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The Effects of Attentional Filter Training on Working Memory (DIIN)

Primary Purpose

Cognitive Decline, Healthy, Age-related Cognitive Decline

Status
Completed
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
filter training
memory training
no training (control)
Sponsored by
German Center for Neurodegenerative Diseases (DZNE)
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Cognitive Decline focused on measuring training intervention, filter training, distractor inhibition

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • right-hander
  • aged between 18-30 or 60-80years

Exclusion Criteria:

  • severe visual impairments (e.g. dyschromatopsia, very low vision)
  • diseases or medication that might impair test performance
  • Montreal Cognitive Assessment Score (MoCA) < 26 points

Sites / Locations

  • DZNE

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Young subjects

Old subjects

Arm Description

Working memory training & attentional filter training for participants (18-30 years)

Working memory training, attentional filter training and no training (control) for participants (60-80 years)

Outcomes

Primary Outcome Measures

Improvements in test performance
Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 & 6 targets

Secondary Outcome Measures

Rey Complex Figure Test
Copying complex figures and reproduce it from memory
Memory from TAP (Test battery of Attentional Performance)
Working Memory (n-back)
Attention from TAP (Test battery of Attentional Performance)
divided attention, Go-NoGo, Flexibility, Incompatibility, Visual scanning
Performance in repeating numbers
Repeating numbers in forward & backward conditions
Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)
Spatial Span Test
Iowa Gambling Task
Decision making
Daily Questionnaires
subjective performance in the training paradigm
Daily Questionnaires
Assessing external circumstances of daily influences
Memory performance without distractors among different setsizes
Working memory performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors
Memory performance with distractors among different setsizes
Working memory performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors
Filtering performance without distractors among different setsizes
Filtering performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors
Filtering performance with distractors among different setsizes
Filtering performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors
Reaction times
Reaction times in each condition
Values of distractor inhibition
Distractor inhibition (DIIN) = Mean of conditions without distractors - Mean of conditions with distractors

Full Information

First Posted
July 12, 2017
Last Updated
February 12, 2019
Sponsor
German Center for Neurodegenerative Diseases (DZNE)
Collaborators
German Research Foundation
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1. Study Identification

Unique Protocol Identification Number
NCT03228446
Brief Title
The Effects of Attentional Filter Training on Working Memory
Acronym
DIIN
Official Title
Improving Cognitive Functions by Training Distractor Inhibition (DIIN) in Younger and Older Healthy Adults
Study Type
Interventional

2. Study Status

Record Verification Date
February 2019
Overall Recruitment Status
Completed
Study Start Date
September 26, 2012 (Actual)
Primary Completion Date
December 2018 (Actual)
Study Completion Date
January 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
German Center for Neurodegenerative Diseases (DZNE)
Collaborators
German Research Foundation

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.
Detailed Description
Two different computer based trainings were applied: an attentional filter training and a working memory training.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cognitive Decline, Healthy, Age-related Cognitive Decline
Keywords
training intervention, filter training, distractor inhibition

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Non-Randomized
Enrollment
60 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Young subjects
Arm Type
Experimental
Arm Description
Working memory training & attentional filter training for participants (18-30 years)
Arm Title
Old subjects
Arm Type
Experimental
Arm Description
Working memory training, attentional filter training and no training (control) for participants (60-80 years)
Intervention Type
Behavioral
Intervention Name(s)
filter training
Intervention Description
one-week filter training on the computer: computerized visual change detection experiment (selective attention )
Intervention Type
Behavioral
Intervention Name(s)
memory training
Intervention Description
one-week storage training on the computer: computerized visual change detection experiment (memory storage)
Intervention Type
Other
Intervention Name(s)
no training (control)
Intervention Description
no training applied
Primary Outcome Measure Information:
Title
Improvements in test performance
Description
Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 & 6 targets
Time Frame
45min pre / post
Secondary Outcome Measure Information:
Title
Rey Complex Figure Test
Description
Copying complex figures and reproduce it from memory
Time Frame
30min pre / post
Title
Memory from TAP (Test battery of Attentional Performance)
Description
Working Memory (n-back)
Time Frame
45min pre / post
Title
Attention from TAP (Test battery of Attentional Performance)
Description
divided attention, Go-NoGo, Flexibility, Incompatibility, Visual scanning
Time Frame
45min pre / post
Title
Performance in repeating numbers
Description
Repeating numbers in forward & backward conditions
Time Frame
10min pre / post
Title
Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)
Description
Spatial Span Test
Time Frame
10min pre / post
Title
Iowa Gambling Task
Description
Decision making
Time Frame
5min on each training day (1-5)
Title
Daily Questionnaires
Description
subjective performance in the training paradigm
Time Frame
2 min on each training day (1-5)
Title
Daily Questionnaires
Description
Assessing external circumstances of daily influences
Time Frame
2min on each training day (1-5)
Title
Memory performance without distractors among different setsizes
Description
Working memory performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors
Time Frame
45min pre / post
Title
Memory performance with distractors among different setsizes
Description
Working memory performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors
Time Frame
45min pre / post
Title
Filtering performance without distractors among different setsizes
Description
Filtering performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors
Time Frame
45min pre / post
Title
Filtering performance with distractors among different setsizes
Description
Filtering performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors
Time Frame
45min pre / post
Title
Reaction times
Description
Reaction times in each condition
Time Frame
45min pre / post
Title
Values of distractor inhibition
Description
Distractor inhibition (DIIN) = Mean of conditions without distractors - Mean of conditions with distractors
Time Frame
45min pre / post

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: right-hander aged between 18-30 or 60-80years Exclusion Criteria: severe visual impairments (e.g. dyschromatopsia, very low vision) diseases or medication that might impair test performance Montreal Cognitive Assessment Score (MoCA) < 26 points
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Notger Müller, Prof. Dr.
Organizational Affiliation
German Center for Neurodegenerative Diseases (DZNE)
Official's Role
Principal Investigator
Facility Information:
Facility Name
DZNE
City
Magdeburg
State/Province
Sachsen-Anhalt
ZIP/Postal Code
39120
Country
Germany

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
26765946
Citation
Schmicker M, Schwefel M, Vellage AK, Muller NG. Training of Attentional Filtering, but Not of Memory Storage, Enhances Working Memory Efficiency by Strengthening the Neuronal Gatekeeper Network. J Cogn Neurosci. 2016 Apr;28(4):636-42. doi: 10.1162/jocn_a_00922. Epub 2016 Jan 14.
Results Reference
result
PubMed Identifier
28386225
Citation
Schmicker M, Muller P, Schwefel M, Muller NG. Attentional Filter Training but Not Memory Training Improves Decision-Making. Front Hum Neurosci. 2017 Mar 23;11:138. doi: 10.3389/fnhum.2017.00138. eCollection 2017.
Results Reference
result

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The Effects of Attentional Filter Training on Working Memory

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