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Predictors of Response to Insomnia Treatments for Gulf War Veterans

Primary Purpose

Insomnia

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Sleep Restriction Therapy
Cognitive Therapy
Sponsored by
VA Office of Research and Development
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Insomnia focused on measuring Insomnia, CBT, Gulf War Veterans, Sleep

Eligibility Criteria

20 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Male or female Gulf War Veterans of any racial or ethnic group
  • Independent Living (not in nursing home or VA Extended Care facility)
  • Subjective complaint of insomnia on the Insomnia Severity Index (ISI) greater than or equal to 10
  • Subjects with PTSD will be included in this study as long as they do not meet criteria for depression described below
  • Stable (3 weeks) CNS active medications that could significantly impact sleep or alertness
  • Stable adult onset diabetes, controlled with insulin, oral medications or diet is acceptable
  • Access to a device with video capabilities and ability to have the video on during study visits.

Exclusion Criteria:

Sleep-Related

  • Excessive caffeine consumption (4 cups of coffee per day) and unable to reduce to 3 cups a day before lunch a day for 3 weeks prior to treatment
  • Subjects will be initially screened by the Berlin Questionnaire (for sleep apnea)

    • Those with responses suggestive of high risk for sleep apnea will be referred to Pulmonary Medicine for standard clinical screening including polysomnography
    • Those in which apnea is primarily responsible for their sleep complaints should be excluded
  • Subjects working a rotating shift or an unconventional daytime shift (ending after 1830 h) will be ineligible

Neuropsychiatric

  • Hamilton Depression Scale (HDRS 24) and classified as high risk on the Columbia Suicide Severity Rating Scale (C-SSRS) in the past month
  • Individuals are considered high risk if they have endorsement of either of the following on the C-SSRS:

    • A positive endorsement, relative to the past 30 days, in the "Suicide Thoughts" section of item #4 (Have you had these thoughts and had some intention of acting on them) or item #5 (Have you started to work out or worked out the details of how to kill yourself? Do you intend to carry out this plan?
    • A positive endorsement, relative to the past 90 days, in the "Suicide Behavior" section of item #6 (Have you ever done anything, started to do anything, or prepared to do anything to end your life?)
  • Current or lifetime history of a psychiatric disorder with primary psychotic features
  • Current or lifetime bipolar disorder; prominent suicidal or homicidal ideation
  • Current exposure to trauma, or exposure to trauma in the past 3 months
  • Current or within the past 30 days: drug abuse or dependence (except nicotine)
  • Current or expected cognitive behavior therapy for another condition (e.g.,: depression)
  • Excessive alcohol consumption

    • >14 drinks per week or > 4 drinks per occasion
  • Presence of any acute or unstable psychiatric condition(s) that requires referral for treatment
  • Montreal Cognitive Assessment (MOCA) < 20 or Montreal Cognitive Assessment Blind (MOCA-Blind) < 15

Medical

  • Acute or unstable chronic illness, including but not limited to:

    • Uncontrolled thyroid disease
    • Kidney disease
    • Prostate or bladder conditions causing excessively frequent urination (> 3 times per night)
    • Medically unstable congestive heart failure
    • Angina
    • Other severe cardiac illness as defined by treatment regimen changes in the prior 3 months
    • Stroke with serious sequelae
    • Cancer if < 1 year since end of treatment
    • Asthma
    • Emphysema
    • Or other severe respiratory diseases uncontrolled with medications
    • Neurological disorders such as Alzheimer's disease, Parkinson's disease, and/or unstable epilepsy as defined by treatment regimen changes in the prior 3 months
  • Unstable adult-onset diabetes will be excluded

Sites / Locations

  • VA Palo Alto Health Care System, Palo Alto, CA
  • Washington DC VA Medical Center, Washington, DC
  • East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Sleep Restriction Therapy

Cognitive Therapy

Arm Description

Sleep Restriction Therapy (SR). The initial Time in Bed (TIB) prescription is calculated on the average total sleep time (TST) reported in the baseline sleep logs. After one week, depending on subject's daily sleep logs and adherence to treatment, the therapist suggests a new TIB prescription. Napping is neither prescribed nor proscribed. However, if subjects find themselves having difficulty staying awake during the day, they are advised to take a brief (15 to 30 minutes) nap to ensure their safety.

