SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke (SEGA)
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring Acute stroke, Cerebral Stroke
Eligibility Criteria
Inclusion Criteria:
Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations that will be treated by endovascular therapy (EVT):
- Internal Carotid Artery (terminal "T" or "L-type"- occlusion)
- Middle Cerebral Artery (MCA) M1 or proximal M2
Anterior Cerebral Artery (ACA) A1 or proximal A2
- Patients who receive IV-tPA thrombolysis are eligible provided the drug was delivered within 4.5 hours of stroke onset or last seen normal and in accordance with local hospital standard of care.
- Ages 18-90.
- National Institute of Health Stroke Scale (NIHSS) score 6-30
- Time of from stroke symptom onset of last seen normal to start of EVT (defined as groin puncture) ≤ 16 hours.
Limited infarct core, as defined below and adapted from the 2018 American Heart Association guidelines
- For patients presenting ≤ 6 hours from time of symptom onset or last seen normal, Alberta Stroke Program Early Computed Tomography Score (ASPECTS) ≥ 6
- For patients presenting > 6 hours and ≤ 16 hours from time of symptom onset or last seen normal, they must satisfy EITHER ONE of the two following criteria:
i. Ischemic core by CT Perfusion or MRI/MR Perfusion < 70 mL, a ratio of volume of penumbral tissue to infarct core of ≥ 1.8, and and absolute volume of penumbral tissue of ≥ 15 mL OR ii. For patients with NIHSS ≥ 10, infarct core of < 31 mL by CT Perfusion or MRI; For patients with NIHSS ≥ 20, infarct core < 51 mL.
- Subject willing/able to return for protocol required follow up visits.
- No significant pre-stroke disability (modified Rankin Score must be ≤ 2).
- Females of childbearing potential must have a negative serum or urine pregnancy test.
- Patient or patient's legally authorized representative has given Informed Consent according to Good Clinical Practices (GCP) and/or local IRB policies.
Exclusion Criteria:
- Coma on admission (Glasgow Coma Scale <8), need for intubation upon ED arrival, or transferred patients who present previously intubated.
- Severe agitation or seizures on admission that preclude safe vascular access.
- Loss of airway protective reflexes and/or vomiting on admission.
- Predicted or known difficult airway.
- Pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations, e.g. dementia.
- Presumed septic embolus, or suspicion of bacterial endocarditis
- Currently participating or has participated in any investigational drug or device study within 30 days.
- Inability to follow-up for 90-day assessment.
- Known history of allergy to anesthesia drugs.
- Known history or family history of malignant hyperthermia
Sites / Locations
- Indiana University College of Medicine
- University of Iowa Hospitals and Clinics
- Henry Ford Health System
- Rochester Regional Health
- Wake Forest Baptist Health
- Geisinger Health
- Temple University
- Memorial Hermann Hospital System - Memorial City Medical Center
- Baylor College of Medicine
- University of Texas Health Science Center Houston with Memorial Hermann Hospital System - The Medical Center
- Memorial Hermann Hospital System - The Woodlands Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Sedation
General Anesthesia
The protocol does not specify a particular combination of drugs that must be used for sedation. The choice of specific drugs and dosages for achieving sedation will be up to the anesthesiologist.
The protocol does not specify a particular combination of drugs that must be used for general anesthesia. The choice of specific drugs and dosages for achieving general anesthesia will be up to the anesthesiologist.