The Computed Tomography-derived Fractional Flow Reserve STAT Trial (CTFFR-STAT)
Heart Disease, Coronary, Chest Pain, Acute Coronary Syndrome
About this trial
This is an interventional diagnostic trial for Heart Disease, Coronary focused on measuring angina, coronary artery disease, coronary artery catheterization, coronary CT angiography, fractional flow reserve CT, emergency department
Eligibility Criteria
Inclusion Criteria:
- Emergency department chest pain suspicious for ACS based on history and physical examination.
- At least one biomarker (troponin) and electrocardiogram with no evidence of definite ACS.
- A completed CCTA demonstrating >50% but <90% stenosis of at least one coronary artery branch.
- CCTA test images with sufficient diagnostic quality for CTFFR analysis.
- Ability and willingness to provide informed consent.
Exclusion Criteria:
- Left main coronary stenosis of 50% or greater.
- CCTA lesions demonstrating stenosis >90% ("subtotal"), or complex, high-risk plaque characteristics resulting in an a priori recommendation for triage to CATH by the CCTA interpreting physician.
- Attending physician a priori decision for CATH.
- Previous coronary stent, coronary bypass or prior known myocardial infarction.
- Clinical instability, such as hypotension, signs of shock, and/or accelerating chest pain requiring admission.
- Pregnancy
Sites / Locations
- Beaumont Health System - Royal Oak
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
SOC Group Management
CTFFR-Guided Group Management
Attending physicians will dictate SOC management according to their own clinical judgment for medical management, stress test plus imaging or coronary artery catheterization with invasive fractional flow reserve.
Patients in this group will be triaged using CTFFR. CTFFR values will be provided to physicians with recommendations for medical management or coronary artery catheterization with invasive fractional flow reserve.