postal Code

47630

Country

United States

Facility Name

University of Iowa/Holden Comprehensive Cancer Center

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242

Country

United States

Facility Name

Coffeyville Regional Medical Center

City

Coffeyville

State/Province

Kansas

ZIP/Postal Code

67337

Country

United States

Facility Name

Central Care Cancer Center - Garden City

City

Garden City

State/Province

Kansas

ZIP/Postal Code

67846

Country

United States

Facility Name

Central Care Cancer Center - Great Bend

City

Great Bend

State/Province

Kansas

ZIP/Postal Code

67530

Country

United States

Facility Name

HaysMed University of Kansas Health System

City

Hays

State/Province

Kansas

ZIP/Postal Code

67601

Country

United States

Facility Name

University of Kansas Cancer Center

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66160

Country

United States

Facility Name

Kansas Institute of Medicine Cancer and Blood Center

City

Lenexa

State/Province

Kansas

ZIP/Postal Code

66219

Country

United States

Facility Name

Minimally Invasive Surgery Hospital

City

Lenexa

State/Province

Kansas

ZIP/Postal Code

66219

Country

United States

Facility Name

Olathe Health Cancer Center

City

Olathe

State/Province

Kansas

ZIP/Postal Code

66061

Country

United States

Facility Name

Menorah Medical Center

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66209

Country

United States

Facility Name

University of Kansas Cancer Center-Overland Park

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66210

Country

United States

Facility Name

University of Kansas Hospital-Indian Creek Campus

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66211

Country

United States

Facility Name

Ascension Via Christi - Pittsburg

City

Pittsburg

State/Province

Kansas

ZIP/Postal Code

66762

Country

United States

Facility Name

Salina Regional Health Center

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

University of Kansas Health System Saint Francis Campus

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Facility Name

University of Kansas Hospital-Westwood Cancer Center

City

Westwood

State/Province

Kansas

ZIP/Postal Code

66205

Country

United States

Facility Name

Louisiana State University Health Science Center

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

University Medical Center New Orleans

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Anne Arundel Medical Center

City

Annapolis

State/Province

Maryland

ZIP/Postal Code

21401

Country

United States

Facility Name

Greater Baltimore Medical Center

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21204

Country

United States

Facility Name

UM Upper Chesapeake Medical Center

City

Bel Air

State/Province

Maryland

ZIP/Postal Code

21014

Country

United States

Facility Name

Lahey Hospital and Medical Center

City

Burlington

State/Province

Massachusetts

ZIP/Postal Code

01805

Country

United States

Facility Name

Winchester Hospital

City

Winchester

State/Province

Massachusetts

ZIP/Postal Code

01890

Country

United States

Facility Name

Henry Ford Cancer Institute-Downriver

City

Brownstown

State/Province

Michigan

ZIP/Postal Code

48183

Country

United States

Facility Name

Henry Ford Macomb Hospital-Clinton Township

City

Clinton Township

State/Province

Michigan

ZIP/Postal Code

48038

Country

United States

Facility Name

Henry Ford Medical Center-Fairlane

City

Dearborn

State/Province

Michigan

ZIP/Postal Code

48126

Country

United States

Facility Name

Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Allegiance Health

City

Jackson

State/Province

Michigan

ZIP/Postal Code

49201

Country

United States

Facility Name

Henry Ford Medical Center-Columbus

City

Novi

State/Province

Michigan

ZIP/Postal Code

48377

Country

United States

Facility Name

Henry Ford West Bloomfield Hospital

City

West Bloomfield

State/Province

Michigan

ZIP/Postal Code

48322

Country

United States

Facility Name

Sanford Joe Lueken Cancer Center

City

Bemidji

State/Province

Minnesota

ZIP/Postal Code

56601

Country

United States

Facility Name

Fairview Ridges Hospital

City

Burnsville

State/Province

Minnesota

ZIP/Postal Code

55337

Country

United States

Facility Name

Cambridge Medical Center

City

Cambridge

State/Province

Minnesota

ZIP/Postal Code

55008

Country

United States

Facility Name

Mercy Hospital

City

Coon Rapids

State/Province

Minnesota

ZIP/Postal Code

55433

Country

United States

Facility Name

Fairview Southdale Hospital

City

Edina

State/Province

Minnesota

ZIP/Postal Code

55435

Country

United States

Facility Name

Unity Hospital

City

Fridley

State/Province

Minnesota

ZIP/Postal Code

55432

Country

United States

Facility Name

Fairview Clinics and Surgery Center Maple Grove

City

Maple Grove

State/Province

Minnesota

ZIP/Postal Code

55369

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Maplewood

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Saint John's Hospital - Healtheast

