Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis, Plaque, Dental, Periodontal Diseases
About this trial
This is an interventional prevention trial for Gingivitis focused on measuring Cetylpyridium Chloride (CPC), Chewing Gum
Eligibility Criteria
Inclusion Criteria:
- Be aged 18 and older
- Be capable of giving informed consent themselves and are able and willing to participate in the study
- Patients willing to forgo any optional dental procedures during the study period, such as dental prophylaxis or teeth whitening
- Patients that regularly brush their teeth twice a day
Exclusion Criteria:
- Pregnant or breastfeeding women
- Patients taking long-term anti-microbial or anti-inflammatory drugs
- Patients unable or unwilling to provide informed consent
- Self-reported use of tobacco products
- Gross oral pathology, including widespread caries or chronic neglect, extensive restoration, pre-existing gross plaque or calculus, or soft or hard tissue tumor of the oral cavity
- Less than 26 teeth in the mouth
- Orthodontic appliances or removable partial dentures that will compromise the ability of the potential subject to participate in the study
- Periodontitis as indicated periodontal pockets greater than 5 millimeters on more than one site
- Inability to comply with assigned treatment regimen
Sites / Locations
- The University of Texas Health Science Center at Houston
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
CPC + Xylitol chewing gum, then Xylitol only chewing gum
Xylitol only chewing gum, then CPC + Xylitol chewing gum
Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum and then Xylitol only chewing gum All subjects will be instructed to chew four times a day, for at least 60 seconds, after which they expectorated. Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum will be used for the first 21 days, then there will be a washout period of 21 days, and finally Xylitol only chewing gum will be used for the last 21 days.
Xylitol only chewing gum and then Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum All subjects will be instructed to chew four times a day, for at least 60 seconds, after which they expectorated. Xylitol only chewing gum will be used for the first 21 days, then there will be a washout period of 21 days, and finally Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum will be used for the last 21 days.