Cognitive Therapy (CT). The CT treatment module is designed to meet three general goals: 1) identify dysfunctional sleep cognitions, 2) challenge their validity, and 3) replace them with more adaptive substitutes. Several specific techniques designed to meet these goals are discussed in materials distributed to subjects. Similar to SR, subjects in CT are provided with information about relevant elements of the science of sleep and healthy sleep practices.

Outcomes

Primary Outcome Measures

Insomnia Severity Index
The Veteran's subjective experience of severity of insomnia using the Insomnia Severity Index (ISI). The ISI has been shown to be a reliable subjective measure of insomnia severity as well as a sensitive measure of symptom change including in Veteran insomnia treatment studies. Recently it has also been related to objective polysomnography measures. The scale ranges from 0 to 28, with a score of 0-7 indicating no clinically significant insomnia, scores 8-14 indicating sub-threshold insomnia, 15-21 indicating moderate insomnia and 22-28 indicating severe insomnia.

Secondary Outcome Measures

Wake After Sleep Onset
Wake After Sleep Onset (WASO) will be measured by daily sleep logs. This is included as a secondary measure because difficulty in maintaining sleep is the most commonly reported insomnia complaint; i.e., they either experience unwanted wake time during the night and/or they wake earlier than they want in the morning.
SF 36-Item Health Survey 1.0 (SF-36)
The SF-36 measures Quality of Life (QOL), including both emotional and physical disabilities, is easy to understand, brief, widely used, and has been found to be useful as a measure of health status. It covers 8 domains of QOL: physical functioning, role functioning/physical, role functioning/emotional, energy/fatigue, emotional well-being, social functioning, pain, general health, and a single-item ninth component: reported health transition (health compared to 1 year ago). Each of the dimensions of the SF-36 yields a score (1-100). Large sample means and standard deviations of the 8 dimensional scales have been published for various subject populations and disease groups. We will use the general health domain as our overall indicator of health-related QOL and perform additional analyses on the 8 individual scales.
Functional Outcomes of Sleep Questionnaire (FOSQ)
The FOSQ is designed to be administered to individuals who have a sleep disorder and is recommended for use in intervention studies as an outcome measure. The questionnaire is designed to measure functional status in situations that produce sleepiness. There are five subscales: vigilance, intimacy and sexual relationships, general productivity, activity level, and social outcome. Test-retest reliability for the scale has been found to be .91 when administered a week apart. The internal consistency of the components and the total score was above .85 (Cronbach's alpha).
Multidimensional Fatigue Inventory (MFI)
The MFI is designed to measure domains of fatigue including General Fatigue, Physical Fatigue, Mental Fatigue Reduced Motivation and Reduced Activity. CBT for insomnia has previously been associated with improvements in overall fatigue levels.

Full Information

First Posted
June 30, 2017
Last Updated
June 1, 2023
Sponsor
VA Office of Research and Development
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1. Study Identification

Unique Protocol Identification Number
NCT03208049
Brief Title
Predictors of Response to Insomnia Treatments for Gulf War Veterans
Official Title
Predictors of Response to Insomnia Treatments for Gulf War Veterans
Study Type
Interventional

2. Study Status

Record Verification Date
June 2023
Overall Recruitment Status
Completed
Study Start Date
August 1, 2017 (Actual)
Primary Completion Date
October 21, 2022 (Actual)
Study Completion Date
May 21, 2023 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
VA Office of Research and Development