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Abbott-Northwestern Hospital

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55407

Country

United States

Facility Name

Hennepin County Medical Center

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55415

Country

United States

Facility Name

Health Partners Inc

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55454

Country

United States

Facility Name

Monticello Cancer Center

City

Monticello

State/Province

Minnesota

ZIP/Postal Code

55362

Country

United States

Facility Name

New Ulm Medical Center

City

New Ulm

State/Province

Minnesota

ZIP/Postal Code

56073

Country

United States

Facility Name

North Memorial Medical Health Center

City

Robbinsdale

State/Province

Minnesota

ZIP/Postal Code

55422

Country

United States

Facility Name

Mayo Clinic in Rochester

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

Park Nicollet Clinic - Saint Louis Park

City

Saint Louis Park

State/Province

Minnesota

ZIP/Postal Code

55416

Country

United States

Facility Name

Regions Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55101

Country

United States

Facility Name

United Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

Saint Francis Regional Medical Center

City

Shakopee

State/Province

Minnesota

ZIP/Postal Code

55379

Country

United States

Facility Name

Lakeview Hospital

City

Stillwater

State/Province

Minnesota

ZIP/Postal Code

55082

Country

United States

Facility Name

Ridgeview Medical Center

City

Waconia

State/Province

Minnesota

ZIP/Postal Code

55387

Country

United States

Facility Name

Rice Memorial Hospital

City

Willmar

State/Province

Minnesota

ZIP/Postal Code

56201

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Woodbury

City

Woodbury

State/Province

Minnesota

ZIP/Postal Code

55125

Country

United States

Facility Name

Fairview Lakes Medical Center

City

Wyoming

State/Province

Minnesota

ZIP/Postal Code

55092

Country

United States

Facility Name

Saint Louis Cancer and Breast Institute-Ballwin

City

Ballwin

State/Province

Missouri

ZIP/Postal Code

63011

Country

United States

Facility Name

Central Care Cancer Center - Bolivar

City

Bolivar

State/Province

Missouri

ZIP/Postal Code

65613

Country

United States

Facility Name

Cox Cancer Center Branson

City

Branson

State/Province

Missouri

ZIP/Postal Code

65616

Country

United States

Facility Name

Siteman Cancer Center at West County Hospital

City

Creve Coeur

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Centerpoint Medical Center LLC

City

Independence

State/Province

Missouri

ZIP/Postal Code

64057

Country

United States

Facility Name

Freeman Health System

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Mercy Hospital Joplin

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Truman Medical Centers

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

The University of Kansas Cancer Center-South

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64131

Country

United States

Facility Name

Research Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64132

Country

United States

Facility Name

University of Kansas Cancer Center - North

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64154

Country

United States

Facility Name

University of Kansas Cancer Center - Lee's Summit

City

Lee's Summit

State/Province

Missouri

ZIP/Postal Code

64064

Country

United States

Facility Name

Delbert Day Cancer Institute at PCRMC

City

Rolla

State/Province

Missouri

ZIP/Postal Code

65401

Country

United States

Facility Name

Mercy Clinic-Rolla-Cancer and Hematology

City

Rolla

State/Province

Missouri

ZIP/Postal Code

65401

Country

United States

Facility Name

Heartland Regional Medical Center

City

Saint Joseph

State/Province

Missouri

ZIP/Postal Code

64506

Country

United States

Facility Name

Saint Louis Cancer and Breast Institute-South City

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63109

Country

United States

Facility Name

Washington University School of Medicine

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

Mercy Hospital South

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63128

Country

United States

Facility Name

Siteman Cancer Center-South County

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63129

Country

United States

Facility Name

Siteman Cancer Center at Christian Hospital

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63136

Country

United States

Facility Name

Mercy Hospital Saint Louis

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Siteman Cancer Center at Saint Peters Hospital

