Ketamine v. Ketorolac for Management of Generalized Tension Type Headache
Migraine
About this trial
This is an interventional treatment trial for Migraine
Eligibility Criteria
Inclusion Criteria:
The inclusion criteria are: Patients 18-65 years old who provides informed consent and presents to the ED with an acute tension type headache (TTH), as classified by meeting the following:
- Have at least 10 episodes of headache occurring on average less than 12 days per year AND Fullfuling B-D B. Lasting 30mins to 7 days C. At least 2 of the following 4 criteria
- bilateral location
- pressing/tightening (non-pulsating)
- mild or moderate
- not aggravated by routine physical activity such as walking or climbing stairs D. Both of the following
- no nausea/vomiting
- No more than one of photophobia or phonophobia
Exclusion Criteria: Non migraine primary headache disorder or unclassifiable, previous enrollment in study, fever >100.3, Patients with suspected secondary headache disorder such as SAH or sinusitis, performance of lumbar puncture or potential need for LP, Severe hypertension (≥180/100), History of CAD or hypertension, presence of/suspected for traumatic head injury in the past 30 days with or without loss of consciousness, Presence of/suspected for myocardial ischemia, presence of/suspected for alcohol intoxication, Hemodynamic instability, history of psychiatric disorders, known or suspected pregnancy or breast feeding, allergy to ketamine, ketorolac, previous enrollment in the study, patients with language barriers, refusal to provide consent to receive intravenous therapy, reported illicit drug use within the past 5 days, patients weighing over 100kg
Sites / Locations
- The Brooklyn Hospital CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intravenous ketamine
ketorolac
Arm will include 0.3 mg/kg intravenous piggyback ketamine over 10 minutes for 1 dose and a 1ml normal saline placebo via intravenous push
Arm will include 30mg ketorolac intravenous push and 50ml normal saline over 10 minutes