Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
About this trial
This is an interventional diagnostic trial for Gastro Esophageal Reflux
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years
- Ability to give informed consent
Exclusion Criteria:
- Pregnancy
- Esophageal varices
- Prior esophageal or gastric surgery
- Active gastrointestinal bleeding
- Evidence of esophageal malignancy
- Inability to provide informed consent
Sites / Locations
- Hunter Holmes McGuire VA Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Non-erosive reflux disease (NERD)
Barrett's esophagus/erosive esophagitis
Control
Patient's with GERD refractory to PPI with no evidence of erosive esophagitis on endoscopy. Confocal endomicroscopy, endoscopic biopsies and mucosal impedance (MI) will be performed.
Patient's with Barrett's esophagus or with erosive esophagitis on endoscopy. Confocal endomicroscopy, endoscopic biopsies and mucosal impedance (MI) will be performed.
Patient's with no h/o GERD or Barrett's esophagus who are undergoing endoscopy for non-GERD related indication. Confocal endomicroscopy, endoscopic biopsies and mucosal impedance (MI) will be performed.