City

Saint Peters

State/Province

Missouri

ZIP/Postal Code

63376

Country

United States

Facility Name

Mercy Hospital Springfield

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65804

Country

United States

Facility Name

CoxHealth South Hospital

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65807

Country

United States

Facility Name

Mercy Hospital Washington

City

Washington

State/Province

Missouri

ZIP/Postal Code

63090

Country

United States

Facility Name

Community Hospital of Anaconda

City

Anaconda

State/Province

Montana

ZIP/Postal Code

59711

Country

United States

Facility Name

Billings Clinic Cancer Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Saint Vincent Healthcare

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Saint Vincent Frontier Cancer Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59102

Country

United States

Facility Name

Bozeman Deaconess Hospital

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

Saint James Community Hospital and Cancer Treatment Center

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Benefis Healthcare- Sletten Cancer Institute

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Great Falls Clinic

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Saint Peter's Community Hospital

City

Helena

State/Province

Montana

ZIP/Postal Code

59601

Country

United States

Facility Name

Kalispell Regional Medical Center

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Community Medical Hospital

City

Missoula

State/Province

Montana

ZIP/Postal Code

59804

Country

United States

Facility Name

The Cancer Institute of New Jersey Hamilton

City

Hamilton

State/Province

New Jersey

ZIP/Postal Code

08690

Country

United States

Facility Name

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

City

New Brunswick

State/Province

New Jersey

ZIP/Postal Code

08903

Country

United States

Facility Name

Rutgers Cancer Institute of New Jersey

City

New Brunswick

State/Province

New Jersey

ZIP/Postal Code

08903

Country

United States

Facility Name

University of New Mexico Cancer Center

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87102

Country

United States

Facility Name

Montefiore Medical Center-Einstein Campus

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Facility Name

Montefiore Medical Center-Weiler Hospital

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Facility Name

Montefiore Medical Center - Moses Campus

City

Bronx

State/Province

New York

ZIP/Postal Code

10467

Country

United States

Facility Name

Roswell Park Cancer Institute

City

Buffalo

State/Province

New York

ZIP/Postal Code

14263

Country

United States

Facility Name

Mount Sinai Union Square

City

New York

State/Province

New York

ZIP/Postal Code

10003

Country

United States

Facility Name

Mount Sinai West

City

New York

State/Province

New York

ZIP/Postal Code

10019

Country

United States

Facility Name

Mount Sinai Hospital

City

New York

State/Province

New York

ZIP/Postal Code

10029

Country

United States

Facility Name

State University of New York Upstate Medical University

City

Syracuse

State/Province

New York

ZIP/Postal Code

13210

Country

United States

Facility Name

SUNY Upstate Medical Center-Community Campus

City

Syracuse

State/Province

New York

ZIP/Postal Code

13215

Country

United States

Facility Name

UNC Lineberger Comprehensive Cancer Center

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599

Country

United States

Facility Name

Carolinas Medical Center/Levine Cancer Institute

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28203

Country

United States

Facility Name

Atrium Health Pineville/LCI-Pineville

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28210

Country

United States

Facility Name

Duke University Medical Center

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

Wake Forest University at Elkin

City

Elkin

State/Province

North Carolina

ZIP/Postal Code

28521

Country

United States

Facility Name

Wake Forest University at Lexington

City

Lexington

State/Province

North Carolina

ZIP/Postal Code

27292

Country

United States

Facility Name

Atrium Health Union/LCI-Union

City

Monroe

State/Province

North Carolina

ZIP/Postal Code

28112

Country

United States

Facility Name

Wake Forest University at Mount Airy

City

Mount Airy

State/Province

