Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia (RAPIDS-GN)
Gram-negative Bacteremia
About this trial
This is an interventional diagnostic trial for Gram-negative Bacteremia focused on measuring Gram-negative Bacteremia, ICU, Critically ill, Intensive Care Unit, Rapid identification, Rapid susceptibility, Accelerate PhenoTest™ BC Kit, Accelerate Pheno™ System (AXDX), Antimicrobial stewardship, Antimicrobial use
Eligibility Criteria
Inclusion Criteria:
- Positive blood culture with Gram stain showing GNB identified during local laboratory business hours.
Exclusion Criteria:
- Identification of GNB outside of local laboratory business hours (e.g. whenever laboratories are staffed to perform both rapid testing and routine testing)
- Positive blood culture for GNB at the same institution within prior 7 days (if known at the time of randomization).
- Deceased at the time of randomization.
- GNB plus gram-positive organism, gram-negative cocci, and/or yeast detected on Gram stain
- Previous enrollment in this study
- No Minnesota research authorization (Rochester site only)
Sites / Locations
- University of California, Los Angeles
- Mayo Clinic
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Standard blood culture and AST
Rapid organism identification and AST
Standard blood culture and antimicrobial susceptibility testing (AST), and antimicrobial stewardship.
Rapid organism identification and AST using the Accelerate PhenoTest™ BC Kit, performed on the Accelerate Pheno™ System (AXDX), and antimicrobial stewardship. The blood sample will also undergo standard culture and AST in addition to the rapid testing.