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Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance (FAT)

Primary Purpose

Exercise-induced Inflammation

Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Fish Oil
Placebo
Sponsored by
Loughborough University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Exercise-induced Inflammation

Eligibility Criteria

18 Years - 55 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Males
  • Healthy

Exclusion Criteria:

  • Resistance exercise training within the past 6 months
  • Vitamin or fish oil supplementation over the past 6 months
  • Habitual use of anti-inflammatory drugs
  • History of heart disease
  • History of coagulation/bleeding disorder
  • History of metabolic disease
  • Serious allergy
  • Known to have blood-borne virus
  • Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured)
  • Currently no symptoms of general illness

Sites / Locations

  • Loughborough University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Fish Oil

Placebo

Arm Description

Fish oil 5.1g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway

Olive Oil 6g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway

Outcomes

Primary Outcome Measures

Strength
Quadriceps and Hamstring strength using an isokinetic dynamometer
Leg power
Dynamic leg power assessed through jump height on force platform

Secondary Outcome Measures

Full Information

First Posted
August 4, 2017
Last Updated
March 26, 2018
Sponsor
Loughborough University
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1. Study Identification

Unique Protocol Identification Number
NCT03259412
Brief Title
Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance
Acronym
FAT
Official Title
Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance, Inflammation, Gene Expression and Epigenetic Signatures
Study Type
Interventional

2. Study Status

Record Verification Date
March 2018
Overall Recruitment Status
Completed
Study Start Date
January 1, 2016 (Actual)
Primary Completion Date
December 20, 2017 (Actual)
Study Completion Date
December 20, 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Loughborough University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance exercise training study. The investigators aim to establish the potential mechanisms that might mediate performance changes at a cellular level.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Exercise-induced Inflammation

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
18 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Fish Oil
Arm Type
Experimental
Arm Description
Fish oil 5.1g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Olive Oil 6g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway
Intervention Type
Dietary Supplement
Intervention Name(s)
Fish Oil
Other Intervention Name(s)
n-3 PUFA, Omega-3
Intervention Description
Fish Oil Capsule
Intervention Type
Dietary Supplement
Intervention Name(s)
Placebo
Other Intervention Name(s)
Olive Oil
Intervention Description
Olive Oil capsule manufactured to mimic fish oil capsule
Primary Outcome Measure Information:
Title
Strength
Description
Quadriceps and Hamstring strength using an isokinetic dynamometer
Time Frame
Change from baseline strength at 11 weeks
Title
Leg power
Description
Dynamic leg power assessed through jump height on force platform
Time Frame
Change from baseline strength at 11 weeks

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Males Healthy Exclusion Criteria: Resistance exercise training within the past 6 months Vitamin or fish oil supplementation over the past 6 months Habitual use of anti-inflammatory drugs History of heart disease History of coagulation/bleeding disorder History of metabolic disease Serious allergy Known to have blood-borne virus Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured) Currently no symptoms of general illness
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Lynsey S Wilson, MSc
Organizational Affiliation
Loughborough University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Loughborough University
City
Leicester
ZIP/Postal Code
LE11 3TU
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
No

Learn more about this trial

Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance

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