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this study is to evaluate the efficacy and effectiveness of Sleep Restriction (SR) and Cognitive Therapy (CT) in Gulf War Veterans with insomnia. The primary hypothesis is that the efficacy of these treatments will depend upon an individual subject's baseline characteristics. For SR we expect that baseline measures of "excessive time spent in bed" may predict response and for CT we expect that baseline measures of cognitive arousal and pain may predict response. Exploratory analyses using signal detection techniques will systematically compare and contrast the potential usefulness of a number of additional potential moderator measures. Insomnia is a serious health problem in Gulf War Veterans that is often associated with extensive prescription of sleeping medications. Although safer, even the latest medications can lead to cognitive impairment and risk of abuse. Thus, non-pharmacological treatments for insomnia have been pursued as alternatives to medications. Cognitive Behavior Therapy for Insomnia (CBT-I) combines behavioral and cognitive components of therapy to address symptoms of insomnia. The combined CBT-I approach has well-documented efficacy. Between 2012 and 2014 over 650 VA mental health clinicians have received extensive training in CBT-I. Although CBT-I is efficacious, the optimal target populations for its major components has not yet been well-defined for Gulf War Veterans. We propose to address this gap and develop tools for clinicians to identify the best treatment for insomnia for individual Gulf War Veterans.
Detailed Description
Our hypotheses will be tested in a randomized parallel groups design. Randomization will be based on type of treatment assignment: either to SR or CT. After screening and randomization in the 2-week baseline phase, subjects will receive SR or CT in the 6-week treatment phase. There will be no more treatment after this point. At the end of the 6-week treatment, subjects will return to repeat many of the psychological tests administered during baseline to determine the short-term benefit. This 4-year proposal will include 100 subjects (2 groups of 50 each) with outcome, mediator, and moderator measures collected at appropriate points. All subjects will receive education about basic sleep hygiene as well as information about the science of sleep including sleep stages and sleep regulation. Sleep Restriction Therapy (SR). The initial Time in Bed (TIB) prescription is calculated from the average total sleep time (TST) reported in the baseline sleep logs. After one week, depending on subject's daily sleep logs and adherence to treatment, the therapist suggests a new TIB prescription. Napping is neither prescribed nor proscribed. However, if subjects find themselves having difficulty staying awake during the day, they are advised to take a brief (15 to 30 minutes) nap to ensure their safety. Cognitive Therapy (CT). CT is designed to meet three general goals: 1) identify dysfunctional sleep cognitions, 2) challenge the validity of these thoughts, and 3) replace them with more adaptive substitutes. Several specific techniques designed to meet these goals are discussed in materials distributed to subjects. We will continue to monitor progress post-treatment during the follow-up period. The complete package of outcome measures will be repeated at the follow-up session. We will tell subjects that we expect the benefits of treatment to continue and/or improve with time and we will also encourage subjects to continue practicing the treatment instructions to maintain their progress after active treatment ends. Subjects will be screened for eligibility via a phone interview and an in-person evaluation. At the in-person evaluation, informed