North Carolina

ZIP/Postal Code

27030

Country

United States

Facility Name

Wake Forest University Health Sciences

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157

Country

United States

Facility Name

Sanford Bismarck Medical Center

City

Bismarck

State/Province

North Dakota

ZIP/Postal Code

58501

Country

United States

Facility Name

Sanford Broadway Medical Center

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58122

Country

United States

Facility Name

Sanford Roger Maris Cancer Center

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58122

Country

United States

Facility Name

UHHS-Chagrin Highlands Medical Center

City

Beachwood

State/Province

Ohio

ZIP/Postal Code

44122

Country

United States

Facility Name

Case Western Reserve University

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44106

Country

United States

Facility Name

Ohio State University Comprehensive Cancer Center

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43210

Country

United States

Facility Name

UH Seidman Cancer Center at Saint John Medical Center

City

Westlake

State/Province

Ohio

ZIP/Postal Code

44145

Country

United States

Facility Name

UHHS-Westlake Medical Center

City

Westlake

State/Province

Ohio

ZIP/Postal Code

44145

Country

United States

Facility Name

University of Oklahoma Health Sciences Center

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73104

Country

United States

Facility Name

Mercy Hospital Oklahoma City

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73120

Country

United States

Facility Name

Saint Alphonsus Medical Center-Baker City

City

Baker City

State/Province

Oregon

ZIP/Postal Code

97814

Country

United States

Facility Name

Saint Alphonsus Medical Center-Ontario

City

Ontario

State/Province

Oregon

ZIP/Postal Code

97914

Country

United States

Facility Name

Jefferson Abington Hospital

City

Abington

State/Province

Pennsylvania

ZIP/Postal Code

19001

Country

United States

Facility Name

UPMC-Heritage Valley Health System Beaver

City

Beaver

State/Province

Pennsylvania

ZIP/Postal Code

15009

Country

United States

Facility Name

Christiana Care Health System-Concord Health Center

City

Chadds Ford

State/Province

Pennsylvania

ZIP/Postal Code

19317

Country

United States

Facility Name

Ephrata Cancer Center

City

Ephrata

State/Province

Pennsylvania

ZIP/Postal Code

17522

Country

United States

Facility Name

Ephrata Community Hospital

City

Ephrata

State/Province

Pennsylvania

ZIP/Postal Code

17522

Country

United States

Facility Name

Adams Cancer Center

City

Gettysburg

State/Province

Pennsylvania

ZIP/Postal Code

17325

Country

United States

Facility Name

UPMC Cancer Centers - Arnold Palmer Pavilion

City

Greensburg

State/Province

Pennsylvania

ZIP/Postal Code

15601

Country

United States

Facility Name

Cherry Tree Cancer Center

City

Hanover

State/Province

Pennsylvania

ZIP/Postal Code

17331

Country

United States

Facility Name

UPMC Pinnacle Harrisburg

City

Harrisburg

State/Province

Pennsylvania

ZIP/Postal Code

17101

Country

United States

Facility Name

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

City

Harrisburg

State/Province

Pennsylvania

ZIP/Postal Code

17109

Country

United States

Facility Name

UPMC-Johnstown/John P. Murtha Regional Cancer Center

City

Johnstown

State/Province

Pennsylvania

ZIP/Postal Code

15901

Country

United States

Facility Name

Sechler Family Cancer Center

City

Lebanon

State/Province

Pennsylvania

ZIP/Postal Code

17042

Country

United States

Facility Name

UPMC Cancer Center at UPMC McKeesport

City

McKeesport

State/Province

Pennsylvania

ZIP/Postal Code

15132

Country

United States

Facility Name

UPMC Hillman Cancer Center in Coraopolis

City

Moon

State/Province

Pennsylvania

ZIP/Postal Code

15108

Country

United States

Facility Name

Allegheny General Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15212

Country

United States

Facility Name

UPMC-Magee Womens Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15213

Country

United States

Facility Name

UPMC-Presbyterian Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15213

Country

United States

Facility Name

UPMC-Saint Margaret

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15215

Country

United States

Facility Name

University of Pittsburgh Cancer Institute (UPCI)

