Effect of FODMAPs on Mucosal Inflammation in IBS Patients
Irritable Bowel Syndrome With Diarrhea
About this trial
This is an interventional basic science trial for Irritable Bowel Syndrome With Diarrhea focused on measuring Irritable bowel syndrome, Low FODMAP diet, Mucosal Inflammation
Eligibility Criteria
Inclusion Criteria:
- Males and females 18 years of older
- Meet the Rome IV criteria for IBS (abdominal pain or discomfort at least 3 days per month in the last three months associated with two or more of the following: defecation, onset associated with change of frequency of stool or change associated with a change in form of stool. The symptoms must be going on for more than six months and be associated with an absence of routine clinical red flags)
Exclusion Criteria:
- Patients with a history of gastric, small bowel or colonic surgery
- Patients with active Inflammatory Bowel Disease
- Patients with celiac disease
- Patients who are unable or unwilling to come off the following medications: antibiotics, stool bulking agents, narcotics, or lactulose.
- Patients who are already on a low-FODMAP diet or a diet that may be have substantially different FODMAP content from usual Canadian diet (paleolithic diet, specific carbohydrate diet, gluten-free diet, Atkins)
- Patients cannot have used antibiotics in the past 4 weeks.
- Pregnant patients will not be invited to participate. (Sexually active women of child-bearing age will be asked if it is possible that they are pregnant, and if there is a doubt, they will not be invited to participate.) Patients will confirm they are using birth control during the time they are participating in the study.
Sites / Locations
Arms of the Study
Arm 1
Experimental
Low and High FODMAP Diets in IBS
This study will be comprised of the following four time periods: "baseline", "run-in", "low FODMAP diet", and "high FODMAP diet". Participants will undergo baseline assessment with questionnaires on demographics, IBS symptoms (IBS symptom severity scoring questionnaire), diet, and psychological parameters. Baseline mucosal colonic biopsies will be obtained, and metabolome analysis from urine samples. These will be repeated 3 other times during each of the above time periods. Low FODMAP Diet followed by a High FODMAP Diet