consent will be received and documented. The evaluation will consist of measures of cognitive impairment and depression, sleep disturbance, and medical and psychiatric history. Exclusion criteria will be evaluated by the following measures: Acute/Unstable Chronic Illness Checklist, Berlin Questionnaire, Columbia Suicide Severity Rating Scale (C-SSRS), the Duke Structured Interview for Sleep Disorders (Duke), Hamilton Depression Rating Scale (HDRS), Life Stressor Checklist, Mini International Neuropsychiatric Interview Version 5 (MINI), Montreal Cognitive Assessment (MOCA), Morningness-Eveningness Questionnaire (MEQ), Sleep Related Behavior Questionnaire, and the Thought Control Questionnaire Insomnia-Revised (TCQI). At Palo Alto, subjects will additionally be provided with and instructed in the use of at-home PSG equipment. A 24-channel EEG cap will be placed on the participant's head before they leave to ensure accurate recordings are obtained. The PSG will be completed in the subject's own home and be used to screen for Obstructive Sleep Apnea (OSA) and Periodic Limb Movement Disorder (PLMD). Subjects will return to the lab the next morning to have the equipment removed. At each visit during Weeks 1-8 and again at Week 32, participants will complete the Anxiety and Preoccupation about Sleep Questionnaire (APSQ), Depression Anxiety and Stress Scale (DASS-21), Epworth Sleepiness Scale, and the Insomnia Severity Index. Sleep diaries will be completed through the treatment phase (Weeks 1-8) and again at follow-up (Week 32). The following measures will be completed at weeks 1, 8, and 32: American Urological Association-8 (AUA-8) Nocturia Subscale; Brief Pain Inventory-Short Form (BPI-SF); Beck Anxiety Inventory (BAI); Beck Depression Inventory (BDI); Clinician Administered PTSD Scale (CAPS); Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS); Glasgow Content of Thoughts; Glasgow Sleep Effort Scale; Multidimensional Fatigue Inventory; Penn State Worry Questionnaire (PSWQ); Perceived Stress Scale (PSS); and the SF-36 (RAND). Subjects will be evaluated on Functional Outcomes of Sleep Questionnaire at weeks 1, 2, 8 and 32. Subjects will be evaluated on the Sleep Associated Monitoring Index (SAMI) at weeks 1 and 8. At Palo Alto, subjects will be evaluated on the Trail Making Test, MOCA, Color Word Interference Test, and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) at weeks 1 and 32. Following the completion of treatment at Week 7, subjects will complete the Treatment Adherence Survey, Treatment Satisfaction Survey, and Working Alliance Inventory. The Working Alliance Inventory will also be given at the second treatment session (Week 3). Blood will be drawn at Baseline and Week 32 to measure levels of C-reactive protein (CRP). Urine samples will be collected during each of the 3 study phases to monitor abstinence from recreational drugs, with the exception of medical marijuana used less than four times per week. Samples will be collected by nurses at the VA Clinical Studies Unit and analyzed by the VA laboratory. Remaining blood will be banked for analysis of genetic factors. Due to the COVID-19 pandemic, participants may complete all study sessions including the evaluations through telehealth. The telehealth study will still be available even after in-person research has resumed. For participants completing the study through telehealth, we will not collect the following measures: urine screen, blood draw, overnight PSG, Trail Making Test, or Color Word Interference test. For telehealth participants, the MOCA-Blind may replace the MOCA. All other measures can feasibly be done through telehealth.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Insomnia
Keywords
Insomnia, CBT, Gulf War Veterans, Sleep