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15232

Country

United States

Facility Name

UPMC-Shadyside Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15232

Country

United States

Facility Name

UPMC-Passavant Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15237

Country

United States

Facility Name

UPMC-Saint Clair Hospital Cancer Center

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15243

Country

United States

Facility Name

UPMC Cancer Center at UPMC Northwest

City

Seneca

State/Province

Pennsylvania

ZIP/Postal Code

16346

Country

United States

Facility Name

UPMC Uniontown Hospital Radiation Oncology

City

Uniontown

State/Province

Pennsylvania

ZIP/Postal Code

15401

Country

United States

Facility Name

UPMC Washington Hospital Radiation Oncology

City

Washington

State/Province

Pennsylvania

ZIP/Postal Code

15301

Country

United States

Facility Name

Reading Hospital

City

West Reading

State/Province

Pennsylvania

ZIP/Postal Code

19611

Country

United States

Facility Name

Wexford Health and Wellness Pavilion

City

Wexford

State/Province

Pennsylvania

ZIP/Postal Code

15090

Country

United States

Facility Name

WellSpan Health-York Cancer Center

City

York

State/Province

Pennsylvania

ZIP/Postal Code

17403

Country

United States

Facility Name

WellSpan Health-York Hospital

City

York

State/Province

Pennsylvania

ZIP/Postal Code

17403

Country

United States

Facility Name

Women and Infants Hospital

City

Providence

State/Province

Rhode Island

ZIP/Postal Code

02905

Country

United States

Facility Name

Prisma Health Cancer Institute - Spartanburg

City

Boiling Springs

State/Province

South Carolina

ZIP/Postal Code

29316

Country

United States

Facility Name

Prisma Health Cancer Institute - Easley

City

Easley

State/Province

South Carolina

ZIP/Postal Code

29640

Country

United States

Facility Name

Prisma Health Cancer Institute - Butternut

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Faris

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Greenville Memorial Hospital