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Our hypotheses will be tested in a randomized parallel groups design. Randomization will be based on type of treatment assignment: either to Sleep Restriction (SR) or to Cognitive Therapy (CT). After screening and randomization in the 2-week baseline phase, subjects will receive SR or CT in the 6-week treatment phase. There will be no more treatment after this point. At the end of the 6-week treatment, subjects will return to repeat many of the psychological tests.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
50 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Sleep Restriction Therapy
Arm Type
Experimental
Arm Description
Sleep Restriction Therapy (SR). The initial Time in Bed (TIB) prescription is calculated on the average total sleep time (TST) reported in the baseline sleep logs. After one week, depending on subject's daily sleep logs and adherence to treatment, the therapist suggests a new TIB prescription. Napping is neither prescribed nor proscribed. However, if subjects find themselves having difficulty staying awake during the day, they are advised to take a brief (15 to 30 minutes) nap to ensure their safety.
Arm Title
Cognitive Therapy
Arm Type
Experimental
Arm Description
Cognitive Therapy (CT). The CT treatment module is designed to meet three general goals: 1) identify dysfunctional sleep cognitions, 2) challenge their validity, and 3) replace them with more adaptive substitutes. Several specific techniques designed to meet these goals are discussed in materials distributed to subjects. Similar to SR, subjects in CT are provided with information about relevant elements of the science of sleep and healthy sleep practices.
Intervention Type
Behavioral
Intervention Name(s)
Sleep Restriction Therapy
Intervention Description
Sleep Restriction Therapy will regulate time spent in bed based on information collected from sleep diaries during evaluation and treatment. Sleep Restriction therapy is designed to improve sleep quality by matching opportunity for sleep to the amount of average total sleep calculated from sleep diaries. Once the quality of sleep has improved, sleep quantity is gradually increased by slowly increasing sleep opportunity. Stimulus control will strengthen the bed/sleep association by eliminating non-sleep activities from the bedroom.
Intervention Type
Behavioral
Intervention Name(s)
Cognitive Therapy
Intervention Description
Cognitive Therapy is designed to identify maladaptive beliefs about sleep, challenge their validity, and replace them with more adaptive thinking patterns. This therapy aims to reduce sleep-related worry, anxiety, and fear. The treatment phase of the study lasts six weeks. During treatment, you will meet with a study therapist for a total of six sessions: once per week for six consecutive weeks. Each session lasts approximately 60 minutes.
Primary Outcome Measure Information:
Title
Insomnia Severity Index
Description
The Veteran's subjective experience of severity of insomnia using the Insomnia Severity Index (ISI). The ISI has been shown to be a reliable subjective measure of insomnia severity as well as a sensitive measure of symptom change including in Veteran insomnia treatment studies. Recently it has also been related to objective polysomnography measures. The scale ranges from 0 to 28, with a score of 0-7 indicating no clinically significant insomnia, scores 8-14 indicating sub-threshold insomnia, 15-21 indicating moderate insomnia and 22-28 indicating severe insomnia.
Time Frame
6 weeks
Secondary Outcome Measure Information:
Title
Wake After Sleep Onset
Description
Wake After Sleep Onset (WASO) will be measured by daily sleep logs. This is included as a secondary measure because difficulty in maintaining sleep is the most commonly reported insomnia complaint; i.e., they either experience unwanted wake time during the night and/or they wake earlier than they want in the morning.
Time Frame
6 weeks
Title
SF 36-Item Health Survey 1.0 (SF-36)
Description
The SF-36 measures Quality of Life (QOL), including both emotional and physical disabilities, is easy to understand, brief, widely used, and has been found to be useful as a measure of health status. It covers 8 domains of QOL: physical functioning, role functioning/physical, role functioning/emotional, energy/fatigue, emotional well-being, social functioning, pain, general health, and a single-item ninth component: reported health transition (health compared to 1 year ago). Each of the dimensions of the SF-36 yields a score (1-100). Large sample means and standard deviations of the 8 dimensional scales have been published for various subject populations and disease groups. We will use the general health domain as our overall indicator of health-related QOL and perform additional analyses on the 8 individual scales.
Time Frame
6 weeks
Title
Functional Outcomes of Sleep Questionnaire (FOSQ)
Description
The FOSQ is designed to be administered to individuals who have a sleep disorder and is recommended for use in intervention studies as an outcome measure. The questionnaire is designed to measure functional status in situations that produce sleepiness. There are five subscales: vigilance, intimacy and sexual relationships, general productivity, activity level, and social outcome. Test-retest reliability for the scale has been found to be .91 when administered a week apart. The internal consistency of the components and the total score was above .85 (Cronbach's alpha).
Time Frame
6 weeks
Title
Multidimensional Fatigue Inventory (MFI)
Description
The MFI is designed to measure domains of fatigue including General Fatigue, Physical Fatigue, Mental Fatigue Reduced Motivation and Reduced Activity. CBT for insomnia has previously been associated with improvements in overall fatigue levels.
Time Frame