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Eastside

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Facility Name

Prisma Health Cancer Institute - Greer

City

Greer

State/Province

South Carolina

ZIP/Postal Code

29650

Country

United States

Facility Name

Prisma Health Cancer Institute - Seneca

City

Seneca

State/Province

South Carolina

ZIP/Postal Code

29672

Country

United States

Facility Name

Sanford Cancer Center Oncology Clinic

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57104

Country

United States

Facility Name

Avera Cancer Institute

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57105

Country

United States

Facility Name

Sanford USD Medical Center - Sioux Falls

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5134

Country

United States

Facility Name

Vanderbilt-Ingram Cancer Center Cool Springs

City

Franklin

State/Province

Tennessee

ZIP/Postal Code

37067

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Memphis

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Facility Name

Vanderbilt Breast Center at One Hundred Oaks

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37204

Country

United States

Facility Name

Vanderbilt University/Ingram Cancer Center

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37232

Country

United States

Facility Name

Houston Methodist Hospital

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

M D Anderson Cancer Center

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Doctor's Hospital of Laredo

City

Laredo

State/Province

Texas

ZIP/Postal Code

78041

Country

United States

Facility Name

Scott and White Healthcare Round Rock

City

Round Rock

State/Province

Texas

ZIP/Postal Code

78665

Country

United States

Facility Name

Houston Methodist Sugar Land Hospital

City

Sugar Land

State/Province

Texas

ZIP/Postal Code

77479

Country

United States

Facility Name

Scott and White Memorial Hospital

City

Temple

State/Province

Texas

ZIP/Postal Code

76508

Country

United States

Facility Name

Farmington Health Center

City

Farmington

State/Province

Utah

ZIP/Postal Code

84025

Country

United States

Facility Name

Huntsman Cancer Institute/University of Utah

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

South Jordan Health Center

City

South Jordan

State/Province

Utah

ZIP/Postal Code

84009

Country

United States

Facility Name

Sentara Cancer Institute at Sentara CarePlex Hospital

City

Hampton

State/Province

Virginia

ZIP/Postal Code

23666

Country

United States

Facility Name

Sentara Leigh Hospital

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23502

Country

United States

Facility Name

Sentara Norfolk General Hospital

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23507

Country

United States

Facility Name

Virginia Commonwealth University/Massey Cancer Center

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23298

Country

United States

Facility Name

Sentara Virginia Beach General Hospital

City

Virginia Beach

State/Province

Virginia

ZIP/Postal Code

23454

Country

United States

Facility Name

Sentara Princess Anne Hospital

City

Virginia Beach

State/Province

Virginia

ZIP/Postal Code

23456

Country

United States

Facility Name

United Hospital Center

City

Bridgeport

State/Province

West Virginia

ZIP/Postal Code

26330

Country

United States

Facility Name

WVUH-Berkely Medical Center

City

Martinsburg

State/Province

West Virginia

ZIP/Postal Code

25401

Country

United States

Facility Name

West Virginia University Healthcare

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26506

Country

United States

Facility Name

Camden Clark Medical Center

City

Parkersburg

State/Province

West Virginia

ZIP/Postal Code

26101

Country

United States

Facility Name

Aurora Cancer Care-Southern Lakes VLCC

City

Burlington

State/Province

Wisconsin

ZIP/Postal Code

53105

Country

United States

Facility Name

Aurora Health Center-Fond du Lac

City

Fond Du Lac

State/Province

Wisconsin

ZIP/Postal Code

54937

Country

United States

Facility Name

Aurora Health Care Germantown Health Center

City

Germantown

State/Province

Wisconsin

ZIP/Postal Code

53022

Country

United States

Facility Name

Aurora Cancer Care-Grafton

City

Grafton

State/Province

Wisconsin

ZIP/Postal Code

53024

Country

United States

Facility Name

Aurora BayCare Medical Center

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54311

Country

United States

Facility Name

Aurora Cancer Care-Kenosha South

City

Kenosha

State/Province

Wisconsin

ZIP/Postal Code

53142

Country

United States

Facility Name

Aurora Bay Area Medical Group-Marinette

City

Marinette

State/Province

Wisconsin

ZIP/Postal Code

54143

Country

United States

Facility Name

Aurora Cancer Care-Milwaukee

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53209

Country

United States

Facility Name

Aurora Saint Luke's Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53215

Country

United States

Facility Name

Aurora Sinai Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53233

Country

United States

Facility Name

Cancer Center of Western Wisconsin

City

New Richmond

State/Province

Wisconsin

ZIP/Postal Code

54017

Country

United States

Facility Name

Vince Lombardi Cancer Clinic - Oshkosh

City

Oshkosh

State/Province

Wisconsin

ZIP/Postal Code

54904

Country

United States

Facility Name

Aurora Cancer Care-Racine

City

Racine

State/Province

Wisconsin

ZIP/Postal Code

53406

Country

United States

Facility Name

Vince Lombardi Cancer Clinic-Sheboygan

City

Sheboygan

State/Province

Wisconsin

ZIP/Postal Code

53081

Country

United States

Facility Name

Aurora Medical Center in Summit

City

Summit

State/Province

Wisconsin

ZIP/Postal Code

53066

Country

United States

Facility Name

Vince Lombardi Cancer Clinic-Two Rivers

City

Two Rivers

State/Province

Wisconsin

ZIP/Postal Code

54241

Country

United States

Facility Name

Aurora Cancer Care-Milwaukee West

City

Wauwatosa

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

Aurora West Allis Medical Center

City

West Allis

State/Province

Wisconsin

ZIP/Postal Code

53227

Country

United States

Facility Name

Cheyenne Regional Medical Center-West

City

Cheyenne

State/Province

Wyoming

ZIP/Postal Code

82001

Country

United States

Facility Name

Billings Clinic-Cody

City

Cody

State/Province

Wyoming

ZIP/Postal Code

82414

Country

United States

Facility Name

Welch Cancer Center

City

Sheridan

State/Province

Wyoming

ZIP/Postal Code

82801

Country

United States

Facility Name

University Health Network-Princess Margaret Hospital

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 2M9

Country

Canada

Facility Name

CHUM - Centre Hospitalier de l'Universite de Montreal

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2X 3E4

Country

Canada

Facility Name

The Research Institute of the McGill University Health Centre (MUHC)

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3H 2R9

Country

Canada

Facility Name

Jewish General Hospital

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1E2

Country

Canada

12. IPD Sharing Statement

Plan to Share IPD

Citations:

PubMed Identifier

33740205

Citation

Gharzai LA, Szczygiel LA, Shumway DA, Bandos H, Julian TB, Mamounas EP, White J, De Los Santos JF, Basik M, Ganz PA, Jagsi R. A qualitative study to evaluate physician attitudes regarding omission of surgery among exceptional responders to neoadjuvant systemic therapy for breast cancer (NRG-CC006). Breast Cancer Res Treat. 2021 Jun;187(3):777-784. doi: 10.1007/s10549-021-06172-0. Epub 2021 Mar 19.

Results Reference

derived

Learn more about this trial

Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

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