6 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male or female Gulf War Veterans of any racial or ethnic group Independent Living (not in nursing home or VA Extended Care facility) Subjective complaint of insomnia on the Insomnia Severity Index (ISI) greater than or equal to 10 Subjects with PTSD will be included in this study as long as they do not meet criteria for depression described below Stable (3 weeks) CNS active medications that could significantly impact sleep or alertness Stable adult onset diabetes, controlled with insulin, oral medications or diet is acceptable Access to a device with video capabilities and ability to have the video on during study visits. Exclusion Criteria: Sleep-Related Excessive caffeine consumption (4 cups of coffee per day) and unable to reduce to 3 cups a day before lunch a day for 3 weeks prior to treatment Subjects will be initially screened by the Berlin Questionnaire (for sleep apnea) Those with responses suggestive of high risk for sleep apnea will be referred to Pulmonary Medicine for standard clinical screening including polysomnography Those in which apnea is primarily responsible for their sleep complaints should be excluded Subjects working a rotating shift or an unconventional daytime shift (ending after 1830 h) will be ineligible Neuropsychiatric Hamilton Depression Scale (HDRS 24) and classified as high risk on the Columbia Suicide Severity Rating Scale (C-SSRS) in the past month Individuals are considered high risk if they have endorsement of either of the following on the C-SSRS: A positive endorsement, relative to the past 30 days, in the "Suicide Thoughts" section of item #4 (Have you had these thoughts and had some intention of acting on them) or item #5 (Have you started to work out or worked out the details of how to kill yourself? Do you intend to carry out this plan? A positive endorsement, relative to the past 90 days, in the "Suicide Behavior" section of item #6 (Have you ever done anything, started to do anything, or prepared to do anything to end your life?) Current or lifetime history of a psychiatric disorder with primary psychotic features Current or lifetime bipolar disorder; prominent suicidal or homicidal ideation Current exposure to trauma, or exposure to trauma in the past 3 months Current or within the past 30 days: drug abuse or dependence (except nicotine) Current or expected cognitive behavior therapy for another condition (e.g.,: depression) Excessive alcohol consumption >14 drinks per week or > 4 drinks per occasion Presence of any acute or unstable psychiatric condition(s) that requires referral for treatment Montreal Cognitive Assessment (MOCA) < 20 or Montreal Cognitive Assessment Blind (MOCA-Blind) < 15 Medical Acute or unstable chronic illness, including but not limited to: Uncontrolled thyroid disease Kidney disease Prostate or bladder conditions causing excessively frequent urination (> 3 times per night) Medically unstable congestive heart failure Angina Other severe cardiac illness as defined by treatment regimen changes in the prior 3 months Stroke with serious sequelae Cancer if < 1 year since end of treatment Asthma Emphysema Or other severe respiratory diseases uncontrolled with medications Neurological disorders such as Alzheimer's disease, Parkinson's disease, and/or unstable epilepsy as defined by treatment regimen changes in the prior 3 months Unstable adult-onset diabetes will be excluded
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jerome A Yesavage, MD
Organizational Affiliation
VA Palo Alto Health Care System, Palo Alto, CA
Official's Role
Principal Investigator
Facility Information:
Facility Name
VA Palo Alto Health Care System, Palo Alto, CA
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304-1207
Country
United States
Facility Name
Washington DC VA Medical Center, Washington, DC
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20422
Country
United States
Facility Name
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
City
East Orange
State/Province
New Jersey
ZIP/Postal Code
07018
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
29969907
Citation
Tao Y, Peters ME, Drye LT, Devanand DP, Mintzer JE, Pollock BG, Porsteinsson AP, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, Munro CA. Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2018 Nov;33(7):450-457. doi: 10.1177/1533317518783278. Epub 2018 Jul 3.
Results Reference
result
PubMed Identifier
29955803
Citation
Yesavage JA, Fairchild JK, Mi Z, Biswas K, Davis-Karim A, Phibbs CS, Forman SD, Thase M, Williams LM, Etkin A, O'Hara R, Georgette G, Beale T, Huang GD, Noda A, George MS; VA Cooperative Studies Program Study Team. Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans: A Randomized Clinical Trial. JAMA Psychiatry. 2018 Sep 1;75(9):884-893. doi: 10.1001/jamapsychiatry.2018.1483.
Results Reference
result
PubMed Identifier
29415058
Citation
McNerney MW, Sheng T, Nechvatal JM, Lee AG, Lyons DM, Soman S, Liao CP, O'Hara R, Hallmayer J, Taylor J, Ashford JW, Yesavage J, Adamson MM. Integration of neural and epigenetic contributions to posttraumatic stress symptoms: The role of hippocampal volume and glucocorticoid receptor gene methylation. PLoS One. 2018 Feb 7;13(2):e0192222. doi: 10.1371/journal.pone.0192222. eCollection 2018.
Results Reference
result
PubMed Identifier
33574646
Citation
Hantke N, Adamson MM, Noda A, Lazzeroni LC, Beaudreau SA, Yutsis M, Fairchild JK, Kinoshita LM, Kong J, Sheng T, Waltzman D, Ashford JW, Yesavage JA. Posttraumatic Stress Disorder-Associated Cognitive Deficits on the Repeatable Battery for the Assessment of Neuropsychological Status in a Veteran Population. Fed Pract. 2021 Jan;38(1):28-34. doi: 10.12788/fp.0083.
Results Reference
result

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Predictors of Response to Insomnia Treatments for Gulf War Veterans

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